GREMLIN Database
YUNF - UPF0759 protein YunF
UniProt: O32135 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 282 (236)
Sequences: 2584 (1816)
Seq/√Len: 118.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_I247_L4.6521.00
228_E266_L4.4991.00
224_Q262_Q4.1201.00
24_K27_Q3.7221.00
21_A24_K3.0751.00
58_T104_K3.0061.00
142_F156_T2.7511.00
32_H261_K2.6261.00
68_A110_F2.5971.00
53_K57_E2.4541.00
73_T110_F2.3801.00
55_V100_L2.2971.00
139_A168_S2.2971.00
90_D94_V2.2961.00
48_A52_E2.2871.00
118_C146_S2.1191.00
227_L266_L2.0691.00
3_Y34_P2.0651.00
2_I238_Q1.9381.00
250_N256_A1.8621.00
46_Q51_N1.8381.00
41_S51_N1.8181.00
161_K185_R1.8171.00
262_Q265_E1.8161.00
196_F246_V1.7961.00
234_L246_V1.7751.00
11_D14_S1.7711.00
65_I247_L1.7631.00
58_T64_F1.7521.00
34_P264_L1.7461.00
191_K245_F1.7081.00
194_V230_W1.6941.00
17_P28_A1.6861.00
26_L58_T1.6861.00
234_L263_M1.6171.00
118_C156_T1.5921.00
100_L103_N1.5861.00
47_P50_N1.5541.00
124_A128_W1.5461.00
6_L29_Y1.5381.00
231_K235_N1.5321.00
106_A245_F1.5301.00
223_N226_E1.5121.00
87_E91_A1.4871.00
129_C133_M1.4861.00
29_Y36_V1.4841.00
86_E132_Q1.4811.00
4_I264_L1.4751.00
140_L160_M1.4741.00
27_Q57_E1.4711.00
59_P104_K1.4611.00
51_N99_Y1.4601.00
166_I188_D1.4551.00
130_K165_W1.4391.00
125_Y129_C1.4331.00
61_T103_N1.4231.00
133_M138_C1.4071.00
166_I191_K1.4001.00
3_Y63_Q1.3991.00
221_R255_D1.3961.00
52_E98_P1.3841.00
159_F163_E1.3811.00
7_T247_L1.3811.00
66_V99_Y1.3771.00
124_A163_E1.3761.00
63_Q245_F1.3701.00
157_L185_R1.3661.00
203_G220_Y1.3531.00
117_D144_N1.3381.00
188_D191_K1.3321.00
127_R163_E1.3301.00
110_F138_C1.3221.00
192_T244_V1.3161.00
63_Q106_A1.2881.00
139_A166_I1.2660.99
127_R131_H1.2590.99
3_Y243_D1.2550.99
89_F93_K1.2340.99
46_Q95_S1.2290.99
158_S162_A1.2270.99
38_L50_N1.2240.99
221_R259_N1.2210.99
52_E56_K1.2150.99
49_R52_E1.1990.99
137_P189_E1.1980.99
259_N262_Q1.1910.99
9_W38_L1.1850.99
16_Y20_T1.1840.99
65_I107_M1.1790.99
221_R258_D1.1780.99
53_K56_K1.1770.99
107_M245_F1.1680.99
55_V104_K1.1560.99
131_H163_E1.1470.99
189_E242_K1.1350.99
22_S25_K1.1310.99
77_R115_W1.1300.99
126_L129_C1.1240.99
91_A94_V1.1160.99
51_N96_L1.1130.99
127_R162_A1.1010.99
27_Q31_S1.0840.98
68_A108_V1.0820.98
38_L64_F1.0800.98
157_L161_K1.0770.98
12_H22_S1.0720.98
3_Y245_F1.0650.98
197_H250_N1.0650.98
8_G11_D1.0650.98
107_M191_K1.0610.98
17_P20_T1.0540.98
55_V103_N1.0490.98
26_L64_F1.0420.98
231_K263_M1.0380.98
112_F123_V1.0360.98
44_A47_P1.0330.98
105_L108_V1.0330.98
164_G189_E1.0320.98
11_D251_N1.0300.98
9_W54_W1.0300.98
158_S161_K1.0280.98
93_K108_V1.0250.98
71_G88_M1.0250.98
4_I263_M1.0240.98
49_R53_K1.0210.98
88_M91_A1.0050.97
224_Q266_L0.9960.97
127_R159_F0.9920.97
197_H259_N0.9910.97
28_A32_H0.9840.97
171_D199_R0.9810.97
219_L252_S0.9740.97
72_M89_F0.9640.97
222_Y248_F0.9590.96
173_P198_G0.9570.96
48_A95_S0.9550.96
157_L167_H0.9520.96
13_D254_G0.9460.96
236_E240_Q0.9450.96
133_M136_I0.9390.96
248_F263_M0.9330.96
248_F259_N0.9260.96
62_F104_K0.9240.96
71_G76_Q0.9150.95
20_T28_A0.9150.95
71_G75_H0.9140.95
55_V99_Y0.9120.95
196_F249_N0.9090.95
218_Y249_N0.9060.95
15_I25_K0.9040.95
41_S92_F0.9030.95
48_A94_V0.9010.95
4_I267_L0.8960.95
137_P243_D0.8950.95
107_M193_L0.8900.95
197_H222_Y0.8780.94
199_R226_E0.8730.94
38_L66_V0.8710.94
126_L133_M0.8710.94
107_M139_A0.8690.94
30_S58_T0.8630.94
140_L165_W0.8600.94
28_A31_S0.8590.94
87_E90_D0.8580.94
197_H249_N0.8560.93
45_I95_S0.8560.93
86_E90_D0.8540.93
234_L244_V0.8540.93
184_L230_W0.8540.93
186_A192_T0.8470.93
42_F113_P0.8460.93
48_A98_P0.8420.93
112_F129_C0.8390.93
70_Q75_H0.8370.93
184_L233_H0.8350.93
235_N239_Q0.8320.92
192_T241_C0.8310.92
65_I193_L0.8290.92
224_Q228_E0.8280.92
230_W233_H0.8240.92
248_F260_G0.8240.92
148_F167_H0.8130.92
197_H251_N0.8100.91
229_D233_H0.8070.91
147_W156_T0.7980.91
198_G220_Y0.7950.91
13_D251_N0.7940.91
74_G113_P0.7910.90
4_I260_G0.7880.90
221_R262_Q0.7840.90
2_I267_L0.7730.89
42_F74_G0.7680.89
93_K136_I0.7630.89
150_P185_R0.7630.89
39_D74_G0.7610.89
231_K267_L0.7610.89
261_K264_L0.7610.89
84_S88_M0.7580.88
140_L156_T0.7570.88
97_T135_D0.7490.88
66_V96_L0.7490.88
198_G250_N0.7480.88
51_N95_S0.7440.88
77_R116_F0.7420.87
199_R220_Y0.7410.87
191_K243_D0.7410.87
137_P191_K0.7390.87
128_W132_Q0.7380.87
19_K99_Y0.7370.87
67_K111_Q0.7350.87
118_C149_S0.7350.87
69_Y72_M0.7350.87
61_T189_E0.7340.87
106_A243_D0.7320.87
60_E104_K0.7310.87
194_V234_L0.7250.86
7_T249_N0.7220.86
94_V97_T0.7200.86
233_H236_E0.7190.86
250_N259_N0.7190.86
16_Y19_K0.7130.85
16_Y24_K0.7080.85
161_K189_E0.7070.85
182_T233_H0.7060.85
169_V237_L0.7030.84
198_G218_Y0.7030.84
109_L250_N0.7020.84
199_R250_N0.7010.84
160_M167_H0.7000.84
85_K88_M0.6970.84
7_T14_S0.6960.84
69_Y91_A0.6920.83
3_Y106_A0.6900.83
265_E269_I0.6880.83
112_F116_F0.6820.83
128_W131_H0.6820.83
110_F140_L0.6810.82
61_T104_K0.6790.82
112_F125_Y0.6780.82
15_I22_S0.6740.82
160_M165_W0.6730.82
124_A131_H0.6700.81
68_A73_T0.6690.81
169_V194_V0.6680.81
196_F230_W0.6670.81
59_P62_F0.6660.81
7_T39_D0.6650.81
68_A138_C0.6610.81
45_I69_Y0.6530.80
169_V182_T0.6520.80
109_L168_S0.6490.79
142_F157_L0.6480.79
38_L41_S0.6470.79
91_A95_S0.6470.79
228_E231_K0.6460.79
35_I245_F0.6440.79
138_C165_W0.6430.79
13_D253_G0.6430.79
145_R148_F0.6420.79
72_M88_M0.6400.78
73_T113_P0.6370.78
142_F147_W0.6360.78
186_A241_C0.6330.78
47_P95_S0.6270.77
222_Y227_L0.6260.77
85_K89_F0.6260.77
51_N66_V0.6250.77
83_D87_E0.6240.77
41_S96_L0.6240.77
186_A240_Q0.6230.77
173_P226_E0.6230.77
10_G22_S0.6190.76
199_R223_N0.6160.76
67_K143_R0.6160.76
167_H170_C0.6140.76
192_T242_K0.6130.75
255_D258_D0.6120.75
200_N226_E0.6080.75
48_A97_T0.6070.75
64_F104_K0.6050.74
223_N259_N0.6050.74
30_S57_E0.6040.74
108_V136_I0.6030.74
96_L105_L0.6020.74
228_E262_Q0.5990.74
123_V127_R0.5980.74
230_W237_L0.5960.73
20_T25_K0.5940.73
69_Y92_F0.5840.72
251_N259_N0.5840.72
111_Q143_R0.5830.72
38_L51_N0.5820.72
130_K164_G0.5810.71
246_V263_M0.5780.71
116_F142_F0.5770.71
109_L197_H0.5760.71
173_P249_N0.5760.71
76_Q84_S0.5720.70
55_V58_T0.5710.70
50_N53_K0.5700.70
222_Y260_G0.5690.70
250_N254_G0.5680.70
8_G193_L0.5670.70
231_K266_L0.5660.70
34_P61_T0.5660.70
7_T11_D0.5640.69
167_H183_V0.5630.69
27_Q32_H0.5620.69
225_Q229_D0.5590.69
235_N238_Q0.5550.68
76_Q88_M0.5520.68
123_V159_F0.5500.67
54_W62_F0.5480.67
10_G40_A0.5470.67
232_K235_N0.5460.67
78_G112_F0.5450.67
96_L108_V0.5440.67
23_Q57_E0.5430.66
2_I15_I0.5430.66
84_S89_F0.5410.66
75_H115_W0.5390.66
232_K236_E0.5370.66
158_S232_K0.5350.65
126_L130_K0.5340.65
109_L116_F0.5340.65
219_L253_G0.5320.65
28_A261_K0.5310.65
37_E54_W0.5300.65
76_Q85_K0.5300.65
41_S248_F0.5290.64
8_G20_T0.5250.64
29_Y33_F0.5250.64
89_F129_C0.5240.64
39_D247_L0.5200.63
192_T237_L0.5190.63
68_A89_F0.5170.63
129_C138_C0.5140.62
238_Q241_C0.5130.62
148_F157_L0.5130.62
170_C220_Y0.5120.62
125_Y128_W0.5120.62
15_I20_T0.5110.62
197_H218_Y0.5100.62
113_P116_F0.5100.62
226_E259_N0.5100.62
74_G78_G0.5090.61
150_P158_S0.5070.61
7_T40_A0.5050.61
31_S34_P0.5040.61
5_G8_G0.5030.61
77_R84_S0.5030.61
130_K159_F0.5010.60
151_P188_D0.5000.60
75_H251_N0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vpyA 1 0.8759 100 0.142 Contact Map
1vpqA 2 0.8936 100 0.152 Contact Map
3wqoA 2 0.8794 88.7 0.943 Contact Map
3aamA 1 0.8546 85.6 0.946 Contact Map
1k77A 1 0.8369 83.1 0.948 Contact Map
3ngfA 1 0.8298 81.3 0.949 Contact Map
3kwsA 2 0.8298 78.3 0.95 Contact Map
2hk0A 3 0.8298 75.7 0.951 Contact Map
4hnoA 1 0.8652 71.5 0.953 Contact Map
2g0wA 1 0.8901 64.7 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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