GREMLIN Database
AMPA - Probable cytosol aminopeptidase
UniProt: O32106 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 500 (452)
Sequences: 3858 (2733)
Seq/√Len: 128.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
331_S337_I3.4511.00
216_E219_E3.2231.00
227_G337_I3.1251.00
391_Q410_Q3.0671.00
312_P353_G3.0001.00
387_M439_A2.8991.00
185_V286_G2.8351.00
263_I314_T2.8031.00
201_A292_L2.7641.00
298_I303_P2.7601.00
236_T321_G2.7051.00
312_P349_V2.6501.00
232_N239_P2.6101.00
375_V385_G2.5341.00
170_V490_E2.5281.00
419_K422_K2.5041.00
197_L288_A2.5011.00
213_E245_K2.4751.00
310_V357_A2.4501.00
298_I307_V2.4061.00
387_M443_G2.3711.00
242_I313_S2.3631.00
193_T237_E2.2881.00
256_V489_A2.2861.00
354_I446_L2.2771.00
211_E245_K2.2571.00
384_T480_V2.2501.00
383_T414_T2.2281.00
230_A323_M2.1921.00
176_Q300_E2.1751.00
230_A329_I2.1661.00
267_T317_M2.1221.00
263_I349_V2.1001.00
340_L432_S2.0851.00
270_Y318_I2.0681.00
200_Y203_E2.0551.00
335_K448_E2.0491.00
487_T491_R2.0051.00
418_K448_E1.9861.00
388_T394_Y1.9651.00
332_L355_T1.9461.00
227_G331_S1.9461.00
219_E222_E1.9161.00
397_V456_V1.9121.00
197_L313_S1.9101.00
32_D37_G1.9011.00
394_Y410_Q1.9001.00
248_G306_N1.8861.00
328_V426_M1.8691.00
216_E240_K1.8371.00
232_N314_T1.7941.00
177_G293_G1.7881.00
425_Q475_A1.7871.00
296_E300_E1.7801.00
330_V336_T1.7771.00
377_V435_R1.7761.00
220_M241_M1.7661.00
368_V485_L1.7581.00
205_A212_C1.7331.00
384_T463_T1.7091.00
195_T237_E1.7001.00
340_L430_S1.6841.00
292_L311_I1.6821.00
173_A177_G1.6771.00
193_T196_D1.6761.00
93_F129_C1.6751.00
411_L439_A1.6731.00
301_L486_A1.6631.00
387_M411_L1.6601.00
272_I275_K1.6581.00
258_L291_V1.6471.00
216_E238_P1.6351.00
257_G357_A1.6311.00
217_K221_E1.6011.00
398_A408_I1.5911.00
96_I104_T1.5821.00
374_G438_H1.5691.00
376_V436_E1.5641.00
192_L196_D1.5621.00
390_D454_P1.5581.00
386_A458_L1.5451.00
323_M329_I1.5391.00
217_K239_P1.5311.00
207_K296_E1.5301.00
375_V411_L1.5301.00
241_M353_G1.4991.00
397_V488_L1.4961.00
233_Q323_M1.4911.00
245_K360_H1.4851.00
183_T186_N1.4821.00
123_H170_V1.4821.00
384_T458_L1.4801.00
177_G297_T1.4791.00
134_Y183_T1.4781.00
367_D455_W1.4741.00
167_G171_G1.4721.00
295_M309_C1.4671.00
424_S427_A1.4661.00
195_T240_K1.4641.00
403_E487_T1.4631.00
258_L294_A1.4631.00
295_M298_I1.4571.00
226_G330_V1.4561.00
221_E233_Q1.4431.00
398_A410_Q1.4331.00
255_V308_L1.4291.00
129_C153_V1.4291.00
329_I339_I1.4291.00
400_A487_T1.4271.00
429_L448_E1.4261.00
375_V439_A1.4231.00
217_K238_P1.4211.00
298_I489_A1.4131.00
57_K70_Y1.4131.00
236_T319_S1.4081.00
171_G175_G1.3951.00
364_V488_L1.3811.00
50_A73_G1.3791.00
279_V340_L1.3731.00
335_K429_L1.3711.00
217_K232_N1.3711.00
245_K306_N1.3681.00
395_Q398_A1.3581.00
136_V139_Y1.3571.00
220_M228_I1.3491.00
386_A456_V1.3481.00
215_L223_L1.3471.00
199_S203_E1.3411.00
333_S355_T1.3401.00
393_F456_V1.3311.00
386_A394_Y1.3301.00
291_V309_C1.3281.00
205_A244_L1.3251.00
249_K306_N1.3221.00
256_V364_V1.3211.00
391_Q395_Q1.3151.00
329_I348_L1.3121.00
271_S275_K1.3111.00
358_K453_T1.3101.00
194_A264_T1.3071.00
332_L359_Q1.3051.00
297_T486_A1.3041.00
487_T490_E1.3031.00
310_V353_G1.2911.00
225_M356_Y1.2881.00
139_Y187_M1.2801.00
189_G326_D1.2761.00
165_Q169_R1.2711.00
309_C368_V1.2671.00
255_V306_N1.2631.00
254_D363_S1.2571.00
242_I311_I1.2541.00
208_Y296_E1.2521.00
225_M332_L1.2491.00
283_S465_T1.2441.00
244_L295_M1.2441.00
417_D437_G1.2361.00
217_K240_K1.2331.00
198_A242_I1.2271.00
263_I312_P1.2251.00
381_T436_E1.2241.00
199_S202_E1.2231.00
81_S84_Q1.2200.99
382_E416_K1.2180.99
294_A298_I1.2170.99
130_L175_G1.2150.99
169_R172_Q1.2150.99
249_K252_W1.2090.99
227_G351_A1.2070.99
196_D199_S1.2030.99
247_Q306_N1.2030.99
97_H135_E1.2020.99
197_L242_I1.2000.99
139_Y191_M1.1980.99
257_G362_A1.1960.99
210_F295_M1.1930.99
233_Q321_G1.1890.99
212_C244_L1.1890.99
383_T407_A1.1870.99
413_I443_G1.1870.99
384_T481_M1.1830.99
430_S433_P1.1760.99
257_G310_V1.1760.99
255_V363_S1.1680.99
368_V481_M1.1610.99
228_I314_T1.1600.99
83_E472_F1.1570.99
271_S278_I1.1550.99
408_I484_T1.1500.99
285_M289_A1.1460.99
395_Q399_D1.1440.99
243_V356_Y1.1360.99
291_V368_V1.1350.99
123_H127_E1.1330.99
76_R79_N1.1310.99
288_A311_I1.1290.99
364_V454_P1.1290.99
122_A167_G1.1270.99
227_G329_I1.1240.99
51_K54_Q1.1220.99
358_K450_A1.1220.99
237_E324_K1.1210.99
358_K452_S1.1180.99
220_M225_M1.1160.99
398_A402_Q1.1110.99
194_A315_D1.1110.99
122_A126_A1.1110.99
323_M339_I1.1080.99
211_E247_Q1.1050.99
218_S221_E1.1050.99
377_V436_E1.1030.99
365_L453_T1.1010.99
418_K422_K1.0990.99
354_I450_A1.0970.99
361_G453_T1.0890.99
331_S355_T1.0890.99
396_Q488_L1.0880.99
323_M348_L1.0880.99
262_G288_A1.0880.99
193_T324_K1.0870.99
274_T377_V1.0800.99
294_A485_L1.0780.99
376_V439_A1.0770.99
181_A293_G1.0770.99
366_V488_L1.0750.99
139_Y328_V1.0740.99
407_A414_T1.0740.99
134_Y186_N1.0730.99
210_F299_G1.0730.99
48_V56_S1.0620.99
209_D302_R1.0600.99
198_A214_I1.0580.99
136_V183_T1.0570.99
228_I241_M1.0570.99
257_G365_L1.0540.99
365_L450_A1.0530.99
246_Y302_R1.0490.98
173_A301_L1.0470.98
215_L243_V1.0470.98
181_A290_A1.0420.98
376_V462_G1.0410.98
32_D40_T1.0410.98
194_A232_N1.0390.98
224_G332_L1.0380.98
393_F488_L1.0350.98
219_E223_L1.0350.98
138_D187_M1.0340.98
213_E243_V1.0340.98
413_I444_T1.0330.98
376_V381_T1.0320.98
215_L219_E1.0280.98
229_L233_Q1.0260.98
196_D200_Y1.0250.98
290_A294_A1.0210.98
86_K127_E1.0190.98
178_T483_R1.0170.98
236_T320_G1.0120.98
89_F125_L1.0110.98
205_A210_F1.0090.98
223_L332_L1.0080.98
314_T349_V1.0040.98
232_N315_D1.0030.98
89_F128_S1.0030.98
198_A240_K1.0020.98
128_S132_A0.9990.98
187_M191_M0.9980.98
354_I365_L0.9980.98
184_L285_M0.9900.98
389_N447_G0.9890.98
204_L296_E0.9830.98
403_E491_R0.9820.98
197_L292_L0.9820.98
444_T447_G0.9800.98
440_I444_T0.9750.98
258_L489_A0.9750.98
357_A365_L0.9740.98
364_V393_F0.9730.97
234_G318_I0.9720.97
384_T408_I0.9710.97
217_K229_L0.9680.97
243_V308_L0.9680.97
89_F92_V0.9660.97
375_V463_T0.9610.97
418_K444_T0.9540.97
276_S435_R0.9530.97
50_A54_Q0.9450.97
245_K308_L0.9430.97
220_M332_L0.9410.97
243_V310_V0.9410.97
303_P490_E0.9350.97
86_K90_A0.9340.97
201_A242_I0.9330.97
417_D440_I0.9320.97
202_E206_A0.9310.97
198_A212_C0.9280.97
220_M229_L0.9250.97
185_V477_A0.9200.96
356_Y360_H0.9180.96
180_S204_L0.9170.96
290_A482_A0.9150.96
228_I232_N0.9150.96
103_E152_A0.9110.96
366_V489_A0.9050.96
47_D68_R0.9040.96
318_I322_A0.8980.96
85_A121_A0.8930.96
202_E212_C0.8920.96
89_F93_F0.8910.96
172_Q176_Q0.8900.96
221_E229_L0.8890.96
85_A125_L0.8870.96
283_S464_A0.8830.96
195_T199_S0.8800.95
197_L311_I0.8760.95
397_V408_I0.8730.95
421_V432_S0.8680.95
257_G360_H0.8680.95
244_L292_L0.8620.95
348_L431_N0.8620.95
368_V458_L0.8610.95
214_I242_I0.8600.95
358_K451_E0.8600.95
213_E219_E0.8580.95
438_H441_M0.8570.95
40_T44_K0.8520.95
220_M240_K0.8500.95
401_A484_T0.8490.95
386_A398_A0.8480.94
366_V485_L0.8460.94
243_V360_H0.8460.94
407_A416_K0.8460.94
479_G482_A0.8420.94
48_V73_G0.8410.94
196_D237_E0.8400.94
418_K447_G0.8360.94
131_L175_G0.8330.94
429_L449_F0.8280.94
215_L356_Y0.8250.94
331_S445_F0.8250.94
126_A171_G0.8250.94
341_N438_H0.8240.94
399_D403_E0.8240.94
420_R433_P0.8230.94
203_E207_K0.8230.94
258_L307_V0.8230.94
337_I429_L0.8200.93
191_M196_D0.8200.93
374_G377_V0.8190.93
124_A127_E0.8180.93
94_Q132_A0.8160.93
234_G319_S0.8160.93
254_D361_G0.8150.93
136_V187_M0.8140.93
422_K448_E0.8110.93
389_N450_A0.8110.93
481_M484_T0.8090.93
397_V484_T0.8090.93
92_V125_L0.8080.93
399_D491_R0.8070.93
127_E483_R0.8070.93
187_M192_L0.8060.93
83_E87_E0.8050.93
130_L172_Q0.8040.93
218_S222_E0.8020.93
274_T277_G0.8020.93
241_M310_V0.8000.93
295_M299_G0.7980.92
308_L360_H0.7970.92
310_V356_Y0.7960.92
198_A202_E0.7950.92
396_Q491_R0.7950.92
437_G440_I0.7940.92
259_V365_L0.7910.92
305_Q489_A0.7900.92
217_K314_T0.7900.92
271_S274_T0.7890.92
294_A489_A0.7880.92
211_E222_E0.7880.92
418_K429_L0.7880.92
286_G290_A0.7880.92
349_V353_G0.7870.92
88_R92_V0.7850.92
341_N432_S0.7840.92
74_L88_R0.7840.92
486_A490_E0.7830.92
310_V360_H0.7800.92
228_I349_V0.7710.91
192_L197_L0.7700.91
180_S296_E0.7700.91
271_S340_L0.7700.91
276_S279_V0.7700.91
283_S477_A0.7700.91
270_Y277_G0.7680.91
220_M314_T0.7670.91
317_M324_K0.7650.91
32_D35_L0.7640.91
294_A309_C0.7640.91
257_G308_L0.7600.91
282_K426_M0.7600.91
313_S349_V0.7580.90
270_Y279_V0.7570.90
227_G339_I0.7540.90
55_V70_Y0.7540.90
420_R441_M0.7540.90
250_K306_N0.7530.90
283_S286_G0.7520.90
400_A404_C0.7500.90
49_S54_Q0.7470.90
179_N183_T0.7410.89
248_G251_E0.7360.89
270_Y280_G0.7340.89
414_T417_D0.7320.89
131_L483_R0.7280.89
204_L210_F0.7270.89
241_M312_P0.7270.89
290_A368_V0.7250.88
415_E447_G0.7240.88
275_K278_I0.7230.88
126_A168_L0.7210.88
208_Y300_E0.7180.88
181_A289_A0.7170.88
377_V439_A0.7160.88
72_V92_V0.7150.88
404_C407_A0.7140.88
204_L292_L0.7120.87
406_E480_V0.7110.87
450_A453_T0.7110.87
173_A300_E0.7100.87
339_I432_S0.7090.87
299_G303_P0.7080.87
279_V326_D0.7040.87
421_V429_L0.7040.87
128_S131_L0.7030.87
303_P489_A0.7020.87
181_A482_A0.7020.87
388_T410_Q0.7010.87
442_A446_L0.7000.87
375_V378_A0.6960.86
387_M440_I0.6940.86
130_L179_N0.6930.86
420_R434_G0.6920.86
331_S335_K0.6910.86
263_I353_G0.6910.86
194_A314_T0.6900.86
280_G467_N0.6900.86
202_E214_I0.6890.86
444_T448_E0.6890.86
398_A401_A0.6890.86
55_V72_V0.6890.86
387_M413_I0.6870.86
469_A474_P0.6850.85
228_I239_P0.6840.85
315_D324_K0.6840.85
104_T153_V0.6840.85
43_L71_F0.6820.85
417_D444_T0.6820.85
331_S351_A0.6800.85
391_Q394_Y0.6800.85
386_A408_I0.6790.85
180_S200_Y0.6790.85
392_S396_Q0.6780.85
124_A128_S0.6770.85
288_A313_S0.6750.85
286_G464_A0.6740.84
83_E86_K0.6730.84
203_E206_A0.6730.84
197_L201_A0.6720.84
131_L182_R0.6710.84
413_I455_W0.6680.84
329_I337_I0.6650.84
95_A98_K0.6640.84
34_M37_G0.6640.84
92_V129_C0.6610.83
186_N477_A0.6610.83
411_L440_I0.6600.83
174_Y486_A0.6590.83
177_G180_S0.6570.83
480_V484_T0.6560.83
433_P441_M0.6560.83
274_T278_I0.6560.83
248_G304_E0.6540.83
271_S279_V0.6520.82
253_E306_N0.6510.82
187_M196_D0.6500.82
341_N374_G0.6490.82
294_A486_A0.6470.82
176_Q296_E0.6470.82
208_Y299_G0.6470.82
255_V362_A0.6440.82
53_N91_H0.6410.81
275_K279_V0.6400.81
339_I342_T0.6400.81
126_A175_G0.6390.81
102_Q151_E0.6390.81
374_G442_A0.6390.81
85_A89_F0.6390.81
105_A156_V0.6330.81
401_A404_C0.6330.81
177_G181_A0.6320.81
157_T164_V0.6290.80
241_M349_V0.6280.80
375_V387_M0.6270.80
206_A209_D0.6270.80
127_E171_G0.6260.80
56_S71_F0.6260.80
421_V424_S0.6260.80
397_V485_L0.6230.80
406_E484_T0.6220.79
170_V174_Y0.6210.79
413_I447_G0.6210.79
272_I318_I0.6190.79
286_G477_A0.6170.79
31_I35_L0.6170.79
256_V488_L0.6170.79
263_I267_T0.6160.79
275_K432_S0.6150.79
234_G322_A0.6150.79
47_D59_F0.6140.79
80_Y85_A0.6140.79
57_K68_R0.6120.78
182_R474_P0.6110.78
394_Y398_A0.6100.78
339_I431_N0.6100.78
206_A222_E0.6070.78
244_L311_I0.6060.78
138_D183_T0.6050.78
117_P120_D0.6050.78
74_L77_E0.6010.77
280_G283_S0.6000.77
415_E419_K0.6000.77
50_A75_G0.6000.77
38_H41_Q0.6000.77
356_Y359_Q0.5990.77
355_T358_K0.5990.77
332_L356_Y0.5960.77
87_E91_H0.5940.76
270_Y326_D0.5940.76
177_G296_E0.5930.76
180_S292_L0.5930.76
389_N455_W0.5930.76
230_A233_Q0.5920.76
466_A469_A0.5910.76
137_Q141_H0.5900.76
31_I36_E0.5890.76
212_C242_I0.5870.75
274_T435_R0.5870.75
344_A373_G0.5860.75
270_Y317_M0.5850.75
64_A69_I0.5830.75
93_F128_S0.5830.75
173_A297_T0.5820.75
409_W412_P0.5820.75
335_K451_E0.5820.75
39_L43_L0.5800.75
230_A348_L0.5790.74
214_I240_K0.5790.74
139_Y183_T0.5760.74
36_E40_T0.5750.74
220_M239_P0.5750.74
204_L208_Y0.5750.74
282_K338_E0.5740.74
267_T270_Y0.5740.74
388_T391_Q0.5730.74
422_K425_Q0.5730.74
188_P282_K0.5710.73
389_N410_Q0.5710.73
168_L171_G0.5710.73
178_T482_A0.5690.73
292_L313_S0.5690.73
183_T187_M0.5690.73
60_P63_S0.5680.73
338_E424_S0.5680.73
210_F244_L0.5680.73
458_L485_L0.5660.73
175_G179_N0.5660.73
87_E472_F0.5650.73
259_V450_A0.5650.73
408_I481_M0.5640.73
180_S293_G0.5640.73
228_I353_G0.5630.72
183_T200_Y0.5630.72
271_S326_D0.5630.72
357_A360_H0.5620.72
123_H174_Y0.5620.72
195_T238_P0.5620.72
299_G309_C0.5600.72
174_Y297_T0.5590.72
229_L232_N0.5590.72
241_M314_T0.5580.72
34_M64_A0.5580.72
219_E240_K0.5580.72
374_G439_A0.5570.72
420_R436_E0.5570.72
190_N270_Y0.5560.71
191_M328_V0.5560.71
328_V425_Q0.5550.71
251_E254_D0.5550.71
104_T150_I0.5540.71
137_Q140_K0.5540.71
210_F296_E0.5540.71
470_T473_G0.5530.71
106_V125_L0.5510.71
295_M307_V0.5510.71
401_A407_A0.5470.70
93_F133_S0.5460.70
220_M349_V0.5460.70
337_I445_F0.5450.70
404_C487_T0.5430.70
251_E306_N0.5420.70
222_E250_K0.5420.70
41_Q60_P0.5420.70
379_L411_L0.5410.69
383_T417_D0.5410.69
137_Q143_S0.5400.69
424_S429_L0.5400.69
187_M200_Y0.5400.69
91_H95_A0.5400.69
414_T444_T0.5380.69
249_K255_V0.5380.69
180_S477_A0.5380.69
408_I480_V0.5370.69
131_L178_T0.5360.69
401_A408_I0.5360.69
271_S318_I0.5360.69
421_V444_T0.5350.69
291_V485_L0.5330.68
236_T272_I0.5300.68
279_V432_S0.5300.68
174_Y178_T0.5300.68
417_D470_T0.5300.68
72_V91_H0.5290.68
35_L38_H0.5280.68
337_I351_A0.5280.68
433_P438_H0.5270.67
220_M232_N0.5270.67
141_H335_K0.5270.67
234_G321_G0.5250.67
170_V486_A0.5250.67
46_G56_S0.5250.67
234_G317_M0.5240.67
417_D441_M0.5240.67
358_K365_L0.5220.67
97_H100_R0.5220.67
221_E226_G0.5210.67
226_G230_A0.5210.67
257_G453_T0.5200.66
79_N84_Q0.5190.66
122_A164_V0.5180.66
392_S395_Q0.5170.66
205_A208_Y0.5160.66
271_S325_P0.5160.66
369_A455_W0.5150.66
237_E314_T0.5130.65
404_C484_T0.5120.65
226_G339_I0.5120.65
201_A311_I0.5120.65
341_N348_L0.5120.65
271_S431_N0.5110.65
308_L357_A0.5100.65
395_Q410_Q0.5090.65
434_G441_M0.5090.65
294_A297_T0.5080.65
290_A479_G0.5080.65
177_G300_E0.5080.65
265_F275_K0.5080.65
355_T451_E0.5060.64
254_D364_V0.5050.64
249_K253_E0.5050.64
212_C309_C0.5050.64
382_E414_T0.5040.64
88_R91_H0.5040.64
82_F124_A0.5040.64
460_I464_A0.5020.64
288_A312_P0.5020.64
280_G465_T0.5010.64
90_A96_I0.5010.64
265_F409_W0.5000.63
52_P84_Q0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gytA 6 0.988 100 0.074 Contact Map
3h8gF 5 0.98 100 0.078 Contact Map
3jruB 5 0.966 100 0.084 Contact Map
3peiA 5 0.902 100 0.092 Contact Map
3kzwA 6 0.974 100 0.106 Contact Map
1lamA 5 0.928 100 0.11 Contact Map
4ksiA 5 0.958 100 0.113 Contact Map
3kr4A 5 0.96 100 0.132 Contact Map
3ij3A 5 0.898 100 0.164 Contact Map
4efdA 5 0.93 100 0.223 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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