GREMLIN Database
YUTK - Uncharacterized transporter YutK
UniProt: O32115 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 404 (396)
Sequences: 1654 (931)
Seq/√Len: 46.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_Y272_G4.8641.00
309_E340_S4.5031.00
307_W310_A4.2341.00
374_R377_D3.7811.00
271_N289_E3.7371.00
23_K26_N3.6721.00
289_E331_N3.6301.00
331_N334_S3.5291.00
98_I256_V3.4921.00
22_E384_K3.2201.00
313_A347_I3.2191.00
168_T207_L3.1891.00
278_F286_V2.9331.00
163_R380_R2.8851.00
313_A343_T2.8791.00
154_I161_L2.8671.00
12_A302_L2.8081.00
20_F387_L2.7211.00
303_I394_L2.6171.00
10_A395_L2.5921.00
77_I261_L2.5801.00
116_L120_V2.5551.00
22_E214_I2.5431.00
250_L254_L2.5411.00
383_L387_L2.5371.00
107_V238_V2.5121.00
18_F24_K2.4471.00
159_A373_S2.3921.00
35_G208_V2.3581.00
205_A392_A2.3451.00
57_L61_S2.3261.00
158_I371_A2.2991.00
319_Q331_N2.2791.00
246_A262_A2.2001.00
357_F383_L2.1931.00
110_H235_A2.1551.00
17_A212_L2.1411.00
66_L104_L2.0491.00
111_L238_V2.0100.99
107_V242_A1.9860.99
22_E163_R1.9800.99
332_F342_K1.9790.99
247_S255_N1.9760.99
297_S314_G1.9560.99
141_A153_V1.9540.99
17_A209_F1.9480.99
242_A266_L1.9360.99
51_A55_V1.9220.99
72_E75_S1.9190.99
7_L11_V1.8860.99
303_I398_A1.8810.99
252_I255_N1.8420.99
194_Y349_F1.8400.99
71_N93_S1.8290.99
355_A393_N1.7950.99
163_R377_D1.7790.99
202_A396_S1.7760.99
213_I388_A1.7660.99
349_F396_S1.7490.98
135_E211_K1.7310.98
44_Y403_F1.7250.98
131_T136_S1.7220.98
162_T216_E1.7120.98
147_Q359_S1.6870.98
213_I387_L1.6710.98
321_L390_T1.6630.98
277_A281_F1.6380.98
45_I49_W1.6340.97
290_S294_Y1.6280.97
251_Q254_L1.6200.97
5_W301_F1.6000.97
148_S252_I1.5920.97
335_H338_E1.5870.97
288_L292_L1.5780.97
120_V123_G1.5770.97
33_I37_C1.5770.97
164_S216_E1.5670.97
124_G128_L1.5640.97
95_L257_G1.5580.97
122_G133_K1.5540.97
32_V208_V1.5520.97
20_F213_I1.5520.97
202_A205_A1.5460.96
23_K217_T1.5020.96
17_A391_L1.4900.96
116_L119_R1.4870.96
4_L8_L1.4750.95
101_F145_V1.4730.95
166_L377_D1.4720.95
322_V357_F1.4620.95
112_K115_Q1.4610.95
147_Q363_M1.4410.95
70_A74_I1.4360.95
286_V291_I1.4270.94
301_F307_W1.4270.94
106_A110_H1.4260.94
269_V273_I1.4160.94
297_S307_W1.4080.94
186_A192_I1.4060.94
64_Q68_D1.3940.94
8_L301_F1.3800.93
255_N259_M1.3780.93
383_L386_V1.3780.93
174_L363_M1.3760.93
167_F388_A1.3750.93
355_A390_T1.3630.93
70_A265_A1.3480.93
265_A358_S1.3440.92
18_F27_I1.3430.92
55_V58_W1.3340.92
308_H312_Q1.3320.92
150_S172_S1.3260.92
253_A257_G1.3160.92
252_I256_V1.3140.92
27_I212_L1.3130.92
238_V242_A1.3060.91
65_L68_D1.3050.91
148_S255_N1.2910.91
72_E268_A1.2770.90
250_L258_A1.2760.90
148_S366_T1.2590.90
74_I92_L1.2540.90
103_A242_A1.2500.89
162_T165_E1.2490.89
294_Y311_L1.2470.89
78_F91_A1.2450.89
28_K31_T1.2440.89
147_Q358_S1.2380.89
273_I276_G1.2380.89
400_A403_F1.2290.89
158_I370_L1.2260.89
342_K346_I1.2130.88
90_F358_S1.2120.88
309_E339_F1.2050.88
15_A19_L1.1980.87
138_A150_S1.1960.87
65_L69_Y1.1940.87
288_L322_V1.1870.87
240_D375_R1.1830.87
120_V124_G1.1800.87
49_W52_G1.1640.86
270_V288_L1.1610.86
316_Y335_H1.1520.85
240_D244_K1.1490.85
97_V180_S1.1460.85
241_A245_G1.1450.85
141_A145_V1.1450.85
297_S311_L1.1420.85
168_T172_S1.1400.85
191_P336_I1.1380.84
300_A317_I1.1230.84
162_T218_E1.1180.83
332_F347_I1.1150.83
19_L24_K1.1110.83
184_G326_F1.1080.83
80_P89_A1.1010.82
80_P86_D1.0990.82
267_I323_L1.0920.82
45_I51_A1.0920.82
103_A246_A1.0850.82
393_N396_S1.0840.81
151_P173_G1.0820.81
61_S64_Q1.0810.81
289_E319_Q1.0790.81
38_T128_L1.0760.81
305_V313_A1.0750.81
262_A361_A1.0740.81
329_Y352_C1.0740.81
307_W314_G1.0740.81
202_A349_F1.0740.81
44_Y48_K1.0720.81
386_V390_T1.0650.80
118_F157_L1.0630.80
43_G343_T1.0500.79
40_V399_I1.0460.79
14_I212_L1.0440.79
147_Q362_I1.0420.79
14_I32_V1.0410.79
287_T290_S1.0300.78
286_V290_S1.0300.78
16_I387_L1.0290.78
323_L327_V1.0260.78
21_S212_L1.0180.77
81_L89_A1.0160.77
324_N358_S1.0130.77
367_L378_I1.0060.76
42_F205_A1.0060.76
255_N366_T1.0040.76
357_F386_V1.0030.76
16_I299_I1.0010.76
138_A172_S0.9960.76
52_G189_G0.9930.75
336_I344_A0.9890.75
121_I143_I0.9880.75
40_V403_F0.9800.74
180_S252_I0.9740.74
315_S319_Q0.9720.74
153_V256_V0.9700.74
209_F388_A0.9700.74
360_I363_M0.9680.73
386_V389_G0.9610.73
188_L330_S0.9610.73
182_L195_L0.9600.73
16_I370_L0.9590.73
67_I183_F0.9590.73
142_N176_A0.9580.73
392_A396_S0.9570.73
62_R65_L0.9570.73
160_G221_Q0.9540.72
147_Q321_L0.9540.72
99_I249_G0.9510.72
111_L114_M0.9440.72
59_F62_R0.9330.71
125_L129_L0.9320.71
35_G129_L0.9310.71
113_I341_K0.9310.71
74_I265_A0.9290.70
68_D71_N0.9270.70
360_I382_G0.9250.70
188_L360_I0.9220.70
162_T217_T0.9190.70
13_I395_L0.9160.69
13_I209_F0.9130.69
30_R34_V0.9130.69
375_R389_G0.9090.69
277_A280_L0.9050.68
5_W8_L0.9040.68
320_K326_F0.9020.68
18_F212_L0.8980.68
42_F105_I0.8900.67
6_G342_K0.8880.67
55_V59_F0.8870.67
172_S203_A0.8840.66
163_R214_I0.8750.66
131_T207_L0.8710.65
43_G314_G0.8700.65
28_K33_I0.8670.65
8_L155_K0.8660.65
339_F344_A0.8660.65
6_G196_L0.8660.65
274_L286_V0.8640.65
145_V153_V0.8610.64
181_T358_S0.8600.64
83_K89_A0.8580.64
260_L264_V0.8560.64
174_L389_G0.8540.64
208_V393_N0.8530.64
360_I386_V0.8510.64
41_A44_Y0.8500.63
199_S202_A0.8440.63
109_Y156_P0.8410.63
94_V253_A0.8390.62
259_M357_F0.8300.62
163_R381_L0.8280.61
37_C302_L0.8270.61
182_L199_S0.8270.61
70_A97_V0.8250.61
35_G48_K0.8250.61
158_I169_I0.8250.61
122_G136_S0.8230.61
81_L87_S0.8220.61
341_K344_A0.8220.61
54_A57_L0.8220.61
14_I402_M0.8180.60
168_T210_G0.8150.60
248_T251_Q0.8120.60
182_L186_A0.8070.59
293_G315_S0.8060.59
49_W53_R0.8050.59
140_A184_G0.8020.59
105_I145_V0.7980.59
34_V129_L0.7980.59
38_T247_S0.7980.59
139_A207_L0.7960.58
236_A380_R0.7950.58
34_V37_C0.7940.58
118_F177_V0.7920.58
142_N182_L0.7910.58
278_F287_T0.7900.58
303_I346_I0.7900.58
177_V181_T0.7870.57
202_A393_N0.7870.57
282_G322_V0.7850.57
92_L96_P0.7830.57
312_Q335_H0.7830.57
75_S80_P0.7830.57
147_Q253_A0.7810.57
289_E334_S0.7800.57
349_F400_A0.7790.57
15_A18_F0.7790.57
12_A15_A0.7780.57
312_Q339_F0.7780.57
80_P85_G0.7770.56
356_N359_S0.7760.56
196_L200_F0.7750.56
321_L355_A0.7740.56
58_W62_R0.7710.56
107_V266_L0.7690.56
122_G125_L0.7660.55
253_A314_G0.7640.55
148_S181_T0.7640.55
212_L302_L0.7620.55
205_A396_S0.7620.55
267_I315_S0.7620.55
114_M156_P0.7620.55
10_A205_A0.7590.55
28_K130_G0.7580.55
299_I394_L0.7580.55
13_I303_I0.7570.55
360_I378_I0.7550.54
105_I114_M0.7540.54
43_G335_H0.7540.54
76_F90_F0.7530.54
105_I176_A0.7520.54
78_F96_P0.7520.54
134_T161_L0.7510.54
58_W61_S0.7510.54
243_A247_S0.7480.54
164_S211_K0.7480.54
10_A396_S0.7470.54
39_Q205_A0.7450.53
91_A257_G0.7400.53
346_I384_K0.7400.53
164_S203_A0.7350.52
106_A235_A0.7350.52
268_A272_G0.7330.52
113_I295_V0.7320.52
157_L389_G0.7310.52
230_D233_E0.7290.52
18_F22_E0.7260.51
101_F263_F0.7260.51
195_L211_K0.7260.51
131_T189_G0.7250.51
104_L266_L0.7240.51
341_K345_T0.7240.51
166_L374_R0.7240.51
324_N328_A0.7210.51
142_N172_S0.7200.51
129_L169_I0.7190.51
88_P93_S0.7180.51
77_I260_L0.7170.51
293_G314_G0.7150.50
59_F196_L0.7140.50
343_T347_I0.7140.50
71_N75_S0.7130.50
237_N286_V0.7120.50
308_H340_S0.7120.50
161_L169_I0.7090.50
69_Y269_V0.7080.50
134_T150_S0.7080.50
25_S127_K0.7080.50
135_E168_T0.7040.49
114_M118_F0.7030.49
178_A181_T0.7030.49
140_A143_I0.7020.49
170_M179_G0.6970.49
278_F285_G0.6970.49
138_A169_I0.6950.48
305_V347_I0.6940.48
325_E328_A0.6930.48
172_S342_K0.6930.48
53_R57_L0.6910.48
349_F393_N0.6910.48
27_I59_F0.6900.48
138_A206_G0.6900.48
60_S264_V0.6900.48
346_I395_L0.6900.48
362_I365_G0.6890.48
214_I308_H0.6840.47
171_T353_G0.6790.47
72_E271_N0.6790.47
80_P83_K0.6780.47
316_Y328_A0.6770.47
45_I290_S0.6750.46
305_V343_T0.6730.46
125_L386_V0.6720.46
82_L92_L0.6720.46
259_M362_I0.6710.46
94_V326_F0.6710.46
29_I145_V0.6700.46
266_L336_I0.6690.46
134_T137_L0.6640.45
7_L376_S0.6630.45
112_K116_L0.6620.45
376_S380_R0.6610.45
43_G307_W0.6610.45
394_L397_A0.6590.45
105_I317_I0.6590.45
28_K129_L0.6590.45
275_G307_W0.6590.45
399_I402_M0.6580.45
64_Q357_F0.6570.45
113_I116_L0.6570.45
324_N356_N0.6550.44
36_L399_I0.6550.44
311_L314_G0.6540.44
94_V184_G0.6520.44
15_A212_L0.6520.44
261_L276_G0.6520.44
52_G135_E0.6520.44
54_A58_W0.6510.44
14_I27_I0.6510.44
163_R374_R0.6500.44
40_V44_Y0.6490.44
6_G402_M0.6470.44
209_F361_A0.6460.44
8_L302_L0.6430.43
216_E220_T0.6420.43
35_G140_A0.6410.43
299_I380_R0.6400.43
86_D89_A0.6390.43
363_M367_L0.6390.43
390_T393_N0.6380.43
34_V155_K0.6360.43
139_A324_N0.6360.43
54_A99_I0.6350.42
102_S176_A0.6340.42
112_K259_M0.6340.42
271_N287_T0.6330.42
14_I36_L0.6320.42
366_T378_I0.6310.42
122_G161_L0.6310.42
43_G345_T0.6300.42
134_T222_T0.6300.42
299_I302_L0.6300.42
255_N365_G0.6270.42
343_T348_S0.6270.42
14_I208_V0.6250.42
253_A256_V0.6230.41
174_L385_A0.6230.41
30_R130_G0.6220.41
160_G289_E0.6220.41
131_T164_S0.6210.41
142_N203_A0.6200.41
82_L88_P0.6190.41
56_F122_G0.6190.41
170_M363_M0.6180.41
194_Y396_S0.6160.41
276_G280_L0.6140.40
104_L258_A0.6140.40
62_R107_V0.6140.40
7_L402_M0.6130.40
98_I326_F0.6130.40
176_A191_P0.6120.40
220_T261_L0.6110.40
196_L346_I0.6100.40
361_A393_N0.6100.40
65_L272_G0.6090.40
178_A319_Q0.6060.40
250_L257_G0.6040.40
10_A286_V0.6040.40
147_Q243_A0.6030.39
320_K356_N0.6010.39
158_I334_S0.6010.39
116_L397_A0.6010.39
51_A54_A0.6010.39
42_F45_I0.6000.39
123_G128_L0.5980.39
346_I390_T0.5980.39
141_A202_A0.5970.39
190_I351_L0.5960.39
183_F187_L0.5940.39
355_A359_S0.5920.38
398_A401_G0.5910.38
184_G192_I0.5900.38
26_N349_F0.5900.38
324_N327_V0.5890.38
132_S165_E0.5890.38
8_L12_A0.5880.38
109_Y115_Q0.5880.38
361_A382_G0.5850.38
270_V365_G0.5840.38
62_R66_L0.5840.38
43_G393_N0.5820.37
52_G190_I0.5820.37
106_A240_D0.5800.37
256_V379_A0.5800.37
5_W9_G0.5800.37
147_Q314_G0.5790.37
43_G389_G0.5790.37
137_L142_N0.5780.37
221_Q299_I0.5770.37
319_Q324_N0.5760.37
257_G260_L0.5750.37
9_G400_A0.5750.37
107_V258_A0.5740.37
45_I346_I0.5740.37
247_S254_L0.5740.37
208_V382_G0.5740.37
139_A202_A0.5740.37
107_V111_L0.5740.37
29_I33_I0.5720.37
214_I381_L0.5720.37
71_N166_L0.5690.36
53_R193_E0.5660.36
124_G308_H0.5640.36
158_I273_I0.5630.36
137_L153_V0.5630.36
49_W213_I0.5610.36
291_I314_G0.5610.36
102_S152_L0.5600.35
364_L399_I0.5600.35
152_L252_I0.5600.35
171_T295_V0.5600.35
390_T394_L0.5590.35
97_V183_F0.5580.35
19_L254_L0.5570.35
330_S333_G0.5570.35
74_I197_A0.5570.35
283_L286_V0.5570.35
161_L400_A0.5560.35
161_L222_T0.5560.35
16_I285_G0.5560.35
142_N150_S0.5560.35
95_L253_A0.5550.35
239_I357_F0.5540.35
100_F135_E0.5530.35
97_V203_A0.5530.35
38_T129_L0.5530.35
249_G253_A0.5510.35
235_A244_K0.5510.35
185_Y389_G0.5510.35
65_L113_I0.5500.35
45_I55_V0.5490.34
114_M202_A0.5470.34
341_K403_F0.5460.34
358_S362_I0.5440.34
70_A93_S0.5440.34
291_I295_V0.5440.34
248_T256_V0.5440.34
329_Y351_L0.5430.34
77_I101_F0.5430.34
158_I274_L0.5430.34
181_T326_F0.5420.34
273_I312_Q0.5420.34
69_Y268_A0.5420.34
371_A377_D0.5410.34
165_E288_L0.5410.34
194_Y205_A0.5410.34
241_A318_G0.5410.34
177_V296_F0.5410.34
17_A390_T0.5400.34
359_S362_I0.5380.33
32_V158_I0.5380.33
129_L172_S0.5370.33
194_Y345_T0.5370.33
181_T362_I0.5370.33
41_A55_V0.5360.33
31_T200_F0.5340.33
81_L92_L0.5300.33
166_L330_S0.5290.33
37_C41_A0.5280.33
41_A45_I0.5260.32
98_I253_A0.5240.32
285_G290_S0.5240.32
242_A400_A0.5240.32
148_S259_M0.5210.32
62_R269_V0.5210.32
83_K86_D0.5210.32
90_F181_T0.5210.32
286_V294_Y0.5200.32
143_I203_A0.5190.32
122_G128_L0.5190.32
91_A261_L0.5170.32
252_I366_T0.5160.32
150_S366_T0.5160.32
70_A209_F0.5160.32
259_M390_T0.5150.31
256_V265_A0.5140.31
14_I370_L0.5130.31
156_P372_P0.5130.31
140_A172_S0.5120.31
142_N173_G0.5120.31
103_A323_L0.5110.31
5_W402_M0.5100.31
4_L242_A0.5100.31
155_K305_V0.5090.31
247_S366_T0.5090.31
174_L360_I0.5080.31
100_F314_G0.5060.31
23_K315_S0.5050.31
228_K231_E0.5040.31
18_F25_S0.5030.30
14_I29_I0.5030.30
244_K375_R0.5020.30
319_Q322_V0.5020.30
207_L366_T0.5020.30
274_L290_S0.5020.30
137_L145_V0.5020.30
113_I376_S0.5020.30
153_V206_G0.5010.30
111_L271_N0.5010.30
132_S329_Y0.5010.30
306_P312_Q0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pd6A 3 0.9629 100 0.111 Contact Map
2cfqA 1 0.8738 30.9 0.978 Contact Map
2mofA 1 0.0792 22 0.98 Contact Map
4ikvA 1 0.4233 13.8 0.981 Contact Map
4f35D 2 0.8738 12.7 0.982 Contact Map
4oh3A 2 0.4208 10.9 0.982 Contact Map
4u4vA 1 0.4158 8.1 0.983 Contact Map
4j05A 3 0.3688 7.3 0.984 Contact Map
4zw9A 1 0.3861 3.9 0.986 Contact Map
4czbA 2 0.2649 3.9 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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