GREMLIN Database
YUBA - UPF0118 membrane protein YubA
UniProt: O32086 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 388 (329)
Sequences: 10936 (8480)
Seq/√Len: 467.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
249_F264_A5.2841.00
251_G303_V5.1441.00
74_F78_R4.3081.00
334_L354_Y3.2821.00
76_E82_R3.0761.00
66_Y227_N2.9271.00
245_G268_A2.9151.00
298_L302_I2.7181.00
74_F77_R2.5921.00
249_F253_L2.5831.00
64_V193_L2.5271.00
245_G264_A2.5241.00
81_R84_Y2.4901.00
118_N121_R2.4021.00
80_I88_L2.3441.00
286_I301_V2.2551.00
358_K362_T2.2041.00
149_N152_D2.0871.00
252_Y257_L2.0831.00
221_T363_H2.0471.00
238_I272_I2.0211.00
194_F198_K1.9411.00
61_T193_L1.9361.00
225_E363_H1.9321.00
299_K302_I1.9031.00
69_N73_D1.8861.00
189_V193_L1.8861.00
236_G319_I1.8801.00
286_I297_L1.8731.00
83_I87_L1.8641.00
131_K134_I1.8541.00
248_L267_A1.8461.00
72_V89_L1.8451.00
211_V219_T1.8401.00
69_N82_R1.8381.00
266_I270_T1.8081.00
226_M356_V1.7861.00
302_I306_I1.7731.00
124_D127_E1.7601.00
129_Q132_Q1.7541.00
208_L220_Y1.7511.00
250_I253_L1.7381.00
260_A264_A1.7251.00
86_I194_F1.7221.00
199_D327_H1.7131.00
318_Q322_K1.7031.00
49_V52_K1.6991.00
71_V89_L1.6891.00
35_L39_K1.6811.00
192_I329_I1.6801.00
72_V86_I1.6641.00
128_N132_Q1.6451.00
249_F260_A1.6281.00
127_E131_K1.6281.00
253_L260_A1.6221.00
86_I90_Y1.6061.00
296_M299_K1.6001.00
156_K159_D1.5681.00
339_G347_I1.5671.00
192_I196_L1.5601.00
58_I333_F1.5591.00
244_I271_S1.5571.00
289_A300_L1.5551.00
83_I198_K1.5471.00
98_T102_V1.5351.00
42_F46_P1.5341.00
152_D155_T1.5341.00
150_I153_L1.5271.00
258_D292_T1.5271.00
75_L92_L1.5191.00
247_L307_V1.4971.00
72_V82_R1.4941.00
305_T309_L1.4921.00
315_I319_I1.4871.00
270_T281_A1.4851.00
248_L307_V1.4681.00
289_A297_L1.4631.00
113_M117_D1.4491.00
125_V128_N1.4481.00
129_Q133_L1.4391.00
68_L197_L1.3971.00
308_Q312_G1.3961.00
41_S45_T1.3961.00
155_T158_S1.3881.00
282_I286_I1.3491.00
128_N131_K1.3361.00
285_A300_L1.3351.00
335_L347_I1.3261.00
154_A157_V1.3211.00
80_I84_Y1.3121.00
121_R124_D1.3121.00
205_V209_K1.2971.00
310_I315_I1.2951.00
301_V305_T1.2921.00
240_V311_E1.2901.00
251_G255_I1.2721.00
121_R125_V1.2721.00
83_I194_F1.2661.00
94_I98_T1.2601.00
61_T189_V1.2601.00
229_R355_A1.2601.00
255_I300_L1.2601.00
299_K303_V1.2561.00
147_N151_S1.2501.00
69_N200_G1.2491.00
105_I109_K1.2481.00
148_I151_S1.2431.00
145_T149_N1.2411.00
222_V360_I1.2361.00
199_D202_K1.2331.00
72_V197_L1.2281.00
158_S162_A1.2231.00
257_L289_A1.2191.00
263_L285_A1.2171.00
120_P124_D1.2141.00
264_A268_A1.2101.00
225_E362_T1.2031.00
212_P216_K1.2011.00
72_V85_S1.1961.00
38_T42_F1.1941.00
57_P61_T1.1931.00
71_V74_F1.1921.00
68_L93_V1.1891.00
330_T354_Y1.1861.00
334_L338_A1.1751.00
130_T134_I1.1691.00
87_L91_L1.1671.00
250_I254_I1.1641.00
241_S271_S1.1631.00
161_A164_I1.1541.00
244_I307_V1.1501.00
65_F196_L1.1481.00
290_I297_L1.1481.00
85_S89_L1.1471.00
82_R201_R1.1461.00
295_L299_K1.1441.00
338_A342_F1.1431.00
80_I85_S1.1431.00
64_V189_V1.1381.00
293_S296_M1.1301.00
163_T166_N1.1261.00
303_V307_V1.1201.00
116_I120_P1.1161.00
235_R239_I1.1101.00
72_V76_E1.1011.00
60_L189_V1.0991.00
58_I192_I1.0951.00
62_G196_L1.0891.00
76_E85_S1.0881.00
84_Y87_L1.0841.00
249_F261_S1.0821.00
242_F268_A1.0791.00
202_K205_V1.0651.00
206_Y209_K1.0641.00
338_A354_Y1.0611.00
221_T225_E1.0561.00
148_I152_D1.0551.00
152_D156_K1.0541.00
312_G316_S1.0531.00
45_T49_V1.0491.00
239_I243_C1.0471.00
90_Y193_L1.0391.00
334_L350_A1.0351.00
245_G249_F1.0341.00
172_V176_I1.0341.00
129_Q134_I1.0331.00
345_V349_L1.0321.00
240_V244_I1.0321.00
160_Q163_T1.0311.00
238_I242_F1.0231.00
188_T192_I1.0231.00
310_I314_L1.0191.00
357_A361_T1.0181.00
237_Q316_S1.0181.00
175_F179_L1.0161.00
125_V129_Q1.0141.00
306_I310_I1.0111.00
314_L318_Q1.0101.00
308_Q311_E1.0091.00
240_V315_I0.9961.00
192_I333_F0.9941.00
266_I281_A0.9911.00
114_S117_D0.9901.00
46_P50_L0.9881.00
73_D76_E0.9821.00
268_A272_I0.9821.00
246_F250_I0.9801.00
145_T148_I0.9781.00
47_I51_L0.9771.00
232_S236_G0.9741.00
124_D128_N0.9731.00
54_I337_T0.9711.00
252_Y263_L0.9691.00
110_E114_S0.9691.00
61_T65_F0.9651.00
75_L89_L0.9651.00
330_T358_K0.9641.00
244_I278_P0.9641.00
288_I292_T0.9611.00
259_Y262_L0.9591.00
251_G307_V0.9561.00
200_G204_P0.9551.00
251_G299_K0.9511.00
264_A267_A0.9501.00
252_Y267_A0.9451.00
131_K135_G0.9421.00
113_M116_I0.9421.00
118_N122_Y0.9361.00
182_I186_I0.9361.00
232_S323_N0.9251.00
246_F249_F0.9251.00
61_T192_I0.9251.00
244_I248_L0.9241.00
222_V363_H0.9221.00
297_L301_V0.9171.00
255_I296_M0.9151.00
107_F110_E0.9121.00
109_K112_I0.9121.00
202_K206_Y0.9111.00
44_F47_I0.9051.00
151_S155_T0.9051.00
291_V294_P0.9021.00
155_T159_D0.8991.00
149_N153_L0.8941.00
74_F79_R0.8931.00
240_V316_S0.8921.00
156_K160_Q0.8901.00
164_I168_T0.8881.00
333_F337_T0.8871.00
102_V106_P0.8821.00
252_Y300_L0.8811.00
228_H232_S0.8761.00
73_D77_R0.8721.00
112_I116_I0.8721.00
36_V40_T0.8651.00
159_D163_T0.8651.00
280_I284_P0.8651.00
204_P208_L0.8571.00
350_A354_Y0.8561.00
208_L216_K0.8531.00
34_I38_T0.8491.00
240_V271_S0.8481.00
320_M331_I0.8451.00
119_I123_V0.8441.00
248_L252_Y0.8441.00
360_I364_L0.8441.00
58_I196_L0.8441.00
96_L100_T0.8411.00
68_L89_L0.8411.00
263_L288_I0.8401.00
271_S278_P0.8401.00
163_T167_S0.8391.00
311_E316_S0.8381.00
255_I303_V0.8371.00
243_C247_L0.8271.00
253_L264_A0.8271.00
162_A166_N0.8261.00
309_L313_K0.8251.00
300_L304_W0.8251.00
39_K42_F0.8121.00
219_T223_L0.8111.00
309_L312_G0.8091.00
181_E185_S0.8091.00
244_I316_S0.8061.00
144_Q148_I0.8041.00
243_C315_I0.8021.00
114_S118_N0.8011.00
242_F246_F0.8001.00
241_S272_I0.7961.00
159_D162_A0.7891.00
295_L298_L0.7851.00
81_R85_S0.7831.00
267_A281_A0.7831.00
130_T133_L0.7821.00
225_E359_V0.7811.00
42_F45_T0.7781.00
193_L197_L0.7751.00
75_L80_I0.7741.00
253_L256_G0.7741.00
146_M149_N0.7731.00
176_I180_T0.7721.00
122_Y126_V0.7711.00
326_I354_Y0.7681.00
75_L85_S0.7681.00
206_Y210_F0.7641.00
239_I319_I0.7611.00
144_Q147_N0.7591.00
166_N170_T0.7541.00
286_I290_I0.7491.00
322_K325_H0.7481.00
76_E79_R0.7471.00
321_G331_I0.7471.00
240_V320_M0.7451.00
101_I105_I0.7441.00
316_S320_M0.7441.00
217_E221_T0.7371.00
218_Q221_T0.7341.00
149_N154_A0.7331.00
220_Y224_S0.7321.00
267_A304_W0.7291.00
218_Q363_H0.7291.00
281_A285_A0.7271.00
241_S245_G0.7261.00
165_V168_T0.7251.00
338_A353_G0.7171.00
290_I294_P0.7171.00
178_A181_E0.7151.00
99_I103_S0.7151.00
73_D201_R0.7131.00
328_P332_I0.7111.00
225_E229_R0.7111.00
287_I291_V0.7101.00
206_Y330_T0.7091.00
108_L112_I0.7021.00
178_A182_I0.7001.00
245_G261_S0.6991.00
255_I299_K0.6981.00
65_F69_N0.6981.00
271_S316_S0.6951.00
146_M150_I0.6931.00
46_P49_V0.6921.00
231_S235_R0.6911.00
132_Q135_G0.6881.00
65_F193_L0.6851.00
167_S171_G0.6831.00
111_Q114_S0.6831.00
37_F41_S0.6811.00
171_G175_F0.6781.00
168_T172_V0.6771.00
92_L95_G0.6771.00
229_R232_S0.6751.00
245_G265_V0.6731.00
184_I188_T0.6711.00
278_P281_A0.6701.00
275_Y328_P0.6681.00
57_P321_G0.6671.00
188_T336_L0.6651.00
205_V208_L0.6641.00
211_V215_L0.6641.00
57_P185_S0.6641.00
173_G177_G0.6641.00
90_Y194_F0.6641.00
150_I154_A0.6611.00
205_V220_Y0.6601.00
226_M359_V0.6601.00
168_T171_G0.6601.00
68_L193_L0.6591.00
331_I351_I0.6591.00
222_V226_M0.6591.00
241_S268_A0.6531.00
267_A271_S0.6511.00
248_L264_A0.6511.00
103_S107_F0.6491.00
39_K46_P0.6481.00
138_F141_Q0.6471.00
244_I308_Q0.6461.00
306_I309_L0.6451.00
167_S170_T0.6431.00
151_S154_A0.6411.00
60_L64_V0.6411.00
40_T44_F0.6401.00
241_S244_I0.6391.00
237_Q271_S0.6381.00
69_N197_L0.6351.00
68_L71_V0.6351.00
316_S319_I0.6351.00
109_K113_M0.6351.00
239_I242_F0.6341.00
204_P224_S0.6331.00
247_L251_G0.6320.99
292_T296_M0.6310.99
335_L351_I0.6300.99
354_Y358_K0.6280.99
218_Q222_V0.6270.99
212_P215_L0.6270.99
208_L211_V0.6260.99
117_D121_R0.6190.99
97_I101_I0.6150.99
257_L260_A0.6130.99
342_F346_G0.6130.99
75_L88_L0.6120.99
344_V347_I0.6110.99
237_Q241_S0.6080.99
244_I311_E0.6070.99
158_S161_A0.6060.99
224_S228_H0.6060.99
196_L329_I0.6040.99
282_I304_W0.6040.99
282_I305_T0.6010.99
324_L351_I0.5960.99
318_Q321_G0.5950.99
165_V169_F0.5940.99
169_F172_V0.5940.99
169_F173_G0.5930.99
315_I318_Q0.5920.99
91_L95_G0.5920.99
39_K45_T0.5910.99
157_V160_Q0.5900.99
130_T135_G0.5900.99
126_V129_Q0.5900.99
182_I185_S0.5890.99
266_I284_P0.5890.99
252_Y304_W0.5880.99
117_D120_P0.5870.99
96_L99_I0.5830.99
293_S297_L0.5810.99
267_A278_P0.5810.99
253_L261_S0.5740.99
240_V278_P0.5730.99
65_F197_L0.5730.99
257_L292_T0.5720.99
240_V319_I0.5710.99
62_G200_G0.5690.99
176_I179_L0.5680.99
179_L183_I0.5670.99
268_A275_Y0.5670.99
107_F111_Q0.5650.99
112_I120_P0.5630.99
139_V146_M0.5610.99
244_I268_A0.5600.99
104_I108_L0.5600.99
332_I336_L0.5600.99
281_A348_I0.5580.99
304_W309_L0.5580.99
119_I122_Y0.5580.99
279_T282_I0.5570.99
359_V363_H0.5570.99
244_I247_L0.5570.99
184_I187_V0.5570.99
39_K43_I0.5560.99
35_L38_T0.5540.99
271_S311_E0.5530.99
89_L93_V0.5530.99
192_I336_L0.5520.99
76_E81_R0.5520.99
82_R86_I0.5500.99
35_L40_T0.5490.99
68_L72_V0.5480.99
278_P308_Q0.5470.99
34_I37_F0.5440.99
281_A308_Q0.5440.99
300_L303_V0.5430.98
45_T48_I0.5430.98
237_Q240_V0.5390.98
243_C311_E0.5380.98
186_I190_P0.5380.98
235_R323_N0.5370.98
111_Q115_L0.5370.98
123_V127_E0.5370.98
153_L157_V0.5350.98
120_P123_V0.5340.98
248_L268_A0.5340.98
270_T284_P0.5330.98
237_Q272_I0.5330.98
98_T101_I0.5330.98
321_G325_H0.5310.98
304_W308_Q0.5310.98
203_L206_Y0.5300.98
95_G98_T0.5300.98
232_S235_R0.5300.98
211_V216_K0.5290.98
216_K220_Y0.5290.98
192_I332_I0.5280.98
181_E313_K0.5270.98
289_A294_P0.5270.98
255_I307_V0.5270.98
281_A351_I0.5260.98
225_E228_H0.5260.98
313_K336_L0.5250.98
226_M229_R0.5240.98
86_I198_K0.5240.98
50_L53_T0.5240.98
44_F48_I0.5230.98
47_I357_A0.5210.98
216_K219_T0.5200.98
147_N153_L0.5180.98
245_G282_I0.5170.98
118_N258_D0.5160.98
318_Q325_H0.5150.98
208_L212_P0.5130.98
195_Y327_H0.5130.98
67_L234_I0.5110.98
230_L233_Y0.5110.98
240_V321_G0.5100.98
245_G267_A0.5080.98
191_F328_P0.5080.98
236_G323_N0.5080.98
160_Q164_I0.5060.98
248_L303_V0.5040.98
271_S279_T0.5030.98
326_I331_I0.5020.97
195_Y199_D0.5010.97
311_E315_I0.5010.97
75_L79_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w4tA 1 0.9021 76.3 0.94 Contact Map
3mktA 1 0.9253 60.5 0.947 Contact Map
4lz6A 1 0.9098 48.2 0.951 Contact Map
4q4hB 1 0.8454 26.4 0.957 Contact Map
4humA 1 0.9356 23.6 0.958 Contact Map
2kluA 1 0.1469 20.6 0.959 Contact Map
4q9hA 1 0.8144 19.8 0.96 Contact Map
4j05A 3 0.4794 19.2 0.96 Contact Map
2kv5A 1 0.0851 16.9 0.961 Contact Map
4pirA 3 0.1443 16.7 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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