YUAI - BACSU - GREMLIN Contacts

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YUAI - Uncharacterized N-acetyltransferase YuaI

UniProt:	O32075	Sequences: MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEFEDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGRALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLGWPDLSALKTLLNR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	173 (146)
Sequences:	12613 (9982)
Seq/√Len:	826.1

ECOLI - RIMI YEDL YAFP MNAT YJGM YPEA YIAC YJAB PHNO YHHY
BACSU - YUAI PAIA YWNH YHFO YHDJ YTMI YQJY RIMI YSNE YBFA YESJ YYAR YYCN YDGE SPSD YOKL
HALSA - Q9HSL3 Q9HMF0 Q9HRK6 Q9HQD2 Q9HMI8
SULSO - Q7LXZ8 Y209

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
5_R	60_Q	3.561	1.00
21_D	92_L	2.966	1.00
102_R	137_Y	2.901	1.00
109_A	139_P	2.871	1.00
70_A	108_G	2.871	1.00
57_F	107_K	2.464	1.00
59_A	100_A	2.414	1.00
67_F	95_R	2.346	1.00
5_R	11_D	2.269	1.00
102_R	136_A	2.255	1.00
107_K	110_E	2.250	1.00
131_I	135_Q	2.168	1.00
111_F	114_Q	1.977	1.00
135_Q	141_R	1.950	1.00
106_A	137_Y	1.931	1.00
84_G	112_L	1.869	1.00
141_R	144_E	1.852	1.00
111_F	115_H	1.850	1.00
7_A	15_I	1.827	1.00
109_A	120_M	1.812	1.00
72_F	108_G	1.772	1.00
58_V	66_V	1.760	1.00
14_D	17_K	1.759	1.00
62_E	95_R	1.753	1.00
105_L	137_Y	1.695	1.00
68_G	91_L	1.657	1.00
132_I	135_Q	1.641	1.00
122_V	134_Y	1.635	1.00
131_I	141_R	1.634	1.00
62_E	98_Q	1.602	1.00
56_V	71_S	1.600	1.00
17_K	21_D	1.551	1.00
95_R	98_Q	1.544	1.00
62_E	67_F	1.494	1.00
102_R	106_A	1.483	1.00
65_S	94_E	1.430	1.00
14_D	66_V	1.401	1.00
4_V	57_F	1.379	1.00
73_G	87_Y	1.371	1.00
60_Q	66_V	1.371	1.00
57_F	111_F	1.363	1.00
112_L	120_M	1.352	1.00
129_P	132_I	1.323	1.00
18_V	66_V	1.319	1.00
84_G	117_F	1.303	1.00
107_K	111_F	1.295	1.00
60_Q	64_G	1.263	1.00
7_A	58_V	1.253	1.00
33_I	37_N	1.251	1.00
18_V	22_S	1.251	1.00
83_D	121_F	1.249	1.00
65_S	92_L	1.248	1.00
16_A	20_V	1.244	1.00
17_K	92_L	1.241	1.00
126_E	144_E	1.239	1.00
74_P	117_F	1.237	1.00
124_V	128_N	1.233	1.00
130_S	134_Y	1.226	1.00
110_E	114_Q	1.214	1.00
45_E	49_K	1.209	1.00
32_P	35_Y	1.187	1.00
83_D	119_S	1.173	1.00
3_T	60_Q	1.145	1.00
14_D	65_S	1.126	1.00
25_T	93_E	1.125	1.00
72_F	112_L	1.114	1.00
6_E	111_F	1.113	1.00
70_A	104_L	1.113	1.00
21_D	93_E	1.086	1.00
22_S	90_Y	1.068	1.00
19_H	69_F	1.060	1.00
124_V	131_I	1.059	1.00
13_K	45_E	1.033	1.00
70_A	86_L	1.030	1.00
21_D	94_E	1.010	1.00
82_Y	118_S	0.997	1.00
120_M	139_P	0.997	1.00
4_V	107_K	0.986	1.00
86_L	105_L	0.978	1.00
44_F	47_K	0.976	1.00
62_E	65_S	0.966	1.00
30_I	35_Y	0.952	1.00
72_F	111_F	0.927	1.00
91_L	100_A	0.916	1.00
67_F	100_A	0.911	1.00
18_V	92_L	0.911	1.00
105_L	134_Y	0.905	1.00
20_V	24_R	0.899	1.00
99_G	102_R	0.896	1.00
122_V	130_S	0.889	1.00
109_A	113_L	0.887	1.00
13_K	17_K	0.885	1.00
112_L	117_F	0.883	1.00
9_L	49_K	0.881	1.00
6_E	57_F	0.878	1.00
9_L	53_L	0.874	1.00
65_S	95_R	0.873	1.00
106_A	110_E	0.870	1.00
49_K	53_L	0.865	1.00
105_L	139_P	0.864	1.00
103_A	106_A	0.861	1.00
4_V	103_A	0.853	1.00
46_D	49_K	0.848	1.00
133_F	137_Y	0.846	1.00
43_E	47_K	0.843	1.00
100_A	103_A	0.841	1.00
75_I	85_E	0.838	1.00
8_K	11_D	0.823	1.00
122_V	139_P	0.820	1.00
85_E	121_F	0.814	1.00
74_P	84_G	0.812	1.00
92_L	95_R	0.806	1.00
12_I	16_A	0.798	1.00
146_N	149_I	0.787	1.00
86_L	122_V	0.786	1.00
14_D	18_V	0.784	1.00
59_A	67_F	0.764	1.00
46_D	50_S	0.760	1.00
31_I	35_Y	0.759	1.00
7_A	56_V	0.757	1.00
124_V	130_S	0.749	1.00
110_E	113_L	0.747	1.00
52_S	55_G	0.745	1.00
15_I	69_F	0.742	1.00
103_A	107_K	0.741	1.00
89_I	134_Y	0.738	1.00
105_L	133_F	0.733	1.00
109_A	137_Y	0.723	1.00
106_A	109_A	0.717	1.00
21_D	25_T	0.716	1.00
9_L	12_I	0.714	1.00
69_F	90_Y	0.712	1.00
101_G	133_F	0.707	1.00
48_W	51_R	0.705	1.00
16_A	45_E	0.698	1.00
19_H	90_Y	0.697	1.00
47_K	51_R	0.693	1.00
70_A	89_I	0.693	1.00
30_I	34_D	0.690	1.00
35_Y	38_S	0.688	1.00
32_P	36_L	0.688	1.00
86_L	120_M	0.687	1.00
11_D	60_Q	0.686	1.00
41_Y	45_E	0.682	1.00
23_W	90_Y	0.680	1.00
17_K	65_S	0.680	1.00
74_P	115_H	0.671	1.00
86_L	108_G	0.671	1.00
7_A	12_I	0.670	1.00
31_I	34_D	0.667	1.00
75_I	121_F	0.662	1.00
85_E	88_A	0.659	1.00
19_H	88_A	0.658	1.00
124_V	134_Y	0.648	1.00
95_R	100_A	0.644	1.00
85_E	123_W	0.642	1.00
5_R	58_V	0.639	1.00
97_R	132_I	0.639	1.00
59_A	104_L	0.637	1.00
14_D	92_L	0.633	1.00
129_P	135_Q	0.626	1.00
23_W	26_T	0.622	1.00
145_D	148_E	0.620	1.00
68_G	104_L	0.616	1.00
148_E	151_G	0.615	1.00
30_I	36_L	0.607	1.00
89_I	105_L	0.605	1.00
132_I	136_A	0.605	1.00
59_A	68_G	0.601	1.00
59_A	103_A	0.599	1.00
22_S	26_T	0.592	1.00
43_E	46_D	0.592	1.00
119_S	142_V	0.590	1.00
28_H	33_I	0.588	1.00
71_S	87_Y	0.588	1.00
59_A	91_L	0.577	1.00
89_I	122_V	0.573	1.00
44_F	48_W	0.572	1.00
102_R	132_I	0.571	1.00
26_T	96_Q	0.571	1.00
97_R	136_A	0.570	1.00
127_Q	131_I	0.570	1.00
29_E	32_P	0.569	1.00
71_S	88_A	0.567	1.00
43_E	48_W	0.565	1.00
19_H	23_W	0.563	1.00
69_F	128_N	0.563	1.00
19_H	48_W	0.561	1.00
45_E	48_W	0.555	1.00
42_K	45_E	0.553	1.00
107_K	114_Q	0.551	1.00
56_V	60_Q	0.548	1.00
4_V	104_L	0.545	1.00
105_L	109_A	0.539	1.00
18_V	90_Y	0.537	1.00
69_F	88_A	0.532	1.00
25_T	96_Q	0.531	1.00
49_K	52_S	0.530	1.00
130_S	133_F	0.529	1.00
14_D	60_Q	0.527	1.00
56_V	69_F	0.525	1.00
28_H	31_I	0.523	1.00
50_S	54_K	0.521	1.00
7_A	11_D	0.519	1.00
145_D	149_I	0.517	1.00
50_S	53_L	0.515	1.00
123_W	149_I	0.514	1.00
35_Y	39_L	0.514	1.00
44_F	51_R	0.514	1.00
84_G	120_M	0.514	1.00
51_R	56_V	0.512	1.00
125_I	128_N	0.509	1.00
41_Y	44_F	0.507	1.00
86_L	134_Y	0.506	1.00
31_I	36_L	0.504	1.00
72_F	115_H	0.503	1.00
82_Y	117_F	0.502	1.00
15_I	58_V	0.502	1.00
12_I	48_W	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2cy2A	1	0.9595	99.9	0.339	Contact Map
2j8mA	2	0.9595	99.9	0.372	Contact Map
3dr6A	2	0.9653	99.9	0.375	Contact Map
3fncA	2	0.9017	99.9	0.379	Contact Map
1tiqA	1	0.9711	99.9	0.384	Contact Map
4e2aA	2	0.9364	99.9	0.385	Contact Map
3fixA	2	0.8613	99.9	0.388	Contact Map
4h89A	2	0.9133	99.9	0.395	Contact Map
1u6mA	1	0.9075	99.9	0.398	Contact Map
1gheA	1	0.9075	99.8	0.403	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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