XDHD - BACSU - GREMLIN Contacts

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XDHD - Probable xanthine dehydrogenase subunit D

UniProt:	O32144	Sequences: MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPHAEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVAAETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEGFQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFDIPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHPMKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGISVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEHRIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRLSLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTASRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKELAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAAGPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLIAIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKGLKQWT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	745 (718)
Sequences:	5409 (3604)
Seq/√Len:	134.5

ECOLI - XDHA XDHD YAGR
BACSU - XDHD
SULSO - Q7LX54 Q97VI4 Q97V74 Q97UK2 Q97TZ2 Q7LXA2 Q97YU6 Q97UR0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
58_M	115_L	4.588	1.00
38_L	116_I	4.205	1.00
169_E	282_K	4.190	1.00
33_L	62_Q	3.978	1.00
105_T	108_I	3.815	1.00
54_K	117_Q	3.654	1.00
171_T	280_T	3.579	1.00
42_Y	45_A	3.541	1.00
286_D	290_N	3.385	1.00
285_A	365_L	3.341	1.00
295_D	330_R	3.300	1.00
48_V	119_E	3.167	1.00
165_D	287_H	3.141	1.00
159_E	163_A	3.134	1.00
165_D	286_D	3.118	1.00
371_I	379_K	3.110	1.00
479_V	519_I	3.105	1.00
58_M	108_I	3.097	1.00
46_E	121_K	3.076	1.00
458_I	485_C	3.063	1.00
291_L	362_L	3.027	1.00
378_R	405_N	3.021	1.00
156_D	159_E	2.959	1.00
38_L	113_L	2.894	1.00
62_Q	104_E	2.875	1.00
169_E	280_T	2.821	1.00
45_A	120_Y	2.816	1.00
482_E	524_K	2.808	1.00
42_Y	122_E	2.786	1.00
297_K	332_E	2.778	1.00
325_R	386_D	2.755	1.00
551_G	561_V	2.743	1.00
375_E	379_K	2.658	1.00
44_H	123_L	2.655	1.00
49_S	119_E	2.627	1.00
102_A	250_L	2.608	1.00
412_I	415_K	2.546	1.00
282_K	295_D	2.544	1.00
199_M	213_L	2.518	1.00
104_E	108_I	2.484	1.00
520_Q	524_K	2.469	1.00
617_D	680_K	2.431	1.00
48_V	121_K	2.419	1.00
711_V	727_I	2.398	1.00
198_T	227_V	2.358	1.00
423_L	605_E	2.353	1.00
35_G	260_I	2.329	1.00
130_E	278_K	2.324	1.00
290_N	379_K	2.320	1.00
104_E	256_R	2.280	1.00
724_K	731_E	2.275	1.00
371_I	376_L	2.240	1.00
52_T	56_E	2.223	1.00
196_G	498_A	2.213	1.00
297_K	334_I	2.202	1.00
190_V	200_Y	2.194	1.00
605_E	616_I	2.187	1.00
225_R	496_D	2.163	1.00
714_V	727_I	2.156	1.00
161_F	284_G	2.149	1.00
365_L	376_L	2.142	1.00
457_K	489_D	2.082	1.00
283_T	361_H	2.073	1.00
301_D	340_N	2.064	1.00
153_S	330_R	2.037	1.00
131_K	134_R	2.033	1.00
35_G	100_A	2.018	1.00
37_V	246_Y	2.004	1.00
375_E	378_R	1.971	1.00
164_S	284_G	1.969	1.00
290_N	325_R	1.962	1.00
641_A	679_M	1.950	1.00
173_E	724_K	1.949	1.00
166_T	287_H	1.945	1.00
563_T	566_E	1.926	1.00
642_A	676_V	1.923	1.00
41_A	98_I	1.906	1.00
166_T	285_A	1.904	1.00
406_A	409_K	1.902	1.00
602_V	709_A	1.897	1.00
527_L	531_K	1.891	1.00
52_T	64_V	1.884	1.00
383_K	386_D	1.872	1.00
457_K	491_S	1.871	1.00
452_L	526_F	1.869	1.00
399_G	402_Q	1.861	1.00
450_L	460_A	1.860	1.00
281_I	361_H	1.859	1.00
7_S	487_A	1.858	1.00
46_E	89_D	1.836	1.00
541_S	544_N	1.820	1.00
51_C	117_Q	1.819	1.00
128_S	131_K	1.814	1.00
46_E	90_R	1.803	1.00
425_R	605_E	1.789	1.00
25_T	259_K	1.781	1.00
53_I	56_E	1.770	1.00
486_A	489_D	1.759	1.00
196_G	223_K	1.754	1.00
453_S	459_T	1.729	1.00
476_E	492_I	1.726	1.00
54_K	115_L	1.725	1.00
62_Q	256_R	1.725	1.00
512_T	628_V	1.723	1.00
100_A	250_L	1.713	1.00
55_A	116_I	1.702	1.00
478_I	516_W	1.699	1.00
453_S	457_K	1.695	1.00
103_A	109_A	1.685	1.00
407_I	601_A	1.683	1.00
286_D	292_L	1.665	1.00
42_Y	120_Y	1.664	1.00
63_A	253_K	1.659	1.00
9_V	631_Q	1.657	1.00
406_A	682_I	1.656	1.00
613_V	732_L	1.655	1.00
186_G	261_H	1.654	1.00
378_R	401_A	1.648	1.00
633_Y	698_V	1.647	1.00
35_G	258_V	1.643	1.00
180_T	665_L	1.630	1.00
394_I	397_T	1.626	1.00
391_E	395_A	1.615	1.00
58_M	112_A	1.605	1.00
102_A	254_S	1.594	1.00
153_S	156_D	1.586	1.00
171_T	278_K	1.583	1.00
181_Y	237_G	1.579	1.00
602_V	618_C	1.579	1.00
164_S	292_L	1.578	1.00
460_A	479_V	1.576	1.00
728_S	731_E	1.575	1.00
166_T	368_M	1.572	1.00
424_Q	608_L	1.572	1.00
283_T	291_L	1.571	1.00
367_G	715_H	1.564	1.00
283_T	365_L	1.562	1.00
392_H	395_A	1.562	1.00
618_C	641_A	1.561	1.00
161_F	282_K	1.559	1.00
626_P	685_E	1.557	1.00
391_E	394_I	1.550	1.00
113_L	116_I	1.549	1.00
61_V	103_A	1.543	1.00
450_L	523_K	1.539	1.00
44_H	90_R	1.535	1.00
627_V	683_A	1.535	1.00
600_A	618_C	1.529	1.00
54_K	57_K	1.516	1.00
422_Y	607_D	1.511	1.00
158_E	162_Q	1.510	1.00
90_R	142_E	1.502	1.00
24_M	186_G	1.500	1.00
29_F	32_M	1.496	1.00
280_T	297_K	1.491	1.00
383_K	401_A	1.490	1.00
405_N	409_K	1.487	1.00
149_R	332_E	1.479	1.00
68_K	89_D	1.477	1.00
458_I	483_L	1.476	1.00
633_Y	683_A	1.473	1.00
100_A	246_Y	1.466	1.00
482_E	693_Y	1.462	1.00
56_E	63_A	1.461	1.00
448_G	519_I	1.458	1.00
198_T	225_R	1.455	1.00
410_S	680_K	1.450	1.00
166_T	286_D	1.440	1.00
167_V	282_K	1.438	1.00
624_A	627_V	1.432	1.00
617_D	678_D	1.428	1.00
615_L	645_L	1.425	1.00
158_E	330_R	1.424	1.00
363_D	712_K	1.422	1.00
432_T	598_G	1.417	1.00
644_A	706_I	1.407	1.00
406_A	410_S	1.404	1.00
37_V	260_I	1.403	1.00
166_T	365_L	1.402	1.00
422_Y	608_L	1.400	1.00
401_A	405_N	1.385	1.00
548_G	553_R	1.383	1.00
166_T	369_L	1.381	1.00
367_G	716_D	1.370	1.00
29_F	190_V	1.369	1.00
613_V	714_V	1.368	1.00
33_L	256_R	1.363	1.00
545_L	552_L	1.362	1.00
288_S	379_K	1.361	1.00
531_K	545_L	1.361	1.00
525_P	528_A	1.357	1.00
173_E	278_K	1.356	1.00
29_F	188_V	1.352	1.00
411_P	601_A	1.352	1.00
214_A	224_I	1.350	1.00
521_R	525_P	1.349	1.00
160_G	293_A	1.347	1.00
482_E	520_Q	1.346	1.00
32_M	259_K	1.345	1.00
291_L	326_I	1.341	1.00
220_P	223_K	1.340	1.00
213_L	224_I	1.337	1.00
475_I	519_I	1.335	1.00
219_I	224_I	1.335	1.00
47_I	50_V	1.334	1.00
423_L	614_K	1.333	1.00
65_V	250_L	1.326	1.00
478_I	512_T	1.324	1.00
47_I	118_V	1.320	1.00
189_A	199_M	1.320	1.00
480_M	490_I	1.318	1.00
646_G	671_P	1.315	1.00
111_A	115_L	1.314	1.00
161_F	293_A	1.312	1.00
25_T	261_H	1.312	1.00
474_A	512_T	1.308	1.00
392_H	397_T	1.301	1.00
532_K	542_A	1.294	1.00
170_E	364_R	1.291	1.00
619_E	680_K	1.284	1.00
302_T	309_G	1.281	1.00
409_K	412_I	1.281	1.00
217_F	248_A	1.277	1.00
90_R	123_L	1.277	1.00
359_E	377_R	1.275	1.00
422_Y	609_L	1.271	1.00
346_F	643_M	1.271	1.00
197_F	219_I	1.270	1.00
391_E	397_T	1.264	1.00
544_N	556_N	1.262	1.00
65_V	254_S	1.257	1.00
285_A	369_L	1.254	1.00
369_L	376_L	1.254	1.00
189_A	251_A	1.253	1.00
250_L	258_V	1.244	1.00
160_G	328_N	1.243	1.00
546_I	553_R	1.243	1.00
157_V	161_F	1.241	1.00
197_F	248_A	1.240	1.00
627_V	633_Y	1.234	1.00
21_L	230_P	1.233	1.00
98_I	118_V	1.232	1.00
149_R	334_I	1.231	1.00
423_L	607_D	1.229	1.00
363_D	373_P	1.227	1.00
41_A	120_Y	1.225	1.00
200_Y	227_V	1.223	1.00
211_F	221_E	1.223	1.00
604_V	714_V	1.219	1.00
276_P	301_D	1.216	1.00
279_I	357_A	1.211	1.00
525_P	529_Q	1.209	1.00
654_K	662_A	1.206	1.00
621_A	682_I	1.190	0.99
180_T	670_I	1.189	0.99
67_H	88_E	1.188	0.99
606_V	613_V	1.188	0.99
36_K	113_L	1.188	0.99
189_A	247_A	1.188	0.99
534_A	567_L	1.182	0.99
272_I	344_G	1.180	0.99
158_E	295_D	1.178	0.99
364_R	723_N	1.178	0.99
408_S	413_L	1.175	0.99
11_P	476_E	1.174	0.99
133_L	146_I	1.173	0.99
36_K	106_E	1.172	0.99
112_A	115_L	1.171	0.99
613_V	649_L	1.166	0.99
611_G	732_L	1.162	0.99
517_H	520_Q	1.159	0.99
425_R	603_E	1.157	0.99
39_R	266_E	1.156	0.99
36_K	110_E	1.152	0.99
170_E	368_M	1.151	0.99
46_E	123_L	1.151	0.99
44_H	339_N	1.150	0.99
11_P	473_A	1.149	0.99
553_R	561_V	1.148	0.99
161_F	167_V	1.143	0.99
390_L	395_A	1.141	0.99
108_I	112_A	1.140	0.99
32_M	188_V	1.139	0.99
44_H	124_E	1.139	0.99
92_R	96_D	1.138	0.99
554_D	557_T	1.136	0.99
393_R	397_T	1.136	0.99
61_V	109_A	1.136	0.99
374_L	429_A	1.135	0.99
299_V	334_I	1.135	0.99
285_A	376_L	1.133	0.99
408_S	412_I	1.131	0.99
637_I	641_A	1.129	0.99
283_T	294_H	1.124	0.99
544_N	555_K	1.124	0.99
15_G	20_E	1.122	0.99
476_E	487_A	1.122	0.99
356_F	711_V	1.120	0.99
14_R	18_T	1.120	0.99
602_V	615_L	1.119	0.99
36_K	109_A	1.117	0.99
477_Q	629_S	1.116	0.99
33_L	254_S	1.112	0.99
28_S	32_M	1.111	0.99
540_C	554_D	1.109	0.99
98_I	120_Y	1.108	0.99
163_A	292_L	1.101	0.99
159_E	162_Q	1.096	0.99
730_E	734_E	1.095	0.99
151_F	332_E	1.092	0.99
395_A	398_D	1.090	0.99
61_V	112_A	1.088	0.99
234_S	467_C	1.088	0.99
181_Y	267_S	1.088	0.99
602_V	710_I	1.086	0.99
141_H	337_F	1.084	0.99
133_L	336_V	1.084	0.99
449_R	461_S	1.082	0.99
530_L	567_L	1.079	0.99
157_V	160_G	1.078	0.99
86_L	246_Y	1.075	0.99
406_A	621_A	1.074	0.99
49_S	117_Q	1.074	0.99
539_G	554_D	1.069	0.99
172_Y	361_H	1.065	0.99
531_K	547_P	1.063	0.99
285_A	291_L	1.062	0.99
66_T	86_L	1.061	0.99
722_I	727_I	1.060	0.99
58_M	111_A	1.060	0.99
390_L	394_I	1.058	0.99
191_P	252_L	1.058	0.99
37_V	100_A	1.049	0.99
50_V	118_V	1.048	0.99
130_E	173_E	1.046	0.99
192_E	198_T	1.045	0.99
540_C	544_N	1.045	0.99
168_F	285_A	1.044	0.99
187_G	247_A	1.043	0.99
655_M	660_Y	1.042	0.99
649_L	710_I	1.041	0.99
528_A	532_K	1.041	0.99
70_V	249_L	1.040	0.99
479_V	523_K	1.038	0.99
151_F	330_R	1.038	0.99
459_T	493_V	1.037	0.99
134_R	137_A	1.037	0.99
192_E	196_G	1.036	0.99
168_F	368_M	1.035	0.99
47_I	98_I	1.032	0.99
157_V	295_D	1.032	0.99
623_A	686_D	1.028	0.98
461_S	493_V	1.027	0.98
645_L	676_V	1.026	0.98
402_Q	405_N	1.026	0.98
129_P	299_V	1.024	0.98
284_G	293_A	1.024	0.98
727_I	732_L	1.022	0.98
65_V	253_K	1.018	0.98
656_T	659_R	1.011	0.98
410_S	682_I	1.010	0.98
317_V	331_T	1.007	0.98
489_D	550_A	1.005	0.98
45_A	123_L	1.004	0.98
62_Q	108_I	1.004	0.98
91_V	120_Y	1.003	0.98
160_G	284_G	1.001	0.98
411_P	619_E	1.001	0.98
163_A	286_D	0.999	0.98
533_R	567_L	0.998	0.98
580_D	583_T	0.996	0.98
524_K	528_A	0.995	0.98
165_D	292_L	0.995	0.98
106_E	110_E	0.994	0.98
362_L	376_L	0.994	0.98
409_K	414_K	0.992	0.98
284_G	292_L	0.987	0.98
378_R	408_S	0.983	0.98
62_Q	102_A	0.982	0.98
652_E	731_E	0.982	0.98
190_V	198_T	0.978	0.98
101_V	113_L	0.976	0.98
191_P	251_A	0.973	0.98
31_G	256_R	0.971	0.98
63_A	254_S	0.971	0.98
178_M	653_A	0.970	0.98
460_A	490_I	0.966	0.98
482_E	523_K	0.965	0.98
473_A	477_Q	0.965	0.98
482_E	527_L	0.964	0.98
727_I	731_E	0.961	0.98
650_M	675_D	0.961	0.98
425_R	616_I	0.960	0.98
231_M	467_C	0.960	0.98
407_I	599_A	0.959	0.98
179_H	237_G	0.958	0.98
299_V	336_V	0.957	0.98
202_G	238_K	0.956	0.98
161_F	295_D	0.956	0.98
157_V	328_N	0.955	0.98
126_M	132_A	0.954	0.98
130_E	171_T	0.952	0.98
544_N	554_D	0.952	0.98
45_A	118_V	0.952	0.98
412_I	416_T	0.950	0.97
168_F	283_T	0.949	0.97
408_S	414_K	0.947	0.97
402_Q	406_A	0.947	0.97
407_I	621_A	0.947	0.97
664_N	667_H	0.942	0.97
275_H	353_Q	0.936	0.97
423_L	608_L	0.934	0.97
127_D	658_G	0.932	0.97
60_G	112_A	0.931	0.97
65_V	102_A	0.930	0.97
38_L	118_V	0.930	0.97
59_E	104_E	0.928	0.97
67_H	89_D	0.928	0.97
35_G	250_L	0.926	0.97
363_D	377_R	0.926	0.97
99_A	116_I	0.925	0.97
210_R	221_E	0.924	0.97
247_A	260_I	0.924	0.97
546_I	555_K	0.923	0.97
96_D	305_Y	0.918	0.97
190_V	251_A	0.917	0.97
52_T	116_I	0.915	0.97
604_V	615_L	0.911	0.97
133_L	299_V	0.911	0.97
470_G	632_G	0.910	0.97
415_K	418_R	0.909	0.97
44_H	125_V	0.908	0.97
204_Q	234_S	0.908	0.97
313_L	333_G	0.904	0.97
547_P	552_L	0.901	0.97
600_A	706_I	0.899	0.96
634_R	638_E	0.899	0.96
68_K	88_E	0.898	0.96
99_A	118_V	0.896	0.96
620_H	641_A	0.894	0.96
37_V	97_A	0.893	0.96
64_V	99_A	0.892	0.96
403_V	599_A	0.890	0.96
219_I	252_L	0.890	0.96
224_I	248_A	0.890	0.96
477_Q	630_P	0.887	0.96
537_W	570_K	0.885	0.96
656_T	661_A	0.883	0.96
50_V	116_I	0.881	0.96
219_I	223_K	0.880	0.96
324_Y	377_R	0.876	0.96
38_L	99_A	0.876	0.96
225_R	498_A	0.875	0.96
109_A	113_L	0.873	0.96
324_Y	359_E	0.873	0.96
451_S	461_S	0.873	0.96
135_P	138_Q	0.872	0.96
374_L	408_S	0.871	0.96
405_N	408_S	0.867	0.96
464_F	471_I	0.867	0.96
15_G	472_L	0.867	0.96
265_K	663_E	0.866	0.96
157_V	293_A	0.863	0.96
464_F	511_G	0.861	0.96
34_Y	259_K	0.860	0.95
410_S	621_A	0.859	0.95
239_D	507_T	0.858	0.95
47_I	120_Y	0.858	0.95
459_T	491_S	0.856	0.95
295_D	332_E	0.856	0.95
191_P	195_G	0.856	0.95
446_A	515_V	0.855	0.95
160_G	292_L	0.853	0.95
65_V	249_L	0.852	0.95
634_R	683_A	0.852	0.95
164_S	293_A	0.851	0.95
530_L	564_Y	0.850	0.95
172_Y	364_R	0.850	0.95
197_F	252_L	0.849	0.95
129_P	278_K	0.849	0.95
6_P	634_R	0.846	0.95
528_A	542_A	0.845	0.95
603_E	617_D	0.843	0.95
50_V	98_I	0.843	0.95
277_M	316_S	0.842	0.95
404_L	429_A	0.842	0.95
552_L	567_L	0.840	0.95
479_V	490_I	0.840	0.95
202_G	231_M	0.839	0.95
452_L	564_Y	0.838	0.95
551_G	563_T	0.837	0.95
409_K	413_L	0.837	0.95
390_L	397_T	0.837	0.95
277_M	300_A	0.834	0.95
521_R	524_K	0.833	0.95
167_V	284_G	0.833	0.95
56_E	68_K	0.833	0.95
450_L	526_F	0.830	0.95
580_D	584_T	0.829	0.94
660_Y	663_E	0.828	0.94
400_A	404_L	0.826	0.94
557_T	560_L	0.826	0.94
15_G	230_P	0.824	0.94
469_Q	506_S	0.820	0.94
285_A	361_H	0.820	0.94
391_E	398_D	0.818	0.94
527_L	547_P	0.814	0.94
69_D	253_K	0.814	0.94
29_F	200_Y	0.813	0.94
185_E	267_S	0.813	0.94
157_V	330_R	0.813	0.94
282_K	330_R	0.809	0.94
577_T	580_D	0.808	0.94
562_V	567_L	0.808	0.94
52_T	55_A	0.808	0.94
364_R	721_W	0.807	0.94
624_A	633_Y	0.806	0.94
421_G	424_Q	0.806	0.94
356_F	360_T	0.804	0.94
703_T	707_T	0.804	0.94
87_C	91_V	0.802	0.93
489_D	565_K	0.801	0.93
579_F	585_P	0.801	0.93
201_A	209_D	0.800	0.93
110_E	263_T	0.800	0.93
485_C	489_D	0.800	0.93
39_R	270_S	0.798	0.93
715_H	721_W	0.798	0.93
474_A	632_G	0.796	0.93
394_I	398_D	0.795	0.93
458_I	526_F	0.795	0.93
292_L	328_N	0.794	0.93
16_K	23_Y	0.794	0.93
303_G	342_V	0.794	0.93
360_T	711_V	0.791	0.93
279_I	296_V	0.791	0.93
294_H	326_I	0.790	0.93
103_A	112_A	0.789	0.93
45_A	91_V	0.789	0.93
623_A	687_L	0.789	0.93
411_P	414_K	0.788	0.93
52_T	66_T	0.788	0.93
618_C	706_I	0.787	0.93
618_C	679_M	0.787	0.93
450_L	522_L	0.786	0.93
653_A	660_Y	0.785	0.93
34_Y	106_E	0.784	0.93
43_P	125_V	0.783	0.93
436_G	594_L	0.783	0.93
624_A	698_V	0.782	0.93
281_I	357_A	0.781	0.93
172_Y	723_N	0.781	0.93
262_Q	267_S	0.780	0.93
42_Y	91_V	0.780	0.93
187_G	243_I	0.780	0.93
92_R	305_Y	0.778	0.92
160_G	163_A	0.778	0.92
53_I	57_K	0.775	0.92
60_G	104_E	0.773	0.92
572_P	575_E	0.772	0.92
126_M	339_N	0.771	0.92
197_F	224_I	0.771	0.92
108_I	111_A	0.770	0.92
225_R	497_T	0.769	0.92
420_C	424_Q	0.768	0.92
304_A	339_N	0.768	0.92
371_I	375_E	0.768	0.92
106_E	263_T	0.768	0.92
452_L	458_I	0.767	0.92
160_G	164_S	0.767	0.92
408_S	411_P	0.767	0.92
607_D	612_D	0.766	0.92
403_V	621_A	0.765	0.92
217_F	249_L	0.765	0.92
691_D	695_P	0.765	0.92
460_A	519_I	0.762	0.92
402_Q	684_I	0.762	0.92
478_I	628_V	0.762	0.92
130_E	299_V	0.762	0.92
479_V	482_E	0.762	0.92
665_L	670_I	0.762	0.92
604_V	613_V	0.760	0.92
172_Y	360_T	0.760	0.92
361_H	365_L	0.758	0.91
184_T	261_H	0.757	0.91
676_V	679_M	0.757	0.91
56_E	69_D	0.756	0.91
481_E	626_P	0.755	0.91
107_E	111_A	0.754	0.91
154_N	329_I	0.753	0.91
206_G	497_T	0.753	0.91
404_L	601_A	0.752	0.91
209_D	213_L	0.751	0.91
195_G	252_L	0.750	0.91
128_S	278_K	0.748	0.91
24_M	27_L	0.746	0.91
321_A	329_I	0.745	0.91
376_L	379_K	0.745	0.91
450_L	479_V	0.743	0.91
539_G	544_N	0.743	0.91
358_L	361_H	0.743	0.91
195_G	223_K	0.742	0.91
437_G	514_M	0.742	0.91
582_P	585_P	0.742	0.91
381_I	401_A	0.742	0.91
146_I	149_R	0.742	0.91
431_I	599_A	0.741	0.90
161_F	164_S	0.741	0.90
11_P	487_A	0.740	0.90
356_F	725_L	0.739	0.90
604_V	713_A	0.738	0.90
250_L	254_S	0.738	0.90
94_V	659_R	0.737	0.90
404_L	431_I	0.737	0.90
289_G	371_I	0.735	0.90
169_E	295_D	0.733	0.90
156_D	328_N	0.733	0.90
177_Q	647_Y	0.733	0.90
161_F	292_L	0.733	0.90
210_R	497_T	0.733	0.90
203_T	209_D	0.732	0.90
645_L	710_I	0.732	0.90
374_L	404_L	0.732	0.90
579_F	583_T	0.730	0.90
424_Q	606_V	0.729	0.90
474_A	628_V	0.728	0.90
56_E	112_A	0.727	0.90
254_S	258_V	0.727	0.90
622_I	637_I	0.727	0.90
6_P	631_Q	0.726	0.90
538_S	562_V	0.725	0.90
49_S	53_I	0.722	0.89
191_P	197_F	0.720	0.89
455_E	491_S	0.720	0.89
361_H	364_R	0.719	0.89
207_Y	497_T	0.718	0.89
718_V	735_A	0.717	0.89
364_R	368_M	0.716	0.89
127_D	131_K	0.715	0.89
712_K	721_W	0.714	0.89
188_V	259_K	0.713	0.89
91_V	118_V	0.712	0.89
153_S	158_E	0.709	0.88
169_E	368_M	0.709	0.88
302_T	335_S	0.709	0.88
523_K	526_F	0.708	0.88
547_P	564_Y	0.706	0.88
201_A	244_Q	0.705	0.88
27_L	200_Y	0.705	0.88
452_L	530_L	0.704	0.88
58_M	61_V	0.704	0.88
530_L	552_L	0.704	0.88
715_H	718_V	0.703	0.88
43_P	94_V	0.703	0.88
619_E	682_I	0.703	0.88
7_S	476_E	0.702	0.88
606_V	732_L	0.702	0.88
47_I	91_V	0.701	0.88
577_T	581_F	0.700	0.88
403_V	406_A	0.699	0.88
42_Y	98_I	0.699	0.88
31_G	257_P	0.696	0.88
401_A	407_I	0.696	0.88
55_A	61_V	0.694	0.87
170_E	723_N	0.694	0.87
55_A	60_G	0.690	0.87
133_L	334_I	0.690	0.87
87_C	96_D	0.689	0.87
40_S	94_V	0.686	0.87
133_L	278_K	0.686	0.87
316_S	354_I	0.685	0.87
29_F	257_P	0.685	0.87
28_S	259_K	0.684	0.87
124_E	131_K	0.684	0.87
153_S	157_V	0.684	0.87
173_E	276_P	0.683	0.87
430_A	709_A	0.682	0.86
294_H	361_H	0.681	0.86
375_E	407_I	0.679	0.86
35_G	247_A	0.679	0.86
528_A	531_K	0.679	0.86
517_H	691_D	0.679	0.86
428_G	431_I	0.678	0.86
291_L	376_L	0.677	0.86
165_D	290_N	0.677	0.86
24_M	261_H	0.676	0.86
571_G	575_E	0.674	0.86
64_V	68_K	0.674	0.86
634_R	681_L	0.674	0.86
50_V	64_V	0.673	0.86
537_W	562_V	0.673	0.86
732_L	735_A	0.672	0.86
92_R	304_A	0.672	0.86
301_D	338_T	0.672	0.86
60_G	108_I	0.672	0.86
486_A	550_A	0.672	0.86
77_G	80_I	0.670	0.85
718_V	732_L	0.670	0.85
567_L	571_G	0.670	0.85
22_K	27_L	0.669	0.85
298_I	316_S	0.668	0.85
51_C	55_A	0.668	0.85
389_P	395_A	0.667	0.85
399_G	403_V	0.666	0.85
355_T	708_P	0.666	0.85
467_C	506_S	0.664	0.85
102_A	258_V	0.664	0.85
146_I	336_V	0.664	0.85
283_T	376_L	0.663	0.85
638_E	681_L	0.663	0.85
185_E	237_G	0.662	0.85
294_H	358_L	0.662	0.85
637_I	681_L	0.662	0.85
187_G	201_A	0.661	0.85
722_I	735_A	0.661	0.85
284_G	295_D	0.660	0.85
291_L	365_L	0.659	0.85
529_Q	532_K	0.659	0.85
601_A	619_E	0.658	0.84
471_I	511_G	0.657	0.84
650_M	669_L	0.657	0.84
286_D	379_K	0.655	0.84
168_F	376_L	0.655	0.84
101_V	116_I	0.654	0.84
27_L	229_S	0.653	0.84
531_K	542_A	0.652	0.84
128_S	299_V	0.651	0.84
420_C	605_E	0.651	0.84
263_T	266_E	0.650	0.84
132_A	137_A	0.650	0.84
205_H	507_T	0.650	0.84
532_K	536_E	0.650	0.84
381_I	431_I	0.650	0.84
519_I	523_K	0.649	0.84
579_F	582_P	0.649	0.84
720_C	735_A	0.647	0.83
448_G	518_A	0.647	0.83
483_L	523_K	0.647	0.83
55_A	112_A	0.647	0.83
296_V	357_A	0.646	0.83
146_I	334_I	0.646	0.83
566_E	569_E	0.646	0.83
718_V	736_I	0.645	0.83
606_V	714_V	0.645	0.83
553_R	556_N	0.645	0.83
309_G	313_L	0.644	0.83
537_W	567_L	0.642	0.83
213_L	241_L	0.640	0.83
141_H	305_Y	0.640	0.83
326_I	329_I	0.639	0.83
421_G	608_L	0.638	0.83
111_A	114_E	0.638	0.83
300_A	335_S	0.638	0.83
427_T	716_D	0.638	0.83
390_L	393_R	0.637	0.83
18_T	21_L	0.637	0.83
309_G	335_S	0.636	0.82
531_K	552_L	0.636	0.82
293_A	328_N	0.635	0.82
577_T	583_T	0.635	0.82
564_Y	568_A	0.634	0.82
130_E	134_R	0.633	0.82
98_I	116_I	0.632	0.82
84_P	88_E	0.632	0.82
534_A	537_W	0.632	0.82
38_L	41_A	0.632	0.82
267_S	271_G	0.632	0.82
28_S	188_V	0.630	0.82
453_S	491_S	0.630	0.82
325_R	383_K	0.630	0.82
178_M	268_V	0.630	0.82
309_G	312_V	0.629	0.82
506_S	511_G	0.629	0.82
400_A	407_I	0.628	0.82
531_K	535_A	0.628	0.82
216_I	245_P	0.628	0.82
174_L	277_M	0.627	0.82
10_R	16_K	0.627	0.82
654_K	661_A	0.626	0.81
175_P	276_P	0.626	0.81
63_A	102_A	0.625	0.81
6_P	477_Q	0.624	0.81
15_G	21_L	0.624	0.81
533_R	571_G	0.624	0.81
370_G	373_P	0.623	0.81
168_F	365_L	0.622	0.81
534_A	545_L	0.621	0.81
475_I	479_V	0.620	0.81
367_G	721_W	0.620	0.81
539_G	556_N	0.619	0.81
210_R	214_A	0.619	0.81
64_V	101_V	0.618	0.81
511_G	515_V	0.618	0.81
351_G	434_H	0.617	0.80
66_T	69_D	0.616	0.80
400_A	403_V	0.616	0.80
156_D	160_G	0.615	0.80
541_S	556_N	0.615	0.80
112_A	116_I	0.615	0.80
59_E	108_I	0.615	0.80
166_T	376_L	0.614	0.80
160_G	327_P	0.614	0.80
51_C	54_K	0.613	0.80
189_A	258_V	0.613	0.80
399_G	684_I	0.613	0.80
477_Q	481_E	0.613	0.80
127_D	340_N	0.611	0.80
373_P	712_K	0.611	0.80
180_T	653_A	0.611	0.80
294_H	320_A	0.610	0.80
210_R	498_A	0.610	0.80
464_F	515_V	0.610	0.80
426_G	716_D	0.609	0.80
174_L	647_Y	0.609	0.80
546_I	556_N	0.608	0.80
340_N	655_M	0.607	0.79
429_A	601_A	0.607	0.79
404_L	407_I	0.605	0.79
365_L	368_M	0.604	0.79
91_V	94_V	0.604	0.79
16_K	230_P	0.603	0.79
27_L	188_V	0.603	0.79
643_M	646_G	0.603	0.79
419_N	424_Q	0.603	0.79
34_Y	261_H	0.603	0.79
644_A	703_T	0.603	0.79
32_M	257_P	0.603	0.79
475_I	515_V	0.603	0.79
477_Q	487_A	0.602	0.79
172_Y	357_A	0.602	0.79
606_V	611_G	0.601	0.79
420_C	425_R	0.599	0.79
13_G	17_V	0.598	0.78
300_A	316_S	0.597	0.78
620_H	637_I	0.596	0.78
360_T	715_H	0.595	0.78
420_C	608_L	0.595	0.78
547_P	551_G	0.594	0.78
613_V	729_R	0.593	0.78
466_E	472_L	0.593	0.78
534_A	538_S	0.592	0.78
3_I	481_E	0.591	0.78
191_P	196_G	0.591	0.78
22_K	28_S	0.591	0.78
533_R	537_W	0.591	0.78
108_I	115_L	0.591	0.78
539_G	557_T	0.591	0.78
67_H	86_L	0.591	0.78
52_T	58_M	0.590	0.77
292_L	376_L	0.590	0.77
278_K	299_V	0.589	0.77
281_I	365_L	0.589	0.77
504_G	507_T	0.588	0.77
159_E	287_H	0.588	0.77
393_R	396_P	0.588	0.77
252_L	255_G	0.587	0.77
548_G	556_N	0.587	0.77
39_R	97_A	0.585	0.77
611_G	736_I	0.585	0.77
475_I	492_I	0.584	0.77
49_S	287_H	0.584	0.77
581_F	584_T	0.584	0.77
13_G	16_K	0.584	0.77
296_V	320_A	0.583	0.77
282_K	297_K	0.583	0.77
384_P	397_T	0.583	0.77
407_I	413_L	0.583	0.77
413_L	416_T	0.583	0.77
360_T	721_W	0.582	0.77
300_A	313_L	0.582	0.77
86_L	97_A	0.582	0.77
83_Q	96_D	0.582	0.77
484_G	547_P	0.582	0.77
122_E	125_V	0.582	0.77
174_L	356_F	0.582	0.77
176_R	653_A	0.581	0.76
483_L	490_I	0.580	0.76
553_R	557_T	0.580	0.76
462_F	475_I	0.580	0.76
408_S	601_A	0.580	0.76
535_A	538_S	0.579	0.76
533_R	536_E	0.579	0.76
69_D	72_G	0.579	0.76
276_P	343_A	0.579	0.76
36_K	266_E	0.579	0.76
24_M	188_V	0.577	0.76
363_D	721_W	0.576	0.76
206_G	465_E	0.576	0.76
414_K	418_R	0.576	0.76
170_E	361_H	0.575	0.76
3_I	477_Q	0.575	0.76
478_I	693_Y	0.575	0.76
381_I	404_L	0.575	0.76
423_L	616_I	0.574	0.76
450_L	519_I	0.574	0.76
59_E	62_Q	0.574	0.76
369_L	379_K	0.572	0.75
57_K	117_Q	0.572	0.75
365_L	371_I	0.570	0.75
268_V	665_L	0.570	0.75
503_S	515_V	0.570	0.75
77_G	81_P	0.570	0.75
389_P	392_H	0.568	0.75
669_L	672_G	0.567	0.75
400_A	406_A	0.567	0.75
624_A	683_A	0.567	0.75
243_I	262_Q	0.566	0.75
420_C	423_L	0.566	0.75
615_L	618_C	0.566	0.75
373_P	377_R	0.565	0.74
67_H	71_P	0.565	0.74
548_G	551_G	0.565	0.74
290_N	327_P	0.562	0.74
446_A	518_A	0.562	0.74
535_A	542_A	0.562	0.74
63_A	250_L	0.561	0.74
33_L	63_A	0.561	0.74
540_C	545_L	0.561	0.74
49_S	54_K	0.560	0.74
584_T	587_P	0.560	0.74
209_D	244_Q	0.560	0.74
433_M	595_Y	0.560	0.74
642_A	645_L	0.559	0.74
577_T	582_P	0.559	0.74
512_T	695_P	0.559	0.74
538_S	545_L	0.558	0.73
125_V	339_N	0.558	0.73
360_T	712_K	0.558	0.73
493_V	499_K	0.558	0.73
368_M	721_W	0.557	0.73
362_L	369_L	0.557	0.73
446_A	514_M	0.556	0.73
407_I	411_P	0.555	0.73
187_G	244_Q	0.555	0.73
313_L	335_S	0.555	0.73
206_G	503_S	0.555	0.73
731_E	734_E	0.554	0.73
535_A	541_S	0.553	0.73
285_A	368_M	0.552	0.73
73_L	218_D	0.552	0.73
548_G	561_V	0.551	0.73
731_E	735_A	0.550	0.72
213_L	218_D	0.549	0.72
607_D	610_T	0.549	0.72
133_L	137_A	0.549	0.72
155_G	160_G	0.549	0.72
6_P	9_V	0.547	0.72
381_I	398_D	0.546	0.72
430_A	708_P	0.546	0.72
410_S	413_L	0.546	0.72
637_I	683_A	0.546	0.72
451_S	459_T	0.546	0.72
427_T	601_A	0.545	0.72
627_V	630_P	0.545	0.72
165_D	288_S	0.544	0.72
484_G	527_L	0.544	0.72
276_P	340_N	0.544	0.72
413_L	427_T	0.544	0.72
126_M	131_K	0.543	0.71
467_C	471_I	0.543	0.71
485_C	490_I	0.543	0.71
130_E	133_L	0.543	0.71
52_T	68_K	0.543	0.71
554_D	560_L	0.543	0.71
372_D	376_L	0.543	0.71
194_D	223_K	0.543	0.71
68_K	71_P	0.541	0.71
174_L	279_I	0.540	0.71
644_A	648_T	0.540	0.71
251_A	254_S	0.540	0.71
579_F	584_T	0.539	0.71
50_V	120_Y	0.539	0.71
159_E	328_N	0.538	0.71
161_F	165_D	0.537	0.71
450_L	458_I	0.536	0.71
128_S	336_V	0.536	0.71
513_S	690_G	0.536	0.71
720_C	732_L	0.536	0.71
315_F	319_H	0.536	0.71
385_H	395_A	0.536	0.71
126_M	138_Q	0.536	0.71
199_M	248_A	0.536	0.71
527_L	552_L	0.535	0.70
399_G	686_D	0.535	0.70
535_A	545_L	0.535	0.70
450_L	490_I	0.535	0.70
119_E	122_E	0.534	0.70
92_R	337_F	0.533	0.70
200_Y	229_S	0.533	0.70
55_A	99_A	0.532	0.70
306_A	337_F	0.532	0.70
471_I	506_S	0.531	0.70
366_S	376_L	0.531	0.70
582_P	586_D	0.531	0.70
289_G	376_L	0.530	0.70
563_T	569_E	0.530	0.70
177_Q	274_R	0.529	0.70
472_L	494_I	0.529	0.70
606_V	717_A	0.529	0.70
56_E	61_V	0.529	0.70
428_G	432_T	0.528	0.69
637_I	702_G	0.528	0.69
47_I	67_H	0.528	0.69
581_F	585_P	0.527	0.69
424_Q	718_V	0.526	0.69
562_V	565_K	0.526	0.69
407_I	619_E	0.526	0.69
697_G	702_G	0.526	0.69
101_V	109_A	0.526	0.69
292_L	327_P	0.525	0.69
447_G	501_P	0.525	0.69
202_G	234_S	0.525	0.69
581_F	586_D	0.525	0.69
50_V	66_T	0.525	0.69
446_A	503_S	0.524	0.69
180_T	268_V	0.523	0.69
77_G	82_D	0.523	0.69
493_V	500_V	0.523	0.69
78_I	81_P	0.522	0.69
281_I	362_L	0.522	0.69
277_M	353_Q	0.521	0.68
349_F	508_A	0.521	0.68
577_T	584_T	0.521	0.68
544_N	557_T	0.520	0.68
212_Q	241_L	0.520	0.68
448_G	462_F	0.520	0.68
430_A	712_K	0.519	0.68
100_A	260_I	0.519	0.68
526_F	530_L	0.519	0.68
638_E	679_M	0.519	0.68
475_I	478_I	0.518	0.68
94_V	660_Y	0.518	0.68
598_G	622_I	0.518	0.68
611_G	733_L	0.517	0.68
289_G	379_K	0.516	0.68
466_E	471_I	0.516	0.68
227_V	496_D	0.516	0.68
44_H	91_V	0.515	0.67
545_L	554_D	0.515	0.67
600_A	620_H	0.514	0.67
205_H	208_K	0.513	0.67
249_L	254_S	0.513	0.67
7_S	473_A	0.513	0.67
626_P	687_L	0.513	0.67
386_D	390_L	0.512	0.67
33_L	258_V	0.511	0.67
603_E	616_I	0.511	0.67
535_A	539_G	0.511	0.67
419_N	608_L	0.510	0.67
160_G	286_D	0.510	0.67
562_V	566_E	0.510	0.67
302_T	343_A	0.509	0.67
41_A	45_A	0.509	0.67
389_P	396_P	0.509	0.67
645_L	650_M	0.509	0.67
61_V	64_V	0.509	0.67
403_V	684_I	0.509	0.67
132_A	135_P	0.508	0.66
517_H	692_V	0.508	0.66
149_R	153_S	0.507	0.66
47_I	87_C	0.507	0.66
168_F	369_L	0.506	0.66
426_G	606_V	0.506	0.66
46_E	49_S	0.506	0.66
570_K	574_A	0.506	0.66
411_P	415_K	0.506	0.66
163_A	328_N	0.505	0.66
70_V	86_L	0.504	0.66
178_M	273_K	0.504	0.66
436_G	513_S	0.504	0.66
392_H	396_P	0.504	0.66
578_A	581_F	0.503	0.66
55_A	115_L	0.502	0.66
12_D	16_K	0.502	0.66
101_V	112_A	0.502	0.66
43_P	656_T	0.501	0.65
508_A	640_G	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1rm6A	2	0.9919	100	0.098	Contact Map
1t3qB	2	0.9839	100	0.111	Contact Map
1ffvB	2	0.9839	100	0.12	Contact Map
2w3sB	2	0.9758	100	0.122	Contact Map
1n62B	2	0.9866	100	0.122	Contact Map
3uncA	2	0.9691	100	0.132	Contact Map
3nvzC	2	0.9691	100	0.144	Contact Map
3zyvA	3	0.9611	100	0.147	Contact Map
4usaA	2	0.9436	100	0.148	Contact Map
1dgjA	1	0.9409	100	0.15	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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