GREMLIN Database
YUAG - Uncharacterized protein YuaG
UniProt: O32076 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 509 (458)
Sequences: 953 (570)
Seq/√Len: 26.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
388_G394_A5.6611.00
389_L393_E4.5661.00
367_L371_E4.3961.00
274_D277_T3.6731.00
374_K378_E3.5941.00
423_K427_A3.4871.00
325_D328_S3.4341.00
378_E382_E3.1141.00
427_A430_S3.0771.00
265_A268_N2.9441.00
330_E334_A2.9331.00
265_A269_A2.8911.00
334_A338_A2.7911.00
342_A345_D2.7291.00
385_R389_L2.7250.99
360_E363_R2.7020.99
354_M358_E2.6910.99
304_E308_L2.6750.99
422_A425_A2.6220.99
362_V368_A2.6080.99
310_R313_Q2.5790.99
254_K257_E2.5440.99
256_A260_R2.5350.99
266_K270_D2.4950.99
285_T288_E2.4560.99
323_D327_Y2.4540.99
420_E423_K2.4420.99
348_K352_E2.4340.99
424_Q427_A2.4140.99
382_E385_R2.3610.99
216_A229_A2.3060.98
260_R264_T2.2710.98
273_Y276_E2.2100.98
349_Y352_E2.2060.98
348_K355_A2.2040.98
312_R315_D2.1980.98
364_I368_A2.1660.97
375_A379_T2.1610.97
359_A366_G2.1500.97
374_K377_G2.1480.97
475_V478_M2.1270.97
225_K229_A2.0600.96
377_G383_V2.0340.96
359_A363_R2.0220.96
226_R230_D1.9970.96
369_K376_K1.9820.96
226_R229_A1.9810.96
194_G198_S1.9410.95
359_A377_G1.9410.95
339_K343_E1.9100.95
31_G34_E1.9020.94
243_E246_E1.8830.94
34_E76_P1.8780.94
249_K258_F1.8510.94
269_A272_A1.8330.93
363_R366_G1.8200.93
319_K327_Y1.8140.93
352_E355_A1.8050.93
320_K323_D1.7950.92
254_K258_F1.7910.92
239_E243_E1.7810.92
7_M11_V1.7790.92
328_S332_S1.7780.92
382_E386_L1.7510.91
248_E252_Q1.7490.91
315_D319_K1.7450.91
412_D416_K1.7420.91
395_K398_I1.7370.91
286_E289_M1.7180.91
348_K353_A1.7020.90
94_E154_E1.6860.90
337_K345_D1.6830.90
333_A344_A1.6770.90
112_S115_E1.6650.89
362_V366_G1.6630.89
237_E240_R1.6620.89
396_E400_A1.6610.89
296_R302_L1.6490.89
262_Q269_A1.6470.89
347_K350_S1.6370.88
60_V65_T1.6360.88
234_K237_E1.6320.88
285_T289_M1.6040.87
405_Y409_A1.6020.87
272_A275_L1.6020.87
202_P206_Q1.5980.87
387_K391_E1.5890.87
269_A278_A1.5860.87
251_N255_M1.5830.87
397_K400_A1.5710.86
263_D266_K1.5690.86
396_E404_Q1.5590.86
345_D349_Y1.5430.85
361_K365_D1.5330.85
337_K341_L1.5260.85
336_E339_K1.5220.84
350_S354_M1.5000.83
287_Q291_V1.4990.83
317_E321_K1.4960.83
363_R367_L1.4770.82
37_I40_G1.4720.82
362_V365_D1.4650.82
252_Q256_A1.4600.82
215_T219_D1.4530.81
279_R283_Q1.4530.81
459_L464_Q1.4390.81
151_T195_Y1.4360.81
230_D233_A1.4350.81
327_Y333_A1.4330.81
366_G377_G1.4240.80
293_I305_K1.4150.80
265_A278_A1.4140.80
340_Q350_S1.4080.79
333_A346_A1.4070.79
425_A428_P1.3900.78
458_N462_S1.3890.78
217_E220_K1.3860.78
298_K301_E1.3700.77
366_G372_A1.3690.77
264_T269_A1.3660.77
259_R263_D1.3650.77
17_I21_A1.3640.77
417_M420_E1.3630.77
201_K205_A1.3610.77
286_E290_Q1.3570.77
245_A248_E1.3560.77
165_E168_R1.3540.77
162_F181_I1.3540.77
152_V195_Y1.3330.75
450_N454_S1.3310.75
467_L471_S1.3240.75
420_E424_Q1.3240.75
275_L278_A1.3190.75
468_K474_D1.3180.75
228_E231_K1.3170.74
110_G115_E1.3150.74
457_T462_S1.3140.74
194_G197_E1.3100.74
314_Y318_V1.2980.73
203_R206_Q1.2940.73
111_G121_E1.2880.73
251_N258_F1.2760.72
37_I120_A1.2750.72
296_R306_E1.2740.72
294_I308_L1.2550.71
228_E232_D1.2500.70
237_E241_A1.2490.70
208_K212_D1.2450.70
384_I387_K1.2270.69
368_A372_A1.2260.69
341_L349_Y1.2240.69
344_A348_K1.2200.69
267_A272_A1.2190.69
249_K256_A1.2190.69
12_V15_L1.2180.68
330_E338_A1.2130.68
403_E406_G1.2120.68
262_Q278_A1.2110.68
337_K342_A1.2050.68
253_L259_R1.2040.68
410_I413_M1.2030.67
302_L305_K1.2010.67
465_E469_A1.1950.67
335_A346_A1.1900.67
456_A463_L1.1850.66
341_L345_D1.1830.66
15_L18_A1.1730.65
287_Q290_Q1.1660.65
313_Q317_E1.1620.65
86_V184_F1.1600.65
201_K215_T1.1590.65
7_M12_V1.1580.64
468_K471_S1.1570.64
336_E340_Q1.1550.64
473_I476_K1.1530.64
349_Y353_A1.1450.64
282_Q285_T1.1400.63
246_E250_I1.1390.63
269_A273_Y1.1380.63
344_A355_A1.1370.63
96_G153_E1.1340.63
245_A253_L1.1330.63
346_A350_S1.1300.63
318_V321_K1.1290.62
135_A150_M1.1230.62
329_V339_K1.1210.62
271_Q274_D1.1200.62
347_K354_M1.1180.62
331_Q344_A1.1140.61
284_V288_E1.1120.61
253_L257_E1.1080.61
460_M467_L1.1070.61
224_I229_A1.1020.61
393_E397_K1.1020.61
368_A379_T1.0960.60
282_Q286_E1.0960.60
42_Y72_Q1.0930.60
7_M10_G1.0870.59
350_S355_A1.0870.59
480_E484_G1.0820.59
9_I21_A1.0810.59
137_E147_L1.0790.59
273_Y278_A1.0720.58
456_A462_S1.0700.58
305_K308_L1.0580.57
267_A273_Y1.0570.57
422_A426_A1.0500.57
338_A342_A1.0490.57
329_V338_A1.0470.57
280_A284_V1.0460.56
7_M13_F1.0450.56
365_D368_A1.0430.56
159_R162_F1.0420.56
350_S353_A1.0400.56
10_G14_F1.0400.56
271_Q275_L1.0390.56
360_E370_A1.0350.56
68_L71_F1.0310.55
97_V147_L1.0290.55
320_K326_R1.0160.54
98_P181_I1.0150.54
108_K121_E1.0140.54
249_K262_Q1.0130.54
37_I77_L1.0110.54
413_M416_K1.0090.54
209_R212_D1.0090.54
114_G367_L1.0030.53
231_K235_K1.0020.53
360_E364_I0.9990.53
348_K356_K0.9990.53
262_Q277_T0.9970.53
97_V152_V0.9950.53
309_R313_Q0.9930.53
346_A355_A0.9930.53
331_Q334_A0.9890.52
369_K373_E0.9870.52
395_K405_Y0.9870.52
268_N278_A0.9860.52
191_D200_G0.9830.52
346_A353_A0.9770.51
9_I13_F0.9760.51
8_I14_F0.9730.51
207_V214_A0.9710.51
27_Y64_G0.9710.51
371_E375_A0.9680.51
277_T281_R0.9660.51
304_E312_R0.9640.50
245_A249_K0.9630.50
376_K380_E0.9590.50
265_A273_Y0.9580.50
361_K364_I0.9570.50
359_A374_K0.9550.50
349_Y355_A0.9530.50
82_S131_R0.9490.49
420_E427_A0.9420.49
438_V466_S0.9420.49
400_A404_Q0.9390.48
256_A259_R0.9370.48
248_E260_R0.9360.48
13_F21_A0.9360.48
332_S336_E0.9310.48
242_T246_E0.9300.48
33_D80_L0.9290.48
314_Y324_A0.9270.48
205_A222_T0.9250.47
449_A453_T0.9240.47
301_E304_E0.9230.47
224_I227_A0.9220.47
369_K372_A0.9210.47
122_Q177_M0.9190.47
282_Q287_Q0.9140.47
270_D274_D0.9110.46
18_A21_A0.9110.46
99_V137_E0.9110.46
223_R237_E0.9100.46
366_G378_E0.9090.46
135_A143_L0.9070.46
293_I302_L0.9010.46
320_K324_A0.9000.46
358_E365_D0.8990.46
329_V335_A0.8940.45
33_D79_L0.8930.45
161_K165_E0.8930.45
143_L184_F0.8920.45
297_Q305_K0.8900.45
213_I217_E0.8900.45
199_L211_A0.8890.45
343_E347_K0.8870.45
386_L390_A0.8850.44
11_V473_I0.8850.44
371_E374_K0.8840.44
231_K240_R0.8790.44
207_V222_T0.8770.44
237_E244_I0.8770.44
28_R341_L0.8760.44
344_A351_I0.8750.44
306_E310_R0.8750.44
14_F18_A0.8740.44
177_M182_V0.8740.44
10_G17_I0.8730.44
279_R287_Q0.8730.44
374_K382_E0.8720.44
363_R368_A0.8700.43
135_A179_L0.8690.43
385_R393_E0.8690.43
197_E201_K0.8680.43
291_V295_E0.8670.43
152_V196_L0.8640.43
351_I355_A0.8620.43
433_D436_T0.8620.43
266_K269_A0.8610.43
224_I228_E0.8600.43
267_A278_A0.8580.42
245_A251_N0.8550.42
8_I21_A0.8540.42
106_I137_E0.8530.42
149_S165_E0.8530.42
283_Q287_Q0.8510.42
60_V369_K0.8490.42
216_A236_S0.8440.41
166_V170_A0.8430.41
267_A275_L0.8430.41
142_H145_S0.8430.41
158_N161_K0.8420.41
202_P215_T0.8390.41
141_G144_R0.8390.41
418_L425_A0.8370.41
353_A357_A0.8340.41
335_A344_A0.8340.41
77_L148_G0.8300.40
170_A181_I0.8260.40
432_I437_V0.8230.40
311_E320_K0.8210.40
276_E283_Q0.8200.40
131_R158_N0.8180.40
449_A454_S0.8170.40
418_L467_L0.8150.39
455_Y462_S0.8140.39
132_E270_D0.8110.39
35_A77_L0.8100.39
210_D221_E0.8080.39
319_K326_R0.8080.39
100_M190_R0.8060.39
162_F166_V0.8050.39
293_I296_R0.8040.39
362_V369_K0.8030.39
287_Q294_I0.8020.38
268_N271_Q0.8010.38
107_I181_I0.7990.38
177_M185_T0.7980.38
373_E376_K0.7940.38
432_I436_T0.7930.38
333_A350_S0.7910.38
11_V18_A0.7880.37
296_R303_E0.7880.37
256_A261_E0.7870.37
271_Q280_A0.7870.37
212_D226_R0.7860.37
276_E396_E0.7840.37
224_I236_S0.7820.37
322_A386_L0.7810.37
58_K250_I0.7810.37
466_S469_A0.7810.37
208_K216_A0.7780.37
122_Q185_T0.7780.37
63_G97_V0.7770.37
393_E396_E0.7760.37
236_S244_I0.7730.36
12_V25_T0.7720.36
30_A36_L0.7650.36
7_M14_F0.7620.36
32_P39_T0.7620.36
323_D328_S0.7590.35
276_E280_A0.7570.35
110_G180_V0.7560.35
81_S106_I0.7550.35
341_L353_A0.7540.35
333_A342_A0.7530.35
236_S239_E0.7520.35
138_V177_M0.7470.35
108_K184_F0.7460.35
380_E387_K0.7460.35
308_L423_K0.7460.35
402_F406_G0.7450.35
300_I311_E0.7440.34
458_N461_S0.7440.34
264_T275_L0.7430.34
22_V66_F0.7430.34
216_A222_T0.7430.34
266_K273_Y0.7430.34
259_R262_Q0.7380.34
88_T91_V0.7380.34
252_Q421_Y0.7380.34
114_G129_D0.7350.34
106_I156_Y0.7350.34
124_L148_G0.7340.34
94_E157_K0.7330.34
459_L462_S0.7320.34
262_Q265_A0.7310.34
366_G375_A0.7300.34
394_A403_E0.7280.33
296_R300_I0.7270.33
366_G374_K0.7270.33
228_E382_E0.7270.33
81_S137_E0.7270.33
365_D377_G0.7240.33
217_E221_E0.7210.33
375_A378_E0.7190.33
35_A59_I0.7160.33
318_V327_Y0.7150.33
38_V72_Q0.7150.33
480_E483_S0.7140.32
365_D369_K0.7130.32
421_Y465_E0.7120.32
194_G208_K0.7120.32
268_N276_E0.7070.32
220_K229_A0.7070.32
373_E377_G0.7070.32
8_I11_V0.7050.32
327_Y331_Q0.7050.32
426_A468_K0.7030.32
32_P124_L0.7020.32
109_I294_I0.7020.32
106_I184_F0.6990.31
253_L265_A0.6960.31
258_F262_Q0.6950.31
206_Q210_D0.6930.31
257_E265_A0.6930.31
331_Q338_A0.6910.31
146_I377_G0.6910.31
272_A276_E0.6890.31
216_A227_A0.6890.31
40_G62_G0.6890.31
249_K255_M0.6870.31
279_R389_L0.6860.31
218_A221_E0.6850.31
249_K253_L0.6830.30
294_I306_E0.6830.30
154_E161_K0.6830.30
250_I256_A0.6820.30
455_Y459_L0.6820.30
147_L196_L0.6800.30
146_I408_A0.6780.30
278_A287_Q0.6760.30
192_K197_E0.6760.30
252_Q257_E0.6760.30
309_R320_K0.6750.30
236_S240_R0.6750.30
198_S208_K0.6740.30
365_D374_K0.6740.30
140_E177_M0.6670.29
241_A339_K0.6670.29
337_K340_Q0.6650.29
36_L72_Q0.6620.29
234_K241_A0.6620.29
91_V139_L0.6610.29
438_V461_S0.6610.29
108_K152_V0.6610.29
320_K331_Q0.6590.29
150_M174_L0.6590.29
321_K325_D0.6580.29
197_E216_A0.6580.29
310_R316_S0.6560.29
363_R371_E0.6540.29
150_M167_Q0.6530.29
336_E345_D0.6530.29
8_I12_V0.6510.28
324_A328_S0.6460.28
418_L428_P0.6450.28
366_G376_K0.6420.28
429_L432_I0.6420.28
473_I479_L0.6380.28
411_F415_V0.6370.28
323_D326_R0.6350.27
477_E482_F0.6350.27
203_R207_V0.6330.27
298_K302_L0.6330.27
389_L397_K0.6330.27
238_L247_A0.6300.27
202_P214_A0.6300.27
96_G152_V0.6290.27
16_L23_F0.6280.27
353_A356_K0.6280.27
12_V154_E0.6260.27
122_Q182_V0.6260.27
12_V19_L0.6260.27
38_V65_T0.6240.27
139_L199_L0.6230.27
150_M286_E0.6220.27
10_G24_I0.6210.27
137_E152_V0.6180.26
456_A459_L0.6170.26
455_Y458_N0.6170.26
254_K261_E0.6170.26
194_G200_G0.6170.26
384_I397_K0.6160.26
419_P428_P0.6160.26
240_R244_I0.6150.26
309_R312_R0.6130.26
169_V196_L0.6130.26
156_Y185_T0.6120.26
201_K204_I0.6120.26
244_I249_K0.6120.26
411_F463_L0.6100.26
191_D199_L0.6100.26
83_K106_I0.6100.26
216_A220_K0.6100.26
291_V294_I0.6080.26
16_L20_I0.6080.26
306_E312_R0.6080.26
18_A454_S0.6070.26
383_V386_L0.6070.26
291_V296_R0.6060.26
27_Y39_T0.6050.26
295_E306_E0.6050.26
440_T453_T0.6030.26
424_Q460_M0.6020.26
15_L22_V0.6010.26
231_K243_E0.6010.26
319_K323_D0.6000.25
462_S470_S0.6000.25
265_A283_Q0.5990.25
35_A109_I0.5990.25
453_T459_L0.5990.25
165_E308_L0.5980.25
391_E405_Y0.5980.25
301_E308_L0.5970.25
106_I138_V0.5950.25
290_Q307_I0.5940.25
396_E403_E0.5920.25
324_A335_A0.5910.25
138_V173_D0.5910.25
266_K274_D0.5910.25
340_Q343_E0.5910.25
108_K140_E0.5900.25
456_A468_K0.5900.25
167_Q171_S0.5850.25
477_E480_E0.5840.25
399_A403_E0.5840.25
67_V94_E0.5840.25
374_K379_T0.5830.25
27_Y150_M0.5830.25
108_K122_Q0.5830.25
300_I303_E0.5820.24
347_K351_I0.5810.24
385_R390_A0.5790.24
465_E468_K0.5790.24
11_V15_L0.5790.24
237_E248_E0.5780.24
450_N453_T0.5780.24
92_Y98_P0.5770.24
29_T34_E0.5760.24
103_G106_I0.5760.24
366_G373_E0.5750.24
19_L24_I0.5740.24
346_A351_I0.5730.24
347_K356_K0.5730.24
462_S466_S0.5720.24
304_E477_E0.5710.24
456_A478_M0.5710.24
207_V211_A0.5710.24
184_F218_A0.5700.24
150_M166_V0.5670.24
365_D371_E0.5670.24
117_A186_I0.5670.24
35_A79_L0.5660.24
357_A375_A0.5660.24
391_E398_I0.5660.24
26_K66_F0.5650.24
100_M155_I0.5650.24
107_I118_T0.5650.24
66_F154_E0.5640.23
250_I254_K0.5640.23
59_I117_A0.5630.23
197_E200_G0.5620.23
456_A460_M0.5610.23
432_I452_V0.5600.23
119_A179_L0.5600.23
205_A216_A0.5580.23
345_D353_A0.5570.23
331_Q350_S0.5570.23
481_N484_G0.5570.23
151_T233_A0.5560.23
367_L375_A0.5560.23
384_I390_A0.5550.23
257_E261_E0.5550.23
39_T83_K0.5540.23
113_I117_A0.5540.23
65_T72_Q0.5540.23
83_K104_T0.5530.23
9_I17_I0.5520.23
300_I306_E0.5510.23
216_A244_I0.5510.23
12_V16_L0.5500.23
141_G211_A0.5500.23
207_V225_K0.5490.23
96_G207_V0.5490.23
10_G13_F0.5490.23
11_V14_F0.5480.23
59_I120_A0.5480.23
10_G70_V0.5470.23
363_R376_K0.5470.23
343_E385_R0.5440.22
107_I131_R0.5440.22
331_Q336_E0.5430.22
171_S175_A0.5430.22
438_V476_K0.5420.22
57_I121_E0.5420.22
263_D267_A0.5420.22
232_D246_E0.5420.22
314_Y344_A0.5410.22
428_P432_I0.5410.22
58_K72_Q0.5400.22
150_M189_V0.5400.22
414_I467_L0.5400.22
81_S138_V0.5390.22
17_I217_E0.5390.22
211_A216_A0.5390.22
395_K432_I0.5380.22
27_Y69_P0.5380.22
188_D205_A0.5380.22
246_E354_M0.5370.22
298_K393_E0.5370.22
457_T464_Q0.5370.22
168_R375_A0.5350.22
334_A342_A0.5350.22
287_Q297_Q0.5350.22
416_K420_E0.5340.22
264_T273_Y0.5330.22
418_L432_I0.5320.22
121_E156_Y0.5320.22
284_V289_M0.5310.22
348_K351_I0.5300.22
241_A473_I0.5300.22
68_L240_R0.5300.22
150_M328_S0.5290.22
170_A273_Y0.5280.22
363_R374_K0.5270.22
63_G198_S0.5260.21
11_V477_E0.5250.21
14_F21_A0.5250.21
105_A184_F0.5230.21
39_T59_I0.5230.21
351_I354_M0.5220.21
395_K409_A0.5220.21
311_E315_D0.5210.21
433_D461_S0.5200.21
97_V204_I0.5200.21
260_R276_E0.5200.21
104_T186_I0.5200.21
449_A452_V0.5200.21
305_K312_R0.5190.21
202_P211_A0.5190.21
437_V440_T0.5180.21
249_K260_R0.5180.21
272_A277_T0.5160.21
211_A222_T0.5160.21
95_Q152_V0.5160.21
160_E191_D0.5130.21
251_N254_K0.5120.21
230_D266_K0.5120.21
458_N473_I0.5120.21
411_F414_I0.5120.21
12_V246_E0.5110.21
135_A167_Q0.5090.21
338_A344_A0.5080.21
133_Q369_K0.5080.21
318_V322_A0.5070.21
109_I239_E0.5070.21
140_E187_K0.5060.20
81_S182_V0.5060.20
251_N256_A0.5050.20
192_K380_E0.5050.20
429_L441_G0.5040.20
327_Y344_A0.5040.20
351_I357_A0.5040.20
248_E255_M0.5040.20
18_A243_E0.5030.20
244_I248_E0.5030.20
456_A480_E0.5030.20
159_R166_V0.5030.20
302_L306_E0.5020.20
290_Q298_K0.5020.20
8_I16_L0.5010.20
81_S156_Y0.5000.20
262_Q290_Q0.5000.20
417_M421_Y0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1winA 1 0.2809 99.9 0.818 Contact Map
4fvgA 2 0.2141 99.8 0.84 Contact Map
3bk6A 3 0.3202 99.8 0.842 Contact Map
2rpbA 1 0.222 99.6 0.874 Contact Map
2zuoA 7 0.7112 95.5 0.95 Contact Map
5a2fA 1 0 67.3 0.968 Contact Map
3v6iB 1 0.1906 51 0.971 Contact Map
4um9B 2 0 43.3 0.972 Contact Map
2k1kA 2 0.0589 33.4 0.974 Contact Map
2jwaA 2 0.0707 31.2 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0131 seconds.