GREMLIN Database
LIPA - Lipoyl synthase
UniProt: O32129 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 298 (281)
Sequences: 2204 (921)
Seq/√Len: 54.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_L84_L5.2301.00
221_M232_M4.2891.00
142_P163_L3.6851.00
172_R216_E3.6621.00
249_K255_E3.5841.00
183_Y223_D3.5361.00
222_D266_K3.4731.00
260_K264_M3.3491.00
194_K230_D3.2841.00
208_I234_I3.2741.00
257_A260_K3.2261.00
171_R184_D2.9651.00
103_H137_T2.9081.00
214_K258_E2.7061.00
218_I262_I2.5581.00
128_A131_R2.5441.00
92_V125_T2.5241.00
204_S224_L2.3861.00
62_I106_I2.3571.00
274_G277_V2.2451.00
126_V140_V2.2441.00
120_G124_E2.2401.00
87_Q90_E2.2321.00
133_S136_T2.2021.00
108_A143_S2.1811.00
214_K255_E2.1551.00
221_M263_A2.1391.00
177_V245_L2.1131.00
32_R41_E2.0631.00
97_A132_K2.0381.00
214_K259_L2.0021.00
262_I265_Q1.9751.00
224_L229_V1.9531.00
117_G151_N1.9461.00
188_E191_R1.9371.00
103_H162_I1.9301.00
73_F181_A1.9131.00
153_K196_M1.8951.00
90_E128_A1.8640.99
39_V43_A1.8220.99
65_S77_K1.8160.99
44_K75_A1.8130.99
251_Y259_L1.7970.99
126_V158_T1.7960.99
163_L193_A1.7630.99
191_R195_E1.7550.99
153_K157_D1.7500.99
171_R174_T1.7370.99
171_R219_E1.7340.99
262_I266_K1.7270.99
106_I129_I1.7250.99
156_M193_A1.7150.99
190_L229_V1.7070.99
145_M155_L1.6880.99
23_N26_G1.6780.99
263_A271_C1.6240.98
50_E281_Y1.5960.98
171_R220_V1.5940.98
130_R138_I1.5610.98
55_R284_D1.5540.98
91_R94_D1.5420.98
61_M76_V1.5330.98
225_L268_F1.5280.98
24_Y48_I1.5250.98
90_E94_D1.5210.98
258_E262_I1.4990.97
255_E259_L1.4460.97
148_N151_N1.4400.97
192_R195_E1.4330.97
124_E127_R1.4300.97
30_L98_L1.3750.96
72_R245_L1.3630.95
153_K192_R1.3620.95
123_A127_R1.3600.95
225_L266_K1.3580.95
184_D188_E1.3390.95
34_N95_S1.3380.95
63_L121_I1.3260.95
128_A132_K1.3250.95
16_I276_L1.3050.94
225_L228_N1.3040.94
33_E98_L1.3000.94
119_A154_T1.2930.94
96_V133_S1.2880.94
129_I136_T1.2860.94
208_I259_L1.2840.94
85_D91_R1.2810.94
149_Y192_R1.2810.94
159_R197_Q1.2550.93
261_E265_Q1.2390.93
34_N98_L1.2350.92
174_T179_A1.2290.92
66_V79_G1.2210.92
156_M197_Q1.2150.92
254_D257_A1.1920.91
87_Q91_R1.1900.91
188_E192_R1.1750.90
94_D98_L1.1750.90
206_I220_V1.1700.90
194_K202_T1.1660.90
207_M210_L1.1570.90
90_E132_K1.1390.89
174_T182_T1.1340.89
42_E65_S1.1280.88
68_T81_P1.1210.88
16_I49_H1.1210.88
257_A261_E1.1150.88
193_A200_I1.0960.87
94_D132_K1.0940.87
110_A185_R1.0900.87
8_L250_Y1.0890.87
224_L232_M1.0780.86
208_I217_I1.0770.86
108_A122_F1.0760.86
218_I266_K1.0630.85
164_N205_S1.0560.85
165_H186_S1.0460.84
56_R99_M1.0410.84
218_I222_D1.0400.84
35_N91_R1.0330.84
150_D153_K1.0210.83
260_K273_A1.0190.83
52_W78_T1.0180.83
156_M196_M1.0180.83
37_H65_S1.0150.83
251_Y255_E1.0090.82
66_V77_K1.0020.82
241_T244_H0.9990.82
219_E223_D0.9940.81
149_Y188_E0.9920.81
222_D226_A0.9890.81
192_R196_M0.9870.81
66_V82_T0.9860.81
156_M163_L0.9850.81
62_I125_T0.9820.80
130_R160_P0.9810.80
97_A133_S0.9800.80
217_I251_Y0.9780.80
214_K218_I0.9750.80
124_E128_A0.9730.80
217_I249_K0.9630.79
24_Y52_W0.9590.79
73_F174_T0.9530.78
176_R248_Q0.9490.78
178_R181_A0.9450.78
10_K44_K0.9450.78
155_L159_R0.9400.77
156_M200_I0.9380.77
28_K41_E0.9360.77
152_L192_R0.9360.77
26_G56_R0.9320.77
101_L104_A0.9200.76
129_I133_S0.9150.75
123_A155_L0.9130.75
140_V160_P0.9070.75
255_E258_E0.9020.74
96_V136_T0.9010.74
23_N56_R0.8830.73
272_E282_H0.8830.73
174_T180_R0.8810.73
120_G154_T0.8740.72
218_I258_E0.8660.71
147_G185_R0.8660.71
140_V164_N0.8660.71
179_A205_S0.8650.71
230_D269_S0.8650.71
221_M262_I0.8630.71
56_R100_N0.8580.71
149_Y152_L0.8540.70
12_E16_I0.8540.70
18_L49_H0.8520.70
93_A132_K0.8500.70
222_D262_I0.8480.70
27_L53_A0.8470.70
75_A241_T0.8460.70
60_F92_V0.8380.69
191_R227_N0.8340.68
78_T110_A0.8220.67
9_R12_E0.8190.67
27_L99_M0.8170.67
204_S234_I0.8110.66
143_S155_L0.8110.66
142_P155_L0.8090.66
127_R157_D0.8090.66
42_E75_A0.8080.66
225_L230_D0.8070.66
84_L121_I0.8050.66
125_T129_I0.8030.66
174_T181_A0.8020.65
191_R228_N0.8000.65
167_I220_V0.7980.65
104_A136_T0.7960.65
96_V104_A0.7950.65
123_A154_T0.7940.65
239_Q250_Y0.7930.65
90_E131_R0.7920.64
110_A174_T0.7900.64
61_M272_E0.7890.64
171_R175_P0.7840.64
224_L227_N0.7830.64
48_I52_W0.7790.63
7_H10_K0.7720.62
30_L34_N0.7710.62
252_H255_E0.7680.62
19_N49_H0.7680.62
252_H257_A0.7670.62
31_M52_W0.7670.62
202_T230_D0.7670.62
221_M266_K0.7660.62
215_E218_I0.7650.62
86_L121_I0.7650.62
126_V138_I0.7630.62
75_A110_A0.7610.61
264_M271_C0.7600.61
193_A197_Q0.7590.61
59_T283_A0.7540.61
96_V129_I0.7520.60
258_E261_E0.7510.60
174_T220_V0.7490.60
233_A277_V0.7430.60
270_H282_H0.7410.59
117_G146_G0.7400.59
221_M225_L0.7390.59
214_K251_Y0.7340.59
32_R42_E0.7270.58
108_A145_M0.7240.58
140_V163_L0.7220.57
13_W253_P0.7190.57
191_R226_A0.7170.57
206_I217_I0.7170.57
152_L189_F0.7160.57
146_G180_R0.7130.56
37_H82_T0.7120.56
174_T184_D0.7110.56
102_K284_D0.7110.56
149_Y153_K0.7090.56
174_T205_S0.7090.56
137_T161_D0.7060.56
52_W174_T0.7060.56
218_I265_Q0.7050.56
272_E286_Q0.7050.56
146_G151_N0.7020.55
163_L189_F0.6990.55
231_I286_Q0.6970.55
110_A145_M0.6960.55
110_A229_V0.6950.54
10_K238_L0.6950.54
142_P193_A0.6940.54
245_L248_Q0.6910.54
204_S227_N0.6880.54
167_I186_S0.6810.53
152_L163_L0.6780.53
14_L276_L0.6770.53
155_L193_A0.6750.52
17_K23_N0.6740.52
183_Y219_E0.6730.52
140_V158_T0.6730.52
234_I259_L0.6720.52
164_N282_H0.6720.52
142_P145_M0.6710.52
41_E48_I0.6680.52
155_L158_T0.6680.52
169_T208_I0.6670.51
29_K33_E0.6660.51
70_A78_T0.6660.51
221_M268_F0.6660.51
70_A110_A0.6650.51
93_A129_I0.6630.51
201_P231_I0.6630.51
164_N179_A0.6610.51
127_R158_T0.6520.50
70_A180_R0.6500.50
270_H286_Q0.6490.50
22_E26_G0.6470.49
106_I140_V0.6460.49
219_E222_D0.6460.49
210_L245_L0.6450.49
122_F164_N0.6440.49
130_R161_D0.6440.49
222_D265_Q0.6420.49
60_F104_A0.6410.49
215_E225_L0.6400.49
213_T248_Q0.6390.48
187_L227_N0.6370.48
130_R163_L0.6370.48
263_A272_E0.6360.48
181_A207_M0.6350.48
42_E122_F0.6340.48
249_K259_L0.6340.48
257_A264_M0.6320.48
17_K20_T0.6320.48
124_E129_I0.6300.47
37_H41_E0.6290.47
121_I272_E0.6280.47
156_M194_K0.6270.47
260_K263_A0.6270.47
142_P189_F0.6240.47
41_E110_A0.6230.47
52_W182_T0.6230.47
105_V235_G0.6230.47
217_I234_I0.6210.47
7_H239_Q0.6200.46
22_E25_T0.6200.46
21_N24_Y0.6170.46
213_T216_E0.6160.46
12_E254_D0.6160.46
171_R182_T0.6150.46
16_I19_N0.6140.46
208_I251_Y0.6120.46
244_H279_S0.6110.45
205_S282_H0.6110.45
232_M263_A0.6080.45
169_T177_V0.6070.45
152_L196_M0.6050.45
18_L44_K0.6020.45
163_L202_T0.6020.45
225_L232_M0.6020.45
179_A182_T0.6010.44
10_K16_I0.5990.44
15_K274_G0.5960.44
167_I204_S0.5950.44
172_R238_L0.5930.44
23_N53_A0.5920.43
76_V282_H0.5920.43
10_K17_K0.5910.43
187_L223_D0.5910.43
180_R205_S0.5900.43
256_F273_A0.5880.43
178_R207_M0.5870.43
75_A78_T0.5870.43
94_D97_A0.5860.43
171_R179_A0.5860.43
169_T173_L0.5830.43
172_R219_E0.5820.42
193_A201_P0.5810.42
261_E264_M0.5800.42
159_R193_A0.5800.42
61_M110_A0.5800.42
16_I48_I0.5790.42
90_E124_E0.5780.42
154_T159_R0.5770.42
24_Y27_L0.5750.42
239_Q242_K0.5720.41
252_H273_A0.5720.41
205_S220_V0.5680.41
167_I206_I0.5680.41
140_V205_S0.5680.41
72_R75_A0.5670.41
34_N99_M0.5670.41
140_V145_M0.5650.41
118_G143_S0.5650.41
174_T189_F0.5630.40
102_K129_I0.5620.40
189_F192_R0.5600.40
35_N87_Q0.5590.40
231_I272_E0.5590.40
216_E219_E0.5580.40
130_R159_R0.5580.40
157_D196_M0.5570.40
28_K48_I0.5560.40
164_N233_A0.5550.40
65_S82_T0.5520.39
167_I183_Y0.5520.39
103_H138_I0.5520.39
72_R180_R0.5500.39
238_L250_Y0.5460.39
24_Y229_V0.5460.39
217_I259_L0.5450.39
284_D287_V0.5450.39
210_L248_Q0.5440.38
63_L108_A0.5440.38
79_G82_T0.5440.38
217_I221_M0.5430.38
39_V179_A0.5410.38
30_L91_R0.5400.38
34_N91_R0.5390.38
177_V207_M0.5390.38
155_L160_P0.5360.38
60_F99_M0.5330.37
253_P275_P0.5330.37
95_S98_L0.5330.37
151_N154_T0.5320.37
130_R164_N0.5310.37
15_K259_L0.5300.37
75_A99_M0.5300.37
162_I179_A0.5300.37
263_A286_Q0.5290.37
106_I125_T0.5280.37
214_K262_I0.5270.37
44_K70_A0.5260.37
52_W229_V0.5250.37
12_E25_T0.5250.37
55_R282_H0.5250.37
149_Y185_R0.5250.37
219_E261_E0.5230.36
27_L31_M0.5220.36
73_F167_I0.5220.36
120_G123_A0.5220.36
231_I239_Q0.5200.36
97_A222_D0.5190.36
86_L120_G0.5180.36
108_A174_T0.5180.36
39_V76_V0.5180.36
123_A157_D0.5170.36
153_K263_A0.5170.36
142_P229_V0.5160.36
92_V104_A0.5160.36
44_K243_K0.5150.36
137_T287_V0.5150.36
24_Y31_M0.5150.36
34_N94_D0.5130.35
160_P164_N0.5130.35
215_E254_D0.5120.35
23_N27_L0.5080.35
122_F143_S0.5080.35
110_A113_D0.5070.35
188_E195_E0.5060.35
77_K239_Q0.5050.35
172_R183_Y0.5020.34
10_K142_P0.5020.34
61_M106_I0.5010.34
222_D225_L0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u0oB 1 0.8926 100 0.642 Contact Map
4wcxA 1 0.9329 99.7 0.877 Contact Map
4r33A 2 0.9631 99.7 0.879 Contact Map
4rtbA 2 0.9463 99.7 0.88 Contact Map
3t7vA 1 0.9094 99.7 0.881 Contact Map
1r30A 2 0.9027 99.6 0.883 Contact Map
3iixA 1 0.8993 99.6 0.884 Contact Map
1oltA 1 0.9094 99.5 0.895 Contact Map
2qgqA 1 0.7383 99.5 0.895 Contact Map
4jc0A 1 0.9564 99.4 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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