GREMLIN Database
XDHD - Probable xanthine dehydrogenase subunit D
UniProt: O32144 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 745 (718)
Sequences: 5409 (3604)
Seq/√Len: 134.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_M115_L4.5881.00
38_L116_I4.2051.00
169_E282_K4.1901.00
33_L62_Q3.9781.00
105_T108_I3.8151.00
54_K117_Q3.6541.00
171_T280_T3.5791.00
42_Y45_A3.5411.00
286_D290_N3.3851.00
285_A365_L3.3411.00
295_D330_R3.3001.00
48_V119_E3.1671.00
165_D287_H3.1411.00
159_E163_A3.1341.00
165_D286_D3.1181.00
371_I379_K3.1101.00
479_V519_I3.1051.00
58_M108_I3.0971.00
46_E121_K3.0761.00
458_I485_C3.0631.00
291_L362_L3.0271.00
378_R405_N3.0211.00
156_D159_E2.9591.00
38_L113_L2.8941.00
62_Q104_E2.8751.00
169_E280_T2.8211.00
45_A120_Y2.8161.00
482_E524_K2.8081.00
42_Y122_E2.7861.00
297_K332_E2.7781.00
325_R386_D2.7551.00
551_G561_V2.7431.00
375_E379_K2.6581.00
44_H123_L2.6551.00
49_S119_E2.6271.00
102_A250_L2.6081.00
412_I415_K2.5461.00
282_K295_D2.5441.00
199_M213_L2.5181.00
104_E108_I2.4841.00
520_Q524_K2.4691.00
617_D680_K2.4311.00
48_V121_K2.4191.00
711_V727_I2.3981.00
198_T227_V2.3581.00
423_L605_E2.3531.00
35_G260_I2.3291.00
130_E278_K2.3241.00
290_N379_K2.3201.00
104_E256_R2.2801.00
724_K731_E2.2751.00
371_I376_L2.2401.00
52_T56_E2.2231.00
196_G498_A2.2131.00
297_K334_I2.2021.00
190_V200_Y2.1941.00
605_E616_I2.1871.00
225_R496_D2.1631.00
714_V727_I2.1561.00
161_F284_G2.1491.00
365_L376_L2.1421.00
457_K489_D2.0821.00
283_T361_H2.0731.00
301_D340_N2.0641.00
153_S330_R2.0371.00
131_K134_R2.0331.00
35_G100_A2.0181.00
37_V246_Y2.0041.00
375_E378_R1.9711.00
164_S284_G1.9691.00
290_N325_R1.9621.00
641_A679_M1.9501.00
173_E724_K1.9491.00
166_T287_H1.9451.00
563_T566_E1.9261.00
642_A676_V1.9231.00
41_A98_I1.9061.00
166_T285_A1.9041.00
406_A409_K1.9021.00
602_V709_A1.8971.00
527_L531_K1.8911.00
52_T64_V1.8841.00
383_K386_D1.8721.00
457_K491_S1.8711.00
452_L526_F1.8691.00
399_G402_Q1.8611.00
450_L460_A1.8601.00
281_I361_H1.8591.00
7_S487_A1.8581.00
46_E89_D1.8361.00
541_S544_N1.8201.00
51_C117_Q1.8191.00
128_S131_K1.8141.00
46_E90_R1.8031.00
425_R605_E1.7891.00
25_T259_K1.7811.00
53_I56_E1.7701.00
486_A489_D1.7591.00
196_G223_K1.7541.00
453_S459_T1.7291.00
476_E492_I1.7261.00
54_K115_L1.7251.00
62_Q256_R1.7251.00
512_T628_V1.7231.00
100_A250_L1.7131.00
55_A116_I1.7021.00
478_I516_W1.6991.00
453_S457_K1.6951.00
103_A109_A1.6851.00
407_I601_A1.6831.00
286_D292_L1.6651.00
42_Y120_Y1.6641.00
63_A253_K1.6591.00
9_V631_Q1.6571.00
406_A682_I1.6561.00
613_V732_L1.6551.00
186_G261_H1.6541.00
378_R401_A1.6481.00
633_Y698_V1.6471.00
35_G258_V1.6431.00
180_T665_L1.6301.00
394_I397_T1.6261.00
391_E395_A1.6151.00
58_M112_A1.6051.00
102_A254_S1.5941.00
153_S156_D1.5861.00
171_T278_K1.5831.00
181_Y237_G1.5791.00
602_V618_C1.5791.00
164_S292_L1.5781.00
460_A479_V1.5761.00
728_S731_E1.5751.00
166_T368_M1.5721.00
424_Q608_L1.5721.00
283_T291_L1.5711.00
367_G715_H1.5641.00
283_T365_L1.5621.00
392_H395_A1.5621.00
618_C641_A1.5611.00
161_F282_K1.5591.00
626_P685_E1.5571.00
391_E394_I1.5501.00
113_L116_I1.5491.00
61_V103_A1.5431.00
450_L523_K1.5391.00
44_H90_R1.5351.00
627_V683_A1.5351.00
600_A618_C1.5291.00
54_K57_K1.5161.00
422_Y607_D1.5111.00
158_E162_Q1.5101.00
90_R142_E1.5021.00
24_M186_G1.5001.00
29_F32_M1.4961.00
280_T297_K1.4911.00
383_K401_A1.4901.00
405_N409_K1.4871.00
149_R332_E1.4791.00
68_K89_D1.4771.00
458_I483_L1.4761.00
633_Y683_A1.4731.00
100_A246_Y1.4661.00
482_E693_Y1.4621.00
56_E63_A1.4611.00
448_G519_I1.4581.00
198_T225_R1.4551.00
410_S680_K1.4501.00
166_T286_D1.4401.00
167_V282_K1.4381.00
624_A627_V1.4321.00
617_D678_D1.4281.00
615_L645_L1.4251.00
158_E330_R1.4241.00
363_D712_K1.4221.00
432_T598_G1.4171.00
644_A706_I1.4071.00
406_A410_S1.4041.00
37_V260_I1.4031.00
166_T365_L1.4021.00
422_Y608_L1.4001.00
401_A405_N1.3851.00
548_G553_R1.3831.00
166_T369_L1.3811.00
367_G716_D1.3701.00
29_F190_V1.3691.00
613_V714_V1.3681.00
33_L256_R1.3631.00
545_L552_L1.3621.00
288_S379_K1.3611.00
531_K545_L1.3611.00
525_P528_A1.3571.00
173_E278_K1.3561.00
29_F188_V1.3521.00
411_P601_A1.3521.00
214_A224_I1.3501.00
521_R525_P1.3491.00
160_G293_A1.3471.00
482_E520_Q1.3461.00
32_M259_K1.3451.00
291_L326_I1.3411.00
220_P223_K1.3401.00
213_L224_I1.3371.00
475_I519_I1.3351.00
219_I224_I1.3351.00
47_I50_V1.3341.00
423_L614_K1.3331.00
65_V250_L1.3261.00
478_I512_T1.3241.00
47_I118_V1.3201.00
189_A199_M1.3201.00
480_M490_I1.3181.00
646_G671_P1.3151.00
111_A115_L1.3141.00
161_F293_A1.3121.00
25_T261_H1.3121.00
474_A512_T1.3081.00
392_H397_T1.3011.00
532_K542_A1.2941.00
170_E364_R1.2911.00
619_E680_K1.2841.00
302_T309_G1.2811.00
409_K412_I1.2811.00
217_F248_A1.2771.00
90_R123_L1.2771.00
359_E377_R1.2751.00
422_Y609_L1.2711.00
346_F643_M1.2711.00
197_F219_I1.2701.00
391_E397_T1.2641.00
544_N556_N1.2621.00
65_V254_S1.2571.00
285_A369_L1.2541.00
369_L376_L1.2541.00
189_A251_A1.2531.00
250_L258_V1.2441.00
160_G328_N1.2431.00
546_I553_R1.2431.00
157_V161_F1.2411.00
197_F248_A1.2401.00
627_V633_Y1.2341.00
21_L230_P1.2331.00
98_I118_V1.2321.00
149_R334_I1.2311.00
423_L607_D1.2291.00
363_D373_P1.2271.00
41_A120_Y1.2251.00
200_Y227_V1.2231.00
211_F221_E1.2231.00
604_V714_V1.2191.00
276_P301_D1.2161.00
279_I357_A1.2111.00
525_P529_Q1.2091.00
654_K662_A1.2061.00
621_A682_I1.1900.99
180_T670_I1.1890.99
67_H88_E1.1880.99
606_V613_V1.1880.99
36_K113_L1.1880.99
189_A247_A1.1880.99
534_A567_L1.1820.99
272_I344_G1.1800.99
158_E295_D1.1780.99
364_R723_N1.1780.99
408_S413_L1.1750.99
11_P476_E1.1740.99
133_L146_I1.1730.99
36_K106_E1.1720.99
112_A115_L1.1710.99
613_V649_L1.1660.99
611_G732_L1.1620.99
517_H520_Q1.1590.99
425_R603_E1.1570.99
39_R266_E1.1560.99
36_K110_E1.1520.99
170_E368_M1.1510.99
46_E123_L1.1510.99
44_H339_N1.1500.99
11_P473_A1.1490.99
553_R561_V1.1480.99
161_F167_V1.1430.99
390_L395_A1.1410.99
108_I112_A1.1400.99
32_M188_V1.1390.99
44_H124_E1.1390.99
92_R96_D1.1380.99
554_D557_T1.1360.99
393_R397_T1.1360.99
61_V109_A1.1360.99
374_L429_A1.1350.99
299_V334_I1.1350.99
285_A376_L1.1330.99
408_S412_I1.1310.99
637_I641_A1.1290.99
283_T294_H1.1240.99
544_N555_K1.1240.99
15_G20_E1.1220.99
476_E487_A1.1220.99
356_F711_V1.1200.99
14_R18_T1.1200.99
602_V615_L1.1190.99
36_K109_A1.1170.99
477_Q629_S1.1160.99
33_L254_S1.1120.99
28_S32_M1.1110.99
540_C554_D1.1090.99
98_I120_Y1.1080.99
163_A292_L1.1010.99
159_E162_Q1.0960.99
730_E734_E1.0950.99
151_F332_E1.0920.99
395_A398_D1.0900.99
61_V112_A1.0880.99
234_S467_C1.0880.99
181_Y267_S1.0880.99
602_V710_I1.0860.99
141_H337_F1.0840.99
133_L336_V1.0840.99
449_R461_S1.0820.99
530_L567_L1.0790.99
157_V160_G1.0780.99
86_L246_Y1.0750.99
406_A621_A1.0740.99
49_S117_Q1.0740.99
539_G554_D1.0690.99
172_Y361_H1.0650.99
531_K547_P1.0630.99
285_A291_L1.0620.99
66_T86_L1.0610.99
722_I727_I1.0600.99
58_M111_A1.0600.99
390_L394_I1.0580.99
191_P252_L1.0580.99
37_V100_A1.0490.99
50_V118_V1.0480.99
130_E173_E1.0460.99
192_E198_T1.0450.99
540_C544_N1.0450.99
168_F285_A1.0440.99
187_G247_A1.0430.99
655_M660_Y1.0420.99
649_L710_I1.0410.99
528_A532_K1.0410.99
70_V249_L1.0400.99
479_V523_K1.0380.99
151_F330_R1.0380.99
459_T493_V1.0370.99
134_R137_A1.0370.99
192_E196_G1.0360.99
168_F368_M1.0350.99
47_I98_I1.0320.99
157_V295_D1.0320.99
623_A686_D1.0280.98
461_S493_V1.0270.98
645_L676_V1.0260.98
402_Q405_N1.0260.98
129_P299_V1.0240.98
284_G293_A1.0240.98
727_I732_L1.0220.98
65_V253_K1.0180.98
656_T659_R1.0110.98
410_S682_I1.0100.98
317_V331_T1.0070.98
489_D550_A1.0050.98
45_A123_L1.0040.98
62_Q108_I1.0040.98
91_V120_Y1.0030.98
160_G284_G1.0010.98
411_P619_E1.0010.98
163_A286_D0.9990.98
533_R567_L0.9980.98
580_D583_T0.9960.98
524_K528_A0.9950.98
165_D292_L0.9950.98
106_E110_E0.9940.98
362_L376_L0.9940.98
409_K414_K0.9920.98
284_G292_L0.9870.98
378_R408_S0.9830.98
62_Q102_A0.9820.98
652_E731_E0.9820.98
190_V198_T0.9780.98
101_V113_L0.9760.98
191_P251_A0.9730.98
31_G256_R0.9710.98
63_A254_S0.9710.98
178_M653_A0.9700.98
460_A490_I0.9660.98
482_E523_K0.9650.98
473_A477_Q0.9650.98
482_E527_L0.9640.98
727_I731_E0.9610.98
650_M675_D0.9610.98
425_R616_I0.9600.98
231_M467_C0.9600.98
407_I599_A0.9590.98
179_H237_G0.9580.98
299_V336_V0.9570.98
202_G238_K0.9560.98
161_F295_D0.9560.98
157_V328_N0.9550.98
126_M132_A0.9540.98
130_E171_T0.9520.98
544_N554_D0.9520.98
45_A118_V0.9520.98
412_I416_T0.9500.97
168_F283_T0.9490.97
408_S414_K0.9470.97
402_Q406_A0.9470.97
407_I621_A0.9470.97
664_N667_H0.9420.97
275_H353_Q0.9360.97
423_L608_L0.9340.97
127_D658_G0.9320.97
60_G112_A0.9310.97
65_V102_A0.9300.97
38_L118_V0.9300.97
59_E104_E0.9280.97
67_H89_D0.9280.97
35_G250_L0.9260.97
363_D377_R0.9260.97
99_A116_I0.9250.97
210_R221_E0.9240.97
247_A260_I0.9240.97
546_I555_K0.9230.97
96_D305_Y0.9180.97
190_V251_A0.9170.97
52_T116_I0.9150.97
604_V615_L0.9110.97
133_L299_V0.9110.97
470_G632_G0.9100.97
415_K418_R0.9090.97
44_H125_V0.9080.97
204_Q234_S0.9080.97
313_L333_G0.9040.97
547_P552_L0.9010.97
600_A706_I0.8990.96
634_R638_E0.8990.96
68_K88_E0.8980.96
99_A118_V0.8960.96
620_H641_A0.8940.96
37_V97_A0.8930.96
64_V99_A0.8920.96
403_V599_A0.8900.96
219_I252_L0.8900.96
224_I248_A0.8900.96
477_Q630_P0.8870.96
537_W570_K0.8850.96
656_T661_A0.8830.96
50_V116_I0.8810.96
219_I223_K0.8800.96
324_Y377_R0.8760.96
38_L99_A0.8760.96
225_R498_A0.8750.96
109_A113_L0.8730.96
324_Y359_E0.8730.96
451_S461_S0.8730.96
135_P138_Q0.8720.96
374_L408_S0.8710.96
405_N408_S0.8670.96
464_F471_I0.8670.96
15_G472_L0.8670.96
265_K663_E0.8660.96
157_V293_A0.8630.96
464_F511_G0.8610.96
34_Y259_K0.8600.95
410_S621_A0.8590.95
239_D507_T0.8580.95
47_I120_Y0.8580.95
459_T491_S0.8560.95
295_D332_E0.8560.95
191_P195_G0.8560.95
446_A515_V0.8550.95
160_G292_L0.8530.95
65_V249_L0.8520.95
634_R683_A0.8520.95
164_S293_A0.8510.95
530_L564_Y0.8500.95
172_Y364_R0.8500.95
197_F252_L0.8490.95
129_P278_K0.8490.95
6_P634_R0.8460.95
528_A542_A0.8450.95
603_E617_D0.8430.95
50_V98_I0.8430.95
277_M316_S0.8420.95
404_L429_A0.8420.95
552_L567_L0.8400.95
479_V490_I0.8400.95
202_G231_M0.8390.95
452_L564_Y0.8380.95
551_G563_T0.8370.95
409_K413_L0.8370.95
390_L397_T0.8370.95
277_M300_A0.8340.95
521_R524_K0.8330.95
167_V284_G0.8330.95
56_E68_K0.8330.95
450_L526_F0.8300.95
580_D584_T0.8290.94
660_Y663_E0.8280.94
400_A404_L0.8260.94
557_T560_L0.8260.94
15_G230_P0.8240.94
469_Q506_S0.8200.94
285_A361_H0.8200.94
391_E398_D0.8180.94
527_L547_P0.8140.94
69_D253_K0.8140.94
29_F200_Y0.8130.94
185_E267_S0.8130.94
157_V330_R0.8130.94
282_K330_R0.8090.94
577_T580_D0.8080.94
562_V567_L0.8080.94
52_T55_A0.8080.94
364_R721_W0.8070.94
624_A633_Y0.8060.94
421_G424_Q0.8060.94
356_F360_T0.8040.94
703_T707_T0.8040.94
87_C91_V0.8020.93
489_D565_K0.8010.93
579_F585_P0.8010.93
201_A209_D0.8000.93
110_E263_T0.8000.93
485_C489_D0.8000.93
39_R270_S0.7980.93
715_H721_W0.7980.93
474_A632_G0.7960.93
394_I398_D0.7950.93
458_I526_F0.7950.93
292_L328_N0.7940.93
16_K23_Y0.7940.93
303_G342_V0.7940.93
360_T711_V0.7910.93
279_I296_V0.7910.93
294_H326_I0.7900.93
103_A112_A0.7890.93
45_A91_V0.7890.93
623_A687_L0.7890.93
411_P414_K0.7880.93
52_T66_T0.7880.93
618_C706_I0.7870.93
618_C679_M0.7870.93
450_L522_L0.7860.93
653_A660_Y0.7850.93
34_Y106_E0.7840.93
43_P125_V0.7830.93
436_G594_L0.7830.93
624_A698_V0.7820.93
281_I357_A0.7810.93
172_Y723_N0.7810.93
262_Q267_S0.7800.93
42_Y91_V0.7800.93
187_G243_I0.7800.93
92_R305_Y0.7780.92
160_G163_A0.7780.92
53_I57_K0.7750.92
60_G104_E0.7730.92
572_P575_E0.7720.92
126_M339_N0.7710.92
197_F224_I0.7710.92
108_I111_A0.7700.92
225_R497_T0.7690.92
420_C424_Q0.7680.92
304_A339_N0.7680.92
371_I375_E0.7680.92
106_E263_T0.7680.92
452_L458_I0.7670.92
160_G164_S0.7670.92
408_S411_P0.7670.92
607_D612_D0.7660.92
403_V621_A0.7650.92
217_F249_L0.7650.92
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731_E734_E0.5540.73
535_A541_S0.5530.73
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607_D610_T0.5490.72
133_L137_A0.5490.72
155_G160_G0.5490.72
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399_G686_D0.5350.70
535_A545_L0.5350.70
450_L490_I0.5350.70
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200_Y229_S0.5330.70
55_A99_A0.5320.70
306_A337_F0.5320.70
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366_S376_L0.5310.70
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407_I619_E0.5260.69
697_G702_G0.5260.69
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447_G501_P0.5250.69
202_G234_S0.5250.69
581_F586_D0.5250.69
50_V66_T0.5250.69
446_A503_S0.5240.69
180_T268_V0.5230.69
77_G82_D0.5230.69
493_V500_V0.5230.69
78_I81_P0.5220.69
281_I362_L0.5220.69
277_M353_Q0.5210.68
349_F508_A0.5210.68
577_T584_T0.5210.68
544_N557_T0.5200.68
212_Q241_L0.5200.68
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430_A712_K0.5190.68
100_A260_I0.5190.68
526_F530_L0.5190.68
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289_G379_K0.5160.68
466_E471_I0.5160.68
227_V496_D0.5160.68
44_H91_V0.5150.67
545_L554_D0.5150.67
600_A620_H0.5140.67
205_H208_K0.5130.67
249_L254_S0.5130.67
7_S473_A0.5130.67
626_P687_L0.5130.67
386_D390_L0.5120.67
33_L258_V0.5110.67
603_E616_I0.5110.67
535_A539_G0.5110.67
419_N608_L0.5100.67
160_G286_D0.5100.67
562_V566_E0.5100.67
302_T343_A0.5090.67
41_A45_A0.5090.67
389_P396_P0.5090.67
645_L650_M0.5090.67
61_V64_V0.5090.67
403_V684_I0.5090.67
132_A135_P0.5080.66
517_H692_V0.5080.66
149_R153_S0.5070.66
47_I87_C0.5070.66
168_F369_L0.5060.66
426_G606_V0.5060.66
46_E49_S0.5060.66
570_K574_A0.5060.66
411_P415_K0.5060.66
163_A328_N0.5050.66
70_V86_L0.5040.66
178_M273_K0.5040.66
436_G513_S0.5040.66
392_H396_P0.5040.66
578_A581_F0.5030.66
55_A115_L0.5020.66
12_D16_K0.5020.66
101_V112_A0.5020.66
43_P656_T0.5010.65
508_A640_G0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rm6A 2 0.9919 100 0.098 Contact Map
1t3qB 2 0.9839 100 0.111 Contact Map
1ffvB 2 0.9839 100 0.12 Contact Map
2w3sB 2 0.9758 100 0.122 Contact Map
1n62B 2 0.9866 100 0.122 Contact Map
3uncA 2 0.9691 100 0.132 Contact Map
3nvzC 2 0.9691 100 0.144 Contact Map
3zyvA 3 0.9611 100 0.147 Contact Map
4usaA 2 0.9436 100 0.148 Contact Map
1dgjA 1 0.9409 100 0.15 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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