GREMLIN Database
CDOA - Cysteine dioxygenase
UniProt: O32085 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 161 (143)
Sequences: 336 (242)
Seq/√Len: 20.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_L137_S4.2241.00
61_I140_V3.7631.00
84_A127_M3.1120.99
119_S122_G2.8390.99
42_E65_N2.7640.99
140_V144_P2.7000.98
81_I118_I2.5840.98
92_L110_F2.4350.97
46_Y70_K2.2390.95
24_T28_Q2.2100.95
36_S87_L2.1820.94
66_I82_G2.1630.94
98_S151_F2.1360.94
49_G135_M2.0410.92
82_G93_N2.0170.91
68_P142_S1.9780.91
53_I101_E1.8920.88
95_I122_G1.7770.85
96_Y153_E1.7670.85
92_L108_S1.7670.85
120_T123_L1.7640.85
52_A61_I1.7350.84
23_A27_K1.7060.83
20_K27_K1.7020.82
109_Y117_L1.6730.81
67_P70_K1.6600.81
88_E133_E1.6410.80
94_S105_L1.6260.79
80_S143_P1.5920.78
26_L84_A1.5870.78
29_I36_S1.5170.74
75_H89_G1.5070.74
66_I72_T1.4940.73
33_A53_I1.4780.72
22_L136_V1.4670.72
30_P35_L1.4650.72
142_S147_D1.4030.68
58_E151_F1.3880.67
59_L70_K1.3800.67
61_I144_P1.3740.67
84_A117_L1.3600.66
83_C142_S1.3560.66
65_N70_K1.3350.64
31_N36_S1.3270.64
145_L148_M1.3100.63
39_Y53_I1.2980.62
90_K110_F1.2970.62
72_T82_G1.2730.60
95_I107_N1.2140.57
41_K44_D1.1940.55
66_I139_H1.1880.55
95_I115_E1.1840.55
42_E59_L1.1670.54
39_Y51_N1.1370.52
152_E155_K1.1210.51
52_A59_L1.1010.49
15_K121_K1.0990.49
77_H89_G1.0980.49
86_V111_V1.0780.48
95_I106_S1.0780.48
48_Y77_H1.0500.46
22_L67_P1.0490.46
30_P112_H1.0420.46
18_S86_V1.0420.46
34_K37_Q1.0290.45
45_Q117_L1.0160.44
90_K133_E1.0070.43
47_A121_K1.0050.43
64_I93_N0.9960.43
22_L65_N0.9820.42
30_P38_P0.9790.42
65_N147_D0.9790.42
90_K112_H0.9770.41
97_R103_A0.9700.41
105_L108_S0.9690.41
109_Y130_P0.9570.40
123_L129_N0.9500.40
96_Y126_K0.9460.39
86_V117_L0.9400.39
34_K38_P0.9360.39
22_L42_E0.9250.38
22_L47_A0.9150.38
59_L145_L0.9150.38
83_C145_L0.9100.37
92_L96_Y0.9080.37
97_R106_S0.9080.37
15_K100_G0.9020.37
58_E94_S0.8860.36
20_K23_A0.8850.36
104_E110_F0.8790.35
22_L83_C0.8790.35
82_G148_M0.8720.35
66_I138_L0.8680.35
47_A98_S0.8580.34
64_I91_L0.8560.34
104_E112_H0.8520.34
20_K30_P0.8500.34
93_N119_S0.8490.34
49_G129_N0.8450.33
31_N60_E0.8410.33
84_A137_S0.8370.33
72_T79_Q0.8360.33
62_I147_D0.8300.33
111_V155_K0.8260.32
72_T127_M0.8240.32
19_V22_L0.8040.31
47_A70_K0.7940.31
30_P63_V0.7930.30
125_H141_Y0.7920.30
17_P80_S0.7890.30
63_V104_E0.7880.30
47_A145_L0.7870.30
98_S126_K0.7830.30
24_T30_P0.7790.30
52_A55_R0.7780.30
19_V145_L0.7750.29
63_V87_L0.7670.29
44_D47_A0.7610.29
37_Q106_S0.7610.29
65_N127_M0.7610.29
121_K132_S0.7580.29
74_V129_N0.7560.28
134_R142_S0.7480.28
42_E67_P0.7450.28
92_L130_P0.7370.27
42_E52_A0.7270.27
78_G81_I0.7260.27
136_V143_P0.7200.27
123_L140_V0.7140.26
88_E100_G0.7090.26
28_Q132_S0.6970.25
13_G102_H0.6950.25
30_P114_G0.6850.25
97_R104_E0.6820.25
26_L40_I0.6820.25
56_N99_T0.6800.25
84_A103_A0.6780.24
55_R59_L0.6720.24
137_S140_V0.6670.24
31_N114_G0.6670.24
88_E134_R0.6660.24
51_N118_I0.6640.24
39_Y71_E0.6600.24
84_A119_S0.6590.24
60_E99_T0.6570.23
125_H139_H0.6550.23
97_R133_E0.6530.23
62_I71_E0.6510.23
27_K113_E0.6470.23
85_M123_L0.6420.23
85_M120_T0.6420.23
132_S154_Q0.6380.23
39_Y132_S0.6340.22
66_I123_L0.6290.22
124_I130_P0.6290.22
26_L57_N0.6270.22
127_M148_M0.6270.22
48_Y141_Y0.6260.22
88_E136_V0.6240.22
76_D124_I0.6180.22
47_A65_N0.6120.21
24_T27_K0.6110.21
59_L65_N0.6100.21
135_M139_H0.6080.21
31_N87_L0.6050.21
153_E157_V0.6050.21
75_H125_H0.6020.21
24_T114_G0.5980.21
47_A106_S0.5960.21
82_G123_L0.5950.21
95_I119_S0.5940.21
22_L147_D0.5910.21
63_V107_N0.5890.20
16_N121_K0.5860.20
89_G125_H0.5860.20
25_S41_K0.5820.20
103_A117_L0.5750.20
45_Q109_Y0.5700.20
19_V83_C0.5690.20
16_N96_Y0.5690.20
23_A37_Q0.5600.19
119_S123_L0.5580.19
39_Y102_H0.5510.19
13_G104_E0.5510.19
70_K88_E0.5500.19
66_I77_H0.5490.19
142_S145_L0.5480.19
21_D24_T0.5480.19
66_I89_G0.5460.19
144_P151_F0.5440.19
39_Y113_E0.5400.18
86_V107_N0.5370.18
92_L133_E0.5340.18
49_G60_E0.5320.18
29_I87_L0.5280.18
61_I126_K0.5280.18
60_E78_G0.5250.18
108_S112_H0.5240.18
88_E113_E0.5210.18
51_N64_I0.5210.18
45_Q59_L0.5200.18
39_Y94_S0.5200.18
38_P132_S0.5180.18
15_K21_D0.5120.17
16_N154_Q0.5090.17
62_I88_E0.5090.17
121_K157_V0.5050.17
118_I123_L0.5050.17
46_Y68_P0.5040.17
54_Y61_I0.5040.17
88_E121_K0.5040.17
50_R77_H0.5020.17
48_Y75_H0.5010.17
60_E85_M0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ieuA 1 0.9876 100 0.418 Contact Map
4tlfA 1 0.9814 100 0.464 Contact Map
4qmaA 1 0.9752 100 0.488 Contact Map
4qm9A 1 0.9503 99.9 0.558 Contact Map
1v70A 2 0.6522 98.4 0.827 Contact Map
3h8uA 2 0.7578 98.2 0.839 Contact Map
2oa2A 2 0.8199 98.1 0.843 Contact Map
2q30A 2 0.6522 98.1 0.843 Contact Map
2q1zB 1 0.7516 98 0.846 Contact Map
4b29A 1 0.8758 97.9 0.848 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0058 seconds.