GREMLIN Database
YUAF - Uncharacterized membrane protein YuaF
UniProt: O32077 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 174 (164)
Sequences: 269 (212)
Seq/√Len: 16.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_V166_L5.0181.00
161_I166_L3.0910.99
55_F74_A2.9890.98
15_T55_F2.8890.98
12_Y77_S2.8820.98
143_V167_S2.8810.98
115_G129_V2.6020.96
19_A56_S2.5170.95
71_L82_I2.4770.95
47_L89_H2.4440.95
117_V121_V2.3420.93
32_V83_M2.2430.92
15_T56_S2.2120.91
12_Y63_E2.1750.90
122_P128_E2.1700.90
12_Y16_L2.1330.89
146_D169_T2.0700.88
17_I27_L2.0680.88
35_G38_E1.9950.86
61_I106_R1.9870.86
8_I19_A1.9480.84
28_F76_L1.8630.82
70_S83_M1.7810.78
60_Y77_S1.6320.72
123_V149_Q1.6200.71
28_F61_I1.6160.71
52_F75_L1.5520.68
41_P67_P1.5500.68
115_G158_V1.5440.68
75_L82_I1.5060.66
51_F143_V1.4870.65
52_F68_L1.4520.63
54_C84_L1.4270.61
42_F115_G1.4170.61
55_F153_G1.4140.61
27_L146_D1.3910.59
63_E70_S1.3680.58
32_V76_L1.3660.58
21_S81_S1.3420.56
117_V141_S1.3230.55
71_L74_A1.3160.55
81_S85_V1.3140.55
50_S85_V1.3050.54
62_G119_T1.3000.54
68_L76_L1.2870.53
42_F60_Y1.2770.53
61_I64_L1.2670.52
58_G62_G1.2460.51
43_L170_P1.2360.50
10_T24_L1.2170.49
17_I21_S1.2130.49
107_E138_I1.2130.49
143_V160_D1.2110.49
117_V139_S1.2000.48
11_M67_P1.1660.46
122_P136_G1.1640.46
81_S158_V1.1570.46
106_R109_D1.1470.45
13_L98_S1.1360.44
49_L139_S1.1290.44
155_T166_L1.1270.44
31_D122_P1.1270.44
90_I136_G1.1250.44
162_N167_S1.1240.44
122_P125_G1.1070.43
31_D81_S1.0890.42
17_I52_F1.0880.42
21_S25_L1.0830.41
8_I56_S1.0770.41
83_M123_V1.0710.41
30_G153_G1.0690.40
103_L113_R1.0670.40
27_L42_F1.0290.38
15_T18_I1.0230.38
72_L79_I1.0200.38
82_I161_I1.0190.38
132_E138_I1.0170.38
45_P95_P1.0120.37
29_F120_A1.0010.37
107_E141_S0.9970.36
27_L75_L0.9890.36
58_G144_S0.9890.36
45_P102_S0.9850.36
27_L41_P0.9840.36
144_S150_I0.9830.36
81_S169_T0.9830.36
16_L135_G0.9810.36
20_G61_I0.9800.36
19_A49_L0.9690.35
117_V142_A0.9630.35
121_V162_N0.9620.35
24_L48_V0.9440.34
13_L149_Q0.9430.34
47_L165_V0.9350.33
105_Y140_K0.9290.33
15_T19_A0.9240.33
120_A149_Q0.9220.32
112_G127_G0.9190.32
24_L27_L0.9180.32
43_L146_D0.9140.32
82_I148_Q0.9130.32
8_I11_M0.9110.32
161_I165_V0.9050.32
14_Y43_L0.9020.31
62_G102_S0.8820.30
19_A94_V0.8820.30
61_I65_V0.8700.30
30_G163_N0.8690.30
123_V147_N0.8670.30
30_G59_G0.8670.30
87_L165_V0.8600.29
121_V167_S0.8590.29
94_V157_L0.8590.29
12_Y69_S0.8580.29
102_S110_L0.8540.29
69_S151_S0.8510.29
63_E86_V0.8490.29
143_V162_N0.8480.29
31_D100_E0.8400.28
17_I108_D0.8380.28
154_T170_P0.8370.28
15_T30_G0.8330.28
43_L148_Q0.8310.28
84_L87_L0.8300.28
115_G156_V0.8260.28
34_S38_E0.8220.27
45_P84_L0.8180.27
89_H165_V0.8150.27
49_L167_S0.8050.27
62_G73_I0.8040.27
58_G77_S0.7950.26
21_S85_V0.7950.26
10_T144_S0.7930.26
17_I97_S0.7840.26
23_T49_L0.7840.26
121_V142_A0.7780.25
45_P53_T0.7770.25
48_V151_S0.7740.25
39_G65_V0.7690.25
21_S158_V0.7600.25
101_E141_S0.7520.24
62_G86_V0.7480.24
40_I160_D0.7420.24
13_L60_Y0.7390.24
109_D171_H0.7340.24
67_P76_L0.7330.24
21_S147_N0.7300.23
55_F86_V0.7250.23
28_F37_S0.7210.23
151_S154_T0.7180.23
167_S170_P0.7140.23
48_V120_A0.7140.23
135_G159_V0.7040.22
11_M46_T0.6950.22
14_Y60_Y0.6900.22
51_F135_G0.6890.22
16_L118_I0.6880.22
22_L52_F0.6860.22
53_T84_L0.6860.22
115_G160_D0.6780.21
72_L75_L0.6770.21
78_C105_Y0.6740.21
28_F41_P0.6720.21
116_K153_G0.6710.21
62_G164_G0.6690.21
12_Y121_V0.6670.21
26_F134_I0.6650.21
35_G115_G0.6630.21
153_G158_V0.6610.21
58_G80_L0.6590.21
92_V141_S0.6590.21
103_L107_E0.6570.20
125_G128_E0.6530.20
24_L154_T0.6530.20
35_G158_V0.6520.20
50_S134_I0.6480.20
111_R147_N0.6470.20
115_G139_S0.6430.20
48_V62_G0.6430.20
12_Y24_L0.6430.20
54_C126_F0.6400.20
159_V171_H0.6390.20
35_G122_P0.6390.20
100_E104_A0.6340.20
80_L151_S0.6320.19
32_V36_L0.6280.19
28_F85_V0.6280.19
51_F96_L0.6280.19
12_Y20_G0.6280.19
16_L159_V0.6270.19
16_L97_S0.6260.19
62_G77_S0.6260.19
32_V65_V0.6260.19
62_G108_D0.6250.19
57_A93_L0.6230.19
9_Q90_I0.6230.19
96_L101_E0.6230.19
11_M69_S0.6110.19
71_L84_L0.6090.19
25_L150_I0.6080.19
81_S119_T0.6060.19
66_L80_L0.6040.18
32_V71_L0.6040.18
21_S154_T0.6040.18
92_V169_T0.6030.18
117_V131_I0.6020.18
37_S50_S0.6010.18
32_V35_G0.5970.18
114_L159_V0.5950.18
27_L78_C0.5940.18
53_T110_L0.5930.18
29_F165_V0.5930.18
52_F87_L0.5920.18
73_I83_M0.5920.18
73_I96_L0.5880.18
68_L74_A0.5870.18
67_P71_L0.5860.18
143_V147_N0.5830.18
70_S155_T0.5820.18
61_I144_S0.5800.18
122_P131_I0.5800.18
41_P164_G0.5700.17
27_L77_S0.5680.17
29_F36_L0.5660.17
76_L165_V0.5660.17
107_E115_G0.5650.17
28_F38_E0.5600.17
91_F94_V0.5570.17
86_V135_G0.5560.17
51_F124_D0.5540.17
23_T95_P0.5520.17
108_D162_N0.5430.16
66_L73_I0.5420.16
12_Y39_G0.5390.16
11_M39_G0.5360.16
96_L126_F0.5340.16
16_L145_F0.5300.16
23_T53_T0.5270.16
39_G51_F0.5250.16
129_V138_I0.5230.16
23_T77_S0.5150.16
33_F37_S0.5120.15
20_G70_S0.5110.15
89_H94_V0.5100.15
79_I167_S0.5010.15
75_L104_A0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k14A 1 0.4828 99.5 0.733 Contact Map
2k5hA 1 0.5632 98.5 0.82 Contact Map
3cp0A 1 0.3563 98.4 0.825 Contact Map
3wwvA 2 0.3678 97.7 0.854 Contact Map
2exdA 1 0.4138 97.6 0.856 Contact Map
3ne5A 3 0.6034 63.5 0.93 Contact Map
4mt1A 3 0.592 60 0.931 Contact Map
3w9iA 3 0.6092 53.1 0.934 Contact Map
4k0jA 3 0.5805 48.2 0.936 Contact Map
3aqpA 1 0.5402 45.4 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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