GREMLIN Database
YUTF - Uncharacterized hydrolase YutF
UniProt: O32125 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 256 (248)
Sequences: 4231 (2894)
Seq/√Len: 183.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_K200_E5.2201.00
215_G222_T5.1181.00
4_Y221_D4.0451.00
33_K68_Q3.2661.00
202_L223_L3.2271.00
184_S188_E2.9291.00
213_M217_N2.9111.00
144_S165_T2.9041.00
221_D243_T2.5051.00
88_S107_T2.3881.00
169_T176_P2.3391.00
51_K66_E2.3061.00
169_T175_Q2.2781.00
31_T35_R2.2451.00
6_G194_L2.2141.00
116_V119_G2.1171.00
248_S251_E2.1031.00
31_T34_D1.9841.00
212_I222_T1.9421.00
196_T201_T1.9231.00
247_D251_E1.8581.00
142_F176_P1.8561.00
30_R34_D1.8021.00
55_D59_S1.7771.00
6_G196_T1.7551.00
91_V101_I1.7481.00
191_M201_T1.6961.00
21_K26_C1.6951.00
226_H247_D1.6611.00
231_K234_H1.6511.00
149_I170_V1.6491.00
18_G154_E1.6351.00
203_M220_M1.6281.00
51_K55_D1.6261.00
17_N20_E1.6241.00
9_I204_V1.6121.00
40_L193_V1.5891.00
76_T143_I1.5651.00
8_L42_V1.5531.00
216_I243_T1.5441.00
166_S169_T1.5441.00
230_T234_H1.5281.00
187_M214_A1.5141.00
76_T117_V1.5031.00
125_T128_K1.4981.00
11_L41_F1.4881.00
226_H245_A1.4731.00
230_T235_M1.4501.00
121_D128_K1.4421.00
11_L16_Y1.4221.00
22_I248_S1.4151.00
26_C30_R1.4091.00
187_M203_M1.4071.00
50_P74_M1.4041.00
134_L137_R1.4021.00
166_S170_V1.3891.00
94_E122_R1.3881.00
15_M41_F1.3821.00
27_E250_T1.3741.00
95_E99_Q1.3701.00
143_I179_I1.3611.00
183_E217_N1.3551.00
54_A66_E1.3491.00
5_K37_V1.3441.00
197_D200_E1.3391.00
188_E198_V1.3371.00
136_I168_L1.3331.00
223_L246_I1.3281.00
7_Y202_L1.3061.00
77_A104_N1.3051.00
134_L155_R1.2971.00
32_L37_V1.2971.00
30_R63_P1.2821.00
7_Y37_V1.2741.00
189_Q192_R1.2701.00
65_T68_Q1.2611.00
89_V106_L1.2591.00
54_A58_V1.2461.00
52_Q55_D1.2241.00
49_T52_Q1.2191.00
151_I160_G1.2091.00
226_H230_T1.1961.00
213_M240_E1.1961.00
48_R56_K1.1871.00
9_I28_F1.1851.00
4_Y202_L1.1811.00
33_K39_Y1.1781.00
50_P100_A1.1701.00
15_M29_V1.1691.00
232_R236_T1.1631.00
47_S120_I1.1621.00
51_K99_Q1.1621.00
99_Q102_E1.1601.00
27_E30_R1.1581.00
55_D58_V1.1471.00
75_A186_I1.1431.00
26_C62_I1.1421.00
11_L14_T1.1421.00
226_H232_R1.1411.00
54_A69_V1.1271.00
84_K87_A1.1251.00
153_T158_L1.1201.00
7_Y32_L1.1161.00
15_M62_I1.1111.00
38_P68_Q1.1041.00
232_R247_D1.1011.00
8_L190_A1.1001.00
73_S77_A1.1001.00
136_I172_T1.0991.00
46_S72_T1.0981.00
25_A62_I1.0981.00
58_V66_E1.0951.00
78_Q82_Q1.0951.00
141_R177_V1.0881.00
24_E27_E1.0881.00
118_V165_T1.0781.00
190_A194_L1.0671.00
129_F167_V1.0631.00
207_N210_T1.0541.00
41_F64_A1.0491.00
115_F141_R1.0471.00
6_G38_P1.0441.00
134_L158_L1.0371.00
187_M220_M1.0331.00
235_M242_P1.0311.00
81_A106_L1.0251.00
92_I132_G1.0191.00
207_N229_V1.0191.00
70_F190_A1.0110.99
224_L230_T0.9960.99
40_L194_L0.9940.99
70_F189_Q0.9930.99
221_D244_H0.9850.99
21_K60_F0.9840.99
149_I166_S0.9790.99
9_I39_Y0.9740.99
39_Y68_Q0.9740.99
90_Y135_A0.9740.99
88_S109_G0.9720.99
43_T71_T0.9670.99
130_A158_L0.9650.99
79_H179_I0.9650.99
188_E192_R0.9650.99
76_T179_I0.9640.99
115_F119_G0.9580.99
165_T178_F0.9520.99
78_Q189_Q0.9440.99
82_Q192_R0.9430.99
42_V203_M0.9390.99
120_I124_I0.9370.99
9_I249_L0.9360.99
130_A134_L0.9340.99
216_I222_T0.9330.99
53_V69_V0.9330.99
136_I139_G0.9310.99
22_I25_A0.9280.99
6_G201_T0.9260.99
177_V185_I0.9260.99
147_G178_F0.9230.99
19_T59_S0.9190.99
132_G168_L0.9060.99
131_V135_A0.9040.99
149_I209_A0.9040.99
79_H143_I0.8970.99
235_M245_A0.8960.99
58_V63_P0.8940.99
130_A159_P0.8940.99
33_K63_P0.8930.99
76_T145_T0.8830.99
53_V71_T0.8780.99
133_C171_S0.8770.99
202_L221_D0.8720.98
58_V64_A0.8710.98
56_K60_F0.8690.98
224_L245_A0.8660.98
83_Q141_R0.8630.98
212_I216_I0.8610.98
86_D107_T0.8600.98
40_L70_F0.8480.98
24_E250_T0.8460.98
52_Q99_Q0.8450.98
19_T56_K0.8400.98
25_A249_L0.8400.98
98_R102_E0.8400.98
40_L68_Q0.8390.98
148_D210_T0.8370.98
42_V186_I0.8340.98
144_S178_F0.8330.98
20_E154_E0.8330.98
95_E98_R0.8320.98
16_Y60_F0.8310.98
116_V132_G0.8260.98
14_T187_M0.8240.98
161_N165_T0.8200.98
163_S167_V0.8180.98
16_Y41_F0.8140.98
115_F118_V0.8050.97
77_A81_A0.8040.97
70_F193_V0.8040.97
209_A229_V0.8030.97
24_E248_S0.8030.97
102_E108_F0.8020.97
191_M198_V0.8010.97
101_I117_V0.8010.97
232_R235_M0.7980.97
14_T120_I0.7970.97
98_R110_G0.7940.97
15_M249_L0.7940.97
77_A100_A0.7920.97
144_S161_N0.7900.97
4_Y7_Y0.7880.97
4_Y243_T0.7860.97
233_E236_T0.7850.97
80_I117_V0.7840.97
38_P194_L0.7800.97
98_R108_F0.7790.97
237_D240_E0.7780.97
14_T214_A0.7770.97
100_A103_E0.7770.97
191_M220_M0.7700.97
90_Y132_G0.7700.97
52_Q96_G0.7600.96
203_M214_A0.7590.96
41_F62_I0.7580.96
29_V41_F0.7570.96
64_A68_Q0.7560.96
80_I106_L0.7520.96
73_S76_T0.7510.96
74_M100_A0.7490.96
163_S170_V0.7490.96
242_P245_A0.7430.96
127_E131_V0.7340.96
189_Q193_V0.7320.95
33_K65_T0.7310.95
190_A214_A0.7300.95
91_V98_R0.7290.95
21_K62_I0.7280.95
48_R53_V0.7270.95
93_G97_I0.7250.95
11_L15_M0.7220.95
136_I142_F0.7190.95
124_I128_K0.7150.95
99_Q103_E0.7130.95
9_I15_M0.7130.95
72_T145_T0.7130.95
72_T146_N0.7100.95
17_N22_I0.7080.95
150_A157_L0.7070.95
56_K59_S0.7030.94
124_I129_F0.6980.94
142_F174_V0.6970.94
238_D241_K0.6970.94
109_G113_A0.6970.94
28_F39_Y0.6960.94
208_Y238_D0.6940.94
222_T243_T0.6870.94
124_I164_L0.6820.93
81_A104_N0.6800.93
17_N154_E0.6800.93
75_A189_Q0.6800.93
167_V170_V0.6780.93
140_A174_V0.6780.93
225_V228_G0.6760.93
120_I164_L0.6730.93
16_Y57_L0.6690.93
79_H177_V0.6640.92
216_I240_E0.6580.92
129_F133_C0.6580.92
26_C61_D0.6550.92
96_G100_A0.6540.92
132_G136_I0.6540.92
136_I174_V0.6530.92
78_Q81_A0.6500.92
19_T154_E0.6500.92
191_M218_A0.6480.92
133_C137_R0.6440.91
148_D152_P0.6440.91
21_K61_D0.6420.91
51_K103_E0.6410.91
77_A106_L0.6390.91
8_L186_I0.6370.91
120_I151_I0.6370.91
11_L57_L0.6350.91
124_I167_V0.6350.91
23_E250_T0.6310.90
146_N161_N0.6290.90
192_R195_G0.6270.90
46_S146_N0.6270.90
78_Q104_N0.6260.90
163_S171_S0.6260.90
8_L201_T0.6250.90
139_G174_V0.6210.90
202_L244_H0.6210.90
196_T200_E0.6190.90
33_K41_F0.6140.89
187_M215_G0.6130.89
78_Q193_V0.6130.89
136_I140_A0.6100.89
198_V220_M0.6070.89
11_L53_V0.6060.89
187_M218_A0.6020.88
43_T53_V0.6010.88
4_Y223_L0.6010.88
150_A207_N0.5990.88
32_L36_G0.5970.88
143_I177_V0.5970.88
147_G165_T0.5930.88
224_L227_T0.5850.87
89_V117_V0.5840.87
10_D13_G0.5820.87
25_A248_S0.5800.86
6_G40_L0.5790.86
73_S97_I0.5780.86
203_M215_G0.5780.86
174_V177_V0.5750.86
118_V144_S0.5700.85
27_E31_T0.5700.85
208_Y212_I0.5680.85
46_S119_G0.5680.85
88_S114_D0.5660.85
150_A229_V0.5640.85
25_A29_V0.5620.85
67_E193_V0.5600.84
87_A107_T0.5590.84
147_G183_E0.5590.84
29_V33_K0.5580.84
135_A138_N0.5550.84
187_M190_A0.5540.84
75_A179_I0.5540.84
188_E191_M0.5530.84
9_I29_V0.5500.83
11_L210_T0.5490.83
15_M21_K0.5480.83
111_E114_D0.5470.83
147_G169_T0.5450.83
78_Q192_R0.5440.83
8_L220_M0.5440.83
185_I188_E0.5430.83
113_A135_A0.5430.83
75_A78_Q0.5400.82
63_P138_N0.5390.82
16_Y56_K0.5390.82
14_T151_I0.5380.82
208_Y242_P0.5380.82
197_D201_T0.5370.82
70_F75_A0.5370.82
14_T121_D0.5370.82
28_F32_L0.5340.82
141_R174_V0.5330.81
148_D160_G0.5300.81
208_Y216_I0.5260.81
40_L190_A0.5250.81
167_V171_S0.5240.80
198_V218_A0.5220.80
97_I145_T0.5210.80
48_R52_Q0.5210.80
168_L172_T0.5200.80
117_V145_T0.5170.80
84_K115_F0.5160.79
19_T60_F0.5150.79
54_A65_T0.5140.79
184_S217_N0.5140.79
33_K36_G0.5130.79
80_I101_I0.5100.79
164_L167_V0.5090.78
46_S118_V0.5080.78
118_V142_F0.5060.78
9_I32_L0.5050.78
94_E97_I0.5030.78
4_Y244_H0.5020.78
214_A218_A0.5010.77
83_Q177_V0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kc2A 2 0.9648 100 0.36 Contact Map
2ho4A 1 0.9688 100 0.398 Contact Map
1zjjA 2 0.9805 100 0.43 Contact Map
4i9fA 2 0.9805 100 0.468 Contact Map
2oycA 2 1 100 0.474 Contact Map
3pdwA 1 0.9766 100 0.482 Contact Map
1vjrA 1 1 100 0.482 Contact Map
3eprA 3 0.9961 100 0.49 Contact Map
1yv9A 2 0.9961 100 0.509 Contact Map
2c4nA 3 0.9766 100 0.517 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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