GREMLIN Database
YUIF - Putative amino acid transporter YuiF
UniProt: O32105 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 442 (432)
Sequences: 518 (324)
Seq/√Len: 15.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
417_W421_V8.1291.00
141_E217_Q6.2111.00
369_C379_T5.3591.00
108_I130_I5.1381.00
157_A198_V4.6331.00
337_A374_F4.4001.00
134_L409_A4.3471.00
429_I433_I4.3051.00
74_T273_L3.5150.99
297_F301_V3.4040.99
250_Q256_T3.3310.99
337_A439_A3.2770.99
152_T399_S3.2700.99
7_A308_F3.1710.99
433_I437_I3.0740.98
338_L432_V3.0020.98
183_L379_T2.8560.97
3_A317_D2.8460.97
194_L384_G2.8250.97
110_I114_F2.8170.97
109_L150_V2.7930.97
341_L389_L2.7880.97
16_L421_V2.6240.96
7_A32_G2.6230.96
207_L211_V2.5350.95
109_L146_L2.4050.93
10_L28_G2.4050.93
39_G43_T2.4040.93
105_V147_I2.3630.92
66_A270_L2.2920.91
161_L198_V2.2570.90
347_I361_I2.1810.89
425_I429_I2.1740.89
39_G42_E2.1730.89
385_A435_G2.1650.88
334_S436_W2.1580.88
7_A28_G2.0970.87
74_T309_S2.0780.86
197_P385_A2.0640.86
36_G39_G2.0410.85
105_V150_V2.0080.84
138_N412_Q1.9950.84
10_L31_A1.9760.83
242_A246_S1.9200.81
193_A377_M1.9140.81
206_I210_I1.8800.80
318_V363_T1.8680.80
183_L370_M1.8570.79
111_V158_P1.8480.79
157_A160_I1.8440.79
161_L195_I1.8420.79
381_A438_A1.7930.77
222_D225_G1.7850.76
369_C382_I1.7810.76
66_A288_I1.7800.76
175_K190_I1.7780.76
111_V129_L1.7750.76
358_I387_A1.7750.76
336_G372_L1.7570.75
108_I129_L1.7540.75
138_N220_T1.7520.75
116_Q166_F1.7520.75
329_I336_G1.6980.73
171_Q190_I1.6890.72
62_A299_G1.6860.72
200_G434_F1.6700.71
47_F304_V1.6690.71
242_A256_T1.6670.71
252_Y265_G1.6650.71
414_H417_W1.6630.71
270_L288_I1.6610.71
42_E45_K1.6500.70
55_A75_G1.6420.70
362_T382_I1.6210.69
117_N166_F1.6000.68
158_P419_T1.5850.67
178_M181_A1.5820.67
389_L427_Y1.5790.67
137_F142_M1.5620.66
112_S154_G1.5430.65
28_G308_F1.5360.65
265_G394_S1.5340.64
190_I264_M1.4960.62
268_A347_I1.4930.62
157_A161_L1.4910.62
197_P200_G1.4850.62
329_I339_L1.4730.61
170_F387_A1.4670.61
71_L252_Y1.4650.61
334_S440_L1.4590.60
142_M150_V1.4590.60
114_F118_V1.4480.60
160_I198_V1.4450.60
197_P384_G1.4430.60
160_I356_A1.4340.59
265_G372_L1.4270.59
206_I211_V1.4110.58
246_S250_Q1.4110.58
38_L193_A1.3990.57
246_S249_V1.3960.57
199_A275_V1.3890.57
133_L137_F1.3850.56
178_M383_I1.3680.55
44_V264_M1.3630.55
377_M381_A1.3610.55
112_S155_L1.3590.55
146_L150_V1.3520.54
6_I35_T1.3350.53
181_A362_T1.3290.53
22_V62_A1.3280.53
106_L210_I1.3250.53
71_L273_L1.3170.52
54_N303_L1.3050.52
47_F308_F1.2940.51
197_P381_A1.2930.51
353_S356_A1.2930.51
176_D180_D1.2920.51
299_G304_V1.2920.51
242_A248_G1.2900.51
289_T292_M1.2880.51
325_S339_L1.2790.50
152_T435_G1.2740.50
358_I361_I1.2720.50
16_L417_W1.2650.49
60_S387_A1.2610.49
203_V207_L1.2580.49
81_V420_C1.2540.49
168_Q356_A1.2430.48
241_L246_S1.2420.48
54_N76_L1.2400.48
20_N189_D1.2360.48
242_A250_Q1.2330.48
63_M266_A1.2240.47
19_V281_R1.2220.47
57_V317_D1.2170.47
156_T198_V1.2050.46
47_F62_A1.1990.46
62_A353_S1.1960.46
183_L366_V1.1860.45
181_A313_T1.1760.44
109_L427_Y1.1730.44
57_V303_L1.1730.44
194_L197_P1.1720.44
31_A35_T1.1710.44
31_A343_V1.1700.44
374_F439_A1.1670.44
203_V266_A1.1630.44
28_G281_R1.1550.43
246_S253_L1.1540.43
210_I426_F1.1530.43
171_Q175_K1.1480.43
24_A112_S1.1440.43
239_A242_A1.1410.42
331_H372_L1.1400.42
437_I440_L1.1370.42
200_G381_A1.1340.42
28_G31_A1.1300.42
178_M292_M1.1230.41
263_I365_F1.1180.41
106_L206_I1.1160.41
9_L13_V1.1090.41
30_L268_A1.1070.41
83_A86_K1.1070.41
183_L387_A1.1030.40
240_V246_S1.1030.40
381_A385_A1.0980.40
207_L426_F1.0970.40
277_G280_K1.0900.40
429_I437_I1.0890.40
310_N314_K1.0880.40
301_V420_C1.0830.39
431_L435_G1.0820.39
103_L209_V1.0800.39
24_A222_D1.0710.39
106_L380_I1.0700.39
133_L164_V1.0680.38
147_I365_F1.0610.38
74_T278_V1.0500.37
385_A399_S1.0500.37
133_L136_I1.0500.37
106_L110_I1.0420.37
32_G312_L1.0420.37
256_T261_G1.0370.37
427_Y434_F1.0360.37
4_V142_M1.0310.36
197_P426_F1.0310.36
22_V340_M1.0290.36
49_D358_I1.0240.36
219_E222_D1.0200.36
20_N168_Q1.0130.35
336_G368_L1.0110.35
62_A356_A1.0060.35
221_K225_G1.0030.35
73_K281_R1.0020.35
170_F199_A1.0000.35
437_I441_V0.9980.35
234_K246_S0.9970.35
299_G356_A0.9850.34
85_V365_F0.9810.34
3_A57_V0.9770.34
54_N306_A0.9730.33
130_I137_F0.9700.33
50_G300_F0.9700.33
245_V248_G0.9660.33
31_A279_M0.9650.33
262_M285_D0.9650.33
133_L312_L0.9610.33
330_G346_L0.9600.33
304_V383_I0.9580.33
70_A436_W0.9560.33
172_G175_K0.9560.33
54_N74_T0.9560.33
208_S426_F0.9560.33
47_F299_G0.9560.33
214_K429_I0.9540.32
119_V250_Q0.9520.32
392_A423_T0.9480.32
9_L272_V0.9400.32
84_S88_I0.9390.32
271_I281_R0.9390.32
176_D301_V0.9370.32
360_V387_A0.9370.32
158_P365_F0.9350.32
280_K283_E0.9330.31
292_M296_A0.9270.31
197_P438_A0.9260.31
290_D293_V0.9220.31
105_V142_M0.9210.31
20_N178_M0.9140.30
50_G302_M0.9110.30
24_A416_I0.9090.30
247_L250_Q0.9090.30
377_M380_I0.9040.30
296_A308_F0.9010.30
58_A64_L0.8990.30
261_G332_S0.8990.30
200_G428_N0.8980.30
5_V9_L0.8980.30
381_A442_L0.8980.30
186_P189_D0.8960.30
220_T225_G0.8950.30
105_V190_I0.8940.30
385_A426_F0.8940.30
168_Q178_M0.8930.29
18_R47_F0.8910.29
325_S387_A0.8910.29
323_K327_G0.8900.29
385_A389_L0.8900.29
152_T423_T0.8880.29
57_V299_G0.8860.29
162_L199_A0.8850.29
108_I363_T0.8810.29
298_I405_S0.8800.29
72_T128_V0.8800.29
39_G382_I0.8750.29
26_I57_V0.8710.28
5_V40_L0.8710.28
356_A420_C0.8710.28
399_S435_G0.8650.28
203_V324_T0.8640.28
338_L436_W0.8590.28
6_I141_E0.8590.28
299_G353_S0.8580.28
399_S403_P0.8550.28
50_G310_N0.8510.28
290_D364_I0.8500.27
133_L394_S0.8470.27
5_V31_A0.8440.27
326_A371_Q0.8440.27
48_T51_L0.8430.27
55_A366_V0.8360.27
439_A442_L0.8340.27
71_L262_M0.8320.27
232_T347_I0.8310.27
140_L405_S0.8300.27
36_G221_K0.8300.27
294_L360_V0.8300.27
206_I209_V0.8290.27
13_V17_L0.8280.26
187_L190_I0.8250.26
25_L44_V0.8250.26
318_V323_K0.8210.26
339_L342_I0.8200.26
54_N420_C0.8200.26
114_F119_V0.8190.26
203_V331_H0.8180.26
214_K222_D0.8170.26
21_I360_V0.8170.26
243_I250_Q0.8100.26
84_S137_F0.8100.26
5_V275_V0.8090.26
398_D403_P0.8090.26
319_E323_K0.8070.26
5_V346_L0.8050.25
206_I426_F0.8030.25
38_L315_T0.8020.25
175_K187_L0.8020.25
252_Y256_T0.8010.25
257_L265_G0.8000.25
309_S313_T0.7980.25
255_Q259_V0.7980.25
53_G306_A0.7970.25
170_F431_L0.7960.25
236_I242_A0.7960.25
238_I243_I0.7940.25
346_L405_S0.7940.25
328_F331_H0.7940.25
183_L369_C0.7920.25
279_M364_I0.7890.25
59_V385_A0.7880.25
71_L253_L0.7840.25
91_K109_L0.7840.25
24_A318_V0.7840.25
231_Y250_Q0.7840.25
23_I176_D0.7830.25
251_L332_S0.7820.24
257_L261_G0.7800.24
53_G347_I0.7790.24
326_A364_I0.7790.24
38_L42_E0.7780.24
262_M299_G0.7770.24
149_C166_F0.7750.24
36_G425_I0.7750.24
387_A432_V0.7750.24
147_I181_A0.7740.24
278_V318_V0.7720.24
80_M279_M0.7690.24
147_I151_I0.7680.24
30_L39_G0.7680.24
8_V279_M0.7680.24
118_V271_I0.7650.24
257_L318_V0.7650.24
112_S151_I0.7650.24
136_I287_L0.7640.24
146_L198_V0.7620.24
130_I298_I0.7620.24
213_R425_I0.7610.24
66_A190_I0.7610.24
18_R283_E0.7580.23
3_A296_A0.7560.23
40_L247_L0.7510.23
185_V380_I0.7480.23
196_I441_V0.7470.23
346_L360_V0.7460.23
51_L62_A0.7440.23
27_I31_A0.7420.23
140_L250_Q0.7410.23
172_G187_L0.7410.23
199_A202_V0.7400.23
189_D380_I0.7400.23
308_F332_S0.7380.23
251_L255_Q0.7380.23
147_I248_G0.7370.23
190_I342_I0.7360.23
89_G264_M0.7360.23
62_A296_A0.7350.23
176_D425_I0.7340.23
45_K119_V0.7340.23
44_V71_L0.7330.22
21_I316_G0.7320.22
114_F245_V0.7320.22
153_F357_T0.7310.22
332_S360_V0.7270.22
279_M310_N0.7260.22
23_I44_V0.7260.22
76_L177_N0.7250.22
341_L436_W0.7250.22
202_V281_R0.7240.22
166_F341_L0.7240.22
318_V421_V0.7240.22
28_G288_I0.7230.22
353_S383_I0.7210.22
301_V365_F0.7200.22
174_L420_C0.7190.22
118_V121_V0.7160.22
55_A197_P0.7150.22
201_M300_F0.7130.22
303_L420_C0.7130.22
57_V262_M0.7090.22
242_A247_L0.7080.21
366_V379_T0.7080.21
56_T118_V0.7080.21
138_N218_Y0.7070.21
121_V293_V0.7070.21
170_F189_D0.7070.21
320_S369_C0.7060.21
400_T403_P0.7050.21
48_T263_I0.7030.21
241_L255_Q0.7010.21
72_T266_A0.7010.21
306_A329_I0.7000.21
268_A272_V0.6980.21
13_V333_Q0.6970.21
27_I199_A0.6970.21
74_T297_F0.6960.21
140_L325_S0.6930.21
105_V209_V0.6920.21
109_L151_I0.6920.21
56_T119_V0.6910.21
62_A304_V0.6900.21
24_A240_V0.6880.21
160_I420_C0.6860.21
156_T299_G0.6860.21
365_F387_A0.6840.21
171_Q420_C0.6820.20
6_I40_L0.6810.20
179_A184_N0.6810.20
200_G385_A0.6750.20
32_G376_P0.6740.20
54_N288_I0.6730.20
218_Y412_Q0.6710.20
160_I194_L0.6700.20
73_K283_E0.6700.20
193_A381_A0.6700.20
121_V310_N0.6680.20
158_P427_Y0.6660.20
381_A439_A0.6650.20
3_A28_G0.6650.20
179_A414_H0.6620.20
13_V227_E0.6580.20
364_I401_L0.6570.20
71_L278_V0.6570.20
384_G399_S0.6560.20
5_V112_S0.6560.20
203_V433_I0.6550.20
306_A358_I0.6520.19
164_V265_G0.6520.19
71_L128_V0.6500.19
332_S335_L0.6500.19
341_L423_T0.6490.19
149_C253_L0.6480.19
102_V288_I0.6470.19
137_F150_V0.6460.19
5_V360_V0.6460.19
15_S366_V0.6450.19
69_A408_S0.6450.19
150_V164_V0.6450.19
185_V270_L0.6420.19
306_A427_Y0.6420.19
336_G340_M0.6420.19
148_A419_T0.6410.19
28_G77_P0.6410.19
11_M32_G0.6400.19
15_S263_I0.6390.19
257_L343_V0.6390.19
4_V298_I0.6390.19
22_V25_L0.6380.19
51_L299_G0.6380.19
81_V365_F0.6380.19
336_G385_A0.6360.19
304_V356_A0.6360.19
36_G43_T0.6350.19
77_P287_L0.6320.19
181_A383_I0.6310.19
33_G43_T0.6310.19
56_T261_G0.6300.19
74_T83_A0.6280.19
226_A282_D0.6280.19
3_A7_A0.6270.19
49_D130_I0.6260.18
114_F150_V0.6250.18
146_L399_S0.6240.18
138_N219_E0.6230.18
381_A441_V0.6200.18
32_G317_D0.6170.18
272_V317_D0.6170.18
5_V137_F0.6170.18
25_L340_M0.6160.18
78_D82_E0.6160.18
286_S290_D0.6160.18
135_K139_E0.6160.18
41_G246_S0.6130.18
73_K263_I0.6130.18
178_M270_L0.6120.18
28_G284_A0.6120.18
222_D234_K0.6120.18
10_L23_I0.6100.18
28_G32_G0.6090.18
108_I180_D0.6080.18
87_L421_V0.6080.18
73_K107_I0.6070.18
276_S405_S0.6050.18
156_T201_M0.6050.18
15_S152_T0.6030.18
30_L66_A0.6030.18
10_L248_G0.6020.18
156_T356_A0.6000.18
5_V211_V0.6000.18
271_I405_S0.5980.18
137_F365_F0.5980.18
69_A297_F0.5980.18
38_L374_F0.5970.18
405_S414_H0.5960.17
23_I293_V0.5950.17
119_V199_A0.5940.17
12_L436_W0.5940.17
77_P318_V0.5930.17
117_N358_I0.5920.17
153_F205_L0.5900.17
74_T135_K0.5900.17
52_G75_G0.5900.17
128_V381_A0.5890.17
161_L193_A0.5890.17
7_A11_M0.5890.17
246_S252_Y0.5880.17
10_L281_R0.5880.17
296_A299_G0.5870.17
57_V79_A0.5870.17
364_I368_L0.5870.17
188_A191_P0.5870.17
24_A151_I0.5860.17
137_F249_V0.5860.17
191_P253_L0.5860.17
304_V309_S0.5820.17
212_Y426_F0.5790.17
60_S63_M0.5790.17
253_L256_T0.5790.17
18_R22_V0.5780.17
262_M274_F0.5750.17
46_A54_N0.5750.17
239_A250_Q0.5740.17
139_E365_F0.5740.17
157_A202_V0.5740.17
87_L365_F0.5730.17
63_M303_L0.5720.17
149_C270_L0.5720.17
370_M405_S0.5720.17
315_T426_F0.5710.17
292_M405_S0.5710.17
333_Q440_L0.5700.17
74_T289_T0.5700.17
18_R414_H0.5690.17
205_L357_T0.5690.17
203_V227_E0.5680.17
168_Q172_G0.5670.17
239_A246_S0.5670.17
50_G201_M0.5670.17
195_I377_M0.5670.17
152_T384_G0.5660.17
74_T175_K0.5660.17
178_M377_M0.5650.16
118_V331_H0.5650.16
273_L276_S0.5650.16
6_I223_I0.5620.16
128_V298_I0.5600.16
47_F109_L0.5590.16
173_M194_L0.5590.16
73_K286_S0.5590.16
319_E331_H0.5590.16
299_G303_L0.5540.16
185_V207_L0.5530.16
190_I314_K0.5530.16
379_T439_A0.5530.16
19_V312_L0.5530.16
274_F301_V0.5530.16
203_V247_L0.5520.16
193_A438_A0.5520.16
128_V292_M0.5520.16
45_K358_I0.5520.16
273_L297_F0.5510.16
230_P379_T0.5500.16
241_L250_Q0.5500.16
24_A405_S0.5490.16
254_S258_G0.5480.16
70_A149_C0.5480.16
381_A426_F0.5480.16
29_A174_L0.5480.16
323_K361_I0.5460.16
234_K242_A0.5450.16
149_C215_P0.5450.16
171_Q288_I0.5430.16
10_L35_T0.5430.16
48_T356_A0.5430.16
242_A252_Y0.5430.16
201_M369_C0.5420.16
246_S256_T0.5410.16
71_L162_L0.5410.16
318_V417_W0.5400.16
248_G278_V0.5390.16
32_G330_G0.5390.16
185_V347_I0.5390.16
108_I349_M0.5380.16
147_I185_V0.5380.16
5_V57_V0.5380.16
246_S251_L0.5380.16
211_V327_G0.5370.16
89_G439_A0.5360.16
19_V284_A0.5360.16
67_F364_I0.5360.16
160_I201_M0.5340.16
53_G343_V0.5340.16
20_N349_M0.5340.16
18_R125_F0.5340.16
314_K414_H0.5340.16
156_T160_I0.5330.15
207_L338_L0.5330.15
265_G383_I0.5320.15
198_V288_I0.5290.15
43_T46_A0.5280.15
109_L113_C0.5280.15
238_I242_A0.5280.15
20_N387_A0.5270.15
136_I365_F0.5270.15
112_S347_I0.5260.15
90_N365_F0.5240.15
168_Q181_A0.5240.15
149_C333_Q0.5230.15
220_T318_V0.5230.15
177_N252_Y0.5230.15
234_K239_A0.5220.15
62_A303_L0.5220.15
11_M364_I0.5220.15
209_V426_F0.5220.15
141_E275_V0.5200.15
339_L362_T0.5200.15
137_F297_F0.5190.15
119_V188_A0.5180.15
54_N85_V0.5180.15
188_A380_I0.5170.15
320_S417_W0.5170.15
250_Q254_S0.5160.15
420_C436_W0.5160.15
209_V229_S0.5150.15
338_L342_I0.5150.15
214_K333_Q0.5140.15
341_L432_V0.5140.15
282_D320_S0.5140.15
365_F420_C0.5130.15
119_V362_T0.5130.15
252_Y306_A0.5120.15
105_V280_K0.5110.15
38_L361_I0.5110.15
47_F309_S0.5100.15
141_E211_V0.5090.15
240_V409_A0.5090.15
270_L301_V0.5070.15
239_A247_L0.5060.15
71_L256_T0.5050.15
18_R353_S0.5040.15
137_F149_C0.5040.15
26_I285_D0.5030.15
19_V51_L0.5030.15
24_A180_D0.5030.15
147_I164_V0.5030.15
270_L274_F0.5020.15
71_L264_M0.5020.15
176_D420_C0.5010.15
134_L245_V0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r1iA 2 0.9253 99.9 0.887 Contact Map
4f35D 2 0.8733 99.9 0.897 Contact Map
4r0cA 3 0.9231 99.8 0.901 Contact Map
3giaA 1 0.4321 29.2 0.985 Contact Map
2kncA 1 0.1018 29.1 0.985 Contact Map
1ldfA 3 0.414 27.6 0.985 Contact Map
4us3A 1 0.4367 23.4 0.985 Contact Map
2cfqA 1 0.4186 23.2 0.985 Contact Map
3zuxA 1 0.4344 23.1 0.985 Contact Map
2kluA 1 0.1448 21.8 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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