GREMLIN Database
YUIC - Uncharacterized protein YuiC
UniProt: O32108 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 218 (170)
Sequences: 326 (287)
Seq/√Len: 22.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
130_P152_T5.7281.00
89_T177_K3.3681.00
116_V150_A3.2451.00
100_T110_G3.0591.00
126_V139_L3.0311.00
113_Y152_T2.9830.99
167_T170_D2.8340.99
128_A149_V2.8280.99
113_Y154_S2.3510.97
85_V181_D2.2890.97
130_P154_S2.2680.96
97_A100_T2.2280.96
100_T109_Y2.0930.94
126_V161_L1.9460.92
95_A118_V1.9270.91
161_L180_L1.9130.91
95_A110_G1.8110.88
120_R124_S1.8010.88
18_A22_T1.7970.88
88_V126_V1.7890.88
100_T171_V1.7860.88
128_A133_F1.7680.87
96_G109_Y1.7150.86
99_S109_Y1.6980.85
90_A144_Y1.6550.83
144_Y175_W1.6380.83
124_S139_L1.5970.81
131_S157_K1.5940.81
94_T100_T1.5730.80
133_F149_V1.5730.80
137_T184_V1.5690.80
140_F183_Y1.5680.80
118_V164_Y1.5480.79
34_L184_V1.5440.79
99_S114_S1.5310.78
75_E79_D1.5140.77
125_T164_Y1.5120.77
23_F31_A1.5090.77
144_Y147_G1.5020.77
96_G100_T1.4950.76
102_K109_Y1.4940.76
94_T110_G1.4680.75
156_I177_K1.4530.74
139_L163_L1.4460.74
142_P145_G1.4130.72
163_L178_K1.4070.72
126_V163_L1.3980.71
175_W180_L1.3960.71
154_S170_D1.3470.68
121_D175_W1.3440.68
175_W178_K1.3420.68
24_L28_G1.3400.68
97_A109_Y1.3130.66
29_I37_W1.2920.65
89_T175_W1.2880.65
91_T127_A1.2830.65
144_Y163_L1.2710.64
87_R181_D1.2650.63
109_Y114_S1.2510.63
133_F161_L1.2390.62
94_T97_A1.2370.62
141_I147_G1.2290.61
164_Y167_T1.2150.60
97_A103_N1.2150.60
144_Y150_A1.1630.57
80_W140_F1.1540.56
181_D184_V1.1420.55
147_G180_L1.1320.55
127_A172_Y1.1150.54
30_E33_D1.1090.53
33_D37_W1.1050.53
101_G109_Y1.0990.53
109_Y171_V1.0890.52
98_E110_G1.0870.52
12_T37_W1.0800.51
60_Q66_A1.0610.50
83_Y183_Y1.0540.49
124_S166_E1.0450.49
92_G149_V1.0390.48
130_P133_F1.0380.48
99_S102_K1.0230.47
77_A186_K1.0100.46
90_A147_G1.0100.46
90_A180_L1.0050.46
99_S147_G0.9980.46
96_G99_S0.9980.46
42_Q46_L0.9970.46
63_T68_E0.9940.45
95_A100_T0.9930.45
35_S161_L0.9930.45
62_Q65_S0.9900.45
138_I147_G0.9870.45
23_F27_S0.9760.44
160_R180_L0.9710.44
17_L34_L0.9700.44
17_L38_V0.9660.44
41_H160_R0.9630.43
17_L31_A0.9510.43
135_I154_S0.9510.43
30_E67_A0.9430.42
75_E78_F0.9420.42
17_L29_I0.9320.41
43_E66_A0.9240.41
21_T131_S0.9200.40
165_F171_V0.9170.40
120_R139_L0.9130.40
120_R175_W0.9120.40
69_D81_D0.9080.40
174_E182_V0.8900.39
83_Y178_K0.8860.38
145_G163_L0.8770.38
97_A101_G0.8750.38
135_I179_T0.8730.37
46_L167_T0.8720.37
21_T31_A0.8650.37
89_T160_R0.8650.37
91_T175_W0.8560.36
45_H178_K0.8500.36
86_Q159_N0.8460.36
27_S31_A0.8390.35
18_A27_S0.8370.35
86_Q133_F0.8280.35
19_F27_S0.8280.35
119_K148_V0.8230.34
133_F147_G0.8220.34
31_A38_V0.8210.34
88_V175_W0.8150.34
64_T81_D0.8110.34
87_R159_N0.8090.33
18_A29_I0.8080.33
74_L185_I0.8020.33
110_G182_V0.8000.33
110_G171_V0.7920.32
124_S175_W0.7910.32
84_P119_K0.7810.32
124_S147_G0.7770.32
154_S157_K0.7760.32
121_D142_P0.7740.31
137_T181_D0.7700.31
110_G114_S0.7690.31
138_I172_Y0.7650.31
35_S40_E0.7550.30
24_L30_E0.7440.30
12_T170_D0.7400.29
96_G114_S0.7260.29
46_L55_A0.7190.28
141_I184_V0.7190.28
57_Q143_N0.7140.28
140_F167_T0.7100.28
114_S125_T0.7000.27
125_T136_G0.6990.27
139_L144_Y0.6990.27
13_C19_F0.6980.27
35_S173_N0.6920.27
109_Y125_T0.6920.27
83_Y186_K0.6900.27
60_Q131_S0.6820.26
88_V144_Y0.6800.26
150_A172_Y0.6780.26
43_E67_A0.6740.26
85_V183_Y0.6710.26
68_E73_P0.6700.26
141_I185_I0.6690.26
89_T103_N0.6670.25
50_G64_T0.6640.25
92_G133_F0.6640.25
124_S144_Y0.6640.25
49_A67_A0.6630.25
17_L41_H0.6610.25
44_K51_L0.6570.25
98_E101_G0.6560.25
50_G53_L0.6460.24
54_K59_K0.6450.24
92_G121_D0.6450.24
129_D149_V0.6440.24
20_G31_A0.6410.24
101_G114_S0.6390.24
114_S165_F0.6350.24
124_S142_P0.6350.24
131_S152_T0.6340.24
102_K125_T0.6340.24
12_T15_F0.6320.24
90_A175_W0.6320.24
138_I150_A0.6290.24
138_I186_K0.6260.23
47_K159_N0.6230.23
156_I160_R0.6190.23
129_D182_V0.6100.23
140_F145_G0.6070.23
98_E160_R0.6040.22
14_L22_T0.6020.22
128_A139_L0.6000.22
138_I146_L0.5990.22
19_F29_I0.5960.22
92_G128_A0.5960.22
54_K58_Q0.5950.22
60_Q174_E0.5950.22
20_G38_V0.5880.22
128_A142_P0.5840.21
114_S164_Y0.5820.21
50_G57_Q0.5810.21
175_W184_V0.5790.21
117_K141_I0.5770.21
92_G142_P0.5730.21
42_Q68_E0.5690.21
102_K164_Y0.5660.21
23_F38_V0.5630.20
14_L18_A0.5620.20
64_T67_A0.5580.20
88_V182_V0.5580.20
48_H56_L0.5570.20
47_K50_G0.5570.20
109_Y124_S0.5570.20
55_A60_Q0.5530.20
143_N173_N0.5530.20
86_Q154_S0.5520.20
152_T156_I0.5520.20
85_V127_A0.5500.20
45_H51_L0.5500.20
30_E42_Q0.5490.20
36_K50_G0.5470.20
66_A186_K0.5460.20
45_H49_A0.5440.20
100_T111_L0.5440.20
66_A89_T0.5410.20
68_E185_I0.5370.19
49_A53_L0.5360.19
129_D152_T0.5340.19
139_L149_V0.5340.19
17_L37_W0.5330.19
144_Y180_L0.5310.19
115_G129_D0.5300.19
171_V175_W0.5260.19
91_T129_D0.5250.19
145_G178_K0.5230.19
63_T66_A0.5220.19
97_A114_S0.5220.19
85_V180_L0.5210.19
15_F26_V0.5180.19
50_G66_A0.5180.19
17_L35_S0.5170.19
19_F38_V0.5160.18
100_T114_S0.5160.18
20_G23_F0.5140.18
139_L167_T0.5130.18
88_V142_P0.5120.18
61_T75_E0.5110.18
152_T155_A0.5100.18
123_Y164_Y0.5070.18
19_F40_E0.5070.18
90_A148_V0.5030.18
59_K65_S0.5020.18
33_D65_S0.5010.18
64_T68_E0.5010.18
166_E170_D0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wjtA 2 0.6697 100 0.342 Contact Map
2ae0X 1 0.7339 99.9 0.68 Contact Map
2g5dA 1 0.7752 99.9 0.703 Contact Map
2pnwA 1 0.7431 99.9 0.714 Contact Map
3czbA 2 0.7248 99.8 0.722 Contact Map
4avrA 2 0.4037 91.8 0.928 Contact Map
4uz3A 1 0.4541 21.3 0.96 Contact Map
2mkxA 1 0.2339 11.2 0.964 Contact Map
4pxvA 1 0.2202 10.3 0.965 Contact Map
4fuoA 2 0.3165 6.8 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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