GREMLIN Database
YTWF - Uncharacterized protein YtwF
UniProt: O32072 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 103 (93)
Sequences: 11188 (8085)
Seq/√Len: 838.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_V36_M2.4161.00
22_Y59_K2.3881.00
29_D42_H2.1791.00
6_I10_A2.1721.00
94_A98_E2.1351.00
10_A14_K2.1231.00
35_G96_E2.0801.00
29_D33_A2.0681.00
7_S10_A2.0421.00
8_T94_A1.7271.00
8_T98_E1.7151.00
49_P53_E1.6441.00
63_F78_L1.6361.00
11_L23_L1.5771.00
60_E85_T1.5611.00
51_K54_T1.5271.00
48_I52_M1.5241.00
31_E70_R1.4751.00
56_D59_K1.4661.00
14_K18_D1.4231.00
14_K60_E1.4181.00
43_I55_L1.3841.00
14_K21_L1.3761.00
26_V74_V1.3701.00
71_S87_N1.3561.00
75_C87_N1.3221.00
57_K83_F1.3211.00
36_M64_I1.3001.00
47_D51_K1.2641.00
21_L62_V1.2591.00
90_G94_A1.2471.00
22_Y41_V1.2311.00
51_K55_L1.2251.00
11_L88_V1.2241.00
23_L64_I1.2141.00
7_S89_E1.2121.00
11_L62_V1.1911.00
64_I92_M1.1841.00
47_D50_E1.1681.00
75_C86_V1.1671.00
92_M96_E1.1651.00
8_T12_K1.1361.00
31_E66_R1.1321.00
50_E54_T1.1181.00
8_T88_V1.1101.00
38_P95_W1.1061.00
43_I51_K1.1061.00
37_I64_I1.1051.00
65_C71_S1.0881.00
28_E31_E1.0651.00
63_F75_C1.0641.00
6_I11_L1.0471.00
93_M97_G1.0421.00
75_C79_D1.0291.00
63_F74_V1.0051.00
93_M96_E0.9971.00
66_R93_M0.9871.00
27_R92_M0.9871.00
37_I40_A0.9851.00
77_Y81_Q0.9801.00
61_Y78_L0.9791.00
79_D84_K0.9701.00
9_A13_E0.9681.00
88_V95_W0.9491.00
27_R66_R0.9391.00
65_C68_G0.9241.00
11_L15_I0.9021.00
52_M78_L0.8951.00
67_S93_M0.8921.00
62_V88_V0.8881.00
26_V63_F0.8851.00
11_L21_L0.8711.00
21_L60_E0.8691.00
12_K15_I0.8671.00
88_V94_A0.8661.00
23_L37_I0.8621.00
40_A64_I0.8521.00
76_K80_E0.8501.00
22_Y56_D0.8481.00
78_L86_V0.8441.00
22_Y61_Y0.8351.00
32_V42_H0.8211.00
94_A97_G0.8201.00
11_L14_K0.8181.00
63_F86_V0.8081.00
10_A13_E0.8071.00
32_V40_A0.8071.00
35_G92_M0.8021.00
72_M87_N0.7671.00
88_V91_G0.7651.00
37_I95_W0.7541.00
31_E34_E0.7471.00
17_A20_E0.7251.00
33_A96_E0.7231.00
79_D86_V0.7221.00
45_M73_N0.7221.00
6_I62_V0.7221.00
9_A98_E0.7091.00
67_S70_R0.7001.00
23_L40_A0.6951.00
48_I51_K0.6921.00
78_L83_F0.6901.00
36_M42_H0.6851.00
61_Y83_F0.6621.00
72_M76_K0.6591.00
67_S71_S0.6361.00
30_E33_A0.6351.00
24_I41_V0.6321.00
66_R70_R0.6261.00
31_E67_S0.6181.00
43_I74_V0.6151.00
52_M55_L0.6151.00
83_F86_V0.6111.00
20_E60_E0.6101.00
49_P81_Q0.6081.00
77_Y80_E0.6071.00
48_I81_Q0.6001.00
48_I77_Y0.5941.00
46_G70_R0.5901.00
79_D85_T0.5901.00
29_D44_R0.5721.00
80_E83_F0.5701.00
14_K19_E0.5681.00
14_K17_A0.5611.00
26_V45_M0.5601.00
66_R69_M0.5451.00
49_P57_K0.5451.00
45_M70_R0.5441.00
14_K62_V0.5431.00
45_M77_Y0.5361.00
24_I43_I0.5331.00
33_A42_H0.5281.00
8_T15_I0.5211.00
96_E99_T0.5211.00
76_K79_D0.5131.00
68_G71_S0.5051.00
24_I74_V0.5031.00
73_N76_K0.5011.00
41_V55_L0.5011.00
24_I63_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fojA 1 0.9709 99.9 0.176 Contact Map
3iwhA 1 0.9806 99.9 0.177 Contact Map
1yt8A 1 0.9903 99.9 0.182 Contact Map
3tp9A 2 0.9903 99.9 0.192 Contact Map
1gmxA 1 0.9806 99.9 0.202 Contact Map
3ilmA 2 0.9515 99.9 0.202 Contact Map
3flhA 3 1 99.9 0.208 Contact Map
3nhvA 3 1 99.9 0.212 Contact Map
1tq1A 1 0.9806 99.9 0.213 Contact Map
1qxnA 2 1 99.9 0.218 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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