GREMLIN Database
XDHE - Probable xanthine dehydrogenase subunit E
UniProt: O32143 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 173 (149)
Sequences: 6864 (4054)
Seq/√Len: 332.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_E159_R3.8911.00
133_D158_C3.7351.00
33_T42_E3.1951.00
96_D122_K2.7091.00
136_I158_C2.5441.00
19_T83_S2.5111.00
47_G87_I2.5011.00
132_S135_D2.5011.00
27_V38_L2.4041.00
65_D82_H2.3171.00
100_T104_E2.2751.00
105_E155_R2.2491.00
17_R26_E2.0021.00
121_L157_A2.0011.00
55_G73_M1.9231.00
36_S50_V1.9051.00
61_S68_L1.8961.00
98_C118_I1.8741.00
64_I69_A1.8601.00
45_L48_T1.8311.00
104_E159_R1.8251.00
122_K126_R1.8141.00
19_T24_A1.8081.00
38_L76_A1.7821.00
63_L119_I1.7801.00
64_I74_T1.7711.00
33_T38_L1.7451.00
87_I118_I1.7341.00
17_R24_A1.6801.00
128_T135_D1.6731.00
137_E154_M1.6711.00
50_V53_G1.5581.00
15_Q28_A1.5141.00
100_T163_E1.4881.00
47_G88_E1.4711.00
75_M78_Q1.4321.00
98_C122_K1.4321.00
21_N88_E1.3821.00
21_N45_L1.3671.00
68_L123_A1.3391.00
95_L99_Q1.3301.00
61_S119_I1.3151.00
140_L157_A1.3121.00
63_L123_A1.2971.00
91_Q95_L1.2651.00
35_L62_I1.2591.00
20_V43_F1.2541.00
133_D155_R1.2531.00
85_T89_G1.2491.00
64_I84_I1.2481.00
29_A76_A1.2361.00
15_Q26_E1.2331.00
18_M25_W1.2241.00
117_M140_L1.2221.00
123_A127_E1.2211.00
124_L139_G1.2181.00
107_G156_S1.2141.00
159_R163_E1.2081.00
63_L122_K1.2071.00
102_F114_T1.1871.00
128_T131_P1.1721.00
74_T79_A1.1391.00
35_L84_I1.1351.00
69_A74_T1.1351.00
131_P161_R1.1161.00
64_I82_H1.1131.00
98_C121_L1.1091.00
151_G155_R1.0911.00
98_C160_I1.0841.00
120_A142_G1.0661.00
20_V25_W1.0581.00
16_F80_D1.0331.00
91_Q94_E1.0101.00
133_D137_E0.9991.00
96_D99_Q0.9961.00
48_T87_I0.9951.00
152_G155_R0.9931.00
38_L43_F0.9921.00
64_I79_A0.9841.00
35_L79_A0.9691.00
90_L122_K0.9671.00
36_S48_T0.9591.00
30_V33_T0.9521.00
29_A42_E0.9201.00
68_L120_A0.9121.00
133_D154_M0.9081.00
107_G114_T0.8971.00
116_G143_N0.8961.00
45_L88_E0.8931.00
34_H37_D0.8881.00
67_K127_E0.8841.00
94_E100_T0.8841.00
27_V43_F0.8751.00
20_V45_L0.8741.00
125_F161_R0.8591.00
91_Q99_Q0.8521.00
85_T126_R0.8401.00
65_D83_S0.8251.00
104_E163_E0.8231.00
22_G25_W0.8221.00
90_L118_I0.8201.00
98_C125_F0.8191.00
63_L85_T0.8081.00
154_M158_C0.8051.00
79_A82_H0.7971.00
62_I71_A0.7911.00
22_G83_S0.7881.00
101_A159_R0.7831.00
102_F121_L0.7771.00
39_L62_I0.7761.00
34_H50_V0.7751.00
121_L140_L0.7731.00
159_R162_R0.7681.00
97_M160_I0.7651.00
117_M149_G0.7641.00
127_E139_G0.7621.00
102_F107_G0.7611.00
106_G149_G0.7571.00
106_G148_T0.7541.00
74_T78_Q0.7510.99
117_M153_I0.7500.99
134_K138_E0.7500.99
134_K137_E0.7500.99
102_F118_I0.7490.99
124_L131_P0.7420.99
17_R80_D0.7350.99
36_S51_S0.7340.99
53_G56_R0.7320.99
46_T115_P0.7240.99
101_A160_I0.7220.99
131_P139_G0.7210.99
37_D50_V0.6990.99
18_M27_V0.6990.99
68_L139_G0.6980.99
95_L103_L0.6960.99
124_L136_I0.6940.99
102_F117_M0.6930.99
136_I154_M0.6920.99
120_A139_G0.6900.99
93_E97_M0.6840.99
29_A38_L0.6820.99
21_N89_G0.6800.99
155_R159_R0.6780.99
105_E156_S0.6740.99
135_D139_G0.6730.99
33_T41_K0.6730.99
32_T77_Y0.6700.99
102_F108_F0.6690.99
128_T139_G0.6690.99
38_L42_E0.6670.99
34_H75_M0.6660.99
117_M143_N0.6660.99
18_M38_L0.6630.99
39_L43_F0.6600.99
160_I163_E0.6600.99
124_L128_T0.6540.99
124_L129_P0.6500.99
93_E96_D0.6490.99
70_N74_T0.6490.99
125_F160_I0.6480.99
89_G95_L0.6460.98
108_F114_T0.6420.98
37_D41_K0.6350.98
46_T49_K0.6300.98
125_F131_P0.6280.98
33_T76_A0.6270.98
63_L68_L0.6260.98
39_L48_T0.6250.98
125_F128_T0.6240.98
57_C60_C0.6200.98
106_G152_G0.6190.98
16_F76_A0.6190.98
92_K95_L0.6170.98
52_C57_C0.6140.98
90_L119_I0.6130.98
85_T122_K0.6080.98
117_M142_G0.6050.98
16_F29_A0.6050.98
49_K115_P0.6030.98
52_C60_C0.6020.98
66_G83_S0.6000.98
50_V56_R0.6000.98
49_K70_N0.5960.97
25_W38_L0.5890.97
39_L46_T0.5860.97
27_V42_E0.5830.97
34_H54_I0.5830.97
74_T82_H0.5820.97
54_I70_N0.5800.97
61_S120_A0.5780.97
120_A143_N0.5720.97
93_E99_Q0.5710.97
148_T151_G0.5710.97
63_L126_R0.5690.97
142_G150_Y0.5680.97
66_G82_H0.5640.96
56_R70_N0.5630.96
41_K46_T0.5590.96
103_L108_F0.5580.96
48_T88_E0.5480.96
47_G99_Q0.5460.96
50_V70_N0.5460.96
76_A79_A0.5430.96
90_L96_D0.5430.96
136_I157_A0.5430.96
49_K106_G0.5420.96
20_V39_L0.5410.96
35_L74_T0.5330.95
95_L100_T0.5300.95
119_I139_G0.5270.95
125_F129_P0.5270.95
61_S143_N0.5200.94
60_C72_C0.5180.94
18_M80_D0.5170.94
52_C72_C0.5160.94
130_Q162_R0.5130.94
117_M148_T0.5130.94
20_V84_I0.5120.94
18_M79_A0.5100.94
57_C72_C0.5080.94
32_T75_M0.5080.94
53_G70_N0.5030.93
31_P77_Y0.5010.93
50_V112_Y0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uncA 2 0.8902 100 0.093 Contact Map
3zyvA 3 0.896 100 0.102 Contact Map
3nvwA 1 0.8728 100 0.14 Contact Map
2w3sA 1 0.896 100 0.146 Contact Map
1dgjA 1 0.9306 100 0.16 Contact Map
4usaA 2 0.9306 100 0.172 Contact Map
1n62A 1 0.9191 100 0.223 Contact Map
3hrdD 1 0.9191 100 0.232 Contact Map
1rm6C 1 0.9017 100 0.282 Contact Map
1t3qA 1 0.9306 100 0.287 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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