GREMLIN Database
HIUH - 5-hydroxyisourate hydrolase
UniProt: O32142 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 114 (107)
Sequences: 1689 (1100)
Seq/√Len: 106.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_I20_V3.4741.00
38_N44_D3.2961.00
92_D95_A3.2691.00
59_V87_R2.8251.00
23_G63_H2.7571.00
17_A20_V2.6451.00
11_L107_G2.5391.00
63_H66_D2.4031.00
31_I34_E2.2431.00
25_K61_E2.2341.00
23_G34_E2.1671.00
21_K63_H2.1651.00
35_V43_V2.1351.00
78_Q91_A1.9761.00
29_E59_V1.9531.00
61_E83_I1.8451.00
21_K36_Y1.8441.00
80_F99_I1.8201.00
64_A84_V1.7521.00
23_G61_E1.7491.00
23_G31_I1.7431.00
21_K34_E1.5871.00
10_D13_C1.4991.00
59_V85_T1.4911.00
22_I60_M1.4901.00
13_C71_K1.4831.00
69_A79_P1.4301.00
40_D114_S1.4241.00
61_E85_T1.4131.00
12_T107_G1.4071.00
19_N36_Y1.3671.00
57_E89_Q1.3511.00
25_K31_I1.3471.00
18_A39_N1.2840.99
25_K59_V1.2520.99
11_L81_L1.2380.99
62_F101_L1.2340.99
68_F103_L1.2140.99
66_D69_A1.2110.99
60_M99_I1.1910.99
35_V45_V1.1900.99
78_Q89_Q1.1610.99
104_S107_G1.1250.98
40_D102_L1.1180.98
6_T60_M1.1110.98
69_A77_D1.0850.98
53_L58_Y1.0760.98
63_H83_I1.0290.97
64_A103_L1.0200.97
83_I87_R0.9860.96
20_V103_L0.9850.96
69_A82_T0.9730.96
3_K50_G0.9500.95
26_R29_E0.9440.95
84_V101_L0.9270.94
72_N77_D0.9220.94
88_F109_Q0.9210.94
62_F99_I0.9070.94
64_A82_T0.8780.92
65_G69_A0.8710.92
21_K66_D0.8660.92
82_T85_T0.8640.92
16_P114_S0.8620.92
20_V64_A0.8480.91
33_K52_E0.8480.91
27_L31_I0.8330.90
8_I37_T0.8290.90
6_T107_G0.8230.90
72_N89_Q0.8130.89
101_L108_Y0.8100.89
25_K29_E0.8070.89
15_K95_A0.7940.88
79_P103_L0.7870.88
22_I37_T0.7860.88
26_R54_M0.7840.87
90_L93_P0.7700.86
49_A52_E0.7610.86
43_V107_G0.7570.86
8_I105_P0.7520.85
9_L42_R0.7480.85
81_L85_T0.7440.85
26_R56_G0.7430.84
22_I43_V0.7420.84
80_F106_F0.7390.84
12_T104_S0.7370.84
22_I83_I0.7220.83
4_L53_L0.7200.83
66_D70_S0.7200.83
64_A81_L0.7190.82
3_K49_A0.7180.82
40_D101_L0.7050.81
91_A95_A0.7030.81
37_T43_V0.6980.81
11_L109_Q0.6830.79
65_G79_P0.6700.78
55_S93_P0.6650.77
81_L110_V0.6650.77
47_L50_G0.6550.76
4_L48_L0.6550.76
36_Y39_N0.6530.76
7_H42_R0.6530.76
51_E54_M0.6520.76
5_T47_L0.6500.76
42_R111_Y0.6480.75
53_L56_G0.6470.75
103_L107_G0.6450.75
32_M58_Y0.6410.75
5_T12_T0.6380.74
58_Y67_Y0.6360.74
57_E87_R0.6360.74
100_P109_Q0.6350.74
40_D99_I0.6340.74
8_I62_F0.6320.74
5_T102_L0.6260.73
27_L59_V0.6230.73
5_T96_H0.6230.73
26_R30_S0.6180.72
20_V37_T0.6170.72
3_K47_L0.6130.71
81_L86_V0.6100.71
106_F109_Q0.6090.71
3_K96_H0.6050.70
11_L40_D0.5980.70
62_F80_F0.5970.69
26_R32_M0.5950.69
29_E87_R0.5950.69
10_D53_L0.5940.69
8_I104_S0.5930.69
6_T99_I0.5930.69
5_T52_E0.5870.68
71_K77_D0.5860.68
99_I102_L0.5800.67
13_C106_F0.5790.67
68_F106_F0.5780.67
23_G83_I0.5760.67
15_K18_A0.5720.66
28_G51_E0.5680.66
68_F84_V0.5670.65
24_L60_M0.5640.65
7_H98_H0.5600.64
69_A72_N0.5580.64
54_M94_D0.5490.63
10_D71_K0.5490.63
20_V67_Y0.5450.62
5_T51_E0.5420.62
47_L60_M0.5400.62
22_I34_E0.5400.62
43_V49_A0.5320.61
3_K60_M0.5210.59
53_L86_V0.5200.59
64_A68_F0.5200.59
111_Y114_S0.5190.59
20_V68_F0.5160.58
65_G89_Q0.5150.58
36_Y54_M0.5140.58
57_E83_I0.5120.58
52_E94_D0.5100.57
38_N108_Y0.5020.56
11_L17_A0.5000.56
28_G65_G0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q14A 2 0.9912 100 0.053 Contact Map
2h0eA 4 0.9912 100 0.07 Contact Map
3iwvA 4 0.9561 100 0.086 Contact Map
2g2nA 5 0.9561 100 0.101 Contact Map
3qvaA 4 0.9211 100 0.109 Contact Map
1f86A 4 0.9474 100 0.167 Contact Map
1oo2A 4 0.9561 100 0.169 Contact Map
4pweA 4 0.9474 100 0.178 Contact Map
4zjhA 1 0.6053 98.7 0.775 Contact Map
4zjgA 1 0.5789 95.5 0.867 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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