GREMLIN Database
YUZA - Uncharacterized membrane protein YuzA
UniProt: O32087 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 78 (64)
Sequences: 543 (383)
Seq/√Len: 47.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_A53_G5.2471.00
24_F47_G3.3101.00
28_D31_A3.1581.00
3_T7_I2.9481.00
10_V60_L2.6221.00
21_L29_L2.2301.00
12_T56_N2.2121.00
31_A46_Y2.0691.00
12_T16_A2.0301.00
48_L52_A1.9160.99
23_G47_G1.6800.98
27_F32_A1.6430.98
5_Q55_I1.5570.97
6_R63_P1.5430.97
58_G62_K1.4660.96
8_C56_N1.4270.95
5_Q62_K1.3410.93
12_T53_G1.3150.92
2_S6_R1.3140.92
56_N59_L1.3050.92
31_A37_Q1.1830.87
17_I54_L1.1300.85
52_A56_N1.1270.85
6_R61_F1.1200.84
50_G54_L1.0970.83
40_A44_I1.0840.82
30_V45_I1.0620.81
20_G27_F1.0170.78
11_L52_A0.9880.76
28_D37_Q0.9560.73
51_I55_I0.9550.73
9_L60_L0.9430.72
20_G47_G0.9330.72
21_L27_F0.9240.71
22_I49_V0.8700.66
29_L46_Y0.8590.65
34_F42_S0.8440.64
63_P66_E0.7740.57
18_N21_L0.7740.57
6_R60_L0.7730.57
2_S5_Q0.7520.55
34_F45_I0.7510.55
3_T55_I0.7490.55
11_L48_L0.7470.54
26_Q38_G0.7470.54
35_G49_V0.7460.54
14_I62_K0.7400.54
28_D42_S0.7190.52
8_C59_L0.7170.51
12_T22_I0.7160.51
7_I55_I0.7130.51
33_I45_I0.7080.51
9_L59_L0.6980.50
12_T20_G0.6980.50
51_I66_E0.6920.49
39_S42_S0.6830.48
55_I58_G0.6740.47
20_G24_F0.6590.46
13_I30_V0.6540.45
6_R57_L0.6520.45
5_Q58_G0.6430.44
17_I49_V0.6420.44
17_I21_L0.6390.44
5_Q38_G0.6370.43
32_A38_G0.6330.43
10_V64_N0.6190.42
21_L33_I0.6020.40
28_D46_Y0.6010.40
33_I65_E0.6000.40
48_L66_E0.5990.40
20_G50_G0.5920.39
11_L41_L0.5910.39
41_L52_A0.5730.37
7_I54_L0.5700.37
5_Q61_F0.5650.37
43_R47_G0.5620.36
26_Q43_R0.5610.36
16_A56_N0.5560.36
6_R17_I0.5420.34
5_Q59_L0.5390.34
44_I51_I0.5310.33
26_Q57_L0.5250.33
41_L60_L0.5220.33
25_F59_L0.5160.32
17_I23_G0.5130.32
57_L61_F0.5130.32
38_G60_L0.5120.32
44_I47_G0.5120.32
62_K65_E0.5080.31
6_R10_V0.5050.31
13_I25_F0.5050.31
14_I63_P0.5040.31
45_I48_L0.5030.31
32_A41_L0.5020.31
45_I54_L0.5020.31
49_V53_G0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fymA 1 0 4.8 0.932 Contact Map
4fbzA 3 0.8205 4 0.935 Contact Map
4hyjA 2 0.7821 3.7 0.936 Contact Map
1oahA 2 0.1026 3.6 0.936 Contact Map
4knfA 3 0.8333 3.5 0.937 Contact Map
3h90A 3 0.8974 3.5 0.937 Contact Map
4qi1A 3 0.7179 3.4 0.937 Contact Map
4tllA 1 0.9231 3.4 0.937 Contact Map
1y9iA 4 0.7436 3.3 0.937 Contact Map
4uqqA 3 0.4872 3.2 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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