GREMLIN Database
YUAD - Putative metal-sulfur cluster biosynthesis proteins YuaD
UniProt: O32079 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 192 (170)
Sequences: 146 (115)
Seq/√Len: 8.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_M179_H5.3021.00
104_T125_E3.9430.98
30_F66_I3.5640.96
104_T184_K3.2770.93
70_S73_E2.9920.90
127_D182_Q2.9630.89
130_I133_G2.8950.88
48_G51_E2.7500.85
27_K171_Y2.3660.75
137_Q145_K2.3280.74
54_F121_L2.3180.73
32_Y167_P2.1680.68
91_L132_P2.0610.64
29_D169_A1.9770.61
71_I98_S1.9450.59
35_I94_N1.8930.57
109_G124_G1.8910.57
104_T157_I1.8340.55
97_V155_L1.8280.54
33_G43_L1.8240.54
114_F118_A1.8050.53
47_A123_E1.7770.52
120_L164_V1.7180.50
49_A56_R1.6350.46
75_N79_L1.6220.46
69_V93_A1.5990.45
39_L135_V1.5840.44
54_F116_S1.5510.43
103_L106_L1.5430.42
170_V176_I1.5300.42
54_F115_P1.5140.41
16_D39_L1.5020.40
95_V106_L1.4940.40
119_A163_I1.4900.40
106_L170_V1.4870.40
77_I81_M1.4780.39
90_W135_V1.4690.39
67_S133_G1.4600.39
52_P179_H1.4340.38
61_F163_I1.4290.38
86_I93_A1.3880.36
81_M104_T1.3790.36
39_L167_P1.3770.35
133_G167_P1.3720.35
113_I163_I1.3720.35
31_D167_P1.3550.35
38_D114_F1.3540.35
69_V100_M1.3390.34
111_R166_R1.3310.34
28_L81_M1.3280.34
20_F38_D1.3050.33
45_K181_Y1.3050.33
109_G178_V1.2700.31
41_F59_E1.2530.31
136_I144_P1.2360.30
45_K107_K1.2150.29
71_I180_S1.2090.29
30_F167_P1.2020.29
31_D47_A1.1870.28
66_I84_P1.1720.28
66_I134_E1.1630.28
33_G167_P1.1490.27
86_I90_W1.1490.27
72_E111_R1.1400.27
127_D132_P1.1110.26
66_I162_C1.1080.26
67_S74_C1.1040.26
151_V157_I1.0980.25
27_K169_A1.0910.25
15_A94_N1.0760.25
113_I119_A1.0730.25
27_K101_P1.0730.25
15_A18_K1.0720.25
15_A39_L1.0670.24
28_L35_I1.0540.24
32_Y36_P1.0460.24
80_K138_S1.0430.24
114_F170_V1.0420.24
134_E137_Q1.0370.23
71_I85_R1.0230.23
90_W165_E1.0200.23
106_L133_G1.0060.22
97_V101_P1.0050.22
47_A58_T1.0040.22
66_I132_P1.0020.22
16_D167_P0.9980.22
76_E157_I0.9970.22
19_S138_S0.9960.22
71_I76_E0.9940.22
83_V155_L0.9930.22
136_I165_E0.9810.22
79_L106_L0.9750.22
124_G184_K0.9690.21
82_G105_S0.9630.21
22_T81_M0.9630.21
24_Q97_V0.9510.21
47_A174_D0.9510.21
123_E131_Q0.9480.21
107_K181_Y0.9460.21
54_F97_V0.9450.21
157_I177_E0.9220.20
38_D46_K0.9140.20
33_G94_N0.9140.20
22_T97_V0.9120.20
37_G80_K0.9100.20
77_I150_F0.9030.20
45_K61_F0.9030.20
53_M121_L0.9030.20
67_S95_V0.8880.19
59_E167_P0.8800.19
114_F176_I0.8730.19
116_S146_L0.8660.19
67_S130_I0.8630.18
87_L101_P0.8580.18
72_E177_E0.8550.18
51_E186_K0.8540.18
86_I91_L0.8470.18
59_E156_G0.8440.18
25_M28_L0.8330.18
32_Y182_Q0.8310.18
114_F146_L0.8300.18
167_P172_T0.8290.18
55_S82_G0.8290.18
121_L177_E0.8250.18
101_P164_V0.8200.17
113_I179_H0.8170.17
19_S77_I0.8150.17
122_C160_I0.8140.17
69_V86_I0.8120.17
98_S175_E0.8110.17
53_M160_I0.8110.17
88_P131_Q0.8100.17
87_L149_A0.8080.17
30_F95_V0.8000.17
72_E166_R0.7930.17
21_V139_Y0.7880.17
17_T122_C0.7810.16
25_M185_V0.7810.16
49_A80_K0.7750.16
126_N158_R0.7740.16
129_C158_R0.7740.16
126_N129_C0.7740.16
21_V135_V0.7670.16
45_K108_E0.7510.16
119_A134_E0.7510.16
35_I81_M0.7500.16
54_F100_M0.7450.16
46_K80_K0.7440.16
124_G161_V0.7420.16
38_D161_V0.7350.15
61_F142_D0.7280.15
63_R118_A0.7250.15
56_R90_W0.7170.15
123_E163_I0.7160.15
44_T152_R0.7140.15
41_F53_M0.7100.15
74_C77_I0.7080.15
22_T160_I0.7040.15
113_I178_V0.7020.15
162_C181_Y0.7020.15
138_S171_Y0.7010.15
41_F155_L0.6950.15
38_D109_G0.6920.14
28_L32_Y0.6910.14
40_H129_C0.6900.14
40_H158_R0.6900.14
40_H126_N0.6900.14
22_T135_V0.6890.14
128_P158_R0.6880.14
63_R124_G0.6860.14
151_V170_V0.6790.14
51_E113_I0.6760.14
58_T157_I0.6750.14
33_G120_L0.6740.14
51_E178_V0.6680.14
25_M76_E0.6660.14
103_L152_R0.6620.14
22_T106_L0.6620.14
48_G182_Q0.6570.14
31_D115_P0.6570.14
45_K112_I0.6510.14
70_S176_I0.6480.14
30_F175_E0.6480.14
37_G122_C0.6450.13
28_L94_N0.6440.13
26_D97_V0.6400.13
22_T35_I0.6350.13
63_R109_G0.6340.13
97_V143_Q0.6280.13
66_I69_V0.6260.13
121_L179_H0.6200.13
28_L33_G0.6170.13
97_V103_L0.6140.13
54_F94_N0.6140.13
69_V155_L0.6100.13
25_M83_V0.6090.13
91_L134_E0.6030.13
40_H128_P0.6020.13
91_L137_Q0.5990.13
21_V124_G0.5970.13
32_Y174_D0.5960.13
59_E101_P0.5960.13
18_K131_Q0.5940.12
21_V106_L0.5930.12
51_E121_L0.5880.12
143_Q185_V0.5880.12
67_S114_F0.5870.12
31_D120_L0.5860.12
112_I153_H0.5860.12
125_E184_K0.5830.12
77_I85_R0.5770.12
44_T179_H0.5720.12
132_P136_I0.5710.12
89_E101_P0.5680.12
147_A178_V0.5680.12
77_I131_Q0.5670.12
24_Q79_L0.5630.12
19_S170_V0.5600.12
109_G123_E0.5590.12
44_T53_M0.5570.12
90_W143_Q0.5560.12
71_I96_A0.5540.12
20_F48_G0.5520.12
20_F124_G0.5520.12
35_I41_F0.5520.12
163_I178_V0.5480.12
21_V94_N0.5420.12
68_I81_M0.5410.12
77_I91_L0.5400.12
104_T169_A0.5400.12
27_K122_C0.5380.11
116_S138_S0.5360.11
58_T62_N0.5350.11
47_A81_M0.5340.11
108_E123_E0.5340.11
43_L52_P0.5340.11
41_F55_S0.5340.11
28_L135_V0.5310.11
59_E84_P0.5270.11
156_G184_K0.5260.11
44_T59_E0.5250.11
19_S39_L0.5220.11
103_L172_T0.5220.11
41_F122_C0.5210.11
113_I186_K0.5180.11
99_G173_G0.5150.11
133_G152_R0.5150.11
121_L135_V0.5150.11
144_P167_P0.5120.11
84_P185_V0.5090.11
66_I83_V0.5080.11
28_L174_D0.5070.11
52_P133_G0.5010.11
79_L84_P0.5000.11
68_I176_I0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1oruA 2 0.9479 100 0.615 Contact Map
1o65A 1 0.8438 99.8 0.77 Contact Map
1l8nA 2 0.8854 43.2 0.961 Contact Map
3b02A 2 0.4323 20.5 0.967 Contact Map
3tg2A 2 0.5052 19.1 0.967 Contact Map
4ev0A 2 0.401 16 0.969 Contact Map
4h17A 2 0.4635 15.9 0.969 Contact Map
4cydA 2 0.401 15.2 0.969 Contact Map
3mcwA 2 0.4219 15.2 0.969 Contact Map
3dkwA 2 0.3958 14.9 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0076 seconds.