GREMLIN Database
KTRA - Ktr system potassium uptake protein A
UniProt: O32080 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 222 (206)
Sequences: 8697 (6136)
Seq/√Len: 427.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_A62_E3.8041.00
185_H203_D3.5471.00
158_A199_I3.4071.00
74_V92_L3.2471.00
12_I57_A3.2211.00
10_A71_F3.2171.00
183_I197_D2.8551.00
39_E54_I2.6761.00
185_H200_R2.6671.00
57_A88_T2.6241.00
168_I196_E2.6091.00
89_T118_A2.4771.00
11_V22_C2.4331.00
166_S169_D2.3131.00
210_H213_D2.2021.00
64_L69_R2.1771.00
8_Q31_E2.0811.00
42_V52_A2.0551.00
185_H197_D2.0041.00
165_K169_D1.9501.00
67_G70_N1.9171.00
166_S198_I1.9121.00
110_H123_H1.8951.00
167_I180_I1.8871.00
10_A74_V1.8841.00
12_I74_V1.8661.00
89_T102_V1.8591.00
39_E43_N1.8581.00
15_G18_G1.8521.00
93_K100_I1.8491.00
74_V88_T1.8011.00
36_D42_V1.7661.00
10_A68_I1.7541.00
164_S200_R1.7531.00
93_K119_D1.7251.00
94_E115_K1.7171.00
177_G213_D1.7091.00
163_D201_E1.6991.00
22_C49_A1.6401.00
14_L34_A1.6361.00
36_D52_A1.5421.00
41_K44_A1.5361.00
9_F73_Y1.4901.00
171_N174_A1.4891.00
81_N84_A1.4831.00
60_E64_L1.4721.00
99_N119_D1.4671.00
162_L170_L1.4531.00
164_S201_E1.4521.00
64_L95_L1.4371.00
168_I195_P1.4341.00
89_T100_I1.4311.00
66_L71_F1.4301.00
19_G45_Y1.4291.00
55_A66_L1.4091.00
53_V66_L1.3801.00
194_A197_D1.3751.00
12_I88_T1.3731.00
14_L45_Y1.3631.00
160_R201_E1.3551.00
182_A189_I1.3311.00
34_A49_A1.3311.00
61_N64_L1.3051.00
180_I207_I1.3021.00
15_G103_K1.2911.00
155_E206_V1.2731.00
155_E204_C1.2691.00
38_N41_K1.2601.00
199_I205_L1.2241.00
173_R179_T1.2121.00
44_A48_Y1.1871.00
23_K48_Y1.1691.00
82_I85_S1.1601.00
129_G133_A1.1441.00
18_G78_I1.1421.00
157_L204_C1.1421.00
33_L71_F1.1401.00
21_I76_V1.1351.00
200_R203_D1.1141.00
110_H114_E1.1081.00
14_L42_V1.1071.00
209_G214_I1.1061.00
183_I203_D1.0981.00
157_L202_Q1.0971.00
213_D216_R1.0941.00
102_V118_A1.0901.00
185_H188_D1.0851.00
53_V62_E1.0831.00
178_C209_G1.0681.00
21_I129_G1.0661.00
60_E91_L1.0591.00
21_I78_I1.0591.00
99_N120_R1.0581.00
158_A163_D1.0571.00
68_I96_D1.0561.00
62_E66_L1.0491.00
84_A88_T1.0411.00
35_V66_L1.0341.00
12_I35_V1.0321.00
22_C34_A1.0121.00
45_Y49_A1.0091.00
35_V62_E0.9921.00
193_P197_D0.9891.00
163_D200_R0.9821.00
61_N65_S0.9811.00
100_I119_D0.9801.00
79_G84_A0.9701.00
14_L36_D0.9651.00
35_V55_A0.9631.00
49_A52_A0.9541.00
15_G36_D0.9541.00
152_S211_K0.9521.00
154_V158_A0.9511.00
127_D131_K0.9481.00
17_F103_K0.9431.00
10_A66_L0.9401.00
168_I194_A0.9261.00
209_G213_D0.9251.00
151_Y208_M0.9151.00
107_Y126_K0.9121.00
93_K117_G0.9121.00
45_Y48_Y0.9101.00
18_G36_D0.8981.00
26_H50_T0.8811.00
40_E43_N0.8781.00
8_Q71_F0.8771.00
79_G85_S0.8751.00
82_I109_H0.8741.00
20_S23_K0.8701.00
74_V97_I0.8691.00
11_V18_G0.8671.00
45_Y52_A0.8661.00
9_F30_H0.8651.00
8_Q72_E0.8631.00
30_H72_E0.8561.00
77_A85_S0.8541.00
156_L207_I0.8481.00
14_L19_G0.8481.00
184_K204_C0.8441.00
170_L199_I0.8431.00
164_S198_I0.8381.00
73_Y101_W0.8341.00
110_H126_K0.8301.00
179_T195_P0.8301.00
40_E44_A0.8231.00
159_T201_E0.8211.00
15_G57_A0.8201.00
33_L66_L0.8151.00
11_V32_V0.8141.00
60_E95_L0.8051.00
182_A206_V0.8041.00
79_G88_T0.8001.00
18_G22_C0.8001.00
30_H137_S0.7951.00
68_I95_L0.7911.00
63_L95_L0.7901.00
43_N47_S0.7871.00
76_V92_L0.7741.00
36_D41_K0.7701.00
166_S196_E0.7691.00
19_G23_K0.7671.00
83_Q87_L0.7661.00
186_H200_R0.7661.00
18_G103_K0.7641.00
165_K170_L0.7631.00
184_K189_I0.7631.00
8_Q33_L0.7631.00
68_I71_F0.7591.00
73_Y99_N0.7571.00
172_V178_C0.7571.00
114_E120_R0.7521.00
169_D198_I0.7501.00
11_V34_A0.7481.00
26_H32_V0.7421.00
63_L66_L0.7331.00
77_A89_T0.7281.00
172_V180_I0.7271.00
36_D54_I0.7241.00
104_A113_L0.7231.00
92_L96_D0.7231.00
131_K135_S0.7201.00
162_L217_F0.7191.00
167_I193_P0.7181.00
8_Q70_N0.7151.00
25_L32_V0.7111.00
126_K130_V0.7091.00
63_L68_I0.7081.00
192_S195_P0.7031.00
11_V21_I0.7031.00
90_L94_E0.7021.00
207_I217_F0.7001.00
90_L127_D0.7001.00
33_L53_V0.6991.00
146_D152_S0.6981.00
85_S109_H0.6961.00
153_I181_L0.6931.00
10_A33_L0.6911.00
46_A52_A0.6901.00
172_V217_F0.6871.00
71_F74_V0.6861.00
24_E28_M0.6851.00
181_L208_M0.6811.00
26_H49_A0.6761.00
177_G210_H0.6731.00
100_I118_A0.6711.00
34_A45_Y0.6711.00
18_G57_A0.6701.00
20_S24_E0.6691.00
107_Y110_H0.6681.00
64_L68_I0.6641.00
118_A121_I0.6631.00
22_C32_V0.6631.00
19_G48_Y0.6580.99
191_L197_D0.6500.99
94_E111_K0.6490.99
35_V53_V0.6480.99
68_I74_V0.6460.99
59_E62_E0.6430.99
166_S170_L0.6380.99
58_T84_A0.6370.99
10_A55_A0.6360.99
24_E27_R0.6340.99
197_D200_R0.6330.99
178_C217_F0.6320.99
80_A105_Q0.6310.99
23_K27_R0.6300.99
82_I105_Q0.6290.99
33_L51_H0.6280.99
120_R135_S0.6280.99
19_G44_A0.6270.99
167_I195_P0.6250.99
85_S102_V0.6210.99
83_Q106_N0.6200.99
14_L18_G0.6200.99
148_S151_Y0.6200.99
20_S129_G0.6150.99
167_I172_V0.6150.99
46_A50_T0.6150.99
184_K206_V0.6140.99
91_L95_L0.6110.99
74_V77_A0.6050.99
163_D199_I0.6050.99
24_E129_G0.6050.99
127_D130_V0.6030.99
88_T92_L0.6020.99
105_Q125_E0.6020.99
46_A53_V0.6000.99
150_E210_H0.5980.99
37_I56_N0.5930.99
83_Q109_H0.5930.99
23_K26_H0.5850.99
173_R178_C0.5840.99
19_G49_A0.5820.99
180_I195_P0.5810.99
82_I106_N0.5800.99
185_H202_Q0.5790.99
9_F25_L0.5740.99
169_D196_E0.5740.99
26_H48_Y0.5720.99
51_H54_I0.5690.98
68_I92_L0.5680.98
43_N46_A0.5630.98
42_V46_A0.5610.98
9_F136_L0.5600.98
78_I103_K0.5550.98
90_L116_I0.5530.98
111_K115_K0.5510.98
106_N109_H0.5500.98
9_F72_E0.5500.98
83_Q86_T0.5470.98
141_V144_Y0.5460.98
131_K134_Q0.5430.98
167_I199_I0.5410.98
21_I87_L0.5400.98
130_V134_Q0.5390.98
67_G71_F0.5380.98
86_T113_L0.5370.98
56_N59_E0.5360.98
42_V54_I0.5360.98
15_G79_G0.5340.98
78_I88_T0.5320.98
133_A136_L0.5300.98
103_K128_M0.5290.98
15_G19_G0.5280.98
160_R163_D0.5270.98
63_L92_L0.5260.98
64_L67_G0.5260.98
207_I214_I0.5230.97
19_G41_K0.5210.97
130_V133_A0.5200.97
13_G18_G0.5200.97
155_E184_K0.5190.97
65_S70_N0.5180.97
146_D149_D0.5170.97
37_I40_E0.5150.97
172_V177_G0.5120.97
125_E156_L0.5120.97
16_R20_S0.5100.97
36_D57_A0.5100.97
77_A88_T0.5100.97
17_F109_H0.5090.97
62_E65_S0.5080.97
69_R95_L0.5070.97
60_E94_E0.5070.97
74_V100_I0.5050.97
154_V209_G0.5030.97
68_I97_I0.5030.97
17_F79_G0.5020.97
39_E61_N0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gx0A 3 0.964 100 0.221 Contact Map
4g65A 2 0.9775 100 0.235 Contact Map
3mt5A 5 0.955 100 0.254 Contact Map
2aefA 2 0.955 100 0.259 Contact Map
1lnqA 6 0.955 100 0.262 Contact Map
3nafA 3 0.9955 100 0.28 Contact Map
4hpfA 3 0.9234 100 0.318 Contact Map
4j91A 3 0.964 100 0.334 Contact Map
3l4bC 2 0.955 100 0.343 Contact Map
3l9wA 2 0.7973 99.9 0.548 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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