GREMLIN Database
ALLB - Allantoinase
UniProt: O32137 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 446 (418)
Sequences: 9354 (6729)
Seq/√Len: 329.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_I47_A4.5861.00
50_K419_S3.9741.00
422_Y427_C3.9421.00
229_K255_E3.5951.00
392_P413_T3.4081.00
12_A21_A3.3771.00
420_A427_C3.3461.00
10_A47_A3.2771.00
26_Q31_A3.2701.00
356_T359_E3.2541.00
10_A52_V3.2351.00
43_E430_N3.0811.00
32_E379_A2.9461.00
353_P356_T2.8491.00
34_G37_I2.8261.00
8_K44_I2.8181.00
23_I52_V2.8121.00
376_R381_C2.8011.00
374_K382_D2.7691.00
377_L385_F2.7681.00
5_M422_Y2.6641.00
11_K20_E2.6341.00
397_R410_E2.5011.00
291_R295_E2.4961.00
47_A387_L2.4681.00
6_V24_V2.4661.00
364_A367_K2.4461.00
25_V385_F2.4291.00
396_T399_S2.4051.00
53_F388_V2.3941.00
82_A119_V2.2821.00
50_K387_L2.2611.00
52_V387_L2.2471.00
55_G87_T2.2431.00
221_V245_A2.2391.00
120_D424_K2.1601.00
28_G382_D2.1491.00
83_A429_Y2.1211.00
378_E381_C2.1031.00
258_D368_R2.0761.00
263_T267_Y2.0481.00
29_V373_K2.0421.00
236_H260_S2.0101.00
253_K307_D1.9871.00
345_E349_E1.9801.00
395_V414_F1.9801.00
172_E175_A1.9611.00
393_Y417_S1.8981.00
367_K376_R1.8951.00
59_C369_F1.8791.00
359_E364_A1.8771.00
82_A428_V1.8491.00
50_K389_S1.8451.00
83_A401_F1.8421.00
9_G46_Q1.8201.00
134_D137_P1.7831.00
291_R294_K1.7681.00
33_I379_A1.7571.00
8_K22_D1.7451.00
392_P415_P1.7401.00
107_L111_E1.7301.00
348_L415_P1.7231.00
12_A23_I1.7191.00
24_V42_T1.7061.00
88_T122_A1.7041.00
222_Y248_L1.6951.00
359_E363_A1.6931.00
325_N328_L1.6831.00
420_A430_N1.6821.00
22_D37_I1.6661.00
45_I422_Y1.6371.00
75_E79_Q1.6151.00
21_A33_I1.6111.00
225_I248_L1.6081.00
51_Y354_F1.6031.00
343_M357_I1.5991.00
63_F77_G1.5971.00
358_A362_A1.5951.00
218_V244_K1.5941.00
86_C339_T1.5741.00
251_E255_E1.5691.00
53_F358_A1.5671.00
343_M361_T1.5631.00
243_A292_Q1.5481.00
108_A112_L1.5471.00
228_A235_V1.5301.00
29_V382_D1.5221.00
18_V355_E1.5211.00
421_T429_Y1.5181.00
427_C430_N1.5131.00
10_A387_L1.5101.00
264_C267_Y1.5031.00
225_I259_V1.5001.00
56_V340_L1.4951.00
250_R303_A1.4851.00
389_S419_S1.4691.00
7_I25_V1.4561.00
139_A178_K1.4561.00
5_M25_V1.4501.00
394_T413_T1.4351.00
167_L230_V1.4331.00
24_V32_E1.4301.00
226_Q230_V1.4301.00
347_A357_I1.4181.00
53_F386_V1.4091.00
23_I377_L1.3901.00
363_A367_K1.3751.00
372_Q381_C1.3751.00
356_T360_W1.3681.00
222_Y226_Q1.3681.00
419_S431_D1.3641.00
73_G403_K1.3601.00
240_I249_I1.3551.00
382_D424_K1.3531.00
70_D317_R1.3501.00
396_T410_E1.3471.00
136_R172_E1.3471.00
173_I180_L1.3421.00
7_I387_L1.3271.00
284_C333_I1.3261.00
45_I420_A1.3211.00
308_M368_R1.3191.00
270_F342_G1.3191.00
24_V41_G1.3171.00
172_E176_A1.3021.00
52_V385_F1.3021.00
51_Y390_M1.3001.00
111_E114_R1.2901.00
162_D165_T1.2831.00
43_E427_C1.2791.00
247_R251_E1.2771.00
249_I261_V1.2771.00
59_C308_M1.2741.00
214_E244_K1.2661.00
352_I360_W1.2641.00
206_D276_R1.2511.00
79_Q401_F1.2501.00
53_F56_V1.2351.00
251_E254_Q1.2291.00
271_S291_R1.2261.00
373_K382_D1.2191.00
229_K257_L1.2171.00
6_V22_D1.2051.00
243_A296_T1.1921.00
196_V200_K1.1881.00
299_E303_A1.1871.00
63_F89_Y1.1791.00
5_M43_E1.1791.00
290_S293_S1.1781.00
111_E115_Q1.1721.00
173_I178_K1.1661.00
334_S404_H1.1651.00
170_M233_C1.1631.00
171_A175_A1.1611.00
423_S428_V1.1601.00
7_I422_Y1.1541.00
181_A238_V1.1531.00
72_E77_G1.1521.00
34_G38_E1.1521.00
108_A111_E1.1511.00
225_I252_A1.1421.00
387_L420_A1.1351.00
268_V297_L1.1341.00
191_S195_M1.1301.00
41_G44_I1.1291.00
16_D376_R1.1231.00
56_V361_T1.1221.00
269_L342_G1.1181.00
271_S274_D1.1181.00
57_I366_A1.1181.00
10_A385_F1.0981.00
395_V400_M1.0981.00
228_A257_L1.0931.00
6_V41_G1.0901.00
105_H108_A1.0851.00
346_L349_E1.0841.00
21_A35_S1.0801.00
196_V199_N1.0761.00
345_E412_H1.0741.00
318_P322_R1.0661.00
170_M180_L1.0631.00
120_D123_L1.0601.00
261_V306_I1.0581.00
13_V51_Y1.0581.00
7_I52_V1.0571.00
165_T168_K1.0561.00
296_T300_T1.0531.00
250_R305_D1.0521.00
11_K51_Y1.0461.00
302_I356_T1.0441.00
22_D34_G1.0411.00
59_C365_P1.0271.00
7_I385_F1.0271.00
177_G370_G1.0261.00
168_K171_A1.0241.00
302_I305_D1.0191.00
12_A377_L1.0171.00
242_T245_A1.0151.00
24_V37_I1.0131.00
299_E302_I1.0131.00
82_A421_T1.0111.00
110_A114_R1.0101.00
301_L360_W1.0061.00
283_K329_S1.0051.00
295_E299_E1.0011.00
385_F422_Y0.9931.00
195_M199_N0.9921.00
162_D188_A0.9921.00
387_L422_Y0.9921.00
240_I245_A0.9901.00
21_A377_L0.9891.00
366_A375_G0.9871.00
221_V237_F0.9861.00
14_T17_G0.9791.00
112_L115_Q0.9751.00
120_D374_K0.9701.00
186_S219_E0.9691.00
32_E37_I0.9691.00
78_S117_S0.9671.00
375_G384_D0.9621.00
102_T105_H0.9581.00
57_I88_T0.9571.00
103_A107_L0.9511.00
13_V18_V0.9471.00
357_I361_T0.9441.00
203_V206_D0.9411.00
250_R254_Q0.9411.00
88_T384_D0.9391.00
354_F390_M0.9321.00
339_T361_T0.9281.00
340_L344_L0.9281.00
338_F341_L0.9261.00
47_A52_V0.9261.00
146_F178_K0.9251.00
309_V360_W0.9201.00
25_V422_Y0.9191.00
224_T235_V0.9181.00
63_F78_S0.9171.00
309_V343_M0.9161.00
51_Y388_V0.9151.00
22_D36_D0.9091.00
20_E355_E0.9071.00
272_H290_S0.9061.00
13_V358_A0.9051.00
127_L169_G0.9041.00
58_D61_V0.9021.00
225_I257_L0.8951.00
248_L251_E0.8941.00
294_K298_I0.8871.00
338_F395_V0.8861.00
73_G76_T0.8771.00
200_K204_D0.8741.00
28_G424_K0.8691.00
244_K247_R0.8691.00
359_E367_K0.8691.00
167_L171_A0.8691.00
132_I136_R0.8661.00
317_R320_L0.8661.00
247_R250_R0.8641.00
386_V418_I0.8631.00
360_W364_A0.8591.00
166_L170_M0.8591.00
100_T106_L0.8581.00
263_T297_L0.8571.00
23_I33_I0.8551.00
292_Q295_E0.8541.00
393_Y418_I0.8471.00
90_F124_W0.8431.00
246_V300_T0.8401.00
9_G48_D0.8371.00
124_W127_L0.8361.00
6_V44_I0.8331.00
234_P258_D0.8321.00
279_G287_P0.8321.00
274_D282_A0.8301.00
24_V31_A0.8271.00
124_W145_G0.8261.00
59_C90_F0.8261.00
17_G355_E0.8251.00
73_G116_K0.8251.00
119_V423_S0.8251.00
56_V86_C0.8241.00
376_R379_A0.8241.00
118_A124_W0.8171.00
362_A365_P0.8171.00
226_Q229_K0.8161.00
334_S400_M0.8161.00
166_L182_L0.8161.00
63_F336_G0.8151.00
215_E230_V0.8141.00
335_G338_F0.8121.00
295_E298_I0.8121.00
341_L393_Y0.8061.00
407_S410_E0.8051.00
13_V355_E0.8031.00
21_A34_G0.8031.00
323_E328_L0.8021.00
374_K384_D0.8011.00
352_I356_T0.8011.00
136_R140_E0.7931.00
298_I346_L0.7931.00
82_A423_S0.7891.00
56_V339_T0.7881.00
133_E136_R0.7851.00
187_D191_S0.7851.00
273_D276_R0.7841.00
271_S294_K0.7841.00
57_I374_K0.7831.00
52_V422_Y0.7811.00
81_M89_Y0.7811.00
320_L330_W0.7801.00
345_E348_L0.7781.00
135_I176_A0.7781.00
90_F369_F0.7761.00
344_L357_I0.7761.00
219_E222_Y0.7751.00
45_I427_C0.7751.00
243_A247_R0.7731.00
136_R176_A0.7731.00
11_K18_V0.7721.00
170_M174_A0.7711.00
397_R400_M0.7711.00
24_V34_G0.7711.00
14_T18_V0.7671.00
107_L141_A0.7651.00
163_E186_S0.7651.00
106_L110_A0.7641.00
16_D378_E0.7631.00
158_F163_E0.7631.00
363_A376_R0.7631.00
135_I146_F0.7621.00
252_A257_L0.7601.00
109_K112_L0.7601.00
164_R168_K0.7591.00
103_A137_P0.7591.00
179_I234_P0.7581.00
344_L348_L0.7540.99
347_A351_Q0.7530.99
311_S339_T0.7530.99
300_T305_D0.7530.99
364_A368_R0.7520.99
65_E69_E0.7520.99
373_K381_C0.7510.99
168_K172_E0.7500.99
91_D109_K0.7490.99
8_K46_Q0.7490.99
104_E107_L0.7480.99
56_V386_V0.7450.99
148_A169_G0.7450.99
417_S431_D0.7440.99
177_G234_P0.7420.99
273_D291_R0.7420.99
5_M427_C0.7410.99
142_G146_F0.7410.99
298_I351_Q0.7400.99
50_K420_A0.7390.99
170_M173_I0.7390.99
163_E223_R0.7380.99
214_E218_V0.7350.99
340_L388_V0.7340.99
122_A125_G0.7330.99
158_F161_V0.7320.99
117_S121_F0.7300.99
33_I377_L0.7280.99
119_V122_A0.7260.99
185_E189_I0.7250.99
150_L224_T0.7240.99
75_E116_K0.7230.99
141_A144_I0.7220.99
344_L354_F0.7210.99
113_G123_L0.7180.99
70_D320_L0.7170.99
82_A118_A0.7170.99
198_A327_F0.7160.99
22_D38_E0.7150.99
118_A123_L0.7130.99
237_F240_I0.7130.99
5_M42_T0.7130.99
50_K391_E0.7120.99
246_V306_I0.7110.99
266_H333_I0.7100.99
120_D423_S0.7080.99
90_F122_A0.7080.99
104_E108_A0.7080.99
125_G138_M0.7070.99
344_L388_V0.7030.99
202_K207_A0.7020.99
99_S126_G0.7010.99
399_S410_E0.7000.99
202_K206_D0.6980.99
388_V418_I0.6960.99
163_E167_L0.6930.99
137_P140_E0.6900.99
348_L391_E0.6880.99
15_P18_V0.6860.99
31_A379_A0.6850.99
215_E219_E0.6850.99
43_E420_A0.6850.99
392_P395_V0.6820.99
228_A258_D0.6820.99
167_L231_T0.6810.99
283_K286_P0.6800.99
418_I421_T0.6800.99
340_L357_I0.6790.99
144_I170_M0.6790.99
109_K114_R0.6780.99
274_D277_Q0.6780.99
400_M410_E0.6780.99
238_V262_E0.6780.99
5_M45_I0.6770.99
280_S329_S0.6770.99
71_W316_C0.6770.99
293_S296_T0.6750.99
134_D138_M0.6730.99
125_G128_V0.6730.99
203_V207_A0.6710.99
222_Y251_E0.6680.99
341_L417_S0.6680.99
334_S406_K0.6670.99
305_D311_S0.6660.99
75_E118_A0.6640.99
337_Q401_F0.6630.99
121_F124_W0.6610.99
68_R97_I0.6600.99
304_G313_H0.6600.99
124_W128_V0.6590.99
16_D363_A0.6580.99
59_C368_R0.6550.99
120_D124_W0.6520.99
415_P418_I0.6520.99
274_D412_H0.6520.99
100_T105_H0.6510.99
120_D384_D0.6500.98
239_H312_D0.6490.98
347_A354_F0.6490.98
7_I45_I0.6480.98
78_S118_A0.6480.98
371_L374_K0.6470.98
61_V86_C0.6450.98
197_L209_A0.6430.98
132_I172_E0.6420.98
110_A113_G0.6420.98
15_P363_A0.6410.98
245_A249_I0.6400.98
237_F249_I0.6400.98
260_S368_R0.6390.98
384_D423_S0.6380.98
57_I365_P0.6370.98
53_F362_A0.6340.98
232_G258_D0.6330.98
253_K305_D0.6320.98
83_A337_Q0.6310.98
107_L110_A0.6310.98
304_G309_V0.6300.98
24_V36_D0.6290.98
284_C288_L0.6290.98
109_K113_G0.6290.98
367_K372_Q0.6280.98
135_I138_M0.6270.98
204_D207_A0.6270.98
112_L116_K0.6260.98
338_F400_M0.6250.98
420_A429_Y0.6200.98
124_W181_A0.6190.98
207_A210_A0.6180.98
133_E138_M0.6170.98
158_F166_L0.6150.98
341_L344_L0.6140.98
263_T268_V0.6130.98
348_L357_I0.6120.98
116_K119_V0.6090.98
59_C310_S0.6080.98
221_V225_I0.6080.98
159_R162_D0.6070.98
100_T109_K0.6060.98
163_E188_A0.6050.98
313_H316_C0.6050.98
141_A146_F0.6020.98
214_E290_S0.6020.98
64_N71_W0.6000.97
36_D39_A0.6000.97
266_H270_F0.6000.97
71_W320_L0.5990.97
252_A256_G0.5980.97
142_G145_G0.5980.97
246_V250_R0.5980.97
311_S315_P0.5980.97
218_V222_Y0.5970.97
63_F91_D0.5960.97
88_T120_D0.5960.97
17_G378_E0.5950.97
218_V248_L0.5950.97
341_L418_I0.5940.97
68_R71_W0.5940.97
78_S89_Y0.5930.97
101_V128_V0.5930.97
316_C320_L0.5920.97
239_H262_E0.5890.97
45_I387_L0.5880.97
344_L390_M0.5850.97
60_H239_H0.5850.97
394_T416_C0.5830.97
87_T421_T0.5820.97
393_Y399_S0.5820.97
161_V165_T0.5810.97
62_H312_D0.5800.97
61_V336_G0.5800.97
142_G147_K0.5800.97
286_P289_R0.5790.97
307_D310_S0.5790.97
361_T365_P0.5790.97
144_I147_K0.5790.97
34_G39_A0.5780.97
88_T374_K0.5770.97
339_T343_M0.5770.97
9_G22_D0.5760.97
8_K37_I0.5760.97
306_I313_H0.5720.97
11_K391_E0.5710.97
136_R175_A0.5710.97
295_E351_Q0.5710.97
246_V297_L0.5700.97
164_R167_L0.5670.96
15_P20_E0.5650.96
79_Q118_A0.5640.96
24_V39_A0.5640.96
88_T366_A0.5630.96
56_V362_A0.5610.96
282_A287_P0.5610.96
392_P416_C0.5600.96
333_I408_I0.5600.96
71_W317_R0.5600.96
106_L109_K0.5580.96
270_F408_I0.5560.96
120_D126_G0.5560.96
122_A126_G0.5560.96
65_E73_G0.5550.96
171_A196_V0.5540.96
181_A369_F0.5540.96
69_E73_G0.5540.96
311_S314_S0.5530.96
346_L351_Q0.5520.96
342_G414_F0.5510.96
307_D312_D0.5500.96
8_K36_D0.5500.96
302_I351_Q0.5500.96
310_S313_H0.5500.96
309_V312_D0.5500.96
116_K121_F0.5490.96
292_Q296_T0.5490.96
400_M405_K0.5490.96
307_D311_S0.5490.96
11_K21_A0.5480.96
303_A306_I0.5470.96
197_L207_A0.5470.96
304_G311_S0.5470.96
347_A352_I0.5440.96
240_I261_V0.5430.95
340_L386_V0.5390.95
124_W147_K0.5380.95
280_S287_P0.5380.95
293_S300_T0.5370.95
395_V404_H0.5370.95
280_S283_K0.5370.95
171_A199_N0.5370.95
350_H353_P0.5360.95
177_G258_D0.5360.95
133_E137_P0.5350.95
64_N316_C0.5340.95
240_I306_I0.5330.95
340_L361_T0.5330.95
311_S321_K0.5320.95
391_E415_P0.5320.95
88_T375_G0.5300.95
304_G307_D0.5300.95
32_E38_E0.5290.95
157_E160_S0.5290.95
147_K183_H0.5280.95
234_P368_R0.5280.95
23_I385_F0.5280.95
245_A248_L0.5270.95
313_H321_K0.5260.95
20_E35_S0.5250.95
6_V37_I0.5240.95
362_A374_K0.5240.95
81_M336_G0.5230.94
281_V318_P0.5220.94
119_V124_W0.5220.94
341_L415_P0.5220.94
319_S322_R0.5210.94
141_A145_G0.5210.94
123_L126_G0.5210.94
302_I308_M0.5190.94
400_M404_H0.5190.94
6_V42_T0.5190.94
62_H239_H0.5180.94
78_S82_A0.5170.94
157_E169_G0.5160.94
221_V240_I0.5150.94
57_I375_G0.5150.94
384_D424_K0.5130.94
144_I148_A0.5110.94
40_S44_I0.5110.94
173_I233_C0.5110.94
323_E330_W0.5110.94
397_R407_S0.5100.94
308_M311_S0.5090.94
284_C289_R0.5080.94
87_T384_D0.5080.94
186_S227_Y0.5070.94
138_M143_A0.5070.94
401_F429_Y0.5060.93
294_K300_T0.5050.93
163_E170_M0.5040.93
198_A201_G0.5040.93
278_R282_A0.5040.93
52_V377_L0.5030.93
266_H284_C0.5030.93
139_A176_A0.5030.93
113_G117_S0.5030.93
197_L210_A0.5030.93
282_A286_P0.5020.93
138_M141_A0.5020.93
123_L127_L0.5020.93
219_E223_R0.5010.93
307_D313_H0.5010.93
196_V201_G0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ftyA 3 0.9865 100 0.263 Contact Map
1gkrA 3 0.991 100 0.266 Contact Map
3e74A 3 0.9641 100 0.267 Contact Map
3dc8A 3 0.9753 100 0.267 Contact Map
3hm7A 2 0.9686 100 0.276 Contact Map
1gkpA 4 0.9843 100 0.278 Contact Map
1nfgA 3 0.9843 100 0.283 Contact Map
3sfwA 3 0.9865 100 0.284 Contact Map
4lcqA 3 0.9888 100 0.287 Contact Map
2ftwA 3 0.9888 100 0.288 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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