GREMLIN Database
DAPF - Diaminopimelate epimerase
UniProt: O32114 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 284 (261)
Sequences: 3870 (2672)
Seq/√Len: 165.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
210_E252_H3.6971.00
208_E244_K3.2561.00
51_I79_G3.2121.00
97_S110_E3.1341.00
124_D267_H3.0591.00
74_K196_E2.9711.00
64_R72_E2.9131.00
252_H257_D2.7941.00
207_N210_E2.7401.00
248_D261_N2.6531.00
234_A249_I2.6101.00
250_T257_D2.3501.00
235_V268_V2.3481.00
85_K89_E2.3141.00
180_P183_T2.3071.00
203_V233_A2.2131.00
6_F280_G2.1561.00
237_S243_S2.1181.00
204_E212_H2.1071.00
43_T224_Q2.1041.00
38_V282_Y2.1031.00
260_I270_M2.0861.00
5_R281_V2.0821.00
62_K101_E2.0421.00
15_S41_V2.0131.00
188_I200_V1.9841.00
131_T134_E1.9051.00
276_T279_E1.9021.00
99_L108_K1.8701.00
210_E250_T1.8391.00
122_T269_M1.8121.00
248_D259_V1.8031.00
21_Q54_C1.7941.00
172_P237_S1.7871.00
10_H275_E1.7731.00
110_E122_T1.7721.00
129_R134_E1.7361.00
159_G169_I1.6971.00
56_S101_E1.6921.00
160_T236_A1.6851.00
12_L225_A1.6851.00
212_H252_H1.6831.00
234_A251_V1.6701.00
39_S47_S1.6441.00
211_L233_A1.6381.00
122_T271_T1.6371.00
127_E266_G1.6181.00
203_V211_L1.6061.00
59_A106_L1.5731.00
5_R279_E1.5581.00
211_L251_V1.5571.00
190_K197_G1.5571.00
189_E197_G1.5561.00
90_H279_E1.5471.00
151_A154_E1.5451.00
201_E229_G1.5211.00
61_V87_A1.5181.00
19_V50_M1.4961.00
175_D178_Q1.4951.00
54_C62_K1.4741.00
97_S108_K1.4731.00
250_T259_V1.4681.00
214_R222_I1.4661.00
60_P95_E1.4451.00
164_M268_V1.4441.00
206_V212_H1.4401.00
122_T261_N1.4221.00
80_L100_I1.4181.00
72_E103_L1.4111.00
130_L239_L1.4101.00
172_P203_V1.3811.00
175_D204_E1.3681.00
201_E215_V1.3541.00
53_I83_V1.3421.00
47_S50_M1.3251.00
112_Q122_T1.3221.00
149_T156_E1.3161.00
11_G82_C1.3151.00
54_C64_R1.3081.00
125_M231_C1.2921.00
172_P242_V1.2851.00
211_L237_S1.2751.00
20_N23_E1.2751.00
83_V100_I1.2611.00
171_F200_V1.2501.00
31_L34_I1.2421.00
127_E267_H1.2281.00
157_L184_L1.2201.00
213_F230_A1.2161.00
10_H43_T1.2141.00
74_K104_S1.2131.00
209_Q244_K1.2061.00
88_Y96_T1.1911.00
7_T279_E1.1861.00
201_E213_F1.1831.00
222_I254_A1.1811.00
28_E35_A1.1771.00
213_F233_A1.1731.00
99_L106_L1.1651.00
153_G187_V1.1651.00
261_N271_T1.1631.00
75_N228_T1.1591.00
206_V210_E1.1571.00
238_V247_Q1.1571.00
68_N220_S1.1491.00
76_C226_C1.1451.00
45_I278_C1.1401.00
40_S44_G1.1351.00
89_E276_T1.1131.00
177_E212_H1.1131.00
35_A50_M1.1121.00
233_A251_V1.1051.00
225_A253_L1.0931.00
17_I38_V1.0911.00
112_Q120_V1.0881.00
58_Q101_E1.0871.00
263_K267_H1.0841.00
84_A109_A1.0841.00
190_K216_W1.0841.00
13_G224_Q1.0801.00
234_A238_V1.0791.00
176_I204_E1.0781.00
88_Y111_V1.0660.99
53_I87_A1.0650.99
61_V93_V1.0600.99
100_I109_A1.0580.99
13_G43_T1.0580.99
160_T240_N1.0570.99
85_K274_A1.0560.99
235_V262_W1.0550.99
33_E36_I1.0450.99
59_A101_E1.0420.99
56_S59_A1.0390.99
66_F72_E1.0320.99
128_P262_W1.0310.99
12_L253_L1.0300.99
162_V236_A1.0280.99
149_T158_T1.0260.99
93_V98_F1.0210.99
22_F55_P1.0190.99
238_V262_W1.0190.99
167_P218_R1.0160.99
17_I47_S1.0070.99
231_C268_V1.0060.99
102_T105_G1.0010.99
181_L202_F0.9990.99
40_S43_T0.9920.99
120_V271_T0.9900.99
137_M161_A0.9880.99
90_H276_T0.9830.99
247_Q264_D0.9830.99
169_I198_I0.9750.99
28_E34_I0.9750.99
41_V46_G0.9750.99
161_A169_I0.9650.99
32_S36_I0.9590.99
74_K103_L0.9570.99
212_H254_A0.9550.99
53_I86_Y0.9520.99
7_T276_T0.9490.99
31_L52_L0.9440.99
111_V121_V0.9440.99
17_I278_C0.9400.99
15_S46_G0.9330.99
42_Y224_Q0.9310.99
18_Y51_I0.9300.99
109_A121_V0.9280.99
186_P216_W0.9210.98
230_A253_L0.9200.98
38_V47_S0.9180.98
17_I45_I0.9120.98
130_L235_V0.9090.98
151_A156_E0.9060.98
52_L66_F0.9010.98
188_I198_I0.8980.98
182_T186_P0.8920.98
120_V259_V0.8880.98
152_F155_V0.8840.98
62_K103_L0.8760.98
16_Y47_S0.8740.98
21_Q52_L0.8700.98
124_D269_M0.8640.98
209_Q248_D0.8610.98
244_K247_Q0.8580.98
263_K269_M0.8490.97
86_Y90_H0.8460.97
4_F281_V0.8460.97
226_C229_G0.8410.97
80_L109_A0.8360.97
150_M159_G0.8340.97
244_K248_D0.8330.97
75_N107_V0.8300.97
189_E216_W0.8260.97
35_A66_F0.8250.97
172_P236_A0.8230.97
234_A260_I0.8220.97
234_A243_S0.8200.97
61_V92_L0.8190.97
65_I73_G0.8170.97
201_E233_A0.8120.97
39_S49_G0.8120.97
132_K137_M0.8070.96
129_R163_S0.8050.96
23_E55_P0.8030.96
84_A98_F0.7980.96
211_L243_S0.7960.96
83_V87_A0.7940.96
159_G171_F0.7890.96
164_M231_C0.7870.96
177_E254_A0.7860.96
114_E120_V0.7780.96
45_I282_Y0.7780.96
84_A111_V0.7780.96
259_V271_T0.7760.96
128_P164_M0.7750.96
166_N201_E0.7710.95
7_T86_Y0.7690.95
101_E106_L0.7670.95
9_M82_C0.7670.95
32_S35_A0.7650.95
205_T211_L0.7630.95
243_S249_I0.7560.95
230_A258_L0.7560.95
185_G189_E0.7530.95
31_L35_A0.7520.95
109_A123_V0.7500.95
28_E33_E0.7500.95
215_V226_C0.7490.95
166_N215_V0.7470.95
43_T255_G0.7430.94
96_T113_V0.7430.94
112_Q271_T0.7410.94
170_V236_A0.7340.94
19_V38_V0.7330.94
11_G225_A0.7250.94
181_L185_G0.7240.94
104_S107_V0.7230.94
79_G84_A0.7230.94
80_L123_V0.7220.94
28_E31_L0.7210.93
37_Q282_Y0.7180.93
132_K139_D0.7120.93
161_A198_I0.7110.93
139_D193_R0.7110.93
22_F92_L0.7100.93
261_N269_M0.7090.93
20_N92_L0.7010.92
98_F109_A0.6990.92
163_S166_N0.6950.92
16_Y39_S0.6950.92
203_V237_S0.6940.92
183_T187_V0.6930.92
12_L230_A0.6920.92
214_R254_A0.6920.92
60_P99_L0.6860.92
63_M75_N0.6790.91
9_M18_Y0.6770.91
10_H277_V0.6760.91
152_F187_V0.6750.91
247_Q265_N0.6740.91
181_L222_I0.6720.91
176_I214_R0.6720.91
69_D219_G0.6710.91
93_V96_T0.6700.91
173_I204_E0.6690.91
96_T110_E0.6680.91
210_E257_D0.6680.91
9_M276_T0.6670.91
176_I212_H0.6660.90
18_Y39_S0.6640.90
169_I188_I0.6640.90
74_K166_N0.6640.90
216_W220_S0.6630.90
169_I200_V0.6630.90
33_E37_Q0.6610.90
157_L171_F0.6590.90
39_S68_N0.6580.90
251_V260_I0.6550.90
34_I37_Q0.6550.90
150_M191_D0.6530.90
258_L270_M0.6510.89
173_I179_A0.6480.89
56_S60_P0.6470.89
237_S242_V0.6270.88
189_E220_S0.6220.87
247_Q261_N0.6190.87
209_Q247_Q0.6190.87
182_T221_G0.6190.87
51_I83_V0.6180.87
230_A251_V0.6170.87
186_P190_K0.6160.87
39_S51_I0.6160.87
181_L186_P0.6150.87
203_V213_F0.6140.87
38_V45_I0.6130.86
74_K167_P0.6100.86
53_I61_V0.6080.86
264_D267_H0.6050.86
96_T111_V0.6050.86
263_K266_G0.6040.86
128_P162_V0.6030.86
21_Q26_L0.6030.86
136_P161_A0.6030.86
108_K124_D0.6020.85
88_Y93_V0.5990.85
7_T90_H0.5960.85
151_A155_V0.5960.85
176_I181_L0.5950.85
164_M235_V0.5940.85
22_F90_H0.5940.85
56_S62_K0.5900.84
62_K72_E0.5890.84
201_E226_C0.5880.84
37_Q275_E0.5880.84
80_L83_V0.5830.84
14_N48_D0.5800.83
102_T107_V0.5790.83
224_Q254_A0.5780.83
12_L273_P0.5770.83
234_A262_W0.5760.83
205_T242_V0.5740.83
51_I65_I0.5720.82
59_A99_L0.5710.82
125_M164_M0.5670.82
231_C260_I0.5670.82
171_F188_I0.5670.82
35_A47_S0.5660.82
205_T208_E0.5650.82
34_I282_Y0.5650.82
16_Y220_S0.5650.82
49_G75_N0.5640.82
238_V249_I0.5640.82
75_N80_L0.5610.81
49_G73_G0.5610.81
67_N218_R0.5590.81
34_I38_V0.5550.81
4_F19_V0.5540.80
11_G273_P0.5530.80
63_M100_I0.5530.80
226_C230_A0.5470.80
73_G220_S0.5460.80
6_F278_C0.5420.79
67_N166_N0.5410.79
20_N90_H0.5390.79
238_V244_K0.5390.79
40_S46_G0.5390.79
41_V44_G0.5350.78
98_F111_V0.5350.78
20_N86_Y0.5330.78
201_E222_I0.5320.78
154_E157_L0.5290.77
51_I63_M0.5280.77
186_P189_E0.5270.77
135_L161_A0.5260.77
20_N24_E0.5250.77
138_L193_R0.5240.77
162_V170_V0.5240.77
100_I107_V0.5230.77
128_P235_V0.5220.76
171_F184_L0.5210.76
79_G86_Y0.5210.76
169_I194_F0.5190.76
153_G156_E0.5170.76
14_N78_N0.5150.75
80_L107_V0.5140.75
12_L270_M0.5130.75
155_V183_T0.5130.75
81_R272_G0.5130.75
74_K228_T0.5120.75
236_A240_N0.5120.75
19_V28_E0.5110.75
185_G188_I0.5110.75
231_C270_M0.5100.75
253_L258_L0.5100.75
125_M270_M0.5080.75
11_G81_R0.5080.75
179_A184_L0.5080.75
170_V229_G0.5070.74
65_I72_E0.5070.74
9_M49_G0.5070.74
157_L200_V0.5060.74
209_Q250_T0.5050.74
58_Q99_L0.5050.74
157_L188_I0.5050.74
152_F157_L0.5050.74
223_T226_C0.5040.74
17_I280_G0.5030.74
87_A92_L0.5020.74
78_N223_T0.5020.74
200_V216_W0.5010.74
8_K15_S0.5000.73
222_I233_A0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2otnA 2 1 100 0.29 Contact Map
3fveA 2 0.9049 100 0.322 Contact Map
3ejxA 5 0.9754 100 0.325 Contact Map
2gkeA 1 0.9542 100 0.333 Contact Map
3ednA 2 0.9472 100 0.44 Contact Map
1ym5A 2 0.9296 100 0.472 Contact Map
3g7kA 3 0.9894 100 0.477 Contact Map
1xubA 2 0.9155 100 0.486 Contact Map
1qyaA 2 0.9296 100 0.486 Contact Map
1u0kA 2 0.919 100 0.489 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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