GREMLIN Database
YUIH - Uncharacterized oxidoreductase YuiH
UniProt: O32103 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 198 (176)
Sequences: 4196 (2410)
Seq/√Len: 181.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_R133_Y3.6951.00
57_S60_D3.2531.00
90_R93_D3.2471.00
51_D99_G3.1551.00
68_E87_Q3.1341.00
47_Y168_Q3.0431.00
47_Y166_G3.0241.00
51_D101_K2.9871.00
109_L167_I2.6601.00
64_F97_K2.5861.00
110_H166_G2.5801.00
87_Q134_A2.5281.00
43_N55_L2.4181.00
45_Q55_L2.3061.00
131_L148_L2.1771.00
96_E125_L2.1341.00
38_D41_K2.1001.00
95_A169_F2.0861.00
54_M98_A2.0501.00
68_E85_V2.0431.00
108_I170_T2.0381.00
93_D96_E2.0381.00
73_I157_F2.0251.00
85_V137_G1.9631.00
84_N135_H1.9271.00
49_L171_K1.9191.00
94_I131_L1.8591.00
70_K85_V1.8531.00
92_C96_E1.8261.00
107_V169_F1.8231.00
119_L152_F1.8101.00
132_A151_V1.7781.00
66_R87_Q1.7681.00
49_L101_K1.7161.00
67_Y90_R1.6441.00
50_V53_P1.5591.00
52_H99_G1.5581.00
110_H168_Q1.5521.00
62_K133_Y1.5431.00
104_A169_F1.5241.00
109_L164_L1.5231.00
112_E165_R1.5051.00
108_I168_Q1.5001.00
89_V94_I1.4911.00
103_E171_K1.4801.00
25_F84_N1.4571.00
72_D83_D1.4551.00
54_M97_K1.4531.00
45_Q166_G1.4411.00
91_A124_F1.4401.00
58_F62_K1.4401.00
131_L164_L1.4381.00
66_R134_A1.3871.00
40_T59_E1.3871.00
63_A97_K1.3811.00
109_L150_G1.3581.00
134_A139_P1.3501.00
56_L97_K1.3061.00
129_S152_F1.2901.00
107_V124_F1.2831.00
60_D63_A1.2821.00
49_L103_E1.2191.00
19_Q135_H1.1971.00
42_W58_F1.1721.00
175_P180_R1.1611.00
19_Q70_K1.1341.00
73_I160_S1.1331.00
91_A167_I1.1251.00
176_G179_E1.1211.00
61_V148_L1.1041.00
126_A129_S1.0981.00
65_P93_D1.0731.00
87_Q133_Y1.0611.00
69_S130_L1.0561.00
49_L104_A1.0471.00
111_A161_A1.0411.00
64_F89_V1.0411.00
44_L148_L1.0331.00
46_V50_V1.0321.00
22_T141_T1.0210.99
152_F160_S1.0140.99
123_D155_L1.0050.99
67_Y93_D0.9780.99
48_G53_P0.9680.99
92_C127_E0.9660.99
117_T158_W0.9610.99
105_G171_K0.9480.99
117_T161_A0.9470.99
121_L169_F0.9440.99
39_M58_F0.9400.99
175_P179_E0.9290.99
25_F135_H0.9260.99
100_V169_F0.9250.99
62_K134_A0.9250.99
73_I84_N0.9240.99
123_D154_H0.9230.99
85_V136_N0.9210.99
65_P90_R0.9150.99
42_W148_L0.9110.99
28_L79_W0.9060.99
29_H33_V0.9050.99
59_E62_K0.9030.99
117_T159_K0.8800.98
120_P123_D0.8640.98
135_H141_T0.8590.98
150_G161_A0.8590.98
50_V169_F0.8570.98
29_H163_W0.8550.98
95_A100_V0.8380.98
56_L98_A0.8320.98
89_V133_Y0.8310.98
135_H144_H0.8290.98
91_A150_G0.8250.98
22_T84_N0.8230.98
168_Q174_H0.8170.98
15_V19_Q0.8160.98
40_T58_F0.8120.97
123_D186_R0.8110.97
84_N136_N0.8070.97
64_F93_D0.8060.97
46_V54_M0.8040.97
67_Y130_L0.8030.97
47_Y53_P0.7970.97
151_V160_S0.7920.97
107_V167_I0.7860.97
45_Q53_P0.7840.97
15_V82_L0.7800.97
100_V121_L0.7780.97
76_V158_W0.7770.97
50_V98_A0.7700.96
25_F82_L0.7610.96
74_H81_R0.7490.96
59_E63_A0.7460.96
31_G34_P0.7440.96
133_Y148_L0.7430.96
27_V143_E0.7410.96
131_L150_G0.7410.96
56_L60_D0.7350.95
25_F163_W0.7350.95
108_I179_E0.7330.95
50_V104_A0.7310.95
141_T144_H0.7290.95
133_Y139_P0.7290.95
30_T33_V0.7260.95
178_W187_G0.7230.95
177_F181_N0.7210.95
89_V93_D0.7180.95
36_Y44_L0.7160.95
110_H116_T0.7150.95
150_G164_L0.7060.94
93_D97_K0.7020.94
89_V131_L0.7010.94
33_V143_E0.6990.94
117_T179_E0.6930.94
22_T138_E0.6920.94
90_R130_L0.6880.94
74_H117_T0.6870.93
66_R89_V0.6810.93
35_Y142_P0.6790.93
130_L151_V0.6730.93
124_F129_S0.6710.93
106_Y174_H0.6700.93
132_A150_G0.6690.93
95_A98_A0.6620.92
22_T135_H0.6600.92
78_G190_W0.6590.92
91_A95_A0.6580.92
108_I174_H0.6540.92
50_V54_M0.6530.92
27_V34_P0.6520.92
39_M146_F0.6500.91
95_A125_L0.6450.91
16_P19_Q0.6440.91
61_V89_V0.6410.91
46_V56_L0.6410.91
106_Y118_N0.6380.91
48_G104_A0.6360.91
44_L56_L0.6290.90
32_D35_Y0.6290.90
126_A154_H0.6260.90
97_K100_V0.6250.90
76_V156_Y0.6240.90
158_W179_E0.6190.89
54_M60_D0.6190.89
73_I151_V0.6190.89
77_T80_S0.6180.89
36_Y112_E0.6100.89
62_K139_P0.6080.89
51_D103_E0.6070.88
33_V36_Y0.6040.88
108_I116_T0.6020.88
115_W158_W0.5970.88
91_A129_S0.5960.88
84_N151_V0.5950.87
89_V148_L0.5910.87
47_Y110_H0.5910.87
18_N70_K0.5890.87
170_T174_H0.5880.87
81_R84_N0.5880.87
16_P138_E0.5880.87
49_L53_P0.5840.86
15_V18_N0.5810.86
123_D126_A0.5780.86
77_T158_W0.5750.86
87_Q90_R0.5740.86
132_A148_L0.5720.85
156_Y159_K0.5710.85
94_I148_L0.5710.85
77_T155_L0.5700.85
43_N57_S0.5700.85
150_G167_I0.5680.85
91_A94_I0.5660.85
108_I175_P0.5650.85
28_L77_T0.5630.84
123_D129_S0.5620.84
74_H77_T0.5610.84
25_F86_W0.5580.84
173_N179_E0.5550.84
46_V100_V0.5530.83
91_A169_F0.5520.83
155_L159_K0.5460.83
128_T154_H0.5440.82
54_M99_G0.5430.82
26_P81_R0.5420.82
70_K82_L0.5410.82
61_V133_Y0.5400.82
132_A140_L0.5400.82
176_G180_R0.5390.82
177_F182_G0.5380.82
106_Y173_N0.5360.81
109_L115_W0.5360.81
73_I76_V0.5350.81
52_H172_E0.5340.81
178_W182_G0.5330.81
105_G121_L0.5320.81
116_T180_R0.5320.81
49_L170_T0.5280.81
119_L150_G0.5270.80
119_L159_K0.5260.80
172_E175_P0.5250.80
53_P56_L0.5240.80
164_L167_I0.5240.80
76_V159_K0.5240.80
181_N184_H0.5220.80
179_E182_G0.5210.80
159_K178_W0.5200.80
127_E130_L0.5200.80
78_G82_L0.5200.80
47_Y50_V0.5180.79
108_I118_N0.5170.79
99_G169_F0.5170.79
71_N151_V0.5140.79
36_Y42_W0.5140.79
44_L131_L0.5110.78
44_L58_F0.5090.78
100_V125_L0.5090.78
28_L80_S0.5070.78
21_V24_S0.5060.78
86_W152_F0.5050.78
56_L64_F0.5030.77
82_L157_F0.5030.77
91_A152_F0.5020.77
44_L166_G0.5010.77
98_A169_F0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ogpA 4 0.9949 100 0.159 Contact Map
1soxA 2 0.9949 100 0.164 Contact Map
2a9dA 2 0.9949 100 0.164 Contact Map
2blfA 1 0.9899 100 0.198 Contact Map
2xtsA 2 0.9848 100 0.201 Contact Map
2bihA 2 0.9949 100 0.202 Contact Map
2biiA 2 0.9798 100 0.203 Contact Map
4pw3A 2 0.9798 100 0.213 Contact Map
1xdyA 3 0.9697 100 0.23 Contact Map
2nptA 1 0.4646 23.3 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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