GREMLIN Database
BESA - Ferri-bacillibactin esterase BesA
UniProt: O32102 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 289 (236)
Sequences: 7716 (5765)
Seq/√Len: 375.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_L183_Y3.6151.00
147_E157_Q3.5031.00
28_S35_T3.4191.00
136_R140_E2.7761.00
145_E149_D2.7501.00
147_E152_I2.6931.00
240_Y244_A2.6221.00
185_A188_P2.5041.00
55_I86_A2.4631.00
256_C273_R2.4441.00
45_T85_P2.3851.00
223_E259_S2.3201.00
201_T204_F2.3171.00
26_M35_T2.3011.00
186_G274_A2.2641.00
87_V152_I2.2481.00
135_F172_V2.2201.00
46_P151_Q2.1921.00
233_N237_R2.1731.00
135_F176_K2.0971.00
153_D156_R2.0921.00
143_K157_Q2.0651.00
54_V89_V2.0581.00
240_Y253_A1.9921.00
52_Y87_V1.9771.00
55_I160_F1.9651.00
237_R257_E1.9551.00
220_A270_L1.9461.00
242_R249_Q1.9301.00
28_S33_N1.9281.00
40_I89_V1.9221.00
89_V146_I1.9181.00
56_Y157_Q1.8841.00
184_I274_A1.8241.00
24_V37_H1.8141.00
158_T182_T1.7981.00
57_L160_F1.7831.00
56_Y143_K1.7441.00
46_P52_Y1.7151.00
26_M37_H1.6641.00
139_E176_K1.6181.00
27_M137_F1.6121.00
146_I152_I1.5861.00
137_F142_L1.5851.00
50_A85_P1.5751.00
197_I200_K1.5721.00
42_K87_V1.5561.00
135_F175_T1.5081.00
25_R38_I1.5041.00
74_Q88_I1.4911.00
82_G276_R1.4681.00
56_Y147_E1.4661.00
143_K179_A1.4581.00
241_E245_V1.4351.00
101_S109_M1.4321.00
238_E241_E1.4281.00
201_T205_V1.4181.00
109_M136_R1.3861.00
193_N196_F1.3741.00
38_I142_L1.3531.00
159_I169_V1.3491.00
69_E72_R1.3421.00
126_P129_G1.3331.00
182_T216_N1.3321.00
171_Q175_T1.3261.00
202_D205_V1.3241.00
223_E257_E1.3241.00
31_N141_D1.3021.00
58_L134_F1.3011.00
183_Y217_I1.2801.00
194_K197_I1.2801.00
84_I275_L1.2721.00
23_E150_Y1.2701.00
240_Y255_F1.2601.00
241_E244_A1.2531.00
29_S141_D1.2421.00
188_P236_A1.2201.00
237_R241_E1.2191.00
170_L190_I1.2011.00
45_T52_Y1.1991.00
191_H238_E1.1991.00
23_E42_K1.1921.00
218_L256_C1.1901.00
24_V39_F1.1861.00
272_S276_R1.1851.00
56_Y89_V1.1801.00
236_A255_F1.1711.00
170_L185_A1.1681.00
196_F200_K1.1661.00
54_V152_I1.1581.00
87_V150_Y1.1561.00
58_L168_F1.1541.00
157_Q179_A1.1501.00
139_E179_A1.1421.00
25_R149_D1.1341.00
160_F184_I1.1331.00
242_R245_V1.1311.00
42_K46_P1.1241.00
31_N140_E1.1231.00
25_R145_E1.1221.00
169_V183_Y1.1141.00
38_I145_E1.1091.00
143_K147_E1.1011.00
41_S75_G1.0981.00
102_A109_M1.0981.00
162_H268_P1.0821.00
55_I88_I1.0721.00
38_I137_F1.0711.00
51_G151_Q1.0461.00
140_E144_P1.0441.00
56_Y146_I1.0411.00
240_Y257_E1.0401.00
140_E176_K1.0321.00
145_E148_R1.0311.00
216_N252_R1.0221.00
187_S268_P1.0121.00
166_G185_A1.0101.00
52_Y151_Q1.0061.00
184_I278_A0.9991.00
200_K204_F0.9981.00
223_E258_F0.9961.00
57_L68_T0.9911.00
160_F186_G0.9911.00
31_N136_R0.9901.00
243_L253_A0.9901.00
139_E172_V0.9871.00
53_P86_A0.9851.00
135_F139_E0.9851.00
216_N277_F0.9821.00
258_F270_L0.9731.00
219_L236_A0.9691.00
103_R109_M0.9671.00
76_R80_K0.9651.00
167_L171_Q0.9521.00
58_L159_I0.9451.00
254_E277_F0.9431.00
86_A279_L0.9391.00
234_D238_E0.9281.00
139_E180_F0.9271.00
39_F92_G0.9271.00
29_S32_E0.9231.00
91_I138_I0.9201.00
69_E73_I0.9191.00
158_T279_L0.9141.00
195_P200_K0.9041.00
37_H65_G0.9001.00
107_F199_K0.8981.00
57_L271_V0.8981.00
196_F199_K0.8931.00
258_F273_R0.8911.00
37_H92_G0.8901.00
83_V86_A0.8901.00
54_V87_V0.8881.00
200_K203_H0.8871.00
194_K198_L0.8871.00
47_P50_A0.8861.00
32_E36_Y0.8831.00
156_R181_Q0.8831.00
30_R141_D0.8821.00
169_V185_A0.8751.00
68_T74_Q0.8741.00
221_A232_M0.8731.00
198_L202_D0.8731.00
76_R272_S0.8731.00
20_P41_S0.8621.00
235_N238_E0.8621.00
48_P52_Y0.8601.00
54_V157_Q0.8571.00
137_F141_D0.8541.00
36_Y137_F0.8501.00
185_A219_L0.8491.00
199_K202_D0.8481.00
106_D109_M0.8441.00
273_R276_R0.8381.00
170_L217_I0.8361.00
57_L90_G0.8331.00
193_N200_K0.8301.00
48_P51_G0.8251.00
162_H265_S0.8241.00
105_R108_T0.8241.00
176_K179_A0.8231.00
144_P180_F0.8141.00
186_G268_P0.8101.00
138_I172_V0.8101.00
58_L91_I0.8101.00
143_K180_F0.8071.00
187_S225_E0.8071.00
42_K52_Y0.8041.00
190_I239_L0.8031.00
239_L243_L0.8001.00
163_S263_H0.7991.00
193_N197_I0.7971.00
244_A253_A0.7941.00
52_Y85_P0.7931.00
219_L239_L0.7931.00
70_A74_Q0.7871.00
159_I183_Y0.7841.00
182_T278_A0.7781.00
56_Y180_F0.7761.00
143_K146_I0.7751.00
131_A168_F0.7731.00
84_I276_R0.7731.00
222_G225_E0.7731.00
219_L240_Y0.7701.00
192_W198_L0.7661.00
224_L260_G0.7651.00
46_P87_V0.7631.00
104_H164_L0.7581.00
107_F168_F0.7571.00
192_W195_P0.7551.00
102_A105_R0.7411.00
105_R109_M0.7391.00
261_E267_L0.7381.00
40_I150_Y0.7311.00
139_E143_K0.7291.00
185_A217_I0.7281.00
195_P199_K0.7281.00
222_G260_G0.7271.00
159_I172_V0.7251.00
223_E260_G0.7181.00
195_P198_L0.7171.00
258_F261_E0.7171.00
258_F267_L0.7151.00
109_M133_G0.7091.00
86_A275_L0.7081.00
140_E179_A0.7070.99
103_R106_D0.7070.99
30_R33_N0.7060.99
108_T111_T0.7050.99
154_K157_Q0.6980.99
232_M235_N0.6960.99
64_F90_G0.6920.99
139_E144_P0.6920.99
147_E154_K0.6890.99
54_V146_I0.6870.99
221_A236_A0.6850.99
157_Q181_Q0.6830.99
210_K213_Q0.6790.99
271_V275_L0.6750.99
173_L215_I0.6740.99
193_N199_K0.6720.99
70_A73_I0.6710.99
220_A258_F0.6710.99
135_F171_Q0.6690.99
66_T70_A0.6680.99
103_R107_F0.6660.99
193_N198_L0.6660.99
198_L203_H0.6650.99
87_V151_Q0.6620.99
67_M265_S0.6620.99
198_L201_T0.6590.99
59_D64_F0.6540.99
243_L251_I0.6480.99
32_E141_D0.6430.99
233_N257_E0.6430.99
186_G220_A0.6410.99
186_G270_L0.6400.99
40_I87_V0.6380.99
54_V88_I0.6380.99
46_P152_I0.6330.99
55_I275_L0.6300.99
89_V142_L0.6270.99
147_E179_A0.6260.99
219_L253_A0.6260.99
187_S222_G0.6240.99
75_G79_E0.6240.99
53_P85_P0.6200.99
68_T72_R0.6180.99
58_L107_F0.6180.99
59_D67_M0.6160.99
144_P148_R0.6150.99
24_V66_T0.6140.99
51_G152_I0.6130.99
197_I202_D0.6100.99
165_G168_F0.6090.99
58_L169_V0.6070.98
59_D63_V0.6060.98
200_K205_V0.6050.98
42_K150_Y0.6050.98
25_R40_I0.6020.98
77_R272_S0.6020.98
47_P51_G0.6010.98
46_P49_P0.6000.98
71_V75_G0.5980.98
232_M236_A0.5910.98
144_P179_A0.5910.98
134_F168_F0.5850.98
158_T184_I0.5840.98
91_I142_L0.5830.98
76_R79_E0.5810.98
106_D110_P0.5800.98
24_V65_G0.5800.98
212_N215_I0.5780.98
77_R276_R0.5750.98
154_K181_Q0.5730.98
213_Q251_I0.5730.98
22_T39_F0.5710.98
39_F65_G0.5710.98
41_S88_I0.5700.98
56_Y152_I0.5700.98
162_H188_P0.5690.98
146_I150_Y0.5670.98
211_N214_P0.5660.98
208_T211_N0.5660.98
68_T162_H0.5650.98
217_I251_I0.5640.98
219_L243_L0.5630.98
181_Q215_I0.5630.98
270_L273_R0.5620.98
105_R111_T0.5610.97
133_G136_R0.5570.97
57_L70_A0.5560.97
36_Y93_Y0.5540.97
25_R150_Y0.5510.97
87_V146_I0.5510.97
215_I251_I0.5510.97
192_W197_I0.5510.97
189_S232_M0.5450.97
168_F172_V0.5440.97
68_T268_P0.5430.97
236_A253_A0.5430.97
70_A75_G0.5420.97
59_D91_I0.5410.97
55_I158_T0.5410.97
220_A267_L0.5380.97
105_R110_P0.5370.97
81_T84_I0.5350.97
48_P151_Q0.5350.97
210_K214_P0.5330.97
69_E90_G0.5330.97
100_S107_F0.5320.97
166_G188_P0.5310.96
101_S105_R0.5300.96
73_I76_R0.5290.96
234_D237_R0.5280.96
41_S44_S0.5210.96
220_A256_C0.5210.96
59_D103_R0.5200.96
238_E242_R0.5190.96
77_R80_K0.5180.96
76_R83_V0.5170.96
72_R76_R0.5160.96
68_T90_G0.5160.96
214_P251_I0.5160.96
142_L145_E0.5160.96
63_V67_M0.5140.96
226_Q231_R0.5100.96
136_R176_K0.5040.95
192_W196_F0.5030.95
31_N133_G0.5030.95
108_T164_L0.5020.95
51_G147_E0.5020.95
196_F201_T0.5010.95
27_M38_I0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gffA 2 0.8858 100 0.441 Contact Map
4w9rA 2 0.827 100 0.45 Contact Map
2gzsA 1 0.8581 100 0.488 Contact Map
2qm0A 3 0.9308 100 0.497 Contact Map
1jjfA 1 0.8512 100 0.498 Contact Map
3c8dA 2 0.8443 100 0.503 Contact Map
3ls2A 2 0.872 100 0.507 Contact Map
3e4dA 3 0.8754 100 0.528 Contact Map
3i6yA 1 0.8789 100 0.529 Contact Map
4rotA 4 0.8131 100 0.533 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0088 seconds.