GREMLIN Database
YUTH - Endospore coat-associated protein YutH
UniProt: O32123 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 339 (306)
Sequences: 790 (677)
Seq/√Len: 38.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_T78_F7.9181.00
106_A254_V6.5281.00
162_S275_Y4.3671.00
11_G72_K4.1051.00
105_L199_M3.7131.00
133_G178_V3.3131.00
34_F89_K3.3071.00
222_S265_L3.3011.00
155_F282_Y2.9391.00
26_C90_A2.9041.00
156_D283_Y2.7621.00
252_E262_K2.6801.00
104_E210_I2.6801.00
70_F76_L2.6731.00
36_I87_L2.5881.00
29_T32_S2.5701.00
203_T212_I2.5601.00
102_G247_F2.5451.00
225_L265_L2.4721.00
58_Q67_V2.3831.00
12_I29_T2.3471.00
159_M279_V2.3471.00
136_I174_I2.3391.00
103_A253_Q2.2891.00
181_E260_F2.2370.99
219_D223_R2.2070.99
199_M210_I2.1830.99
24_Y212_I2.1490.99
53_M194_I2.0880.99
155_F159_M2.0380.99
12_I87_L2.0210.99
10_Y71_T2.0170.99
37_V212_I1.9630.99
168_G171_E1.9350.98
196_H203_T1.9120.98
62_D104_E1.8930.98
34_F69_I1.8800.98
168_G172_N1.8680.98
67_V89_K1.7900.97
101_I228_Y1.7700.97
110_R255_T1.7350.97
102_G250_E1.7330.97
298_D302_N1.7270.97
136_I170_S1.7220.97
13_H30_P1.7110.97
37_V214_A1.7070.97
176_Y267_S1.7050.96
113_R191_S1.6670.96
35_L90_A1.6440.96
244_G310_F1.6410.96
56_Y114_G1.6280.95
235_H274_H1.6260.95
173_A267_S1.6030.95
24_Y37_V1.6020.95
158_K298_D1.5630.94
29_T34_F1.5570.94
38_P83_K1.5540.94
12_I34_F1.5460.94
90_A238_Q1.5310.94
182_L185_K1.5240.93
230_R274_H1.5200.93
149_T156_D1.5120.93
143_W164_P1.5020.93
134_K229_M1.4940.93
153_E156_D1.4790.92
136_I171_E1.4780.92
222_S261_S1.4580.92
195_C310_F1.4570.92
198_R212_I1.4480.92
229_M233_F1.4400.91
172_N175_Q1.4400.91
226_A268_R1.4340.91
203_T214_A1.4230.91
16_Q28_Q1.4140.91
169_L307_Y1.4090.90
175_Q179_D1.3950.90
172_N176_Y1.3740.89
184_D187_Q1.3700.89
237_R306_R1.3660.89
57_L247_F1.3650.89
37_V203_T1.3630.89
71_T77_T1.3610.89
177_L182_L1.3590.89
233_F238_Q1.3110.87
112_G193_T1.3080.87
18_S26_C1.3070.87
211_R214_A1.2950.86
60_Q207_E1.2830.86
37_V211_R1.2780.85
31_N207_E1.2620.85
108_F213_P1.2440.84
6_I10_Y1.2440.84
225_L251_Y1.2360.83
9_K73_E1.2350.83
195_C271_F1.2270.83
197_Q200_E1.2260.83
166_Y275_Y1.2190.83
35_L88_L1.2060.82
77_T84_T1.2050.82
227_E268_R1.1990.82
24_Y35_L1.1770.80
177_L180_T1.1720.80
143_W163_F1.1710.80
113_R121_A1.1690.80
37_V196_H1.1670.80
181_E184_D1.1660.80
130_D133_G1.1620.79
221_A255_T1.1550.79
185_K261_S1.1530.79
170_S238_Q1.1470.79
56_Y115_Y1.1370.78
262_K314_A1.1240.77
288_S296_Q1.1220.77
173_A177_L1.1100.76
37_V198_R1.1040.76
105_L109_H1.0850.75
230_R276_F1.0840.74
160_I275_Y1.0820.74
10_Y135_R1.0820.74
176_Y266_Y1.0800.74
55_Q67_V1.0790.74
66_S88_L1.0780.74
205_S208_S1.0770.74
179_D263_R1.0760.74
128_W219_D1.0730.74
24_Y211_R1.0730.74
96_N101_I1.0720.74
229_M248_L1.0710.74
274_H277_E1.0650.73
198_R202_H1.0520.72
163_F275_Y1.0440.72
66_S199_M1.0370.71
135_R277_E1.0350.71
113_R255_T1.0340.71
17_L27_F1.0320.71
57_L229_M1.0310.71
155_F278_I1.0240.70
197_Q223_R1.0100.69
32_S177_L1.0100.69
96_N204_W1.0010.68
210_I265_L1.0010.68
202_H231_H0.9930.68
200_E219_D0.9900.68
108_F216_W0.9890.67
112_G221_A0.9830.67
156_D296_Q0.9780.67
66_S212_I0.9750.66
276_F310_F0.9750.66
202_H296_Q0.9750.66
85_Y141_A0.9730.66
34_F87_L0.9670.66
217_V223_R0.9630.65
139_L159_M0.9570.65
90_A196_H0.9510.64
135_R156_D0.9500.64
172_N311_L0.9480.64
68_F86_A0.9460.64
213_P234_L0.9460.64
24_Y214_A0.9460.64
298_D301_L0.9400.63
51_Y70_F0.9380.63
229_M276_F0.9370.63
159_M282_Y0.9340.63
196_H214_A0.9290.63
282_Y296_Q0.9260.62
210_I222_S0.9250.62
39_V47_L0.9250.62
130_D205_S0.9220.62
102_G106_A0.9210.62
106_A251_Y0.9210.62
135_R271_F0.9180.62
166_Y173_A0.9180.62
251_Y257_L0.9160.61
176_Y270_L0.9150.61
169_L304_C0.9070.61
178_V305_G0.8980.60
34_F172_N0.8850.59
204_W226_A0.8800.58
184_D259_S0.8780.58
199_M204_W0.8770.58
137_D175_Q0.8740.58
79_E84_T0.8700.57
37_V90_A0.8670.57
229_M244_G0.8640.57
163_F167_L0.8630.57
54_S213_P0.8630.57
12_I94_Y0.8590.56
176_Y263_R0.8580.56
252_E256_P0.8560.56
159_M304_C0.8560.56
7_K221_A0.8560.56
27_F297_L0.8540.56
106_A256_P0.8420.55
7_K10_Y0.8420.55
154_P298_D0.8410.55
223_R227_E0.8400.55
116_P137_D0.8400.55
108_F153_E0.8400.55
93_P96_N0.8390.55
65_V106_A0.8350.54
199_M216_W0.8290.54
136_I140_E0.8290.54
10_Y86_A0.8270.54
19_M37_V0.8220.53
213_P216_W0.8220.53
17_L25_Q0.8210.53
157_K161_E0.8150.53
14_I29_T0.8140.52
313_T316_E0.8050.52
49_E112_G0.8030.51
28_Q33_Y0.8010.51
136_I271_F0.8000.51
127_Q130_D0.7980.51
156_D197_Q0.7970.51
166_Y169_L0.7970.51
185_K264_L0.7970.51
10_Y78_F0.7930.51
246_L250_E0.7920.50
90_A159_M0.7910.50
7_K265_L0.7890.50
202_H307_Y0.7870.50
196_H212_I0.7840.50
90_A214_A0.7840.50
9_K165_Y0.7840.50
103_A312_N0.7830.50
224_D272_P0.7800.49
134_K138_Q0.7800.49
153_E157_K0.7760.49
109_H251_Y0.7710.49
32_S261_S0.7690.48
153_E291_H0.7630.48
49_E198_R0.7580.47
30_P207_E0.7530.47
231_H288_S0.7520.47
12_I107_E0.7490.47
165_Y168_G0.7450.46
277_E280_E0.7430.46
200_E274_H0.7390.46
99_F250_E0.7380.46
103_A259_S0.7340.45
305_G312_N0.7340.45
57_L71_T0.7330.45
40_S118_E0.7310.45
135_R303_D0.7300.45
200_E212_I0.7290.45
197_Q215_D0.7270.45
196_H213_P0.7260.45
190_D248_L0.7240.44
180_T263_R0.7240.44
226_A273_L0.7230.44
153_E290_K0.7230.44
14_I32_S0.7190.44
192_G218_F0.7170.44
57_L193_T0.7170.44
140_E174_I0.7170.44
32_S89_K0.7170.44
230_R268_R0.7140.43
15_R30_P0.7140.43
52_Y115_Y0.7140.43
253_Q299_F0.7110.43
156_D212_I0.7080.43
90_A194_I0.7030.43
307_Y310_F0.7020.42
231_H296_Q0.7020.42
69_I210_I0.7010.42
78_F210_I0.6980.42
47_L86_A0.6980.42
138_Q155_F0.6970.42
99_F246_L0.6960.42
125_I128_W0.6960.42
38_P138_Q0.6940.42
6_I90_A0.6920.42
165_Y171_E0.6910.41
163_F178_V0.6910.41
139_L282_Y0.6890.41
165_Y308_E0.6880.41
175_Q178_V0.6870.41
8_E74_G0.6860.41
304_C311_L0.6840.41
103_A250_E0.6830.41
126_G135_R0.6820.41
26_C37_V0.6810.41
93_P97_R0.6800.40
203_T238_Q0.6790.40
203_T213_P0.6750.40
52_Y87_L0.6750.40
304_C307_Y0.6720.40
20_Y225_L0.6720.40
198_R203_T0.6700.40
253_Q309_Q0.6660.39
60_Q129_K0.6650.39
168_G179_D0.6650.39
28_Q91_A0.6640.39
26_C35_L0.6630.39
199_M203_T0.6630.39
292_Y296_Q0.6630.39
149_T276_F0.6610.39
164_P283_Y0.6610.39
141_A284_M0.6610.39
10_Y122_A0.6600.39
266_Y311_L0.6590.39
179_D242_Q0.6570.39
105_L310_F0.6560.38
250_E254_V0.6560.38
57_L60_Q0.6560.38
6_I27_F0.6560.38
264_L268_R0.6550.38
128_W284_M0.6550.38
71_T148_Q0.6540.38
140_E258_S0.6470.38
91_A212_I0.6460.38
72_K187_Q0.6450.37
262_K265_L0.6440.37
128_W182_L0.6430.37
50_L234_L0.6420.37
61_S207_E0.6410.37
14_I27_F0.6400.37
92_P168_G0.6380.37
75_E253_Q0.6350.37
90_A203_T0.6340.37
220_H264_L0.6340.37
6_I299_F0.6340.37
26_C66_S0.6330.36
115_Y194_I0.6320.36
94_Y198_R0.6270.36
24_Y112_G0.6250.36
44_E139_L0.6240.36
197_Q213_P0.6230.36
200_E227_E0.6220.36
303_D310_F0.6220.36
48_A108_F0.6220.36
50_L53_M0.6210.35
158_K161_E0.6210.35
16_Q220_H0.6200.35
7_K14_I0.6190.35
197_Q214_A0.6160.35
204_W233_F0.6160.35
68_F76_L0.6130.35
129_K174_I0.6100.35
238_Q310_F0.6090.34
74_G309_Q0.6090.34
26_C31_N0.6080.34
73_E305_G0.6060.34
51_Y76_L0.6060.34
119_V171_E0.6050.34
91_A209_L0.6020.34
154_P177_L0.6010.34
250_E304_C0.6000.34
10_Y212_I0.5990.34
63_P253_Q0.5980.34
242_Q313_T0.5980.34
109_H272_P0.5970.34
227_E277_E0.5940.33
69_I74_G0.5930.33
105_L272_P0.5930.33
187_Q257_L0.5900.33
24_Y204_W0.5900.33
128_W227_E0.5890.33
221_A235_H0.5890.33
135_R276_F0.5880.33
195_C229_M0.5880.33
194_I222_S0.5870.33
66_S274_H0.5850.33
91_A97_R0.5850.33
201_R231_H0.5830.32
233_F292_Y0.5830.32
194_I314_A0.5820.32
68_F160_I0.5820.32
16_Q207_E0.5800.32
10_Y68_F0.5770.32
132_W223_R0.5770.32
139_L225_L0.5760.32
115_Y212_I0.5760.32
94_Y247_F0.5750.32
58_Q63_P0.5720.32
69_I77_T0.5710.31
168_G175_Q0.5690.31
219_D268_R0.5690.31
166_Y284_M0.5680.31
183_D257_L0.5670.31
226_A230_R0.5670.31
97_R276_F0.5660.31
199_M289_E0.5650.31
137_D143_W0.5650.31
112_G211_R0.5650.31
275_Y278_I0.5630.31
15_R254_V0.5620.31
228_Y233_F0.5620.31
172_N270_L0.5620.31
161_E301_L0.5600.31
27_F95_S0.5600.31
115_Y123_G0.5600.31
93_P279_V0.5600.31
59_E297_L0.5590.31
15_R28_Q0.5590.31
97_R305_G0.5590.31
156_D282_Y0.5580.30
7_K27_F0.5570.30
144_Q309_Q0.5560.30
204_W248_L0.5560.30
93_P203_T0.5540.30
66_S90_A0.5510.30
160_I283_Y0.5510.30
132_W140_E0.5500.30
175_Q258_S0.5490.30
249_Q253_Q0.5470.30
151_P290_K0.5460.30
23_T66_S0.5460.30
84_T211_R0.5450.29
59_E206_P0.5440.29
180_T185_K0.5430.29
282_Y293_F0.5410.29
213_P282_Y0.5400.29
121_A157_K0.5390.29
138_Q282_Y0.5380.29
19_M95_S0.5370.29
108_F210_I0.5360.29
190_D260_F0.5360.29
253_Q256_P0.5360.29
99_F239_D0.5360.29
143_W147_V0.5350.29
135_R197_Q0.5350.29
198_R215_D0.5350.29
78_F142_F0.5340.29
163_F266_Y0.5340.29
40_S313_T0.5330.29
54_S68_F0.5330.29
12_I110_R0.5280.28
227_E230_R0.5270.28
129_K163_F0.5250.28
102_G114_G0.5250.28
140_E269_L0.5230.28
176_Y262_K0.5230.28
49_E54_S0.5230.28
9_K14_I0.5220.28
103_A245_F0.5200.28
19_M25_Q0.5180.27
289_E293_F0.5170.27
169_L172_N0.5130.27
30_P237_R0.5130.27
49_E216_W0.5120.27
5_T34_F0.5120.27
223_R268_R0.5100.27
175_Q242_Q0.5090.27
217_V267_S0.5090.27
183_D259_S0.5080.27
116_P218_F0.5080.27
186_P189_A0.5080.27
93_P98_A0.5080.27
112_G147_V0.5070.27
176_Y179_D0.5060.27
195_C219_D0.5040.27
110_R254_V0.5030.26
238_Q271_F0.5030.26
230_R235_H0.5030.26
12_I127_Q0.5020.26
235_H286_S0.5010.26
59_E245_F0.5010.26
197_Q314_A0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pdyA 1 0.9174 100 0.412 Contact Map
2q83A 1 0.9056 100 0.474 Contact Map
2ppqA 2 0.823 100 0.668 Contact Map
4ocvA 1 0.8879 99.9 0.679 Contact Map
3i1aA 1 0.8761 99.9 0.709 Contact Map
1zylA 1 0.882 99.9 0.722 Contact Map
3jr1A 1 0.7847 99.8 0.76 Contact Map
3mesA 2 0.8702 99.7 0.769 Contact Map
4dcaA 1 0.7817 99.7 0.774 Contact Map
3csvA 2 0.8555 99.7 0.777 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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