GREMLIN Database
YUEF - UPF0118 membrane protein YueF
UniProt: O32095 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 369 (325)
Sequences: 10931 (8499)
Seq/√Len: 471.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
234_F249_G5.1591.00
236_G288_V4.9771.00
319_L339_Y3.2571.00
62_E67_R3.0901.00
283_L287_I2.9221.00
52_F212_S2.9121.00
230_G253_A2.8591.00
66_P69_L2.8101.00
280_A284_F2.7111.00
234_F238_L2.6111.00
230_G249_G2.5521.00
50_L178_L2.4241.00
103_N106_D2.3401.00
343_K347_L2.2551.00
65_I73_L2.2411.00
60_L63_K2.2301.00
271_V286_I2.1931.00
21_F25_K1.9801.00
55_N59_R1.9801.00
237_Y242_L1.9751.00
210_D348_N1.9371.00
206_K348_N1.9341.00
47_A178_L1.9091.00
223_L257_I1.8971.00
174_V178_L1.8741.00
134_S137_K1.8581.00
114_L117_D1.8581.00
221_G304_V1.8401.00
245_A249_G1.8041.00
233_C252_M1.8021.00
284_F287_I1.8001.00
179_F183_K1.7981.00
251_V255_T1.7931.00
58_V74_I1.7921.00
68_T72_L1.7611.00
211_L341_V1.7461.00
193_V205_L1.7431.00
55_N67_R1.7391.00
271_V282_A1.7351.00
71_I75_Y1.7311.00
58_V71_I1.6791.00
57_V74_I1.6731.00
68_T183_K1.6611.00
303_L307_K1.6591.00
235_I238_L1.6541.00
71_I179_F1.6511.00
141_S144_S1.6451.00
58_V67_R1.6441.00
61_L77_L1.6301.00
35_V38_S1.6271.00
83_A87_A1.6251.00
196_L204_G1.6211.00
238_L245_A1.6181.00
287_I291_I1.6091.00
177_I314_L1.6081.00
184_D312_H1.6081.00
28_F32_P1.6021.00
113_A117_D1.5971.00
234_F245_A1.5881.00
98_T102_N1.5801.00
274_G285_A1.5801.00
112_Q116_K1.5771.00
44_M318_L1.5691.00
324_G332_M1.5461.00
281_K284_F1.5261.00
243_P277_D1.5151.00
177_I181_M1.5131.00
300_L304_V1.5131.00
143_T147_Q1.5101.00
229_V256_N1.5071.00
113_A116_K1.5061.00
116_K119_S1.5021.00
135_I138_I1.4851.00
109_K112_Q1.4741.00
233_C292_V1.4731.00
137_K140_Q1.4671.00
290_V294_Q1.4611.00
255_T266_G1.4591.00
295_L300_L1.4321.00
132_Y136_S1.4261.00
267_A271_V1.4051.00
54_F182_L1.3931.00
149_L153_I1.3871.00
236_G240_A1.3841.00
130_Q134_S1.3751.00
114_L118_L1.3711.00
274_G282_A1.3631.00
137_K141_S1.3621.00
140_Q143_T1.3601.00
280_A283_L1.3561.00
286_I290_V1.3401.00
106_D110_Q1.3261.00
214_T340_A1.3241.00
115_T119_S1.3221.00
232_A292_V1.3061.00
117_D121_S1.3041.00
144_S148_N1.2781.00
248_L270_A1.2731.00
320_L332_M1.2621.00
90_G94_T1.2551.00
235_I239_I1.2491.00
284_F288_V1.2481.00
54_F78_F1.2361.00
106_D109_K1.2361.00
105_P109_K1.2361.00
242_L274_G1.2351.00
47_A174_V1.2341.00
101_F105_P1.2301.00
57_V60_L1.2291.00
79_I83_A1.2231.00
270_A285_A1.2211.00
116_K120_H1.2181.00
43_P47_A1.2111.00
184_D187_R1.2081.00
145_F148_N1.2071.00
27_S31_Q1.2061.00
190_H194_K1.2061.00
139_E142_L1.2031.00
65_I70_S1.2031.00
32_P36_F1.2011.00
58_V70_S1.1991.00
55_N185_G1.1981.00
118_L121_S1.1931.00
293_Q297_G1.1921.00
240_A285_A1.1891.00
157_L161_F1.1871.00
114_L119_S1.1841.00
210_D347_L1.1831.00
110_Q113_A1.1811.00
225_I296_D1.1751.00
220_Q224_L1.1691.00
207_I345_F1.1611.00
58_V62_E1.1601.00
68_T179_F1.1581.00
50_L174_V1.1531.00
229_V292_V1.1511.00
67_R186_H1.1461.00
191_L194_K1.1451.00
315_T339_Y1.1431.00
24_T28_F1.1361.00
133_V137_K1.1341.00
58_V182_L1.1311.00
103_N107_Y1.1311.00
48_G181_M1.1281.00
319_L323_A1.1221.00
51_Y181_M1.1181.00
69_L72_L1.1161.00
249_G253_A1.1151.00
65_I69_L1.1081.00
134_S138_I1.1071.00
185_G189_P1.1011.00
187_R190_H1.1001.00
46_I174_V1.1001.00
72_L76_L1.0941.00
291_I295_L1.0901.00
70_S74_I1.0851.00
323_A327_G1.0811.00
117_D120_H1.0801.00
275_F282_A1.0751.00
121_S124_F1.0711.00
223_L227_L1.0651.00
197_P201_R1.0631.00
95_A99_G1.0621.00
44_M177_I1.0561.00
62_E70_S1.0531.00
234_F246_L1.0481.00
330_L334_L1.0451.00
177_I318_L1.0361.00
161_F165_T1.0321.00
47_A51_Y1.0301.00
226_C256_N1.0271.00
297_G301_S1.0241.00
323_A339_Y1.0231.00
133_V136_S1.0191.00
295_L299_L1.0191.00
206_K210_D1.0171.00
99_G102_N1.0171.00
222_Q301_S1.0091.00
224_L228_F1.0091.00
237_Y248_L1.0091.00
288_V292_V1.0071.00
319_L335_A1.0071.00
299_L303_L1.0011.00
31_Q35_V0.9991.00
227_L253_A0.9981.00
33_F37_I0.9921.00
135_I139_E0.9901.00
230_G234_F0.9881.00
87_A91_P0.9871.00
253_A257_I0.9861.00
60_L64_K0.9851.00
173_T177_I0.9821.00
229_V263_P0.9741.00
229_V233_C0.9681.00
94_T97_V0.9671.00
136_S140_Q0.9661.00
136_S139_E0.9641.00
75_Y178_L0.9631.00
315_T343_K0.9621.00
187_R191_L0.9621.00
40_L322_G0.9601.00
225_I229_V0.9591.00
251_V266_G0.9571.00
59_R62_E0.9511.00
61_L74_I0.9481.00
134_S139_E0.9461.00
110_Q114_L0.9451.00
240_A281_K0.9411.00
342_V346_F0.9391.00
47_A177_I0.9361.00
231_T235_I0.9351.00
98_T101_F0.9351.00
148_N151_Q0.9321.00
217_A221_G0.9281.00
22_V26_V0.9261.00
237_Y252_M0.9261.00
141_S145_F0.9261.00
202_T206_K0.9231.00
189_P193_V0.9231.00
225_I300_L0.9191.00
160_V164_V0.9171.00
92_I95_A0.9131.00
130_Q133_V0.9121.00
213_D217_A0.9101.00
237_Y285_A0.9081.00
146_L149_L0.9041.00
150_P154_T0.8991.00
236_G292_V0.8971.00
244_Y247_I0.8941.00
193_V201_R0.8931.00
167_I171_I0.8921.00
228_F232_A0.8851.00
273_V277_D0.8831.00
30_F33_F0.8821.00
231_T234_F0.8791.00
282_A286_I0.8771.00
217_A308_R0.8721.00
265_L269_P0.8711.00
225_I301_S0.8711.00
207_I348_N0.8681.00
142_L145_F0.8661.00
99_G103_N0.8591.00
140_Q144_S0.8541.00
335_A339_Y0.8501.00
249_G252_M0.8481.00
153_I157_L0.8471.00
104_L108_I0.8471.00
305_I316_I0.8431.00
228_F300_L0.8411.00
119_S125_T0.8331.00
345_F349_I0.8331.00
115_T121_S0.8321.00
318_L322_G0.8321.00
131_D135_I0.8291.00
61_L70_S0.8291.00
32_P35_V0.8291.00
238_L241_G0.8161.00
294_Q298_N0.8161.00
20_I24_T0.8101.00
96_Q99_G0.8051.00
227_L231_T0.8011.00
256_N263_P0.8011.00
229_V301_S0.7941.00
54_F74_I0.7911.00
248_L273_V0.7901.00
252_M266_G0.7861.00
148_N152_N0.7851.00
296_D301_S0.7851.00
233_C237_Y0.7851.00
226_C257_I0.7801.00
226_C230_G0.7781.00
252_M289_V0.7741.00
275_F279_P0.7711.00
279_P282_A0.7701.00
236_G284_F0.7681.00
191_L195_I0.7651.00
107_Y111_I0.7631.00
271_V275_F0.7621.00
205_L209_K0.7571.00
156_S160_V0.7571.00
240_A288_V0.7531.00
238_L249_G0.7521.00
44_M181_M0.7511.00
216_A220_Q0.7491.00
24_T27_S0.7461.00
163_V166_N0.7461.00
86_S90_G0.7451.00
153_I156_S0.7451.00
152_N155_S0.7441.00
102_N106_D0.7441.00
178_L182_L0.7431.00
225_I256_N0.7431.00
55_N182_L0.7431.00
144_S147_Q0.7421.00
20_I23_A0.7411.00
210_D344_A0.7331.00
307_K310_N0.7331.00
84_F88_S0.7281.00
59_R63_K0.7231.00
149_L152_N0.7221.00
210_D214_T0.7191.00
272_I276_M0.7181.00
214_T217_A0.7171.00
81_L85_I0.7161.00
51_Y178_L0.7141.00
204_G208_F0.7131.00
293_Q296_D0.7121.00
104_L107_Y0.7101.00
301_S305_I0.7091.00
276_M279_P0.7081.00
266_G270_A0.7081.00
278_S281_K0.7081.00
115_T118_L0.7061.00
152_N156_S0.7031.00
28_F31_Q0.7031.00
207_I211_L0.7001.00
233_C249_G0.6951.00
313_P317_I0.6911.00
252_M256_N0.6901.00
197_P200_Y0.6901.00
92_I96_Q0.6891.00
46_I50_L0.6831.00
61_L73_L0.6831.00
203_E206_K0.6831.00
51_Y55_N0.6821.00
224_L304_V0.6811.00
154_T157_L0.6801.00
306_G316_I0.6791.00
61_L65_I0.6791.00
62_E66_P0.6791.00
311_T339_Y0.6781.00
224_L227_L0.6781.00
111_I114_L0.6761.00
230_G250_I0.6751.00
211_L344_A0.6751.00
102_N105_P0.6751.00
138_I141_S0.6741.00
163_V167_I0.6731.00
25_K28_F0.6731.00
291_I294_Q0.6721.00
316_I336_V0.6711.00
54_F57_V0.6701.00
323_A338_V0.6671.00
93_I97_V0.6661.00
147_Q151_Q0.6641.00
203_E348_N0.6601.00
145_F149_L0.6581.00
139_E143_T0.6571.00
329_I332_M0.6571.00
66_P70_S0.6561.00
21_F26_V0.6551.00
225_I305_I0.6501.00
267_A289_V0.6491.00
230_G246_L0.6461.00
132_Y135_I0.6451.00
88_S92_I0.6411.00
189_P209_K0.6411.00
217_A220_Q0.6391.00
59_R186_H0.6371.00
25_K29_V0.6371.00
54_F178_L0.6331.00
151_Q155_S0.6321.00
167_I170_V0.6311.00
125_T134_S0.6301.00
158_S162_G0.6270.99
166_N170_V0.6260.99
210_D213_D0.6240.99
198_A201_R0.6240.99
81_L84_F0.6230.99
97_V105_P0.6180.99
242_L245_A0.6180.99
256_N301_S0.6160.99
309_L336_V0.6130.99
200_Y204_G0.6130.99
303_L306_G0.6120.99
97_V101_F0.6100.99
240_A284_F0.6070.99
294_Q297_G0.6050.99
23_A27_S0.6050.99
190_H193_V0.6040.99
171_I175_P0.6030.99
339_Y343_K0.6000.99
327_G331_G0.6000.99
311_T316_I0.5990.99
226_C229_V0.5980.99
191_L315_T0.5970.99
80_G83_A0.5970.99
232_A236_G0.5960.99
260_Y313_P0.5950.99
277_D281_K0.5940.99
111_I115_T0.5940.99
150_P153_I0.5930.99
154_T158_S0.5930.99
301_S304_V0.5920.99
158_S161_F0.5910.99
229_V293_Q0.5900.99
220_Q308_R0.5880.99
26_V30_F0.5860.99
82_L86_S0.5840.99
75_Y179_F0.5820.99
287_I290_V0.5810.99
51_Y182_L0.5800.99
196_L200_Y0.5800.99
222_Q256_N0.5790.99
36_F39_T0.5790.99
251_V269_P0.5770.99
181_M314_L0.5770.99
306_G310_N0.5760.99
169_L173_T0.5740.99
346_F350_V0.5740.99
317_I321_I0.5740.99
225_I306_G0.5740.99
240_A292_V0.5730.99
21_F24_T0.5730.99
93_I247_I0.5730.99
139_E145_F0.5720.99
94_T98_T0.5710.99
173_T321_I0.5700.99
300_L303_L0.5670.99
180_Y184_D0.5670.99
89_V93_I0.5630.99
243_P246_L0.5630.99
166_N298_N0.5630.99
43_P170_V0.5610.99
190_H205_L0.5610.99
30_F34_I0.5610.99
263_P266_G0.5600.99
222_Q226_C0.5600.99
143_T146_L0.5590.99
275_F278_S0.5580.99
252_M263_P0.5550.99
267_A282_A0.5550.99
77_L80_G0.5550.99
188_F191_L0.5540.99
93_I96_Q0.5540.99
225_I263_P0.5530.99
53_I219_F0.5510.99
209_K213_D0.5500.99
215_L218_Y0.5480.99
71_I183_K0.5470.99
195_I346_F0.5470.99
160_V163_V0.5470.99
320_L336_V0.5460.99
135_I141_S0.5440.99
221_G340_A0.5430.99
161_F164_V0.5420.99
229_V296_D0.5420.99
22_V25_K0.5420.99
285_A289_V0.5390.98
83_A86_S0.5390.98
211_L214_T0.5360.98
256_N296_D0.5360.98
115_T120_H0.5360.98
109_K113_A0.5350.98
226_C253_A0.5350.98
177_I321_I0.5340.98
124_F131_D0.5340.98
42_F45_L0.5330.98
266_G336_V0.5320.98
225_I304_V0.5310.98
253_A260_Y0.5310.98
33_F342_V0.5310.98
267_A290_V0.5300.98
221_G308_R0.5290.98
229_V232_A0.5280.98
193_V196_L0.5280.98
214_T344_A0.5270.98
228_F296_D0.5230.98
303_L310_N0.5230.98
269_P272_I0.5230.98
133_V138_I0.5210.98
192_A195_I0.5210.98
263_P293_Q0.5190.98
222_Q257_I0.5180.98
29_V32_P0.5170.98
54_F58_V0.5160.98
131_D134_S0.5160.98
222_Q225_I0.5150.98
48_G185_G0.5130.98
242_L277_D0.5110.98
344_A348_N0.5100.98
111_I118_L0.5060.98
285_A288_V0.5050.98
237_Y289_V0.5020.98
233_C236_G0.5000.98
283_L288_V0.5000.98
108_I112_Q0.5000.98
232_A296_D0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4humA 1 0.9729 46.7 0.948 Contact Map
3mktA 1 0.9783 44.3 0.948 Contact Map
3w4tA 1 0.8726 43.6 0.948 Contact Map
4ltoA 3 0.3035 40.8 0.949 Contact Map
3tx3A 2 0.5827 29.1 0.953 Contact Map
4lz6A 1 0.8699 19 0.957 Contact Map
2cfqA 1 0.9566 18.3 0.957 Contact Map
2kv5A 1 0.0894 17.4 0.958 Contact Map
4tkrA 2 0.3144 17.1 0.958 Contact Map
4rp9A 2 0.8238 14.1 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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