GREMLIN Database
SUFA - Uncharacterized protein SufA
UniProt: O32113 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 120 (106)
Sequences: 3617 (1814)
Seq/√Len: 176.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_V94_D4.5211.00
14_H17_D3.6121.00
28_F66_L3.0681.00
12_A61_H3.0231.00
68_D71_S2.9491.00
32_G44_G2.7641.00
6_T79_V2.7091.00
59_D64_T2.6161.00
98_A101_S2.5951.00
9_E61_H2.4551.00
57_V64_T2.2471.00
5_V80_I2.2291.00
24_E49_H2.1741.00
34_K44_G2.1581.00
30_R55_D2.0951.00
8_T81_D1.9411.00
78_T93_I1.8761.00
51_K66_L1.8561.00
59_D62_G1.7781.00
84_Q89_G1.6941.00
16_K20_K1.6121.00
16_K62_G1.5811.00
28_F64_T1.5801.00
9_E60_Q1.5221.00
41_L74_I1.4511.00
51_K57_V1.3531.00
36_G86_M1.3451.00
100_A109_R1.3151.00
10_A81_D1.2971.00
83_K92_T1.2621.00
48_E51_K1.2611.00
7_I15_I1.2441.00
56_S69_K1.1961.00
15_I29_L1.1801.00
24_E27_A1.1741.00
13_L16_K1.1611.00
9_E13_L1.1331.00
31_V75_M1.1151.00
48_E52_S1.0901.00
85_S92_T1.0881.00
14_H91_F1.0801.00
4_P76_N1.0731.00
73_D76_N1.0661.00
23_E26_N1.0651.00
78_T106_S1.0521.00
70_E73_D1.0060.99
14_H18_M0.9430.99
10_A13_L0.9410.99
11_A103_G0.9270.99
35_G39_S0.9250.99
77_G96_P0.9180.99
83_K88_G0.9140.99
13_L61_H0.9120.99
12_A63_I0.9090.99
58_F72_L0.9030.99
71_S80_I0.9000.99
69_K73_D0.8940.98
99_I110_T0.8810.98
39_S109_R0.8490.98
85_S90_G0.8470.98
12_A60_Q0.8450.98
7_I65_V0.8410.98
14_H82_Y0.8330.98
52_S55_D0.8320.98
20_K25_E0.8270.97
7_I91_F0.8120.97
16_K61_H0.8010.97
14_H87_L0.7970.97
31_V80_I0.7970.97
16_K63_I0.7960.97
33_V108_F0.7960.97
36_G42_S0.7890.97
29_L91_F0.7850.97
72_L76_N0.7720.96
36_G98_A0.7720.96
27_A51_K0.7490.96
83_K90_G0.7460.95
75_M97_N0.7400.95
11_A88_G0.7290.95
4_P72_L0.7200.94
7_I60_Q0.7170.94
48_E55_D0.7150.94
18_M91_F0.7100.94
27_A49_H0.7090.94
32_G46_G0.7010.94
19_M28_F0.7000.94
56_S72_L0.6990.94
21_E27_A0.6970.93
98_A108_F0.6930.93
99_I109_R0.6900.93
11_A99_I0.6890.93
57_V66_L0.6880.93
85_S88_G0.6880.93
7_I12_A0.6860.93
104_C107_S0.6840.93
19_M26_N0.6780.92
19_M47_F0.6760.92
15_I63_I0.6710.92
19_M27_A0.6700.92
39_S108_F0.6670.92
30_R48_E0.6600.91
12_A62_G0.6570.91
9_E12_A0.6550.91
35_G41_L0.6540.91
41_L108_F0.6510.91
13_L20_K0.6490.91
95_N98_A0.6440.90
23_E49_H0.6400.90
28_F51_K0.6370.90
102_C107_S0.6310.90
51_K64_T0.6290.89
15_I91_F0.6270.89
41_L45_M0.6180.89
37_G107_S0.6140.88
85_S89_G0.6100.88
33_V36_G0.6100.88
7_I80_I0.6060.88
45_M74_I0.6060.88
5_V78_T0.6050.88
14_H84_Q0.6030.87
84_Q103_G0.6030.87
56_S73_D0.5980.87
15_I19_M0.5950.87
39_S100_A0.5950.87
82_Y89_G0.5920.86
60_Q65_V0.5890.86
36_G39_S0.5890.86
39_S74_I0.5840.86
77_G97_N0.5790.85
104_C108_F0.5770.85
105_G108_F0.5750.85
76_N97_N0.5690.84
56_S76_N0.5650.84
28_F65_V0.5630.84
25_E49_H0.5630.84
35_G45_M0.5630.84
54_S69_K0.5610.83
41_L103_G0.5570.83
28_F57_V0.5550.83
53_E69_K0.5550.83
20_K23_E0.5550.83
45_M88_G0.5530.82
83_K87_L0.5480.82
102_C105_G0.5390.81
30_R68_D0.5350.80
93_I106_S0.5350.80
17_D20_K0.5310.80
5_V77_G0.5300.80
77_G95_N0.5280.79
45_M78_T0.5270.79
82_Y91_F0.5140.78
20_K52_S0.5110.77
5_V90_G0.5090.77
15_I21_E0.5090.77
63_I78_T0.5040.76
42_S93_I0.5040.76
12_A16_K0.5030.76
8_T87_L0.5010.76
26_N49_H0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d2aA 2 0.9083 100 0.196 Contact Map
1x0gA 4 0.9167 100 0.207 Contact Map
1nwbA 1 0.8 100 0.208 Contact Map
2apnA 1 0.9167 100 0.209 Contact Map
1r94A 3 0.8083 100 0.218 Contact Map
2k4zA 1 0.8833 100 0.365 Contact Map
2p2eA 1 0.8833 99.9 0.491 Contact Map
2qgoA 1 0.8083 99.8 0.51 Contact Map
3k6qA 2 0.9667 8.7 0.94 Contact Map
4awxB 1 0.3167 8.6 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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