GREMLIN Database
YUBD - Uncharacterized MFS-type transporter YubD
UniProt: O32084 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 511 (444)
Sequences: 32378 (23377)
Seq/√Len: 1109.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_G98_L5.4131.00
84_I172_S4.5661.00
82_V109_A3.8181.00
91_A166_F3.6681.00
89_L102_G3.2251.00
208_L240_L3.1491.00
204_L246_V3.0221.00
97_A101_A2.9391.00
384_G392_R2.9151.00
258_K388_D2.7101.00
51_I104_F2.6751.00
72_A123_L2.6681.00
95_D98_L2.6541.00
345_Q361_L2.6501.00
406_G409_I2.5311.00
315_A367_A2.5051.00
207_F239_L2.4951.00
311_G363_I2.4621.00
215_S233_F2.4441.00
200_A246_V2.4131.00
212_S236_T2.3631.00
439_F443_I2.2921.00
77_L180_Y2.2921.00
219_L224_L2.2261.00
55_A104_F2.1861.00
40_T96_I2.1821.00
297_S300_H2.1551.00
159_G163_W2.1551.00
129_R132_Y2.1321.00
59_L108_A2.1311.00
385_P388_D2.1241.00
77_L176_V2.1031.00
86_G109_A2.0951.00
241_I245_I2.0781.00
177_A181_F2.0591.00
90_I102_G2.0491.00
340_V446_V2.0371.00
179_S183_L2.0261.00
256_S388_D2.0201.00
198_D201_G1.9941.00
273_A403_V1.9861.00
98_L102_G1.9451.00
342_V365_L1.9411.00
347_L439_F1.9371.00
155_A163_W1.9261.00
230_W234_G1.9191.00
86_G105_L1.9151.00
41_S44_T1.9011.00
344_F442_F1.8971.00
30_V156_T1.8771.00
16_A76_Y1.8311.00
336_G448_L1.8021.00
79_S112_V1.7991.00
160_H163_W1.7771.00
208_L236_T1.7591.00
250_V253_P1.7431.00
291_R301_L1.7421.00
405_M409_I1.7381.00
406_G411_I1.7271.00
63_G112_V1.7231.00
86_G102_G1.7211.00
289_L294_Y1.6791.00
431_M435_H1.6761.00
14_V140_G1.6631.00
337_L449_V1.6581.00
125_F133_A1.6541.00
211_A232_G1.6481.00
68_K390_V1.6471.00
196_P252_N1.6281.00
96_I100_A1.6161.00
44_T96_I1.6041.00
405_M408_P1.5981.00
157_S299_E1.5861.00
18_G144_S1.5791.00
278_T445_S1.5741.00
131_N324_D1.5721.00
354_S357_M1.5671.00
211_A239_L1.5651.00
340_V449_V1.5631.00
243_L247_E1.5441.00
321_L325_K1.5361.00
87_S168_F1.5281.00
77_L179_S1.5281.00
208_L239_L1.5141.00
51_I100_A1.5141.00
9_I124_S1.4981.00
231_I235_V1.4971.00
406_G413_F1.4881.00
218_F222_W1.4751.00
246_V250_V1.4741.00
88_L92_C1.4711.00
58_L206_V1.4691.00
428_D432_T1.4611.00
407_V411_I1.4581.00
218_F221_K1.4551.00
67_R72_A1.4451.00
211_A235_V1.4441.00
93_S98_L1.4431.00
73_R77_L1.4421.00
406_G415_T1.4361.00
227_G231_I1.4361.00
65_L69_K1.4321.00
245_I249_K1.4321.00
338_I368_G1.4261.00
296_I304_L1.4251.00
277_I407_V1.4251.00
260_M266_V1.4221.00
127_I130_R1.4221.00
340_V442_F1.4161.00
340_V344_F1.4131.00
248_Y258_K1.4131.00
199_R203_L1.4081.00
40_T44_T1.4081.00
74_P185_D1.4061.00
432_T436_D1.4021.00
88_L169_G1.3991.00
90_I99_M1.3951.00
33_L36_K1.3931.00
66_L75_V1.3901.00
330_M333_I1.3901.00
126_P129_R1.3861.00
268_G380_A1.3831.00
93_S102_G1.3781.00
266_V270_L1.3731.00
347_L442_F1.3661.00
122_V130_R1.3641.00
244_L248_Y1.3611.00
342_V368_G1.3611.00
215_S236_T1.3601.00
52_G110_T1.3601.00
300_H303_L1.3511.00
436_D440_I1.3401.00
23_S26_A1.3371.00
339_L445_S1.3311.00
81_P176_V1.3281.00
214_V218_F1.3201.00
67_R116_I1.3161.00
404_Y407_V1.3151.00
406_G414_F1.2951.00
78_A82_V1.2941.00
204_L239_L1.2921.00
355_L359_A1.2871.00
154_I158_C1.2861.00
48_P99_M1.2821.00
335_G371_L1.2781.00
30_V164_L1.2741.00
244_L257_I1.2691.00
35_Q45_S1.2471.00
342_V361_L1.2361.00
12_L182_F1.2331.00
245_I248_Y1.2321.00
356_Y360_A1.2311.00
337_L341_F1.2281.00
89_L98_L1.2251.00
409_I413_F1.2181.00
84_I176_V1.2101.00
97_A100_A1.2081.00
296_I300_H1.2081.00
333_I453_F1.2071.00
26_A164_L1.2041.00
59_L111_G1.2041.00
256_S391_K1.1931.00
201_G246_V1.1901.00
235_V239_L1.1851.00
308_L366_A1.1851.00
329_G333_I1.1851.00
12_L178_V1.1841.00
327_G330_M1.1821.00
14_V136_V1.1811.00
290_L304_L1.1791.00
21_L141_F1.1771.00
178_V182_F1.1751.00
236_T240_L1.1711.00
267_L454_C1.1621.00
215_S229_V1.1621.00
430_M434_Y1.1571.00
173_L177_A1.1571.00
409_I415_T1.1521.00
222_W228_Y1.1451.00
85_L89_L1.1441.00
311_G315_A1.1441.00
356_Y359_A1.1401.00
321_L324_D1.1401.00
269_L399_L1.1341.00
55_A107_G1.1311.00
407_V415_T1.1311.00
10_S125_F1.1251.00
320_A324_D1.1231.00
12_L175_G1.1221.00
442_F446_V1.1221.00
263_P267_L1.1191.00
315_A370_G1.1181.00
76_Y179_S1.1151.00
439_F442_F1.1151.00
77_L81_P1.1121.00
7_W11_L1.1051.00
157_S297_S1.1041.00
350_Q353_S1.0971.00
335_G372_T1.0971.00
300_H304_L1.0961.00
23_S168_F1.0941.00
207_F211_A1.0851.00
450_C454_C1.0841.00
92_C166_F1.0821.00
80_L175_G1.0781.00
19_P172_S1.0731.00
319_S371_L1.0691.00
435_H439_F1.0631.00
15_L175_G1.0631.00
64_P68_K1.0621.00
304_L355_L1.0591.00
443_I447_L1.0561.00
204_L242_G1.0531.00
181_F184_H1.0511.00
330_M334_I1.0481.00
262_L266_V1.0461.00
72_A185_D1.0441.00
322_L326_V1.0381.00
62_A202_I1.0381.00
84_I88_L1.0361.00
224_L229_V1.0281.00
240_L244_L1.0231.00
446_V450_C1.0231.00
153_T298_Q1.0201.00
90_I165_F1.0181.00
336_G449_V1.0171.00
281_V411_I1.0151.00
121_L137_L1.0151.00
128_E132_Y1.0141.00
342_V364_M1.0101.00
344_F347_L1.0071.00
68_K72_A1.0051.00
274_A448_L1.0041.00
333_I449_V1.0041.00
233_F237_L1.0031.00
222_W229_V1.0021.00
71_G74_P1.0011.00
334_I371_L1.0001.00
89_L92_C1.0001.00
265_P269_L0.9991.00
24_N53_N0.9971.00
237_L241_I0.9961.00
242_G245_I0.9941.00
82_V86_G0.9861.00
122_V389_L0.9781.00
222_W226_S0.9771.00
348_H361_L0.9771.00
151_L154_I0.9741.00
225_S230_W0.9721.00
84_I169_G0.9721.00
344_F348_H0.9691.00
347_L435_H0.9691.00
73_R180_Y0.9661.00
264_K456_N0.9661.00
94_G97_A0.9641.00
50_L217_I0.9581.00
47_N51_I0.9571.00
275_G372_T0.9571.00
163_W170_T0.9551.00
333_I452_S0.9521.00
215_S232_G0.9511.00
258_K261_L0.9511.00
271_I452_S0.9481.00
380_A396_V0.9441.00
51_I55_A0.9431.00
75_V78_A0.9431.00
255_I395_A0.9401.00
407_V412_G0.9321.00
408_P411_I0.9311.00
269_L395_A0.9311.00
169_G173_L0.9271.00
410_L414_F0.9261.00
66_L70_F0.9261.00
432_T435_H0.9241.00
48_P96_I0.9241.00
436_D439_F0.9231.00
8_V182_F0.9181.00
155_A159_G0.9161.00
285_A437_L0.9131.00
262_L388_D0.9131.00
263_P266_V0.9131.00
262_L385_P0.9121.00
315_A319_S0.9111.00
357_M360_A0.9061.00
345_Q348_H0.9061.00
26_A152_G0.9051.00
101_A104_F0.9011.00
351_D431_M0.8971.00
178_V181_F0.8961.00
407_V413_F0.8931.00
413_F417_K0.8901.00
55_A59_L0.8881.00
357_M361_L0.8841.00
203_L207_F0.8801.00
405_M415_T0.8791.00
201_G250_V0.8791.00
360_A363_I0.8791.00
310_I314_I0.8781.00
33_L37_T0.8781.00
75_V112_V0.8781.00
206_V210_A0.8751.00
155_A167_I0.8731.00
216_F219_L0.8721.00
162_R166_F0.8711.00
238_C242_G0.8701.00
74_P78_A0.8691.00
273_A399_L0.8691.00
315_A318_L0.8641.00
92_C102_G0.8641.00
349_I353_S0.8621.00
318_L321_L0.8571.00
131_N135_L0.8561.00
340_V445_S0.8521.00
27_L48_P0.8511.00
339_L368_G0.8511.00
13_A117_M0.8501.00
61_P205_S0.8481.00
412_G416_K0.8451.00
265_P392_R0.8451.00
78_A81_P0.8441.00
308_L365_L0.8431.00
98_L101_A0.8421.00
28_S49_I0.8421.00
248_Y257_I0.8411.00
131_N320_A0.8411.00
228_Y232_G0.8401.00
280_A404_Y0.8351.00
197_L202_I0.8351.00
267_L451_L0.8341.00
317_I321_L0.8331.00
334_I338_I0.8291.00
315_A371_L0.8291.00
272_I396_V0.8281.00
94_G102_G0.8241.00
404_Y408_P0.8241.00
117_M137_L0.8211.00
20_G113_M0.8211.00
319_S370_G0.8201.00
73_R185_D0.8181.00
264_K383_G0.8171.00
291_R298_Q0.8161.00
262_L383_G0.8161.00
407_V414_F0.8161.00
410_L413_F0.8121.00
353_S357_M0.8121.00
228_Y231_I0.8111.00
290_L358_F0.8071.00
290_L294_Y0.8071.00
176_V180_Y0.8011.00
411_I415_T0.8001.00
242_G246_V0.7991.00
326_V331_L0.7991.00
336_G372_T0.7971.00
335_G368_G0.7961.00
408_P412_G0.7941.00
414_F418_D0.7941.00
433_A437_L0.7921.00
343_N441_S0.7911.00
270_L451_L0.7881.00
86_G89_L0.7871.00
246_V249_K0.7861.00
185_D188_H0.7851.00
123_L389_L0.7841.00
207_F235_V0.7821.00
343_N365_L0.7811.00
21_L144_S0.7811.00
158_C299_E0.7791.00
440_I443_I0.7781.00
201_G247_E0.7781.00
359_A363_I0.7771.00
94_G162_R0.7761.00
326_V330_M0.7751.00
208_L244_L0.7711.00
410_L415_T0.7711.00
333_I337_L0.7701.00
31_Q45_S0.7691.00
68_K391_K0.7681.00
277_I444_L0.7681.00
290_L296_I0.7661.00
40_T45_S0.7651.00
196_P251_K0.7641.00
414_F417_K0.7641.00
226_S229_V0.7621.00
9_I12_L0.7621.00
49_I284_S0.7611.00
101_A105_L0.7611.00
209_A398_F0.7581.00
211_A236_T0.7581.00
72_A119_P0.7571.00
80_L176_V0.7531.00
202_I254_F0.7521.00
34_V99_M0.7511.00
70_F75_V0.7501.00
241_I244_L0.7491.00
209_A402_F0.7461.00
44_T97_A0.7451.00
58_L210_A0.7431.00
34_V45_S0.7421.00
214_V232_G0.7401.00
120_M124_S0.7351.00
195_Q252_N0.7311.00
329_G457_A0.7291.00
118_I137_L0.7291.00
202_I206_V0.7251.00
122_V134_L0.7241.00
142_Y312_V0.7231.00
233_F236_T0.7211.00
163_W166_F0.7211.00
22_M26_A0.7201.00
271_I451_L0.7181.00
381_A393_M0.7181.00
287_Q301_L0.7151.00
404_Y409_I0.7141.00
336_G445_S0.7131.00
303_L307_T0.7131.00
135_L139_G0.7121.00
377_L396_V0.7111.00
207_F210_A0.7111.00
103_R106_Q0.7111.00
267_L455_M0.7071.00
79_S109_A0.7071.00
360_A364_M0.7071.00
311_G367_A0.7041.00
412_G415_T0.7031.00
261_L266_V0.7001.00
17_V141_F0.6991.00
408_P415_T0.6971.00
34_V38_V0.6971.00
405_M411_I0.6941.00
154_I299_E0.6921.00
157_S298_Q0.6921.00
231_I234_G0.6921.00
220_Q223_G0.6911.00
205_S254_F0.6911.00
200_A204_L0.6881.00
322_L331_L0.6881.00
440_I444_L0.6861.00
443_I450_C0.6851.00
139_G143_G0.6821.00
351_D428_D0.6821.00
12_L179_S0.6811.00
74_P77_L0.6801.00
81_P85_L0.6781.00
409_I414_F0.6761.00
225_S228_Y0.6761.00
170_T173_L0.6761.00
307_T311_G0.6751.00
30_V34_V0.6751.00
229_V232_G0.6741.00
329_G456_N0.6741.00
89_L105_L0.6721.00
119_P390_V0.6721.00
336_G340_V0.6701.00
341_F344_F0.6681.00
338_I364_M0.6671.00
16_A80_L0.6671.00
146_I309_L0.6661.00
449_V453_F0.6661.00
144_S149_T0.6641.00
72_A186_E0.6641.00
67_R119_P0.6631.00
234_G238_C0.6611.00
31_Q49_I0.6601.00
177_A180_Y0.6591.00
447_L451_L0.6581.00
84_I173_L0.6551.00
56_F401_L0.6531.00
397_Q400_R0.6531.00
200_A203_L0.6521.00
323_Y378_M0.6511.00
331_L334_I0.6511.00
286_F438_F0.6511.00
180_Y184_H0.6511.00
52_G103_R0.6501.00
265_P380_A0.6481.00
414_F440_I0.6471.00
341_F345_Q0.6461.00
64_P394_T0.6441.00
288_G292_Q0.6441.00
378_M382_M0.6431.00
404_Y415_T0.6411.00
188_H191_A0.6381.00
318_L322_L0.6381.00
327_G331_L0.6381.00
335_G342_V0.6371.00
16_A113_M0.6371.00
56_F110_T0.6351.00
269_L396_V0.6351.00
247_E250_V0.6341.00
226_S230_W0.6331.00
170_T174_I0.6321.00
235_V242_G0.6311.00
7_W125_F0.6281.00
55_A108_A0.6271.00
281_V441_S0.6261.00
339_L342_V0.6251.00
38_V96_I0.6251.00
67_R390_V0.6241.00
124_S184_H0.6211.00
323_Y375_A0.6211.00
87_S106_Q0.6211.00
349_I361_L0.6191.00
314_I317_I0.6191.00
334_I337_L0.6181.00
18_G140_G0.6181.00
154_I159_G0.6171.00
153_T302_I0.6171.00
166_F170_T0.6171.00
119_P393_M0.6161.00
306_L309_L0.6141.00
450_C453_F0.6141.00
406_G410_L0.6121.00
408_P413_F0.6121.00
174_I178_V0.6111.00
58_L202_I0.6111.00
304_L307_T0.6101.00
371_L375_A0.6081.00
121_L133_A0.6071.00
187_H190_A0.6071.00
132_Y321_L0.6061.00
323_Y327_G0.6061.00
37_T162_R0.6061.00
333_I340_V0.6051.00
63_G79_S0.6051.00
343_N347_L0.6051.00
57_A401_L0.6041.00
45_S48_P0.6041.00
286_F362_F0.6031.00
407_V410_L0.6031.00
248_Y261_L0.6021.00
411_I414_F0.6021.00
346_W349_I0.6011.00
426_V430_M0.6001.00
80_L172_S0.5961.00
282_S365_L0.5951.00
333_I336_G0.5941.00
125_F129_R0.5941.00
237_L240_L0.5931.00
197_L201_G0.5931.00
55_A109_A0.5921.00
91_A162_R0.5911.00
208_L211_A0.5911.00
23_S167_I0.5901.00
196_P200_A0.5891.00
63_G115_M0.5871.00
453_F456_N0.5861.00
141_F145_V0.5851.00
198_D246_V0.5841.00
123_L186_E0.5811.00
441_S445_S0.5801.00
148_G152_G0.5791.00
102_G105_L0.5791.00
57_A402_F0.5791.00
200_A250_V0.5791.00
34_V156_T0.5791.00
271_I336_G0.5791.00
337_L340_V0.5771.00
380_A383_G0.5761.00
239_L242_G0.5761.00
152_G156_T0.5761.00
328_P457_A0.5751.00
433_A436_D0.5741.00
218_F229_V0.5711.00
279_V369_T0.5711.00
448_L452_S0.5711.00
134_L138_I0.5681.00
366_A370_G0.5661.00
90_I93_S0.5651.00
25_T145_V0.5641.00
456_N459_G0.5621.00
271_I376_G0.5601.00
243_L255_I0.5591.00
205_S209_A0.5591.00
156_T160_H0.5591.00
88_L166_F0.5591.00
303_L306_L0.5581.00
278_T441_S0.5581.00
273_A406_G0.5581.00
13_A124_S0.5561.00
64_P116_I0.5561.00
144_S148_G0.5561.00
227_G230_W0.5541.00
277_I406_G0.5541.00
147_I150_I0.5541.00
213_A405_M0.5511.00
19_P168_F0.5511.00
267_L456_N0.5511.00
296_I355_L0.5511.00
394_T398_F0.5491.00
68_K71_G0.5491.00
196_P199_R0.5491.00
297_S301_L0.5471.00
264_K268_G0.5461.00
274_A444_L0.5461.00
266_V269_L0.5461.00
132_Y136_V0.5461.00
335_G375_A0.5451.00
149_T302_I0.5441.00
406_G412_G0.5441.00
415_T437_L0.5441.00
276_T400_R0.5441.00
208_L241_I0.5431.00
344_F439_F0.5431.00
59_L62_A0.5431.00
260_M265_P0.5431.00
35_Q41_S0.5421.00
215_S219_L0.5411.00
264_K379_G0.5411.00
223_G226_S0.5411.00
405_M414_F0.5391.00
7_W132_Y0.5381.00
427_Q430_M0.5381.00
83_F109_A0.5381.00
128_E131_N0.5371.00
405_M413_F0.5371.00
82_V108_A0.5361.00
90_I106_Q0.5361.00
264_K267_L0.5351.00
389_L393_M0.5351.00
47_N54_M0.5331.00
434_Y438_F0.5321.00
226_S231_I0.5321.00
19_P23_S0.5311.00
168_F172_S0.5311.00
53_N404_Y0.5291.00
386_L389_L0.5291.00
138_I142_Y0.5271.00
205_S243_L0.5261.00
348_H357_M0.5251.00
185_D189_G0.5251.00
64_P390_V0.5251.00
343_N445_S0.5231.00
134_L378_M0.5221.00
218_F228_Y0.5211.00
33_L291_R0.5181.00
28_S284_S0.5161.00
403_V407_V0.5161.00
36_K39_G0.5151.00
429_S433_A0.5151.00
408_P414_F0.5141.00
140_G144_S0.5131.00
219_L229_V0.5131.00
426_V429_S0.5131.00
23_S103_R0.5121.00
156_T159_G0.5121.00
156_T164_L0.5121.00
92_C98_L0.5101.00
158_C163_W0.5101.00
19_P80_L0.5101.00
219_L222_W0.5101.00
331_L371_L0.5091.00
69_K196_P0.5071.00
58_L111_G0.5071.00
26_A167_I0.5061.00
289_L293_M0.5041.00
128_E324_D0.5041.00
73_R184_H0.5041.00
381_A389_L0.5031.00
199_R202_I0.5031.00
45_S288_G0.5031.00
286_F290_L0.5031.00
204_L208_L0.5021.00
34_V37_T0.5011.00
413_F416_K0.5011.00
453_F457_A0.5011.00
410_L417_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wdoA 1 0.8552 100 0.42 Contact Map
4pypA 1 0.816 100 0.422 Contact Map
1pw4A 1 0.8004 100 0.439 Contact Map
4j05A 3 0.7476 100 0.448 Contact Map
4zw9A 1 0.8532 100 0.461 Contact Map
4ldsA 2 0.8043 100 0.478 Contact Map
4gc0A 1 0.8513 100 0.478 Contact Map
2gfpA 2 0.7339 100 0.48 Contact Map
4tphA 2 0.8317 100 0.483 Contact Map
3o7qA 1 0.7495 100 0.492 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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