GREMLIN Database
THIT - Thiamine transporter ThiT
UniProt: O32074 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 192 (165)
Sequences: 629 (509)
Seq/√Len: 39.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_I49_I3.4251.00
12_E52_R3.3201.00
128_S169_F3.2331.00
7_L11_I3.0451.00
136_V154_W2.9671.00
132_Y136_V2.9561.00
63_L92_A2.8671.00
49_I61_T2.8531.00
50_S97_S2.5611.00
136_V158_L2.5211.00
82_Q142_F2.4581.00
55_V59_L2.4581.00
96_I130_L2.3821.00
12_E53_W2.2691.00
91_F131_R2.2250.99
133_A137_I2.0340.99
160_Y164_Y2.0340.99
100_F126_I2.0090.99
140_A154_W2.0010.99
55_V99_C1.9340.99
164_Y167_P1.8710.98
125_F169_F1.8660.98
59_L92_A1.8630.98
77_A83_L1.8390.98
43_M131_R1.8130.98
21_V72_I1.7690.97
122_S126_I1.7300.97
70_I77_A1.7220.97
90_A135_H1.6860.97
36_G160_Y1.6710.96
96_I99_C1.6350.96
128_S165_M1.5760.95
144_G147_A1.5680.95
151_T159_T1.5560.95
37_G160_Y1.5410.94
17_T64_L1.5390.94
170_I174_I1.5310.94
51_F123_A1.4930.93
9_R53_W1.4860.93
13_I64_L1.4840.93
148_P151_T1.4660.93
85_L90_A1.4250.91
93_A134_A1.4110.91
9_R57_A1.4100.91
89_V134_A1.3920.90
23_L45_P1.3910.90
38_S131_R1.3840.90
10_L14_A1.3680.90
163_T167_P1.3680.90
47_F124_V1.3600.89
47_F172_C1.3430.89
66_G92_A1.3390.89
35_Q143_F1.3380.89
24_D69_Q1.3220.88
155_I159_T1.3070.87
162_A166_V1.3060.87
33_M164_Y1.2900.87
78_Q83_L1.2880.87
144_G157_S1.2640.86
137_I141_V1.2630.86
86_D138_S1.2560.85
33_M163_T1.1980.82
120_V176_L1.1810.81
93_A96_I1.1730.81
70_I83_L1.1660.81
132_Y163_T1.1560.80
27_S32_S1.1320.79
140_A157_S1.1220.78
37_G86_D1.1220.78
138_S143_F1.0900.76
36_G156_Y1.0900.76
169_F173_A1.0890.76
33_M160_Y1.0850.75
32_S174_I1.0760.75
85_L89_V1.0580.74
168_S172_C1.0570.74
129_L133_A1.0540.73
47_F51_F1.0440.73
77_A82_Q1.0370.72
155_I158_L1.0220.71
86_D160_Y1.0090.70
162_A167_P1.0050.70
94_I128_S0.9990.69
121_V173_A0.9660.67
145_S150_G0.9640.66
49_I57_A0.9570.66
48_L123_A0.9460.65
47_F127_G0.9390.64
42_M168_S0.9360.64
78_Q143_F0.9310.64
59_L63_L0.9270.63
44_I85_L0.9260.63
166_V170_I0.9200.63
132_Y158_L0.9170.63
84_L174_I0.9170.63
78_Q82_Q0.9020.61
93_A130_L0.9010.61
37_G164_Y0.8900.60
85_L134_A0.8880.60
128_S176_L0.8810.59
143_F147_A0.8780.59
86_D164_Y0.8700.58
57_A61_T0.8620.58
99_C126_I0.8620.58
54_G58_G0.8590.57
24_D27_S0.8520.57
17_T65_T0.8480.56
63_L66_G0.8470.56
24_D42_M0.8400.56
151_T155_I0.8330.55
121_V176_L0.8280.55
82_Q88_I0.8250.54
81_V141_V0.8220.54
79_H141_V0.8200.54
13_I61_T0.8180.54
77_A143_F0.8140.53
106_K174_I0.8070.53
94_I123_A0.8050.53
34_P37_G0.8030.52
125_F173_A0.8000.52
17_T57_A0.7990.52
73_G76_F0.7890.51
36_G164_Y0.7820.50
84_L88_I0.7820.50
39_V106_K0.7810.50
126_I130_L0.7810.50
85_L137_I0.7780.50
69_Q91_F0.7750.50
148_P152_P0.7740.50
17_T63_L0.7710.49
36_G86_D0.7690.49
14_A99_C0.7630.49
9_R13_I0.7600.48
13_I24_D0.7550.48
70_I78_Q0.7490.47
37_G165_M0.7480.47
133_A136_V0.7400.47
64_L71_A0.7340.46
13_I46_I0.7340.46
16_M23_L0.7330.46
131_R165_M0.7270.45
93_A133_A0.7200.45
59_L130_L0.7170.45
140_A158_L0.7130.44
152_P155_I0.7120.44
25_I72_I0.7090.44
101_A105_R0.7050.43
126_I178_L0.7040.43
135_H166_V0.6950.43
21_V42_M0.6880.42
121_V177_C0.6840.42
43_M172_C0.6820.41
82_Q180_F0.6750.41
5_K8_V0.6750.41
158_L162_A0.6700.40
148_P163_T0.6680.40
120_V173_A0.6630.40
9_R49_I0.6600.39
71_A77_A0.6570.39
35_Q86_D0.6490.39
81_V84_L0.6470.38
150_G153_V0.6470.38
140_A155_I0.6450.38
35_Q145_S0.6410.38
64_L119_S0.6400.38
162_A165_M0.6360.37
127_G130_L0.6350.37
137_I154_W0.6350.37
9_R50_S0.6340.37
82_Q127_G0.6280.37
46_I177_C0.6280.37
51_F120_V0.6260.37
129_L174_I0.6170.36
22_I125_F0.6140.36
139_G157_S0.6110.35
96_I127_G0.6090.35
83_L142_F0.6050.35
16_M49_I0.6000.34
31_L34_P0.5990.34
147_A150_G0.5990.34
21_V68_V0.5980.34
40_S168_S0.5960.34
121_V169_F0.5950.34
129_L160_Y0.5930.34
8_V53_W0.5890.34
71_A74_N0.5860.33
26_V41_I0.5860.33
14_A31_L0.5860.33
79_H145_S0.5820.33
34_P160_Y0.5810.33
64_L179_L0.5780.33
8_V183_A0.5770.33
101_A141_V0.5750.32
56_K155_I0.5740.32
4_S158_L0.5740.32
147_A157_S0.5710.32
14_A154_W0.5690.32
96_I178_L0.5640.31
18_A97_S0.5620.31
48_L84_L0.5620.31
53_W57_A0.5610.31
167_P170_I0.5610.31
17_T85_L0.5580.31
132_Y157_S0.5580.31
25_I177_C0.5570.31
172_C176_L0.5570.31
123_A168_S0.5530.31
90_A131_R0.5510.30
154_W158_L0.5480.30
126_I174_I0.5480.30
136_V140_A0.5470.30
11_I118_V0.5460.30
132_Y153_V0.5430.30
33_M165_M0.5420.30
16_M73_G0.5400.30
145_S159_T0.5400.30
44_I48_L0.5380.29
59_L96_I0.5380.29
44_I47_F0.5360.29
140_A152_P0.5350.29
34_P74_N0.5340.29
16_M42_M0.5330.29
69_Q131_R0.5270.29
20_A65_T0.5260.29
100_F123_A0.5260.29
157_S162_A0.5260.29
26_V98_G0.5220.28
147_A153_V0.5210.28
12_E15_I0.5200.28
145_S149_K0.5200.28
66_G147_A0.5190.28
50_S62_G0.5170.28
83_L89_V0.5150.28
48_L169_F0.5150.28
89_V137_I0.5150.28
15_I170_I0.5150.28
42_M46_I0.5140.28
13_I77_A0.5120.28
14_A17_T0.5110.27
80_P88_I0.5100.27
44_I168_S0.5080.27
58_G96_I0.5060.27
133_A158_L0.5060.27
26_V64_L0.5020.27
7_L19_A0.5020.27
135_H138_S0.5020.27
49_I53_W0.5020.27
56_K71_A0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tkrA 2 0.9635 100 0.526 Contact Map
3rlbA 1 0.9219 100 0.538 Contact Map
4rfsS 1 0.9167 99.9 0.649 Contact Map
3p5nA 2 0.8385 99.7 0.72 Contact Map
4z7fA 2 0.8594 99.5 0.749 Contact Map
4hzuS 1 0.8438 99.5 0.754 Contact Map
4huqS 1 0.8438 99.4 0.77 Contact Map
4dveA 3 0.9062 99.2 0.794 Contact Map
2ksfA 1 0.5469 84.2 0.925 Contact Map
4m5bA 1 0.8646 80.3 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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