GREMLIN Database
YUAI - Uncharacterized N-acetyltransferase YuaI
UniProt: O32075 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 173 (146)
Sequences: 12613 (9982)
Seq/√Len: 826.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_R60_Q3.5611.00
21_D92_L2.9661.00
102_R137_Y2.9011.00
109_A139_P2.8711.00
70_A108_G2.8711.00
57_F107_K2.4641.00
59_A100_A2.4141.00
67_F95_R2.3461.00
5_R11_D2.2691.00
102_R136_A2.2551.00
107_K110_E2.2501.00
131_I135_Q2.1681.00
111_F114_Q1.9771.00
135_Q141_R1.9501.00
106_A137_Y1.9311.00
84_G112_L1.8691.00
141_R144_E1.8521.00
111_F115_H1.8501.00
7_A15_I1.8271.00
109_A120_M1.8121.00
72_F108_G1.7721.00
58_V66_V1.7601.00
14_D17_K1.7591.00
62_E95_R1.7531.00
105_L137_Y1.6951.00
68_G91_L1.6571.00
132_I135_Q1.6411.00
122_V134_Y1.6351.00
131_I141_R1.6341.00
62_E98_Q1.6021.00
56_V71_S1.6001.00
17_K21_D1.5511.00
95_R98_Q1.5441.00
62_E67_F1.4941.00
102_R106_A1.4831.00
65_S94_E1.4301.00
14_D66_V1.4011.00
4_V57_F1.3791.00
73_G87_Y1.3711.00
60_Q66_V1.3711.00
57_F111_F1.3631.00
112_L120_M1.3521.00
129_P132_I1.3231.00
18_V66_V1.3191.00
84_G117_F1.3031.00
107_K111_F1.2951.00
60_Q64_G1.2631.00
7_A58_V1.2531.00
33_I37_N1.2511.00
18_V22_S1.2511.00
83_D121_F1.2491.00
65_S92_L1.2481.00
16_A20_V1.2441.00
17_K92_L1.2411.00
126_E144_E1.2391.00
74_P117_F1.2371.00
124_V128_N1.2331.00
130_S134_Y1.2261.00
110_E114_Q1.2141.00
45_E49_K1.2091.00
32_P35_Y1.1871.00
83_D119_S1.1731.00
3_T60_Q1.1451.00
14_D65_S1.1261.00
25_T93_E1.1251.00
72_F112_L1.1141.00
6_E111_F1.1131.00
70_A104_L1.1131.00
21_D93_E1.0861.00
22_S90_Y1.0681.00
19_H69_F1.0601.00
124_V131_I1.0591.00
13_K45_E1.0331.00
70_A86_L1.0301.00
21_D94_E1.0101.00
82_Y118_S0.9971.00
120_M139_P0.9971.00
4_V107_K0.9861.00
86_L105_L0.9781.00
44_F47_K0.9761.00
62_E65_S0.9661.00
30_I35_Y0.9521.00
72_F111_F0.9271.00
91_L100_A0.9161.00
67_F100_A0.9111.00
18_V92_L0.9111.00
105_L134_Y0.9051.00
20_V24_R0.8991.00
99_G102_R0.8961.00
122_V130_S0.8891.00
109_A113_L0.8871.00
13_K17_K0.8851.00
112_L117_F0.8831.00
9_L49_K0.8811.00
6_E57_F0.8781.00
9_L53_L0.8741.00
65_S95_R0.8731.00
106_A110_E0.8701.00
49_K53_L0.8651.00
105_L139_P0.8641.00
103_A106_A0.8611.00
4_V103_A0.8531.00
46_D49_K0.8481.00
133_F137_Y0.8461.00
43_E47_K0.8431.00
100_A103_A0.8411.00
75_I85_E0.8381.00
8_K11_D0.8231.00
122_V139_P0.8201.00
85_E121_F0.8141.00
74_P84_G0.8121.00
92_L95_R0.8061.00
12_I16_A0.7981.00
146_N149_I0.7871.00
86_L122_V0.7861.00
14_D18_V0.7841.00
59_A67_F0.7641.00
46_D50_S0.7601.00
31_I35_Y0.7591.00
7_A56_V0.7571.00
124_V130_S0.7491.00
110_E113_L0.7471.00
52_S55_G0.7451.00
15_I69_F0.7421.00
103_A107_K0.7411.00
89_I134_Y0.7381.00
105_L133_F0.7331.00
109_A137_Y0.7231.00
106_A109_A0.7171.00
21_D25_T0.7161.00
9_L12_I0.7141.00
69_F90_Y0.7121.00
101_G133_F0.7071.00
48_W51_R0.7051.00
16_A45_E0.6981.00
19_H90_Y0.6971.00
47_K51_R0.6931.00
70_A89_I0.6931.00
30_I34_D0.6901.00
35_Y38_S0.6881.00
32_P36_L0.6881.00
86_L120_M0.6871.00
11_D60_Q0.6861.00
41_Y45_E0.6821.00
23_W90_Y0.6801.00
17_K65_S0.6801.00
74_P115_H0.6711.00
86_L108_G0.6711.00
7_A12_I0.6701.00
31_I34_D0.6671.00
75_I121_F0.6621.00
85_E88_A0.6591.00
19_H88_A0.6581.00
124_V134_Y0.6481.00
95_R100_A0.6441.00
85_E123_W0.6421.00
5_R58_V0.6391.00
97_R132_I0.6391.00
59_A104_L0.6371.00
14_D92_L0.6331.00
129_P135_Q0.6261.00
23_W26_T0.6221.00
145_D148_E0.6201.00
68_G104_L0.6161.00
148_E151_G0.6151.00
30_I36_L0.6071.00
89_I105_L0.6051.00
132_I136_A0.6051.00
59_A68_G0.6011.00
59_A103_A0.5991.00
22_S26_T0.5921.00
43_E46_D0.5921.00
119_S142_V0.5901.00
28_H33_I0.5881.00
71_S87_Y0.5881.00
59_A91_L0.5771.00
89_I122_V0.5731.00
44_F48_W0.5721.00
102_R132_I0.5711.00
26_T96_Q0.5711.00
97_R136_A0.5701.00
127_Q131_I0.5701.00
29_E32_P0.5691.00
71_S88_A0.5671.00
43_E48_W0.5651.00
19_H23_W0.5631.00
69_F128_N0.5631.00
19_H48_W0.5611.00
45_E48_W0.5551.00
42_K45_E0.5531.00
107_K114_Q0.5511.00
56_V60_Q0.5481.00
4_V104_L0.5451.00
105_L109_A0.5391.00
18_V90_Y0.5371.00
69_F88_A0.5321.00
25_T96_Q0.5311.00
49_K52_S0.5301.00
130_S133_F0.5291.00
14_D60_Q0.5271.00
56_V69_F0.5251.00
28_H31_I0.5231.00
50_S54_K0.5211.00
7_A11_D0.5191.00
145_D149_I0.5171.00
50_S53_L0.5151.00
123_W149_I0.5141.00
35_Y39_L0.5141.00
44_F51_R0.5141.00
84_G120_M0.5141.00
51_R56_V0.5121.00
125_I128_N0.5091.00
41_Y44_F0.5071.00
86_L134_Y0.5061.00
31_I36_L0.5041.00
72_F115_H0.5031.00
82_Y117_F0.5021.00
15_I58_V0.5021.00
12_I48_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cy2A 1 0.9595 99.9 0.339 Contact Map
2j8mA 2 0.9595 99.9 0.372 Contact Map
3dr6A 2 0.9653 99.9 0.375 Contact Map
3fncA 2 0.9017 99.9 0.379 Contact Map
1tiqA 1 0.9711 99.9 0.384 Contact Map
4e2aA 2 0.9364 99.9 0.385 Contact Map
3fixA 2 0.8613 99.9 0.388 Contact Map
4h89A 2 0.9133 99.9 0.395 Contact Map
1u6mA 1 0.9075 99.9 0.398 Contact Map
1gheA 1 0.9075 99.8 0.403 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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