GREMLIN Database
BIOYB - Putative biotin transporter BioYB
UniProt: O32104 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 200 (173)
Sequences: 2699 (2132)
Seq/√Len: 162.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_M64_M4.0101.00
68_A96_I3.1361.00
24_G47_F3.0621.00
71_G78_F3.0171.00
57_S111_E2.8551.00
140_M160_F2.6741.00
56_G107_G2.6691.00
14_I59_R2.5551.00
10_D59_R2.4441.00
56_G60_A2.2761.00
53_L125_S2.2581.00
102_A132_M2.2471.00
141_Y148_I2.2441.00
105_A131_I2.2131.00
61_A100_I2.1841.00
109_F124_A2.0671.00
53_L179_A1.9841.00
22_A77_V1.9091.00
137_T161_M1.8631.00
17_F51_A1.8611.00
65_I100_I1.8351.00
70_V75_A1.7781.00
158_W162_I1.7771.00
93_G139_Y1.7751.00
82_S87_P1.7661.00
68_A100_I1.7651.00
157_A162_I1.7521.00
42_S45_P1.7431.00
61_A104_F1.7261.00
25_A67_Y1.7021.00
133_Y168_D1.6871.00
98_S135_I1.6641.00
44_Q99_Y1.6251.00
90_G93_G1.5791.00
18_A66_V1.5771.00
101_P135_I1.5381.00
60_A107_G1.4381.00
57_S104_F1.4211.00
133_Y161_M1.4141.00
165_M169_T1.4121.00
18_A70_V1.4121.00
98_S132_M1.4081.00
21_M51_A1.4011.00
26_N81_F1.3941.00
18_A63_A1.3911.00
135_I138_T1.3751.00
71_G77_V1.3671.00
118_K122_L1.3491.00
117_S120_R1.3461.00
8_A12_A1.3121.00
18_A22_A1.3091.00
31_A37_A1.3011.00
162_I166_V1.2861.00
137_T156_T1.2821.00
62_I65_I1.2771.00
31_A36_V1.2701.00
126_L172_A1.2591.00
129_T133_Y1.2141.00
140_M144_L1.2131.00
106_A128_G1.2111.00
139_Y143_A1.2111.00
72_L85_F1.1741.00
42_S99_Y1.1571.00
95_F160_F1.1401.00
53_L110_L1.1351.00
68_A88_F1.1251.00
169_T173_V1.1231.00
46_F175_L1.1031.00
140_M146_L1.0971.00
101_P131_I1.0790.99
72_L83_A1.0750.99
21_M48_C1.0680.99
64_M103_A1.0650.99
67_Y78_F1.0600.99
51_A55_L1.0570.99
163_W166_V1.0560.99
134_L138_T1.0550.99
6_L9_G1.0540.99
139_Y142_L1.0520.99
125_S176_S1.0330.99
52_A60_A1.0290.99
122_L176_S1.0280.99
106_A124_A1.0280.99
46_F174_I1.0220.99
55_L63_A1.0190.99
57_S107_G1.0160.99
41_L167_K1.0120.99
67_Y99_Y1.0110.99
20_L47_F0.9980.99
70_V77_V0.9980.99
58_K111_E0.9810.99
137_T157_A0.9750.99
95_F132_M0.9720.99
95_F140_M0.9700.99
93_G97_I0.9660.99
57_S108_W0.9660.99
30_V36_V0.9640.99
167_K171_L0.9630.99
104_F108_W0.9620.99
85_F89_A0.9610.99
29_S32_P0.9590.99
129_T172_A0.9540.99
56_G59_R0.9530.99
67_Y71_G0.9460.99
181_A184_R0.9460.99
95_F161_M0.9320.98
125_S172_A0.9280.98
17_F55_L0.9230.98
49_L106_A0.9230.98
59_R63_A0.9200.98
98_S102_A0.9180.98
43_M46_F0.9110.98
21_M47_F0.9100.98
72_L93_G0.9080.98
108_W112_R0.9080.98
51_A63_A0.8970.98
101_P105_A0.8950.98
13_L59_R0.8920.98
164_F171_L0.8880.98
45_P132_M0.8880.98
14_I62_I0.8870.98
51_A64_M0.8810.98
45_P129_T0.8770.98
138_T141_Y0.8580.97
181_A185_S0.8560.97
113_N120_R0.8540.97
88_F96_I0.8540.97
176_S180_P0.8520.97
95_F133_Y0.8490.97
49_L129_T0.8420.97
122_L173_V0.8350.97
8_A11_M0.8330.97
141_Y147_W0.8280.97
172_A176_S0.8260.97
98_S131_I0.8220.97
109_F127_I0.8170.96
159_G163_W0.8110.96
30_V37_A0.7930.96
11_M15_G0.7920.96
120_R123_I0.7850.96
61_A64_M0.7740.95
123_I127_I0.7660.95
48_C103_A0.7660.95
118_K176_S0.7640.95
49_L132_M0.7630.95
6_L10_D0.7610.95
10_D14_I0.7580.95
141_Y156_T0.7550.95
74_G84_G0.7520.94
45_P167_K0.7510.94
180_P183_Y0.7500.94
97_I135_I0.7480.94
135_I139_Y0.7460.94
80_Q90_G0.7420.94
121_F176_S0.7330.94
126_L169_T0.7320.94
103_A107_G0.7240.93
101_P104_F0.7240.93
129_T168_D0.7140.93
97_I139_Y0.7080.92
122_L172_A0.7080.92
97_I101_P0.7070.92
17_F63_A0.7050.92
161_M165_M0.7040.92
119_I123_I0.7040.92
21_M24_G0.6990.92
108_W111_E0.6970.92
54_L182_I0.6910.92
143_A147_W0.6810.91
84_G93_G0.6800.91
177_F181_A0.6780.91
88_F93_G0.6760.91
14_I18_A0.6720.90
61_A103_A0.6710.90
79_A82_S0.6700.90
39_I92_S0.6670.90
138_T142_L0.6560.89
61_A101_P0.6550.89
144_L148_I0.6540.89
131_I135_I0.6530.89
15_G19_A0.6480.89
89_A93_G0.6440.88
49_L102_A0.6390.88
110_L121_F0.6370.88
133_Y137_T0.6370.88
22_A70_V0.6350.88
114_I120_R0.6270.87
102_A131_I0.6260.87
92_S96_I0.6240.87
17_F54_L0.6240.87
121_F125_S0.6230.87
88_F97_I0.6210.87
173_V177_F0.6200.87
19_A70_V0.6180.86
105_A127_I0.6140.86
67_Y77_V0.6140.86
87_P90_G0.6130.86
145_K149_H0.6090.86
22_A75_A0.6070.85
52_A106_A0.6070.85
130_A134_L0.6060.85
22_A26_N0.6040.85
24_G27_I0.6030.85
40_P140_M0.6000.85
78_F88_F0.5980.85
6_L62_I0.5960.84
122_L126_L0.5930.84
45_P48_C0.5930.84
21_M63_A0.5900.84
15_G66_V0.5880.84
109_F120_R0.5870.83
137_T160_F0.5840.83
53_L176_S0.5840.83
40_P79_A0.5840.83
28_T87_P0.5820.83
166_V169_T0.5820.83
52_A61_A0.5800.83
72_L88_F0.5800.83
12_A16_M0.5770.82
99_Y103_A0.5750.82
39_I164_F0.5750.82
39_I140_M0.5750.82
48_C52_A0.5740.82
107_G110_L0.5670.81
20_L24_G0.5660.81
180_P184_R0.5650.81
46_F178_I0.5640.81
9_G13_L0.5620.81
22_A67_Y0.5560.80
41_L166_V0.5550.80
157_A161_M0.5530.80
109_F128_G0.5530.80
82_S85_F0.5500.79
112_R115_Q0.5480.79
106_A125_S0.5460.79
144_L160_F0.5420.78
178_I182_I0.5410.78
118_K177_F0.5380.78
121_F183_Y0.5350.77
19_A23_V0.5310.77
10_D13_L0.5310.77
29_S41_L0.5270.76
21_M67_Y0.5250.76
92_S163_W0.5250.76
172_A175_L0.5190.75
55_L59_R0.5180.75
45_P171_L0.5170.75
31_A38_G0.5170.75
72_L97_I0.5150.75
107_G111_E0.5140.75
146_L157_A0.5130.74
105_A109_F0.5130.74
110_L183_Y0.5120.74
121_F180_P0.5100.74
99_Y132_M0.5060.73
54_L179_A0.5060.73
100_I103_A0.5030.73
140_M157_A0.5010.73
156_T160_F0.5010.73
129_T169_T0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dveA 3 0.915 100 0.288 Contact Map
4z7fA 2 0.815 99.9 0.585 Contact Map
3p5nA 2 0.825 99.9 0.595 Contact Map
4huqS 1 0.8 99.9 0.605 Contact Map
4tkrA 2 0.86 99.8 0.631 Contact Map
4hzuS 1 0.8 99.8 0.633 Contact Map
3rlbA 1 0.86 99.8 0.635 Contact Map
4rfsS 1 0.85 99.7 0.67 Contact Map
4m5bA 1 0.835 93.8 0.896 Contact Map
1mhsA 2 0.895 7.6 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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