GREMLIN Database
YUAE - Uncharacterized protein YuaE
UniProt: O32078 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 162 (153)
Sequences: 353 (302)
Seq/√Len: 24.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_K30_E5.4911.00
45_D105_R3.1701.00
152_M156_K3.1081.00
28_S31_E2.8761.00
37_V155_I2.8440.99
23_L97_M2.7690.99
26_K33_S2.7170.99
31_E155_I2.7000.99
74_D147_R2.6160.99
18_L156_K2.6080.99
34_I156_K2.5460.99
34_I152_M2.5440.99
8_R105_R2.4900.99
41_L145_E2.2350.97
78_K154_E2.0690.95
142_G146_K2.0150.95
19_S22_K1.9770.94
82_P127_P1.9410.94
75_R147_R1.9140.93
18_L152_M1.7540.90
44_I48_A1.7340.89
18_L34_I1.7160.89
36_E89_H1.6320.86
21_E29_A1.6120.85
39_D87_P1.5780.84
153_K157_E1.5500.83
103_V106_E1.5240.82
87_P147_R1.5190.81
15_L38_L1.5120.81
40_H148_H1.4490.78
26_K91_F1.4300.77
106_E153_K1.4290.77
8_R145_E1.4290.77
116_K119_D1.3570.73
75_R154_E1.3530.73
11_T152_M1.3320.72
36_E97_M1.3180.71
83_S86_E1.3120.71
41_L44_I1.3070.70
144_H148_H1.3010.70
40_H144_H1.3010.70
7_A56_V1.3000.70
102_D119_D1.2970.70
45_D104_V1.2910.69
32_W148_H1.2790.69
32_W40_H1.2790.69
10_E13_N1.2740.68
76_N147_R1.2700.68
33_S37_V1.2650.68
39_D89_H1.2630.68
101_L137_W1.2440.67
29_A58_D1.2400.66
62_K65_E1.2370.66
81_A85_L1.2110.64
35_R97_M1.2000.64
27_P33_S1.1800.62
28_S33_S1.1560.61
75_R150_S1.1360.59
14_E92_I1.1320.59
32_W144_H1.1240.59
74_D154_E1.1190.58
52_L85_L1.1170.58
8_R141_I1.1160.58
61_I132_L1.1120.58
106_E119_D1.0880.56
11_T149_L1.0780.55
45_D81_A1.0700.55
97_M142_G1.0670.55
50_K54_E1.0620.54
101_L145_E1.0540.54
15_L23_L1.0540.54
55_R140_F1.0540.54
81_A87_P1.0530.54
24_N97_M1.0460.53
77_N132_L1.0420.53
80_K86_E1.0270.52
55_R138_I1.0260.52
14_E156_K1.0160.51
11_T101_L0.9950.49
89_H99_R0.9940.49
52_L57_K0.9930.49
14_E41_L0.9930.49
38_L142_G0.9820.48
81_A127_P0.9800.48
148_H151_Q0.9740.48
40_H151_Q0.9740.48
37_V118_E0.9640.47
127_P137_W0.9540.46
49_Q111_A0.9440.46
56_V90_D0.9420.46
85_L100_E0.9310.45
107_Q110_A0.9300.45
69_L108_L0.9240.44
13_N128_V0.9100.43
20_D153_K0.9000.43
123_V134_V0.8930.42
18_L131_E0.8870.42
34_I58_D0.8840.41
112_I119_D0.8730.41
108_L150_S0.8730.41
12_W60_P0.8420.39
15_L22_K0.8360.38
44_I85_L0.8330.38
57_K66_E0.8210.37
22_K25_Q0.8190.37
39_D142_G0.8100.36
19_S98_K0.8090.36
23_L146_K0.8070.36
144_H151_Q0.8040.36
76_N154_E0.7990.36
23_L50_K0.7920.35
13_N58_D0.7870.35
126_H132_L0.7840.35
32_W151_Q0.7830.35
83_S111_A0.7800.34
28_S153_K0.7770.34
10_E18_L0.7760.34
72_A140_F0.7750.34
7_A103_V0.7710.34
53_K113_A0.7690.34
76_N128_V0.7640.33
15_L63_E0.7630.33
36_E101_L0.7620.33
147_R154_E0.7550.33
57_K89_H0.7460.32
41_L111_A0.7430.32
11_T38_L0.7370.32
9_L60_P0.7310.31
39_D100_E0.7270.31
57_K113_A0.7250.31
22_K154_E0.7240.31
129_F141_I0.7170.31
58_D99_R0.7170.31
87_P145_E0.7110.30
56_V118_E0.7080.30
41_L67_K0.7070.30
23_L100_E0.7040.30
142_G145_E0.6980.29
6_E116_K0.6880.29
61_I119_D0.6880.29
53_K102_D0.6860.29
24_N146_K0.6840.29
22_K133_T0.6800.28
10_E110_A0.6790.28
37_V127_P0.6740.28
16_K155_I0.6720.28
105_R112_I0.6700.28
93_S113_A0.6680.28
16_K47_T0.6630.27
7_A146_K0.6630.27
43_K87_P0.6620.27
44_I47_T0.6620.27
51_M124_L0.6590.27
13_N95_S0.6570.27
103_V112_I0.6520.27
5_N112_I0.6500.27
17_G61_I0.6480.27
33_S126_H0.6450.26
23_L51_M0.6400.26
47_T84_H0.6390.26
45_D136_Q0.6350.26
28_S98_K0.6340.26
62_K117_E0.6330.26
72_A147_R0.6320.26
10_E109_T0.6310.26
20_D95_S0.6290.25
19_S129_F0.6280.25
93_S96_Q0.6250.25
136_Q152_M0.6230.25
8_R101_L0.6210.25
15_L60_P0.6180.25
8_R104_V0.6180.25
58_D118_E0.6180.25
23_L130_Q0.6170.25
87_P154_E0.6130.25
35_R91_F0.6090.24
85_L88_A0.6070.24
12_W18_L0.6070.24
68_P145_E0.6070.24
79_R128_V0.6040.24
13_N77_N0.6030.24
64_I133_T0.6030.24
14_E140_F0.5980.24
27_P31_E0.5940.24
125_P132_L0.5920.23
39_D92_I0.5910.23
13_N54_E0.5900.23
39_D91_F0.5860.23
36_E93_S0.5840.23
69_L136_Q0.5820.23
9_L13_N0.5810.23
10_E149_L0.5750.23
84_H87_P0.5740.23
43_K52_L0.5740.23
97_M136_Q0.5720.22
10_E153_K0.5670.22
117_E135_R0.5660.22
9_L110_A0.5650.22
33_S92_I0.5630.22
96_Q109_T0.5610.22
49_Q154_E0.5610.22
48_A136_Q0.5610.22
8_R68_P0.5600.22
69_L150_S0.5510.21
41_L149_L0.5480.21
14_E153_K0.5470.21
125_P131_E0.5460.21
5_N109_T0.5430.21
30_E150_S0.5420.21
17_G141_I0.5420.21
13_N118_E0.5400.21
30_E53_K0.5400.21
72_A129_F0.5370.21
84_H125_P0.5370.21
55_R72_A0.5340.21
47_T127_P0.5320.21
125_P150_S0.5300.20
41_L97_M0.5240.20
29_A94_G0.5230.20
129_F137_W0.5220.20
123_V147_R0.5150.20
133_T143_H0.5120.20
13_N64_I0.5090.19
54_E121_E0.5080.19
78_K145_E0.5060.19
133_T152_M0.5050.19
7_A98_K0.5040.19
52_L149_L0.5030.19
30_E56_V0.5020.19
92_I157_E0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yqyA 2 0.7469 99.9 0.516 Contact Map
2rd9A 4 0.9136 99.8 0.594 Contact Map
1rxqA 3 0.9259 99.7 0.604 Contact Map
3cexA 2 0.9877 99.7 0.634 Contact Map
3gorA 2 0.8395 99.6 0.636 Contact Map
2qe9A 2 0.8395 99.6 0.637 Contact Map
3dkaA 2 0.8395 99.6 0.637 Contact Map
2p1aA 2 0.858 99.6 0.645 Contact Map
3di5A 1 0.8395 99.6 0.649 Contact Map
2hkvA 2 0.8148 99.5 0.662 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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