GREMLIN Database
YUNE - UPF0721 transmembrane protein YunE
UniProt: O32134 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 273 (241)
Sequences: 9215 (6295)
Seq/√Len: 405.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_T242_I3.7391.00
90_G163_F3.5661.00
97_V167_F3.0961.00
76_D194_V2.9121.00
7_V231_G2.7601.00
70_I77_Y2.5891.00
64_S233_W2.5841.00
249_K253_M2.4471.00
60_F229_V2.4311.00
9_L31_S2.4081.00
250_T253_M2.3841.00
84_F205_L2.3121.00
55_L210_G2.2721.00
241_A245_K2.2431.00
119_L123_L2.2331.00
161_I183_A2.1531.00
64_S237_K2.1461.00
80_G201_F2.1271.00
86_G159_I2.1241.00
191_P194_V2.1001.00
264_C268_Y2.0341.00
49_V52_G1.9621.00
92_M213_S1.9551.00
68_A240_A1.9081.00
111_G263_G1.8551.00
118_S263_G1.8541.00
53_T225_A1.8361.00
79_S190_F1.8081.00
118_S260_I1.7741.00
69_Y74_T1.7741.00
56_L225_A1.7681.00
10_G228_L1.7621.00
247_Q250_T1.7591.00
76_D79_S1.7171.00
13_A27_V1.7151.00
112_I116_L1.7071.00
78_K81_L1.7051.00
32_L228_L1.6991.00
96_Y100_L1.6881.00
11_L234_F1.6861.00
122_M256_R1.6681.00
163_F167_F1.6161.00
165_V179_L1.6161.00
11_L235_G1.6001.00
260_I264_C1.5891.00
118_S256_R1.5861.00
81_L85_I1.5421.00
15_T238_L1.5371.00
221_N224_Y1.5271.00
69_Y243_N1.5271.00
115_I263_G1.5101.00
80_G198_T1.5051.00
215_M222_W1.5011.00
111_G267_I1.4871.00
88_G209_T1.4621.00
63_L204_F1.4531.00
78_K82_I1.4511.00
253_M257_I1.4341.00
74_T197_A1.4281.00
66_T201_F1.4181.00
72_Y244_R1.3931.00
93_I163_F1.3871.00
8_V12_I1.3851.00
74_T244_R1.3771.00
180_M202_I1.3671.00
226_L230_P1.3551.00
223_L227_A1.3551.00
230_P234_F1.3421.00
81_L84_F1.3341.00
181_V195_A1.3251.00
45_V224_Y1.3101.00
237_K241_A1.3081.00
212_V216_I1.2971.00
67_L71_K1.2951.00
4_V8_V1.2871.00
7_V227_A1.2841.00
105_S109_W1.2831.00
90_G94_G1.2751.00
91_S210_G1.2731.00
156_S160_A1.2721.00
65_S200_M1.2621.00
33_M47_P1.2501.00
49_V221_N1.2431.00
126_K129_P1.2211.00
65_S236_G1.2181.00
59_I208_M1.2181.00
46_T49_V1.2131.00
10_G231_G1.2101.00
86_G162_A1.1991.00
77_Y81_L1.1991.00
257_I261_L1.1981.00
92_M96_Y1.1921.00
51_I214_H1.1681.00
213_S217_S1.1661.00
111_G115_I1.1601.00
87_S206_S1.1601.00
113_F172_F1.1591.00
203_I206_S1.1501.00
185_M195_A1.1491.00
86_G90_G1.1481.00
69_Y240_A1.1481.00
44_D50_A1.1461.00
66_T70_I1.1451.00
123_L126_K1.1361.00
156_S159_I1.1271.00
219_H223_L1.1181.00
95_A210_G1.1141.00
77_Y80_G1.1091.00
52_G220_V1.0931.00
265_Q268_Y1.0911.00
235_G238_L1.0871.00
7_V230_P1.0861.00
158_G188_F1.0751.00
95_A213_S1.0741.00
101_F171_L1.0661.00
121_L255_M1.0581.00
63_L67_L1.0571.00
93_I96_Y1.0561.00
250_T254_I1.0471.00
235_G239_G1.0441.00
176_G180_M1.0351.00
231_G235_G1.0281.00
83_F184_M1.0261.00
66_T77_Y1.0191.00
20_I254_I1.0141.00
174_I178_S1.0001.00
98_S214_H0.9951.00
83_F202_I0.9951.00
70_I75_V0.9941.00
5_I8_V0.9881.00
185_M192_P0.9871.00
7_V11_L0.9861.00
68_A237_K0.9801.00
53_T220_V0.9741.00
90_G167_F0.9671.00
160_A164_V0.9631.00
61_T232_A0.9601.00
104_N108_V0.9581.00
59_I211_S0.9491.00
126_K130_I0.9471.00
28_I228_L0.9471.00
176_G182_P0.9451.00
66_T204_F0.9451.00
69_Y197_A0.9431.00
54_S58_I0.9391.00
75_V198_T0.9321.00
85_I89_P0.9311.00
68_A72_Y0.9301.00
193_K243_N0.9231.00
181_V196_V0.9231.00
87_S202_I0.9231.00
49_V53_T0.9151.00
108_V112_I0.9131.00
105_S108_V0.9111.00
181_V199_S0.9061.00
6_L227_A0.9011.00
70_I73_K0.8981.00
72_Y241_A0.8981.00
261_L264_C0.8951.00
226_L229_V0.8941.00
180_M184_M0.8921.00
29_V54_S0.8871.00
64_S236_G0.8861.00
192_P196_V0.8831.00
124_K252_V0.8821.00
243_N251_I0.8801.00
116_L120_S0.8601.00
14_G24_G0.8601.00
241_A244_R0.8561.00
11_L231_G0.8531.00
154_Q157_V0.8491.00
18_S65_S0.8481.00
68_A241_A0.8471.00
183_A187_L0.8461.00
255_M259_L0.8451.00
6_L224_Y0.8401.00
95_A209_T0.8391.00
223_L226_L0.8371.00
115_I260_I0.8351.00
93_I167_F0.8311.00
17_G25_G0.8281.00
91_S95_A0.8271.00
6_L228_L0.8211.00
52_G211_S0.8191.00
173_G176_G0.8161.00
124_K127_A0.8141.00
227_A231_G0.8141.00
263_G267_I0.8131.00
162_A180_M0.8121.00
169_G206_S0.8111.00
151_Y154_Q0.8111.00
25_G170_G0.8111.00
108_V111_G0.8101.00
246_M250_T0.8021.00
77_Y201_F0.7991.00
115_I119_L0.7871.00
103_S107_S0.7841.00
93_I97_V0.7821.00
26_I114_M0.7811.00
80_G202_I0.7781.00
10_G28_I0.7751.00
68_A71_K0.7711.00
64_S68_A0.7661.00
28_I32_L0.7651.00
75_V80_G0.7641.00
25_G58_I0.7641.00
45_V49_V0.7601.00
83_F162_A0.7581.00
119_L260_I0.7571.00
201_F205_L0.7571.00
214_H219_H0.7511.00
55_L173_G0.7501.00
17_G22_L0.7501.00
234_F237_K0.7501.00
62_G203_I0.7461.00
18_S240_A0.7461.00
60_F233_W0.7421.00
19_L251_I0.7411.00
35_L45_V0.7411.00
15_T235_G0.7401.00
99_K217_S0.7371.00
200_M203_I0.7331.00
169_G176_G0.7311.00
62_G173_G0.7301.00
236_G240_A0.7301.00
86_G89_P0.7291.00
95_A214_H0.7291.00
13_A28_I0.7261.00
261_L265_Q0.7261.00
96_Y99_K0.7251.00
192_P255_M0.7191.00
10_G14_G0.7161.00
67_L70_I0.7141.00
19_L239_G0.7141.00
13_A31_S0.7101.00
157_V160_A0.7081.00
56_L211_S0.7051.00
11_L238_L0.7041.00
89_P93_I0.7031.00
17_G169_G0.7011.00
165_V176_G0.7001.00
152_S156_S0.6981.00
87_S180_M0.6951.00
211_S225_A0.6941.00
184_M188_F0.6921.00
109_W172_F0.6921.00
97_V100_L0.6921.00
96_Y217_S0.6901.00
57_V232_A0.6901.00
33_M50_A0.6841.00
48_Q106_F0.6841.00
104_N107_S0.6821.00
48_Q52_G0.6780.99
94_G167_F0.6750.99
82_I155_A0.6720.99
173_G199_S0.6670.99
5_I9_L0.6650.99
176_G203_I0.6630.99
165_V180_M0.6630.99
51_I55_L0.6630.99
160_A163_F0.6630.99
150_T154_Q0.6600.99
82_I85_I0.6600.99
51_I98_S0.6550.99
7_V10_G0.6520.99
130_I133_A0.6500.99
55_L58_I0.6480.99
220_V225_A0.6420.99
7_V234_F0.6400.99
53_T221_N0.6380.99
189_L195_A0.6340.99
74_T194_V0.6320.99
45_V221_N0.6270.99
194_V197_A0.6270.99
58_I62_G0.6250.99
117_I178_S0.6230.99
63_L66_T0.6230.99
10_G224_Y0.6230.99
225_A229_V0.6210.99
17_G61_T0.6190.99
176_G199_S0.6190.99
115_I267_I0.6170.99
55_L169_G0.6170.99
158_G184_M0.6150.99
173_G214_H0.6140.99
238_L241_A0.6130.99
128_R131_N0.6110.99
152_S155_A0.6090.99
233_W237_K0.6080.99
56_L229_V0.5980.99
102_N105_S0.5980.99
58_I207_S0.5970.99
28_I58_I0.5970.99
19_L246_M0.5940.99
169_G174_I0.5910.99
193_K248_T0.5900.99
58_I169_G0.5880.99
256_R260_I0.5860.99
179_L182_P0.5860.99
78_K155_A0.5850.99
17_G27_V0.5850.99
162_A166_G0.5820.98
177_G199_S0.5780.98
211_S215_M0.5780.98
11_L15_T0.5770.98
238_L242_I0.5760.98
101_F105_S0.5740.98
157_V183_A0.5720.98
222_W226_L0.5700.98
96_Y213_S0.5690.98
47_P51_I0.5690.98
23_G59_I0.5670.98
19_L242_I0.5660.98
14_G18_S0.5660.98
121_L256_R0.5640.98
58_I203_I0.5610.98
51_I106_F0.5600.98
34_F265_Q0.5560.98
56_L222_W0.5560.98
155_A159_I0.5530.98
76_D81_L0.5500.98
92_M216_I0.5470.98
28_I57_V0.5470.98
94_G98_S0.5460.98
103_S171_L0.5450.98
199_S203_I0.5440.98
62_G204_F0.5410.98
34_F266_L0.5380.97
242_I245_K0.5370.97
25_G174_I0.5370.97
58_I176_G0.5340.97
150_T153_Y0.5340.97
247_Q251_I0.5310.97
79_S194_V0.5310.97
184_M202_I0.5290.97
20_I236_G0.5290.97
97_V101_F0.5260.97
227_A230_P0.5260.97
47_P106_F0.5250.97
25_G175_G0.5230.97
47_P107_S0.5200.97
74_T193_K0.5190.97
14_G232_A0.5190.97
242_I246_M0.5180.97
47_P103_S0.5170.97
95_A98_S0.5160.97
177_G236_G0.5140.97
20_I258_V0.5140.97
258_V261_L0.5120.97
18_S28_I0.5120.97
118_S259_L0.5090.96
84_F87_S0.5080.96
18_S236_G0.5070.96
173_G206_S0.5060.96
34_F262_I0.5050.96
17_G203_I0.5050.96
180_M203_I0.5040.96
111_G266_L0.5040.96
157_V187_L0.5040.96
133_A152_S0.5020.96
24_G27_V0.5010.96
15_T19_L0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o7qA 1 0.8535 88.5 0.901 Contact Map
1pw4A 1 0.8278 81.5 0.91 Contact Map
2cfqA 1 0.8425 74 0.915 Contact Map
2gfpA 2 0.8425 72.1 0.917 Contact Map
4pypA 1 0.7802 64.4 0.921 Contact Map
4oh3A 2 0.4176 53.8 0.926 Contact Map
3qe7A 2 0.4469 51.3 0.927 Contact Map
4j05A 3 0.3407 50.8 0.927 Contact Map
4xnjA 1 0.9048 48.9 0.928 Contact Map
3wdoA 1 0.8242 42.6 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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