GREMLIN Database
LYTG - Exo-glucosaminidase LytG
UniProt: O32083 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 282 (230)
Sequences: 375 (298)
Seq/√Len: 19.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
167_A186_S5.7701.00
178_D184_K4.6971.00
62_L140_A3.7371.00
226_S241_V3.4301.00
193_D196_E3.4061.00
74_I197_Y3.2931.00
48_Q83_W3.1660.99
114_V179_P3.0760.99
79_L184_K2.7750.99
112_D121_T2.7660.99
102_Y106_H2.4880.97
93_N128_K2.4180.97
164_K190_E2.2650.95
249_S257_V2.2130.94
169_A174_G2.1920.94
72_I167_A2.1530.93
48_Q78_I2.1070.93
237_A252_Q2.1040.93
226_S232_I2.0170.91
234_L245_I1.9680.90
62_L136_M1.9390.89
102_Y130_S1.9310.89
115_E120_K1.8820.87
187_A191_K1.8750.87
144_V158_L1.8660.87
237_A248_V1.8650.87
69_L73_T1.8280.86
234_L254_G1.8010.85
226_S237_A1.7490.83
127_R138_D1.6950.81
114_V118_K1.6450.79
95_L132_F1.6350.79
87_E109_M1.6290.78
72_I186_S1.6160.78
115_E118_K1.5910.77
234_L249_S1.5900.77
77_A136_M1.5870.77
172_T182_A1.5700.76
231_S252_Q1.5610.75
231_S237_A1.5540.75
243_K247_V1.5500.75
254_G259_Y1.5420.74
112_D119_R1.5100.73
63_Y69_L1.5010.72
228_D237_A1.4760.71
232_I252_Q1.4750.71
228_D232_I1.4640.70
60_Q200_V1.4610.70
131_T134_E1.4380.69
139_H179_P1.4350.69
74_I173_S1.4290.69
69_L158_L1.4220.68
72_I163_Y1.4040.67
55_L136_M1.4030.67
100_G130_S1.3840.66
249_S256_S1.3810.66
99_K126_F1.3730.65
162_N174_G1.3300.63
63_Y73_T1.3230.62
228_D262_Q1.3230.62
83_W188_I1.3200.62
153_K174_G1.2960.61
87_E91_K1.2670.59
79_L188_I1.2630.59
126_F177_T1.2570.58
89_A93_N1.2470.58
160_A165_E1.2460.58
142_L153_K1.2320.57
114_V119_R1.2280.56
130_S134_E1.2270.56
51_F124_A1.2230.56
92_A167_A1.2070.55
47_E85_N1.1980.55
244_D259_Y1.1940.54
114_V122_I1.1930.54
102_Y105_H1.1910.54
79_L178_D1.1900.54
129_Y138_D1.1890.54
233_R239_S1.1870.54
122_I125_K1.1840.54
88_L126_F1.1830.54
78_I83_W1.1660.53
180_D212_S1.1660.53
100_G105_H1.1580.52
35_P38_I1.1520.52
72_I170_L1.1470.51
139_H143_F1.1400.51
136_M140_A1.1390.51
33_S39_S1.1380.51
55_L74_I1.1370.51
259_Y262_Q1.1240.50
259_Y263_I1.1210.50
99_K177_T1.1180.49
73_T157_V1.1150.49
88_L99_K1.1100.49
232_I240_Y1.1010.48
162_N165_E1.1000.48
226_S231_S1.1000.48
180_D184_K1.0770.47
234_L243_K1.0740.47
83_W109_M1.0680.46
107_V128_K1.0590.46
73_T139_H1.0530.45
228_D263_I1.0500.45
120_K179_P1.0430.45
136_M139_H1.0410.45
228_D231_S1.0350.44
108_T125_K1.0310.44
135_S175_Y1.0300.44
51_F83_W1.0190.43
156_P159_E1.0130.43
157_V174_G1.0060.42
102_Y107_V1.0060.42
111_T124_A1.0030.42
100_G103_K0.9960.42
92_A186_S0.9950.42
254_G262_Q0.9950.42
105_H128_K0.9820.41
130_S145_R0.9660.40
88_L177_T0.9610.40
67_H160_A0.9600.39
228_D248_V0.9450.39
73_T174_G0.9430.38
233_R241_V0.9420.38
127_R154_Y0.9400.38
129_Y166_A0.9380.38
248_V252_Q0.9350.38
219_Q224_K0.9330.38
56_S188_I0.9280.38
75_A176_A0.9280.38
180_D183_D0.9220.37
134_E179_P0.9220.37
29_A33_S0.9200.37
139_H158_L0.9200.37
156_P173_S0.9170.37
206_S210_N0.9130.37
114_V121_T0.9130.37
220_D223_S0.9120.37
55_L132_F0.9070.36
208_D225_P0.9060.36
95_L166_A0.9030.36
68_V166_A0.9020.36
232_I237_A0.8980.36
254_G263_I0.8950.36
42_T45_I0.8940.35
103_K239_S0.8920.35
231_S248_V0.8910.35
29_A32_L0.8910.35
33_S36_I0.8820.35
70_P184_K0.8780.35
153_K157_V0.8780.35
119_R139_H0.8760.34
98_V138_D0.8700.34
139_H157_V0.8680.34
118_K139_H0.8670.34
234_L263_I0.8640.34
180_D253_K0.8610.34
69_L157_V0.8610.34
30_T34_K0.8570.33
53_D57_G0.8560.33
61_I133_F0.8510.33
139_H169_A0.8430.33
163_Y190_E0.8410.32
34_K39_S0.8380.32
221_V259_Y0.8340.32
209_L216_S0.8330.32
68_V173_S0.8320.32
232_I259_Y0.8270.32
135_S138_D0.8220.31
157_V173_S0.8210.31
69_L166_A0.8210.31
162_N167_A0.8170.31
52_I192_Y0.8160.31
205_K208_D0.8120.31
49_Q53_D0.8120.31
160_A170_L0.8110.31
168_T186_S0.8110.31
232_I262_Q0.8080.31
54_S131_T0.8080.31
252_Q263_I0.8070.31
51_F55_L0.8070.31
72_I138_D0.8060.30
104_G107_V0.8050.30
162_N172_T0.8030.30
207_V216_S0.8000.30
82_D143_F0.7960.30
71_S198_D0.7940.30
67_H159_E0.7900.30
160_A172_T0.7890.30
59_A74_I0.7850.29
33_S37_E0.7840.29
100_G106_H0.7840.29
55_L95_L0.7780.29
254_G261_F0.7680.28
56_S178_D0.7620.28
32_L36_I0.7610.28
69_L139_H0.7590.28
157_V169_A0.7560.28
211_A218_V0.7550.28
233_R245_I0.7520.28
29_A34_K0.7510.28
159_E170_L0.7460.27
83_W89_A0.7450.27
249_S258_W0.7330.27
246_K249_S0.7320.27
131_T200_V0.7300.27
73_T158_L0.7290.26
212_S218_V0.7280.26
129_Y185_I0.7220.26
252_Q262_Q0.7210.26
113_E166_A0.7180.26
222_W253_K0.7120.26
118_K179_P0.7100.26
114_V139_H0.7090.25
73_T173_S0.7080.25
82_D169_A0.7080.25
138_D163_Y0.7080.25
228_D233_R0.7080.25
232_I257_V0.7070.25
102_Y134_E0.7070.25
86_S111_T0.7040.25
196_E200_V0.7000.25
34_K38_I0.6970.25
69_L162_N0.6950.25
69_L113_E0.6910.25
234_L261_F0.6900.25
232_I248_V0.6880.24
232_I241_V0.6880.24
127_R190_E0.6870.24
228_D241_V0.6860.24
63_Y68_V0.6830.24
100_G166_A0.6780.24
134_E196_E0.6770.24
233_R261_F0.6710.24
73_T162_N0.6690.24
228_D252_Q0.6660.23
73_T140_A0.6640.23
184_K188_I0.6620.23
69_L132_F0.6610.23
45_I193_D0.6600.23
226_S244_D0.6600.23
228_D254_G0.6590.23
63_Y173_S0.6580.23
232_I263_I0.6520.23
68_V174_G0.6510.23
207_V212_S0.6500.23
70_P197_Y0.6440.22
246_K250_K0.6430.22
36_I39_S0.6400.22
245_I261_F0.6380.22
100_G113_E0.6360.22
232_I254_G0.6320.22
236_S246_K0.6300.22
69_L95_L0.6280.22
187_A218_V0.6270.22
130_S193_D0.6260.22
68_V157_V0.6250.22
61_I89_A0.6240.22
88_L175_Y0.6220.21
221_V225_P0.6220.21
95_L113_E0.6200.21
53_D56_S0.6190.21
53_D229_D0.6160.21
74_I77_A0.6160.21
143_F154_Y0.6150.21
52_I70_P0.6120.21
98_V142_L0.6080.21
211_A222_W0.6080.21
160_A174_G0.6080.21
70_P74_I0.6070.21
243_K252_Q0.6070.21
114_V180_D0.6040.21
142_L157_V0.5980.20
258_W263_I0.5960.20
72_I173_S0.5940.20
63_Y143_F0.5930.20
51_F166_A0.5910.20
143_F157_V0.5910.20
118_K172_T0.5900.20
51_F113_E0.5890.20
249_S254_G0.5880.20
47_E161_G0.5870.20
69_L174_G0.5860.20
143_F158_L0.5840.20
137_D141_Q0.5830.20
243_K251_K0.5830.20
237_A262_Q0.5810.20
243_K248_V0.5800.20
206_S209_L0.5800.20
145_R233_R0.5780.20
72_I100_G0.5760.20
113_E126_F0.5720.19
75_A185_I0.5710.19
108_T124_A0.5700.19
72_I101_N0.5690.19
244_D262_Q0.5680.19
232_I244_D0.5670.19
237_A244_D0.5670.19
51_F95_L0.5660.19
217_A244_D0.5650.19
60_Q86_S0.5650.19
69_L136_M0.5640.19
226_S254_G0.5600.19
193_D223_S0.5590.19
212_S215_D0.5580.19
155_K218_V0.5570.19
215_D224_K0.5560.19
92_A132_F0.5490.18
231_S263_I0.5460.18
126_F175_Y0.5430.18
126_F176_A0.5420.18
252_Q259_Y0.5410.18
178_D188_I0.5410.18
95_L136_M0.5410.18
207_V213_I0.5400.18
229_D246_K0.5400.18
61_I131_T0.5400.18
103_K106_H0.5380.18
63_Y70_P0.5380.18
140_A184_K0.5350.18
216_S220_D0.5310.18
217_A223_S0.5310.18
128_K245_I0.5270.18
101_N111_T0.5260.18
63_Y136_M0.5230.17
78_I139_H0.5220.17
233_R252_Q0.5200.17
100_G104_G0.5200.17
68_V73_T0.5200.17
136_M166_A0.5200.17
68_V127_R0.5190.17
81_S93_N0.5190.17
114_V120_K0.5160.17
59_A95_L0.5150.17
234_L244_D0.5150.17
247_V257_V0.5120.17
254_G257_V0.5110.17
60_Q64_E0.5080.17
212_S238_Q0.5050.17
51_F125_K0.5050.17
218_V221_V0.5040.17
231_S259_Y0.5030.17
54_S61_I0.5030.17
50_V243_K0.5000.17
52_I120_K0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fi7A 4 0.6135 100 0.47 Contact Map
2zycA 1 0.5319 100 0.498 Contact Map
4qdnA 2 0.4113 100 0.561 Contact Map
4kt3A 1 0.4858 100 0.591 Contact Map
4q2wA 1 0.5532 100 0.652 Contact Map
2l9yA 1 0.422 99 0.872 Contact Map
2djpA 1 0.2624 98.2 0.903 Contact Map
2mkxA 1 0.1809 98 0.906 Contact Map
4xcmA 2 0.2092 97.8 0.911 Contact Map
2mpwA 1 0.2943 97.8 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0082 seconds.