GREMLIN Database
PNCA - Uncharacterized isochorismatase family protein PncA
UniProt: O32091 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 183 (163)
Sequences: 9660 (6826)
Seq/√Len: 534.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_E119_R3.4751.00
115_E149_F2.8121.00
107_S143_D2.7951.00
125_E150_R2.7831.00
41_F46_D2.6661.00
3_K125_E2.5531.00
34_I129_A2.4151.00
125_E152_V2.3711.00
115_E147_K2.3571.00
10_Y34_I2.3241.00
37_L154_H2.3151.00
128_L141_A2.2551.00
163_Q167_A2.1101.00
113_D117_K2.0671.00
138_L142_V2.0301.00
13_D78_G2.0231.00
4_A123_I1.9511.00
12_N77_E1.9371.00
33_A157_A1.8931.00
40_E44_N1.8651.00
52_V102_E1.8651.00
33_A36_N1.8171.00
144_A151_I1.8161.00
49_V117_K1.7731.00
108_A140_T1.7621.00
3_K127_H1.6961.00
12_N83_G1.6831.00
7_C38_T1.5841.00
127_H154_H1.5821.00
51_A108_A1.5701.00
41_F127_H1.5571.00
15_V82_Y1.5491.00
35_V39_K1.5371.00
47_Y121_R1.5361.00
42_I98_V1.5081.00
54_S79_K1.4601.00
77_E80_D1.4361.00
7_C129_A1.4321.00
101_M117_K1.4291.00
137_V153_V1.4221.00
126_L144_A1.4201.00
133_T158_V1.4201.00
99_Y117_K1.3991.00
138_L172_H1.3911.00
128_L140_T1.3851.00
164_E167_A1.3721.00
134_D160_S1.3611.00
133_T166_H1.3591.00
117_K121_R1.3571.00
6_I128_L1.3551.00
64_E70_P1.3351.00
153_V158_V1.3291.00
26_P29_M1.3041.00
160_S166_H1.3031.00
39_K43_T1.2671.00
35_V84_K1.2651.00
38_T42_I1.2651.00
7_C34_I1.2541.00
143_D147_K1.2511.00
133_T170_L1.2281.00
33_A156_Q1.2251.00
167_A171_S1.2251.00
52_V81_L1.2231.00
119_R149_F1.2171.00
7_C10_Y1.2131.00
116_L120_E1.2111.00
74_K102_E1.2061.00
32_E84_K1.2041.00
5_L41_F1.1831.00
95_E98_V1.1641.00
127_H152_V1.1621.00
30_I34_I1.1491.00
3_K46_D1.1361.00
54_S74_K1.1241.00
37_L157_A1.1211.00
8_I136_C1.1201.00
12_N80_D1.1091.00
139_H142_V1.1021.00
141_A153_V1.0911.00
54_S102_E1.0871.00
56_D74_K1.0591.00
113_D116_L1.0451.00
155_K170_L1.0221.00
30_I159_A1.0201.00
38_T50_L1.0131.00
133_T160_S1.0121.00
126_L151_I0.9821.00
138_L169_A0.9751.00
154_H157_A0.9671.00
124_G150_R0.9591.00
4_A49_V0.9501.00
117_K120_E0.9461.00
171_S175_N0.9451.00
10_Y131_V0.9341.00
40_E43_T0.9331.00
80_D86_L0.9301.00
36_N40_E0.9281.00
36_N39_K0.9261.00
50_L81_L0.9241.00
129_A157_A0.9201.00
17_S28_R0.9141.00
47_Y123_I0.9051.00
6_I114_L0.9051.00
162_N165_G0.9021.00
164_E171_S0.8971.00
35_V87_P0.8941.00
141_A173_F0.8921.00
165_G168_W0.8781.00
171_S174_A0.8691.00
158_V166_H0.8641.00
70_P73_I0.8591.00
110_A147_K0.8531.00
105_R148_G0.8451.00
109_F144_A0.8421.00
143_D146_N0.8401.00
8_I128_L0.8351.00
118_L149_F0.8341.00
108_A114_L0.8291.00
38_T48_V0.8291.00
76_T79_K0.8211.00
166_H170_L0.8191.00
37_L129_A0.8021.00
18_D22_T0.8001.00
31_E35_V0.7961.00
50_L87_P0.7951.00
49_V121_R0.7881.00
87_P98_V0.7811.00
4_A118_L0.7761.00
29_M32_E0.7741.00
168_W171_S0.7711.00
7_C50_L0.7651.00
169_A173_F0.7631.00
32_E35_V0.7631.00
34_I157_A0.7621.00
19_G22_T0.7591.00
47_Y117_K0.7511.00
50_L98_V0.7431.00
128_L137_V0.7421.00
32_E36_N0.7411.00
105_R111_G0.7371.00
82_Y85_L0.7341.00
131_V159_A0.7301.00
41_F45_G0.7261.00
77_E83_G0.7191.00
13_D19_G0.7131.00
164_E168_W0.7121.00
10_Y82_Y0.7101.00
35_V86_L0.7061.00
132_C135_I0.7011.00
110_A146_N0.6931.00
116_L119_R0.6901.00
14_F136_C0.6901.00
52_V100_Y0.6891.00
10_Y30_I0.6891.00
49_V99_Y0.6881.00
73_I76_T0.6821.00
31_E82_Y0.6771.00
30_I131_V0.6741.00
12_N82_Y0.6721.00
42_I97_N0.6721.00
42_I95_E0.6721.00
27_G131_V0.6711.00
128_L151_I0.6711.00
165_G171_S0.6701.00
5_L37_L0.6681.00
15_V31_E0.6681.00
56_D59_D0.6601.00
168_W172_H0.6591.00
5_L129_A0.6571.00
52_V96_P0.6531.00
83_G86_L0.6481.00
165_G175_N0.6451.00
39_K86_L0.6441.00
134_D161_F0.6431.00
155_K174_A0.6361.00
15_V27_G0.6351.00
75_G80_D0.6331.00
127_H156_Q0.6321.00
39_K95_E0.6311.00
151_I154_H0.6241.00
31_E85_L0.6191.00
58_G101_M0.6171.00
129_A154_H0.6171.00
50_L85_L0.6101.00
134_D172_H0.6091.00
37_L127_H0.6081.00
172_H175_N0.6061.00
38_T98_V0.6031.00
9_D103_K0.6021.00
132_C160_S0.5981.00
86_L95_E0.5981.00
141_A151_I0.5961.00
134_D165_G0.5961.00
99_Y121_R0.5921.00
41_F47_Y0.5921.00
137_V158_V0.5911.00
52_V80_D0.5880.99
23_C26_P0.5870.99
38_T41_F0.5870.99
132_C161_F0.5870.99
68_F71_H0.5840.99
111_G116_L0.5830.99
10_Y85_L0.5810.99
5_L38_T0.5780.99
101_M113_D0.5770.99
106_Y140_T0.5730.99
106_Y146_N0.5710.99
110_A143_D0.5710.99
42_I48_V0.5710.99
87_P100_Y0.5700.99
107_S146_N0.5700.99
21_L24_G0.5700.99
65_T69_P0.5690.99
14_F132_C0.5680.99
37_L41_F0.5680.99
65_T68_F0.5660.99
135_I161_F0.5640.99
13_D72_N0.5580.99
49_V101_M0.5550.99
52_V79_K0.5520.99
8_I137_V0.5490.99
5_L48_V0.5460.99
153_V173_F0.5440.99
26_P159_A0.5420.99
105_R110_A0.5400.99
106_Y135_I0.5360.99
63_P66_R0.5350.99
106_Y145_Y0.5330.99
10_Y31_E0.5280.99
49_V114_L0.5270.99
3_K152_V0.5270.99
155_K166_H0.5260.99
155_K158_V0.5240.99
66_R69_P0.5200.99
56_D104_T0.5190.99
22_T28_R0.5160.99
28_R84_K0.5150.99
145_Y151_I0.5140.99
42_I50_L0.5100.99
53_D72_N0.5090.99
17_S22_T0.5080.99
47_Y99_Y0.5080.99
170_L174_A0.5010.98
19_G23_C0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o94A 4 0.9945 100 0.118 Contact Map
3v8eA 2 0.9563 100 0.155 Contact Map
1nbaA 4 0.9508 100 0.171 Contact Map
3hb7A 3 0.929 100 0.173 Contact Map
1im5A 1 0.9344 100 0.176 Contact Map
3irvA 2 0.9508 100 0.177 Contact Map
3eefA 4 0.9126 100 0.182 Contact Map
3hu5A 3 0.9508 100 0.182 Contact Map
4l07A 4 0.9454 100 0.184 Contact Map
3ot4A 4 0.9454 100 0.189 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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