GREMLIN Database
KTRB - Ktr system potassium uptake protein B
UniProt: O32081 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 445 (403)
Sequences: 5191 (3939)
Seq/√Len: 196.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
365_G412_I4.4051.00
305_A311_A4.3021.00
49_D406_K3.5191.00
145_A166_L3.4181.00
199_T270_Y3.4001.00
48_I407_C3.2271.00
148_L198_I3.2171.00
368_A408_I3.1111.00
144_A201_L2.9441.00
85_Q141_E2.9191.00
151_R191_D2.7531.00
183_D187_S2.5931.00
285_D288_S2.5731.00
306_G316_L2.5241.00
181_W187_S2.4981.00
372_T405_G2.4921.00
376_P379_Q2.4121.00
147_I197_V2.4101.00
369_L405_G2.3891.00
151_R193_T2.3811.00
84_I171_S2.3811.00
261_H264_D2.3321.00
81_M167_F2.3251.00
51_L410_I2.3141.00
366_I381_V2.2711.00
32_A47_W2.2681.00
149_S162_L2.2191.00
372_T404_A2.2061.00
276_P297_T2.1411.00
74_V78_T2.1401.00
77_Q163_F2.1351.00
48_I410_I2.1081.00
151_R197_V2.0971.00
55_A410_I2.0421.00
168_H179_S2.0201.00
145_A162_L2.0171.00
195_N268_A2.0111.00
227_H231_M1.9981.00
171_S281_F1.9901.00
195_N267_W1.9811.00
75_F79_V1.9491.00
199_T274_V1.9371.00
386_S398_T1.8871.00
206_G277_R1.8771.00
48_I403_T1.8661.00
365_G408_I1.8561.00
151_R194_V1.8551.00
322_I355_S1.8311.00
185_L198_I1.8141.00
193_T197_V1.8091.00
247_F251_Y1.7991.00
36_M47_W1.7821.00
46_S49_D1.7821.00
147_I193_T1.7741.00
67_D70_T1.7701.00
173_F205_G1.7651.00
149_S165_S1.7531.00
362_V385_F1.7521.00
368_A404_A1.7461.00
263_V267_W1.7441.00
64_A68_T1.7221.00
45_L71_Q1.7101.00
45_L66_V1.6991.00
298_L385_F1.6991.00
192_P267_W1.6851.00
196_L200_F1.6851.00
203_I274_V1.6831.00
195_N283_S1.6421.00
68_T71_Q1.6221.00
181_W188_Y1.6171.00
321_V343_I1.6161.00
245_T296_F1.6021.00
362_V388_F1.5911.00
386_S391_V1.5801.00
196_L267_W1.5561.00
366_I384_T1.5451.00
327_I331_R1.5441.00
225_S231_M1.5351.00
145_A169_A1.5341.00
229_K233_T1.5241.00
314_I319_F1.5221.00
372_T402_T1.5131.00
278_T391_V1.5111.00
379_Q395_M1.5081.00
131_K135_L1.4771.00
189_V268_A1.4551.00
202_F275_T1.4481.00
56_S178_F1.4461.00
167_F180_L1.4421.00
202_F279_A1.4391.00
273_A276_P1.4261.00
63_L398_T1.4241.00
200_F204_T1.4241.00
40_S75_F1.4181.00
36_M40_S1.4161.00
196_L263_V1.4161.00
358_S388_F1.4151.00
225_S229_K1.4151.00
53_T65_V1.4071.00
148_L194_V1.4061.00
246_V293_T1.4041.00
303_I316_L1.4021.00
375_A397_L1.3881.00
55_A414_F1.3801.00
77_Q81_M1.3781.00
84_I176_A1.3781.00
172_A198_I1.3751.00
147_I151_R1.3681.00
234_G320_I1.3651.00
21_A414_F1.3641.00
232_L236_L1.3421.00
286_F297_T1.3381.00
47_W51_L1.3361.00
51_L407_C1.3331.00
407_C411_V1.3281.00
164_A181_W1.3251.00
407_C410_I1.3191.00
45_L72_F1.3171.00
48_I406_K1.3171.00
69_G182_P1.3151.00
160_S194_V1.3131.00
239_N274_V1.3081.00
196_L270_Y1.3041.00
242_A273_A1.3041.00
160_S164_A1.3011.00
299_L303_I1.2961.00
179_S182_P1.2951.00
172_A281_F1.2921.00
206_G233_T1.2871.00
42_T73_T1.2841.00
162_L166_L1.2791.00
127_I131_K1.2661.00
298_L381_V1.2471.00
365_G384_T1.2471.00
196_L266_L1.2461.00
149_S161_G1.2431.00
294_I395_M1.2411.00
375_A380_I1.2401.00
32_A51_L1.2291.00
214_D225_S1.2271.00
272_Q283_S1.2261.00
168_H180_L1.2251.00
246_V297_T1.2111.00
74_V163_F1.2111.00
72_F80_I1.2111.00
54_A83_L1.1971.00
235_T239_N1.1951.00
57_A178_F1.1921.00
32_A55_A1.1911.00
321_V348_I1.1831.00
251_Y265_K1.1821.00
192_P195_N1.1781.00
237_M241_I1.1771.00
228_T231_M1.1731.00
144_A169_A1.1701.00
186_M282_N1.1641.00
68_T182_P1.1631.00
401_L409_I1.1621.00
140_I204_T1.1591.00
195_N199_T1.1591.00
81_M163_F1.1591.00
226_L229_K1.1551.00
49_D65_V1.1501.00
51_L55_A1.1471.00
189_V192_P1.1431.00
262_I266_L1.1431.00
411_V415_I1.1411.00
303_I319_F1.1401.00
183_D186_M1.1331.00
268_A272_Q1.1301.00
384_T412_I1.1291.00
290_R293_T1.1281.00
335_E342_S1.1211.00
264_D268_A1.1191.00
35_L54_A1.1191.00
39_I83_L1.1161.00
366_I380_I1.1141.00
369_L409_I1.1131.00
286_F289_M1.1111.00
39_I75_F1.1091.00
32_A36_M1.1091.00
189_V195_N1.1051.00
325_S352_L1.1011.00
355_S359_L1.0961.00
140_I212_L1.0921.00
245_T248_I1.0921.00
362_V366_I1.0851.00
46_S403_T1.0851.00
186_M285_D1.0791.00
298_L382_F1.0721.00
81_M166_L1.0711.00
302_F362_V1.0601.00
144_A198_I1.0601.00
241_I245_T1.0581.00
268_A284_L1.0571.00
260_L268_A1.0571.00
78_T82_G1.0541.00
172_A201_L1.0521.00
22_I26_L1.0481.00
307_S317_T1.0471.00
27_T58_T1.0391.00
135_L139_S1.0291.00
66_V72_F1.0291.00
345_Y349_I1.0271.00
202_F274_V1.0261.00
65_V68_T1.0241.00
196_L199_T1.0231.00
141_E169_A1.0201.00
401_L405_G1.0151.00
370_T380_I1.0061.00
144_A197_V1.0031.00
74_V77_Q1.0031.00
81_M170_I1.0001.00
203_I234_G1.0001.00
42_T77_Q0.9971.00
321_V351_A0.9961.00
368_A372_T0.9951.00
161_G165_S0.9951.00
286_F395_M0.9921.00
294_I379_Q0.9891.00
402_T405_G0.9861.00
253_N258_G0.9851.00
146_L150_I0.9820.99
369_L384_T0.9800.99
240_A300_L0.9750.99
192_P263_V0.9700.99
192_P196_L0.9670.99
168_H181_W0.9640.99
203_I239_N0.9640.99
361_I415_I0.9620.99
53_T68_T0.9620.99
148_L197_V0.9500.99
387_A409_I0.9500.99
228_T232_L0.9480.99
296_F367_F0.9450.99
243_M266_L0.9410.99
248_I252_S0.9390.99
247_F265_K0.9380.99
404_A408_I0.9370.99
236_L240_A0.9330.99
292_G367_F0.9300.99
383_E394_T0.9290.99
148_L172_A0.9280.99
240_A243_M0.9270.99
31_G83_L0.9260.99
217_K220_R0.9230.99
78_T163_F0.9160.99
226_L231_M0.9120.99
144_A148_L0.9100.99
67_D182_P0.9100.99
323_L327_I0.9100.99
179_S184_N0.9080.99
248_I251_Y0.9060.99
89_L134_F0.9060.99
386_S394_T0.9020.99
242_A245_T0.9020.99
366_I377_F0.9010.99
287_G294_I0.9000.99
238_L242_A0.8990.99
397_L400_E0.8980.99
361_I412_I0.8930.99
384_T409_I0.8910.99
25_F414_F0.8870.99
144_A172_A0.8840.99
329_Y349_I0.8830.99
140_I173_F0.8820.99
233_T339_F0.8800.99
185_L194_V0.8790.99
23_G91_F0.8780.99
247_F269_S0.8780.99
150_I193_T0.8770.99
176_A278_T0.8710.99
53_T80_I0.8710.99
40_S47_W0.8700.99
302_F358_S0.8700.99
268_A283_S0.8680.99
204_T212_L0.8650.99
180_L188_Y0.8620.99
301_M391_V0.8600.99
57_A80_I0.8590.99
81_M84_I0.8530.99
148_L185_L0.8440.98
227_H233_T0.8440.98
405_G409_I0.8400.98
232_L320_I0.8400.98
55_A423_F0.8380.98
142_L146_L0.8320.98
189_V260_L0.8310.98
383_E398_T0.8300.98
239_N243_M0.8290.98
40_S73_T0.8290.98
276_P393_L0.8280.98
220_R223_T0.8270.98
26_L30_I0.8270.98
68_T72_F0.8270.98
229_K339_F0.8240.98
161_G164_A0.8220.98
324_T338_I0.8200.98
191_D194_V0.8180.98
324_T336_T0.8180.98
369_L380_I0.8180.98
287_G395_M0.8150.98
243_M273_A0.8130.98
307_S316_L0.8130.98
388_F412_I0.8110.98
44_P73_T0.8100.98
199_T243_M0.8090.98
185_L188_Y0.8050.98
84_I174_N0.8040.98
37_L75_F0.8040.98
291_E378_L0.8020.98
191_D195_N0.8010.98
203_I235_T0.8000.98
370_T377_F0.7950.98
145_A149_S0.7930.98
273_A300_L0.7930.98
230_L233_T0.7900.98
111_R125_G0.7880.98
136_F140_I0.7870.98
125_G128_G0.7860.98
242_A248_I0.7830.97
81_M171_S0.7820.97
263_V266_L0.7770.97
28_I58_T0.7770.97
68_T80_I0.7760.97
211_V227_H0.7750.97
247_F293_T0.7740.97
132_V213_F0.7660.97
146_L149_S0.7630.97
199_T203_I0.7630.97
58_T83_L0.7620.97
326_V357_T0.7610.97
247_F250_E0.7610.97
37_L41_T0.7600.97
326_V353_A0.7600.97
301_M386_S0.7590.97
245_T249_L0.7570.97
206_G305_A0.7570.97
239_N242_A0.7560.97
272_Q297_T0.7560.97
259_H265_K0.7540.97
212_L224_F0.7510.97
229_K232_L0.7490.97
28_I55_A0.7480.97
33_V51_L0.7480.97
357_T421_L0.7450.97
325_S348_I0.7450.97
207_I230_L0.7450.97
284_L289_M0.7450.97
243_M247_F0.7440.97
164_A168_H0.7410.97
272_Q286_F0.7390.96
230_L324_T0.7380.96
247_F262_I0.7340.96
47_W407_C0.7310.96
234_G316_L0.7310.96
328_A336_T0.7300.96
175_N277_R0.7280.96
73_T76_G0.7240.96
41_T45_L0.7230.96
382_F393_L0.7230.96
128_G131_K0.7230.96
33_V36_M0.7180.96
53_T64_A0.7160.96
162_L165_S0.7160.96
262_I265_K0.7160.96
298_L378_L0.7160.96
260_L265_K0.7130.96
94_F134_F0.7100.96
203_I237_M0.7080.95
70_T182_P0.7080.95
378_L395_M0.7070.95
167_F171_S0.7050.95
66_V69_G0.7050.95
25_F423_F0.7040.95
289_M293_T0.7030.95
139_S143_I0.7010.95
48_I409_I0.7010.95
41_T71_Q0.7010.95
270_Y274_V0.7000.95
322_I352_L0.6970.95
230_L320_I0.6950.95
241_I270_Y0.6920.95
322_I326_V0.6890.95
400_E403_T0.6870.95
295_V377_F0.6870.95
385_F389_G0.6860.95
45_L65_V0.6860.95
366_I370_T0.6840.95
207_I212_L0.6830.95
150_I165_S0.6820.94
175_N205_G0.6820.94
372_T408_I0.6810.94
175_N279_A0.6810.94
214_D228_T0.6790.94
292_G371_I0.6790.94
234_G238_L0.6780.94
236_L303_I0.6770.94
136_F212_L0.6770.94
358_S389_G0.6760.94
168_H198_I0.6750.94
64_A80_I0.6750.94
369_L372_T0.6730.94
233_T237_M0.6730.94
244_L247_F0.6730.94
66_V71_Q0.6710.94
144_A147_I0.6710.94
299_L363_F0.6710.94
328_A345_Y0.6700.94
212_L216_M0.6660.94
70_T181_W0.6630.94
186_M283_S0.6610.94
41_T44_P0.6600.93
272_Q275_T0.6600.93
382_F394_T0.6600.93
266_L270_Y0.6590.93
186_M189_V0.6590.93
420_P424_V0.6590.93
111_R127_I0.6570.93
195_N272_Q0.6560.93
159_S163_F0.6560.93
175_N310_T0.6560.93
260_L264_D0.6540.93
84_I281_F0.6530.93
20_L23_G0.6530.93
233_T236_L0.6470.93
227_H230_L0.6460.93
141_E145_A0.6440.93
249_L371_I0.6440.93
29_I32_A0.6440.93
369_L408_I0.6430.93
106_I127_I0.6420.93
210_T308_A0.6420.93
314_I355_S0.6410.92
415_I423_F0.6410.92
137_S174_N0.6410.92
282_N285_D0.6400.92
276_P300_L0.6400.92
42_T76_G0.6390.92
63_L387_A0.6380.92
276_P286_F0.6360.92
322_I356_V0.6340.92
84_I170_I0.6340.92
295_V366_I0.6340.92
32_A54_A0.6330.92
310_T315_K0.6330.92
366_I385_F0.6320.92
161_G188_Y0.6310.92
403_T406_K0.6290.92
377_F380_I0.6270.92
238_L241_I0.6260.92
246_V249_L0.6240.91
221_F224_F0.6240.91
85_Q137_S0.6230.91
63_L386_S0.6210.91
163_F167_F0.6200.91
232_L316_L0.6150.91
362_V384_T0.6150.91
324_T327_I0.6120.91
231_M306_G0.6100.90
295_V299_L0.6090.90
282_N393_L0.6090.90
169_A201_L0.6090.90
63_L394_T0.6090.90
139_S142_L0.6080.90
406_K410_I0.6070.90
40_S50_A0.6060.90
217_K221_F0.6040.90
67_D399_P0.6030.90
224_F228_T0.6030.90
222_K225_S0.6010.90
225_S233_T0.6010.90
228_T339_F0.6000.90
64_A171_S0.6000.90
193_T196_L0.5960.89
360_F364_L0.5950.89
69_G77_Q0.5940.89
231_M234_G0.5930.89
298_L302_F0.5930.89
375_A401_L0.5920.89
185_L195_N0.5910.89
36_M44_P0.5900.89
164_A180_L0.5900.89
226_L230_L0.5890.89
225_S228_T0.5890.89
330_L428_A0.5870.89
134_F138_I0.5870.89
227_H339_F0.5860.89
362_V381_V0.5830.88
142_L145_A0.5790.88
71_Q182_P0.5790.88
151_R188_Y0.5790.88
50_A54_A0.5780.88
393_L398_T0.5780.88
66_V80_I0.5770.88
111_R114_V0.5750.88
184_N391_V0.5740.88
388_F420_P0.5740.88
266_L269_S0.5720.87
179_S183_D0.5710.87
361_I388_F0.5700.87
272_Q289_M0.5690.87
334_K432_Q0.5690.87
63_L393_L0.5680.87
168_H281_F0.5660.87
380_I397_L0.5660.87
369_L375_A0.5640.87
273_A297_T0.5640.87
398_T401_L0.5630.87
25_F29_I0.5610.86
221_F225_S0.5600.86
49_D399_P0.5600.86
240_A273_A0.5600.86
59_T312_S0.5600.86
381_V385_F0.5590.86
275_T286_F0.5590.86
137_S141_E0.5590.86
271_F281_F0.5560.86
301_M389_G0.5550.86
305_A316_L0.5540.86
141_E170_I0.5530.86
230_L234_G0.5520.86
275_T393_L0.5510.85
361_I365_G0.5480.85
129_L309_S0.5480.85
65_V406_K0.5480.85
246_V250_E0.5480.85
39_I76_G0.5470.85
227_H232_L0.5460.85
298_L395_M0.5460.85
243_M270_Y0.5460.85
326_V356_V0.5440.85
382_F386_S0.5440.85
182_P397_L0.5430.85
185_L271_F0.5420.85
278_T312_S0.5420.85
383_E386_S0.5390.84
394_T398_T0.5390.84
282_N286_F0.5380.84
141_E173_F0.5370.84
29_I238_L0.5370.84
202_F273_A0.5370.84
60_V278_T0.5370.84
184_N188_Y0.5360.84
369_L383_E0.5350.84
383_E393_L0.5350.84
241_I244_L0.5340.84
78_T81_M0.5340.84
239_N270_Y0.5340.84
71_Q74_V0.5340.84
64_A282_N0.5330.84
383_E409_I0.5330.84
46_S50_A0.5320.83
337_V342_S0.5290.83
329_Y353_A0.5280.83
17_P425_F0.5270.83
224_F230_L0.5260.83
292_G370_T0.5260.83
56_S62_G0.5260.83
210_T214_D0.5250.83
379_Q401_L0.5250.83
166_L169_A0.5240.83
93_T97_L0.5230.82
400_E404_A0.5230.82
203_I238_L0.5230.82
170_I174_N0.5230.82
206_G279_A0.5220.82
140_I205_G0.5220.82
356_V360_F0.5210.82
245_T269_S0.5210.82
63_L383_E0.5210.82
57_A83_L0.5200.82
45_L50_A0.5200.82
56_S61_T0.5200.82
64_A69_G0.5190.82
82_G170_I0.5190.82
375_A379_Q0.5180.82
236_L316_L0.5180.82
148_L281_F0.5180.82
243_M269_S0.5160.82
228_T233_T0.5160.82
380_I384_T0.5150.81
195_N271_F0.5120.81
198_I281_F0.5120.81
291_E294_I0.5110.81
75_F78_T0.5080.81
185_L283_S0.5070.80
345_Y348_I0.5060.80
61_T390_T0.5060.80
16_P19_V0.5060.80
45_L49_D0.5060.80
228_T320_I0.5060.80
60_V175_N0.5050.80
369_L387_A0.5040.80
358_S362_V0.5040.80
184_N283_S0.5040.80
139_S200_F0.5040.80
133_L417_R0.5030.80
211_V231_M0.5030.80
383_E387_A0.5030.80
143_I147_I0.5010.80
89_L133_L0.5010.80
50_A72_F0.5000.80
219_R222_K0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j7cI 2 0.964 100 0.147 Contact Map
3pjzA 2 0.9034 100 0.197 Contact Map
3ukmA 2 0.4944 96.3 0.939 Contact Map
4bw5A 2 0.5079 95.6 0.943 Contact Map
4twkA 2 0.4539 94.7 0.946 Contact Map
4wfeA 2 0.4315 92.2 0.951 Contact Map
1lnqA 6 0.1933 91.7 0.951 Contact Map
2k1eA 3 0.2157 91 0.952 Contact Map
2ih3C 4 0.2022 86.9 0.956 Contact Map
3effK 4 0.2225 84.9 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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