GREMLIN Database
YUND - Uncharacterized metallophosphoesterase YunD
UniProt: O32133 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 462 (436)
Sequences: 5381 (3940)
Seq/√Len: 188.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
357_K417_K3.6341.00
350_R420_Q3.4051.00
354_E358_E3.3551.00
280_A330_P3.2611.00
10_T74_I3.1671.00
28_E32_K3.1161.00
352_T355_E3.0631.00
122_Y163_T2.9421.00
125_K135_F2.9331.00
394_E407_R2.8761.00
32_K259_S2.8251.00
44_F135_F2.8201.00
416_E419_K2.7931.00
263_K267_N2.7641.00
408_I415_I2.6811.00
392_E409_T2.6621.00
357_K408_I2.6521.00
267_N271_R2.6051.00
166_E170_Q2.5881.00
154_T159_S2.5501.00
76_G135_F2.5441.00
134_A167_V2.5291.00
187_A191_A2.5041.00
163_T166_E2.4971.00
161_K165_L2.4861.00
138_V160_I2.3741.00
134_A171_A2.3611.00
396_K399_D2.3401.00
6_R230_C2.3101.00
258_E263_K2.2771.00
4_K234_T2.2621.00
399_D403_T2.2081.00
44_F177_L2.1921.00
189_A198_I2.1881.00
283_E330_P2.1841.00
307_K389_A2.1811.00
31_R43_V2.1221.00
350_R422_S2.1021.00
70_N100_E2.0591.00
43_V74_I2.0401.00
7_L175_V2.0371.00
409_T414_D2.0321.00
124_I132_S2.0151.00
109_F154_T1.9921.00
71_R265_F1.9731.00
167_V171_A1.8651.00
354_E417_K1.8601.00
351_L423_V1.8541.00
43_V72_L1.8531.00
6_R232_E1.8461.00
230_C250_Q1.8431.00
197_V231_V1.8391.00
304_Y389_A1.8381.00
4_K232_E1.8311.00
124_I171_A1.8291.00
164_I192_V1.8201.00
127_L133_I1.8001.00
70_N101_F1.7971.00
105_V139_T1.7911.00
260_A264_A1.7881.00
30_K228_V1.7441.00
168_K174_I1.7291.00
131_M173_I1.7141.00
168_K194_E1.7121.00
400_D403_T1.7071.00
351_L356_L1.6781.00
66_V70_N1.6731.00
335_D338_R1.6641.00
111_K150_G1.6621.00
110_D113_G1.6601.00
352_T420_Q1.6551.00
348_A422_S1.6531.00
44_F76_G1.6481.00
76_G123_H1.6451.00
99_A103_V1.6211.00
154_T162_E1.6011.00
7_L197_V1.5911.00
165_L169_G1.5891.00
126_S132_S1.5791.00
176_L195_I1.5611.00
197_V217_L1.5551.00
76_G102_P1.5421.00
314_I356_L1.5351.00
76_G104_I1.5281.00
38_G41_T1.5221.00
217_L245_K1.5191.00
136_L160_I1.5141.00
284_L331_V1.5131.00
361_V404_H1.5111.00
360_I408_I1.5001.00
126_S130_G1.4991.00
362_H437_L1.4981.00
155_D158_E1.4981.00
10_T45_D1.4901.00
11_N221_A1.4901.00
287_D328_A1.4851.00
9_H199_L1.4691.00
42_L125_K1.4561.00
31_R35_Q1.4551.00
197_V233_I1.4531.00
354_E418_H1.4521.00
198_I218_L1.4521.00
71_R261_E1.4421.00
281_V336_L1.4361.00
159_S163_T1.4291.00
34_H37_D1.4281.00
234_T244_S1.4121.00
34_H230_C1.4121.00
46_I199_L1.4081.00
359_T437_L1.3851.00
413_E419_K1.3831.00
203_T220_S1.3671.00
454_D458_W1.3631.00
349_V430_T1.3521.00
143_Y153_V1.3511.00
30_K33_E1.3491.00
102_P123_H1.3461.00
279_D333_K1.3411.00
356_L415_I1.3401.00
8_Y41_T1.3351.00
164_I174_I1.3331.00
91_E94_A1.3251.00
351_L355_E1.3191.00
121_P163_T1.3111.00
302_L322_I1.3091.00
355_E440_D1.3041.00
122_Y166_E1.3011.00
77_A101_F1.2881.00
9_H229_G1.2831.00
179_H202_H1.2701.00
50_L95_L1.2681.00
164_I194_E1.2581.00
171_A174_I1.2551.00
7_L199_L1.2491.00
30_K256_T1.2471.00
35_Q43_V1.2391.00
197_V245_K1.2381.00
233_I242_I1.2371.00
388_Y391_V1.2361.00
18_E270_E1.2341.00
313_D419_K1.2321.00
109_F159_S1.2311.00
111_K152_T1.2311.00
364_A395_T1.2311.00
394_E406_T1.2271.00
25_D263_K1.2251.00
187_A190_E1.2211.00
45_D74_I1.2181.00
16_H224_Y1.2111.00
122_Y134_A1.2081.00
274_E278_S1.2061.00
141_P156_A1.2041.00
78_A104_I1.2021.00
236_D243_N1.2011.00
396_K406_T1.1961.00
264_A267_N1.1931.00
327_K335_D1.1921.00
199_L231_V1.1871.00
295_E300_L1.1821.00
278_S334_L1.1821.00
136_L163_T1.1811.00
27_I228_V1.1781.00
333_K457_A1.1771.00
280_A332_T1.1711.00
82_N86_T1.1681.00
399_D406_T1.1671.00
361_V402_I1.1651.00
66_V99_A1.1601.00
120_V123_H1.1591.00
316_M356_L1.1571.00
173_I235_V1.1561.00
199_L219_A1.1521.00
161_K193_P1.1491.00
161_K191_A1.1411.00
353_G421_Y1.1391.00
451_F454_D1.1321.00
42_L135_F1.1311.00
310_C348_A1.1301.00
223_K226_H1.1301.00
110_D114_N1.1291.00
48_D81_N1.1221.00
13_L225_G1.1211.00
76_G125_K1.1201.00
222_E226_H1.1141.00
63_K67_D1.1141.00
306_L315_S1.1101.00
29_Q33_E1.1101.00
27_I31_R1.1091.00
71_R262_T1.1091.00
13_L24_V1.1061.00
123_H135_F1.1031.00
77_A103_V1.1011.00
162_E166_E1.1011.00
157_L191_A1.1001.00
167_V174_I1.0971.00
280_A283_E1.0961.00
11_N220_S1.0931.00
29_Q256_T1.0901.00
186_Q190_E1.0841.00
32_K261_E1.0811.00
192_V195_I1.0751.00
33_E37_D1.0731.00
186_Q211_Q1.0671.00
159_S162_E1.0621.00
160_I195_I1.0601.00
136_L167_V1.0591.00
9_H46_I1.0571.00
78_A137_G1.0561.00
235_V242_I1.0551.00
352_T418_H1.0541.00
8_Y34_H1.0421.00
28_E262_T1.0421.00
290_V294_E1.0401.00
364_A393_V1.0341.00
5_L133_I1.0331.00
270_E274_E1.0271.00
230_C248_S1.0231.00
70_N99_A1.0221.00
89_H93_A1.0191.00
131_M172_D1.0181.00
180_L188_V1.0141.00
346_P424_A1.0101.00
136_L176_L1.0061.00
268_E272_E1.0030.99
75_D127_L0.9990.99
105_V108_L0.9990.99
79_I96_Y0.9970.99
302_L340_C0.9970.99
158_E161_K0.9960.99
314_I423_V0.9950.99
6_R41_T0.9930.99
396_K404_H0.9930.99
345_N427_D0.9910.99
314_I410_L0.9850.99
206_L227_Y0.9850.99
96_Y103_V0.9830.99
55_F58_E0.9790.99
63_K94_A0.9780.99
363_A386_M0.9720.99
45_D49_H0.9720.99
391_V410_L0.9710.99
181_G203_T0.9710.99
309_W458_W0.9690.99
222_E227_Y0.9670.99
303_A315_S0.9670.99
164_I195_I0.9660.99
284_L287_D0.9640.99
69_L101_F0.9640.99
27_I225_G0.9610.99
276_K279_D0.9600.99
69_L74_I0.9600.99
33_E36_S0.9520.99
416_E421_Y0.9490.99
219_A231_V0.9470.99
81_N202_H0.9460.99
30_K252_M0.9450.99
157_L161_K0.9440.99
287_D327_K0.9430.99
30_K34_H0.9400.99
410_L421_Y0.9370.99
301_L305_A0.9370.99
318_N321_V0.9330.99
29_Q257_G0.9310.99
262_T265_F0.9250.99
354_E357_K0.9190.99
135_F177_L0.9170.99
26_Y258_E0.9170.99
298_L339_I0.9130.99
89_H151_W0.9090.99
42_L127_L0.9090.99
160_I176_L0.9080.99
8_Y230_C0.9050.99
81_N179_H0.9030.99
91_E95_L0.9030.99
286_Q297_E0.9010.99
79_I119_A0.8990.99
154_T158_E0.8980.99
323_L342_H0.8940.99
86_T147_D0.8930.99
299_P387_V0.8900.99
67_D265_F0.8890.99
94_A97_D0.8840.99
336_L457_A0.8800.99
179_H204_H0.8800.99
160_I188_V0.8770.99
314_I391_V0.8740.99
182_I207_L0.8740.99
303_A317_V0.8710.99
126_S133_I0.8700.99
355_E358_E0.8680.99
313_D411_N0.8670.99
89_H150_G0.8660.99
400_D404_H0.8620.98
213_V218_L0.8610.98
450_E458_W0.8590.98
392_E412_G0.8590.98
212_V215_G0.8580.98
106_S159_S0.8560.98
361_V405_V0.8560.98
271_R275_E0.8540.98
108_L151_W0.8530.98
173_I233_I0.8530.98
14_H52_R0.8500.98
141_P155_D0.8430.98
78_A105_V0.8400.98
189_A218_L0.8350.98
236_D239_Q0.8340.98
5_L233_I0.8330.98
113_G116_P0.8320.98
355_E441_A0.8320.98
25_D262_T0.8290.98
102_P120_V0.8290.98
49_H77_A0.8290.98
304_Y308_E0.8270.98
307_K315_S0.8270.98
437_L440_D0.8260.98
63_K98_H0.8260.98
163_T167_V0.8250.98
213_V216_V0.8250.98
33_E257_G0.8250.98
315_S424_A0.8250.98
48_D179_H0.8230.98
124_I134_A0.8190.98
360_I393_V0.8190.98
14_H204_H0.8150.98
206_L222_E0.8130.98
66_V95_L0.8100.98
264_A268_E0.8080.98
132_S172_D0.8060.98
7_L42_L0.8050.98
81_N204_H0.8040.98
425_V430_T0.8020.98
68_L262_T0.8020.98
158_E162_E0.8020.98
122_Y167_V0.8010.98
312_T424_A0.7990.97
359_T438_I0.7980.97
357_K415_I0.7920.97
157_L192_V0.7920.97
28_E259_S0.7850.97
355_E437_L0.7840.97
299_P322_I0.7840.97
136_L164_I0.7840.97
134_A174_I0.7820.97
48_D204_H0.7810.97
185_D200_E0.7800.97
14_H202_H0.7780.97
360_I405_V0.7780.97
6_R34_H0.7780.97
30_K250_Q0.7760.97
10_T43_V0.7710.97
307_K311_E0.7710.97
206_L249_V0.7700.97
349_V425_V0.7700.97
178_S200_E0.7690.97
232_E246_T0.7680.97
156_A188_V0.7660.97
342_H428_M0.7660.97
67_D269_K0.7660.97
360_I391_V0.7650.97
174_I194_E0.7650.97
320_G323_L0.7640.97
127_L135_F0.7640.97
314_I421_Y0.7630.97
427_D431_L0.7630.97
133_I175_V0.7610.97
181_G202_H0.7600.97
413_E416_E0.7590.97
48_D202_H0.7590.97
306_L346_P0.7580.97
165_L171_A0.7560.96
317_V321_V0.7550.96
43_V228_V0.7530.96
165_L193_P0.7530.96
75_D125_K0.7530.96
8_Y43_V0.7520.96
95_L98_H0.7490.96
24_V27_I0.7480.96
12_D204_H0.7470.96
25_D258_E0.7470.96
109_F152_T0.7440.96
284_L288_A0.7430.96
138_V178_S0.7400.96
40_E129_N0.7370.96
310_C424_A0.7370.96
14_H181_G0.7340.96
46_I78_A0.7340.96
447_F450_E0.7310.96
164_I168_K0.7290.96
324_G338_R0.7280.96
144_P153_V0.7280.96
106_S121_P0.7250.96
182_I186_Q0.7240.96
125_K133_I0.7200.95
48_D82_N0.7200.95
174_I195_I0.7190.95
186_Q218_L0.7190.95
82_N179_H0.7180.95
303_A389_A0.7180.95
414_D417_K0.7170.95
109_F114_N0.7170.95
122_Y170_Q0.7160.95
46_I177_L0.7140.95
34_H228_V0.7140.95
5_L131_M0.7130.95
358_E440_D0.7130.95
10_T27_I0.7120.95
57_T87_L0.7110.95
242_I245_K0.7110.95
307_K422_S0.7080.95
386_M393_V0.7040.95
156_A159_S0.7040.95
108_L139_T0.7020.95
307_K312_T0.7010.95
108_L153_V0.7000.95
200_E220_S0.6990.95
146_Y202_H0.6990.95
336_L453_R0.6970.95
291_K296_S0.6970.95
284_L326_L0.6970.95
60_T269_K0.6960.94
309_W455_L0.6940.94
68_L266_L0.6930.94
265_F269_K0.6910.94
167_V170_Q0.6900.94
37_D230_C0.6890.94
362_H377_G0.6860.94
306_L426_L0.6860.94
234_T243_N0.6850.94
356_L359_T0.6850.94
221_A229_G0.6850.94
28_E72_L0.6850.94
109_F115_R0.6840.94
257_G260_A0.6830.94
176_L198_I0.6810.94
395_T405_V0.6810.94
23_I26_Y0.6790.94
267_N270_E0.6770.94
358_E437_L0.6770.94
386_M435_F0.6760.94
407_R414_D0.6740.93
288_A326_L0.6730.93
5_L235_V0.6710.93
321_V344_I0.6710.93
426_L429_F0.6710.93
316_M423_V0.6700.93
358_E403_T0.6700.93
5_L173_I0.6690.93
417_K421_Y0.6680.93
312_T422_S0.6670.93
46_I201_S0.6670.93
351_L441_A0.6660.93
142_Y145_V0.6650.93
272_E275_E0.6640.93
15_S65_N0.6630.93
104_I123_H0.6620.93
27_I30_K0.6610.93
324_G339_I0.6600.93
60_T272_E0.6600.93
300_L304_Y0.6570.93
133_I173_I0.6560.93
288_A297_E0.6550.92
67_D268_E0.6550.92
314_I390_G0.6520.92
399_D404_H0.6520.92
109_F116_P0.6500.92
332_T335_D0.6490.92
326_L339_I0.6480.92
175_V197_V0.6480.92
344_I426_L0.6470.92
450_E455_L0.6460.92
19_N23_I0.6460.92
42_L133_I0.6440.92
302_L339_I0.6430.92
345_N447_F0.6430.92
31_R228_V0.6430.92
178_S198_I0.6420.92
166_E169_G0.6420.92
16_H53_F0.6410.92
358_E362_H0.6400.92
131_M235_V0.6400.92
306_L340_C0.6400.92
367_Q395_T0.6400.92
24_V266_L0.6400.92
61_F87_L0.6400.92
14_H220_S0.6390.92
344_I427_D0.6380.92
362_H365_S0.6370.91
79_I103_V0.6370.91
361_V400_D0.6330.91
45_D77_A0.6320.91
6_R38_G0.6320.91
60_T64_A0.6320.91
317_V426_L0.6310.91
74_I77_A0.6310.91
82_N342_H0.6290.91
265_F268_E0.6280.91
312_T315_S0.6260.91
124_I170_Q0.6260.91
360_I388_Y0.6250.91
113_G152_T0.6240.91
13_L69_L0.6240.91
353_G415_I0.6230.91
45_D69_L0.6230.91
343_P453_R0.6210.90
14_H179_H0.6210.90
340_C456_L0.6200.90
45_D78_A0.6180.90
193_P216_V0.6180.90
11_N46_I0.6180.90
160_I192_V0.6170.90
415_I421_Y0.6160.90
318_N341_P0.6150.90
316_M359_T0.6140.90
399_D402_I0.6130.90
231_V247_A0.6090.90
261_E264_A0.6080.89
313_D422_S0.6040.89
143_Y147_D0.6040.89
140_V143_Y0.6040.89
14_H48_D0.6030.89
32_K36_S0.6030.89
13_L49_H0.6030.89
10_T13_L0.6010.89
271_R274_E0.6000.89
33_E256_T0.5990.89
79_I85_I0.5990.89
334_L338_R0.5990.89
137_G177_L0.5990.89
31_R72_L0.5990.89
81_N86_T0.5950.88
127_L130_G0.5940.88
318_N344_I0.5940.88
176_L188_V0.5940.88
221_A227_Y0.5930.88
305_A455_L0.5920.88
309_W450_E0.5910.88
300_L389_A0.5910.88
68_L265_F0.5890.88
24_V68_L0.5890.88
14_H224_Y0.5880.88
168_K196_D0.5880.88
136_L195_I0.5880.88
19_N258_E0.5870.88
112_N115_R0.5870.88
17_F266_L0.5870.88
179_H201_S0.5870.88
9_H200_E0.5870.88
199_L229_G0.5870.88
11_N341_P0.5850.88
388_Y393_V0.5850.88
121_P166_E0.5810.87
26_Y30_K0.5810.87
13_L45_D0.5800.87
427_D452_L0.5790.87
34_H250_Q0.5780.87
350_R444_K0.5780.87
79_I105_V0.5780.87
182_I200_E0.5760.87
82_N204_H0.5750.87
228_V250_Q0.5740.87
49_H74_I0.5710.86
356_L391_V0.5700.86
10_T228_V0.5700.86
121_P136_L0.5700.86
356_L423_V0.5690.86
126_S129_N0.5660.86
106_S160_I0.5650.86
320_G342_H0.5650.86
227_Y249_V0.5650.86
93_A97_D0.5650.86
357_K361_V0.5630.86
309_W346_P0.5630.86
386_M429_F0.5630.86
82_N344_I0.5630.86
307_K313_D0.5620.85
90_E94_A0.5610.85
17_F65_N0.5600.85
263_K266_L0.5600.85
9_H219_A0.5590.85
407_R415_I0.5580.85
184_D187_A0.5570.85
161_K192_V0.5560.85
307_K424_A0.5560.85
6_R37_D0.5560.85
94_A98_H0.5550.85
13_L74_I0.5530.85
78_A139_T0.5520.84
135_F175_V0.5510.84
51_D83_E0.5510.84
29_Q32_K0.5500.84
6_R39_E0.5470.84
366_E369_E0.5470.84
112_N152_T0.5470.84
13_L65_N0.5460.84
362_H435_F0.5450.84
321_V426_L0.5430.83
390_G410_L0.5420.83
48_D80_G0.5410.83
212_V217_L0.5400.83
15_S56_V0.5400.83
79_I92_L0.5370.83
32_K35_Q0.5360.83
319_S387_V0.5350.83
391_V408_I0.5350.83
401_G404_H0.5310.82
44_F199_L0.5310.82
392_E407_R0.5310.82
132_S171_A0.5290.82
321_V342_H0.5290.82
83_E320_G0.5260.82
217_L247_A0.5250.81
297_E300_L0.5240.81
31_R34_H0.5230.81
351_L438_I0.5220.81
350_R445_E0.5220.81
78_A177_L0.5220.81
106_S136_L0.5210.81
291_K295_E0.5210.81
318_N342_H0.5200.81
106_S163_T0.5180.81
347_V430_T0.5180.81
165_L194_E0.5170.80
292_W319_S0.5160.80
85_I153_V0.5160.80
201_S221_A0.5160.80
24_V225_G0.5140.80
82_N202_H0.5140.80
299_P303_A0.5140.80
183_L186_Q0.5140.80
8_Y228_V0.5130.80
417_K420_Q0.5130.80
395_T406_T0.5130.80
17_F56_V0.5120.80
425_V438_I0.5110.80
14_H51_D0.5100.80
104_I121_P0.5100.80
7_L233_I0.5100.80
85_I108_L0.5090.79
316_M386_M0.5080.79
368_M375_G0.5080.79
44_F125_K0.5070.79
446_Y450_E0.5070.79
315_S389_A0.5070.79
110_D115_R0.5050.79
310_C346_P0.5050.79
156_A180_L0.5040.79
204_H223_K0.5040.79
351_L359_T0.5030.79
227_Y251_N0.5030.79
289_E297_E0.5030.79
169_G174_I0.5010.78
395_T407_R0.5000.78
159_S165_L0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iveA 1 0.9589 100 0.185 Contact Map
2z1aA 1 0.9632 100 0.204 Contact Map
3ztvA 2 0.9719 100 0.215 Contact Map
4h2gA 2 0.9632 100 0.216 Contact Map
4q7fA 1 0.9654 100 0.225 Contact Map
1hp1A 1 0.9481 100 0.228 Contact Map
2wdcA 1 0.9567 100 0.24 Contact Map
3c9fA 2 0.9697 100 0.389 Contact Map
3gveA 2 0.5952 100 0.533 Contact Map
3jyfA 2 0.5974 100 0.535 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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