GREMLIN Database
YRBD - Putative sodium/proton-dependent alanine carrier protein YrbD
UniProt: O32060 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 484 (434)
Sequences: 3790 (2342)
Seq/√Len: 112.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_V307_A4.7801.00
114_I443_A4.1411.00
217_S305_A3.5781.00
131_I432_A3.4611.00
107_V440_A3.3821.00
225_V228_L3.2651.00
117_V133_K3.0991.00
304_S308_F3.0581.00
135_L435_L3.0111.00
106_F444_L2.9681.00
233_S237_K2.9441.00
219_I223_M2.7931.00
37_V99_F2.7601.00
227_E230_A2.7181.00
232_I236_F2.7101.00
202_A366_T2.6651.00
31_M441_L2.6311.00
24_I434_V2.5671.00
201_A205_I2.5021.00
132_E138_K2.4371.00
375_A395_L2.4101.00
148_A378_N2.4091.00
6_A10_A2.4081.00
184_V400_L2.3691.00
234_L238_S2.3661.00
143_L147_A2.3511.00
115_Y439_P2.2371.00
171_A357_A2.1811.00
211_I215_L2.1791.00
7_S11_V2.1731.00
24_I430_V2.1481.00
26_F100_I2.1311.00
230_A233_S2.1171.00
132_E381_Y2.0791.00
197_R200_N2.0641.00
131_I141_A2.0631.00
241_A244_S2.0491.00
188_G400_L2.0311.00
9_N420_A1.9991.00
283_H446_D1.9921.00
75_N298_D1.9781.00
31_M438_K1.9661.00
231_V311_L1.9631.00
5_V420_A1.9311.00
91_V235_I1.9031.00
27_A437_A1.9001.00
181_C185_L1.8761.00
412_S416_A1.8731.00
222_V225_V1.8661.00
42_E45_V1.8611.00
41_K45_V1.8421.00
184_V404_F1.8291.00
142_V382_L1.8291.00
283_H450_Q1.8231.00
393_L396_K1.8071.00
5_V416_A1.7981.00
296_Y300_L1.7811.00
186_L361_F1.7711.00
282_S286_K1.7361.00
427_W431_I1.7311.00
177_F404_F1.7091.00
205_I362_F1.7061.00
376_E396_K1.6871.00
285_V443_A1.6791.00
255_S259_K1.6701.00
147_A424_I1.6691.00
83_I91_V1.6671.00
231_V308_F1.6631.00
29_S36_Q1.6521.00
77_A336_G1.6201.00
61_Q199_A1.6021.00
256_W259_K1.5891.00
233_S236_F1.5871.00
33_R445_K1.5761.00
38_R448_E1.5741.00
42_E447_Y1.5691.00
4_F8_L1.5681.00
175_S178_V1.5681.00
13_W423_G1.5571.00
246_F249_L1.5361.00
228_L231_V1.5131.00
85_F256_W1.5081.00
223_M226_S1.5031.00
188_G192_F1.4911.00
254_I258_V1.4891.00
112_A277_A1.4881.00
21_L262_I1.4881.00
379_I383_A1.4881.00
191_I372_Y1.4781.00
438_K442_L1.4781.00
215_L219_I1.4721.00
443_A446_D1.4651.00
397_L401_A1.4581.00
144_F425_M1.4461.00
64_S202_A1.4391.00
42_E46_Q1.4381.00
221_I312_F1.4371.00
178_V182_G1.4361.00
393_L397_L1.4321.00
132_E142_V1.4261.00
138_K141_A1.4221.00
102_A296_Y1.4221.00
3_D6_A1.4151.00
221_I228_L1.4121.00
276_A291_Q1.4121.00
446_D450_Q1.4111.00
71_V302_V1.4101.00
217_S309_M1.4041.00
29_S34_F1.4021.00
180_G407_T1.4011.00
61_Q203_Q1.4011.00
20_I434_V1.4001.00
165_A179_T1.3991.00
221_I308_F1.3951.00
223_M347_V1.3921.00
164_I183_L1.3901.00
142_V146_A1.3891.00
114_I439_P1.3891.00
31_M437_A1.3861.00
32_T35_L1.3771.00
15_T19_Y1.3701.00
238_S242_L1.3661.00
234_L311_L1.3591.00
95_W304_S1.3501.00
229_P233_S1.3451.00
33_R448_E1.3431.00
449_R453_Q1.3371.00
8_L420_A1.3371.00
59_S281_V1.3331.00
200_N203_Q1.3331.00
441_L445_K1.3221.00
73_T360_L1.3201.00
131_I140_F1.3191.00
231_V312_F1.3060.99
222_V226_S1.2880.99
345_D353_A1.2870.99
5_V413_L1.2820.99
27_A31_M1.2780.99
144_F273_P1.2760.99
417_L421_G1.2670.99
159_V418_G1.2550.99
278_A373_Y1.2530.99
221_I225_V1.2520.99
269_Q426_V1.2340.99
175_S179_T1.2250.99
174_I179_T1.2240.99
439_P442_L1.2080.99
40_L44_I1.2030.99
34_F37_V1.1990.99
60_F64_S1.1980.99
186_L365_F1.1970.99
58_S61_Q1.1910.99
105_A109_S1.1840.99
118_K123_Y1.1820.99
27_A441_L1.1710.99
200_N204_M1.1690.99
226_S229_P1.1680.99
275_P374_I1.1660.99
39_H448_E1.1650.99
201_A369_M1.1650.99
237_K243_D1.1650.99
218_L222_V1.1640.99
404_F408_V1.1640.99
99_F300_L1.1620.99
180_G404_F1.1610.99
368_I403_T1.1590.99
63_L297_I1.1570.99
161_S407_T1.1560.99
149_L379_I1.1530.99
134_G436_L1.1520.99
214_I218_L1.1470.99
8_L11_V1.1440.99
76_I337_P1.1410.99
177_F181_C1.1390.99
234_L237_K1.1380.99
36_Q103_A1.1330.99
315_M342_A1.1270.98
238_S241_A1.1270.98
39_H289_L1.1260.98
136_G139_W1.1240.98
219_I348_L1.1220.98
149_L152_M1.1210.98
20_I427_W1.1210.98
247_G251_G1.1180.98
348_L351_F1.1130.98
383_A391_A1.1130.98
28_F107_V1.1120.98
7_S10_A1.1080.98
109_S291_Q1.1000.98
77_A163_S1.0900.98
342_A346_S1.0890.98
224_N312_F1.0860.98
40_L296_Y1.0820.98
130_Y432_A1.0810.98
306_T340_T1.0800.98
19_Y23_G1.0770.98
342_A345_D1.0720.98
313_T347_V1.0640.98
313_T343_A1.0620.98
97_I258_V1.0600.98
205_I366_T1.0580.98
156_M371_Y1.0560.98
252_M256_W1.0540.98
166_A338_G1.0530.98
84_A339_F1.0520.98
178_V181_C1.0450.98
214_I305_A1.0440.98
187_L365_F1.0430.98
310_I339_F1.0420.97
135_L139_W1.0420.97
224_N227_E1.0380.97
65_I195_V1.0380.97
110_T288_G1.0360.97
22_L97_I1.0310.97
310_I340_T1.0300.97
354_G358_I1.0290.97
193_G197_R1.0280.97
106_F110_T1.0270.97
379_I391_A1.0260.97
139_W143_L1.0260.97
106_F285_V1.0250.97
185_L189_F1.0240.97
220_I347_V1.0240.97
293_F297_I1.0230.97
3_D7_S1.0190.97
69_G370_A1.0170.97
110_T285_V1.0160.97
338_G342_A1.0140.97
225_V229_P1.0050.97
355_F359_A1.0040.97
228_L232_I1.0020.97
152_M271_T1.0000.97
230_A234_L0.9990.97
445_K449_R0.9970.97
47_M290_V0.9960.97
59_S290_V0.9950.97
124_R377_T0.9920.97
426_V430_V0.9910.97
401_A405_Y0.9900.97
246_F250_I0.9870.97
39_H42_E0.9850.96
102_A300_L0.9840.96
220_I344_I0.9830.96
80_A340_T0.9770.96
243_D249_L0.9760.96
17_V423_G0.9640.96
245_A248_G0.9640.96
138_K142_V0.9630.96
61_Q200_N0.9600.96
307_A311_L0.9520.96
244_S247_G0.9510.96
22_L262_I0.9510.96
43_M293_F0.9490.96
405_Y409_K0.9490.96
4_F7_S0.9470.96
95_W232_I0.9440.96
80_A310_I0.9440.96
392_M396_K0.9420.95
42_E451_K0.9380.95
208_F212_G0.9360.95
266_E271_T0.9350.95
148_A425_M0.9350.95
196_K200_N0.9330.95
117_V132_E0.9330.95
252_M255_S0.9320.95
450_Q454_G0.9240.95
444_L448_E0.9240.95
83_I310_I0.9210.95
150_I421_G0.9190.95
83_I307_A0.9140.95
227_E312_F0.9100.95
163_S360_L0.9100.95
335_A338_G0.9080.94
44_I293_F0.9080.94
162_N415_W0.9070.94
352_G356_V0.9070.94
32_T441_L0.9060.94
245_A249_L0.9040.94
79_V303_C0.9040.94
127_P273_P0.9020.94
302_V305_A0.9020.94
170_N338_G0.9020.94
187_L368_I0.9010.94
20_I24_I0.9000.94
169_Q176_P0.8990.94
172_F354_G0.8980.94
264_S298_D0.8960.94
140_F432_A0.8950.94
102_A292_A0.8900.94
221_I231_V0.8880.94
312_F347_V0.8880.94
56_G280_E0.8870.94
398_I401_A0.8820.94
434_V437_A0.8820.94
109_S294_S0.8820.94
43_M292_A0.8810.94
123_Y280_E0.8770.93
88_P234_L0.8750.93
219_I222_V0.8640.93
166_A169_Q0.8620.93
83_I311_L0.8620.93
267_A295_V0.8590.93
28_F433_I0.8580.93
67_L71_V0.8570.93
439_P443_A0.8550.92
85_F250_I0.8530.92
156_M269_Q0.8530.92
168_I361_F0.8510.92
212_G359_A0.8470.92
77_A80_A0.8450.92
167_G341_Q0.8450.92
435_L438_K0.8430.92
190_I201_A0.8410.92
70_R105_A0.8400.92
18_I22_L0.8390.92
92_F240_F0.8380.92
131_I139_W0.8360.92
437_A441_L0.8340.92
92_F96_A0.8320.91
416_A420_A0.8310.91
31_M34_F0.8300.91
161_S368_I0.8270.91
158_G409_K0.8260.91
187_L403_T0.8260.91
76_I356_V0.8220.91
296_Y301_F0.8220.91
152_M395_L0.8200.91
83_I316_Y0.8180.91
57_V199_A0.8180.91
282_S447_Y0.8150.91
46_Q290_V0.8130.90
107_V110_T0.8130.90
273_P277_A0.8120.90
305_A309_M0.8120.90
345_D350_G0.8090.90
300_L304_S0.8080.90
6_A416_A0.8050.90
220_I309_M0.8040.90
29_S37_V0.8040.90
216_L359_A0.8030.90
81_T256_W0.8030.90
204_M208_F0.7960.90
232_I308_F0.7950.89
113_Q116_K0.7950.89
119_Q385_G0.7920.89
75_N264_S0.7910.89
156_M422_L0.7890.89
71_V210_A0.7890.89
50_G53_S0.7880.89
314_G317_N0.7880.89
107_V441_L0.7870.89
12_L16_P0.7840.89
147_A428_L0.7820.89
198_I373_Y0.7820.89
206_V209_M0.7810.89
157_P418_G0.7810.89
291_Q294_S0.7800.89
23_G434_V0.7800.89
117_V124_R0.7790.89
377_T380_A0.7780.88
63_L290_V0.7740.88
140_F143_L0.7730.88
127_P130_Y0.7720.88
125_G277_A0.7710.88
281_V286_K0.7690.88
163_S337_P0.7670.88
234_L316_Y0.7670.88
12_L427_W0.7660.88
242_L245_A0.7660.88
169_Q179_T0.7640.88
35_L444_L0.7600.87
180_G408_V0.7580.87
226_S230_A0.7570.87
16_P19_Y0.7570.87
25_G101_G0.7560.87
286_K447_Y0.7550.87
216_L355_F0.7530.87
264_S299_T0.7530.87
192_F393_L0.7500.87
345_D349_P0.7500.87
43_M289_L0.7490.86
402_A405_Y0.7480.86
70_R291_Q0.7470.86
216_L348_L0.7470.86
235_I307_A0.7430.86
49_K52_S0.7420.86
4_F11_V0.7400.86
438_K445_K0.7390.86
409_K414_A0.7380.86
17_V426_V0.7370.86
391_A394_G0.7370.86
195_V373_Y0.7370.86
25_G100_I0.7340.85
232_I304_S0.7330.85
105_A272_G0.7300.85
11_V15_T0.7300.85
238_S243_D0.7270.85
35_L39_H0.7270.85
210_A302_V0.7260.85
64_S203_Q0.7260.85
290_V294_S0.7240.85
440_A444_L0.7240.85
354_G357_A0.7230.85
351_F354_G0.7220.84
313_T318_T0.7220.84
84_A335_A0.7210.84
177_F408_V0.7150.84
168_I179_T0.7120.84
206_V210_A0.7110.84
18_I262_I0.7110.84
69_G371_Y0.7090.83
101_G104_S0.7090.83
228_L308_F0.7070.83
313_T316_Y0.7050.83
169_Q173_G0.7000.83
32_T444_L0.6990.82
47_M293_F0.6980.82
81_T84_A0.6980.82
209_M264_S0.6950.82
276_A294_S0.6950.82
166_A170_N0.6910.82
159_V415_W0.6900.82
49_K53_S0.6880.81
109_S276_A0.6880.81
15_T18_I0.6870.81
341_Q345_D0.6870.81
451_K454_G0.6860.81
55_A280_E0.6850.81
445_K448_E0.6850.81
195_V198_I0.6820.81
184_V188_G0.6800.81
46_Q447_Y0.6790.81
139_W142_V0.6780.81
283_H447_Y0.6760.80
223_M227_E0.6750.80
68_S295_V0.6750.80
237_K241_A0.6730.80
65_I370_A0.6730.80
394_G397_L0.6720.80
152_M371_Y0.6700.80
167_G337_P0.6690.80
356_V359_A0.6690.80
371_Y422_L0.6680.80
158_G161_S0.6670.79
236_F311_L0.6670.79
186_L189_F0.6660.79
33_R41_K0.6660.79
156_M418_G0.6650.79
32_T107_V0.6640.79
214_I217_S0.6630.79
73_T364_A0.6620.79
237_K242_L0.6600.79
85_F252_M0.6600.79
308_F312_F0.6600.79
438_K441_L0.6600.79
350_G353_A0.6590.79
337_P360_L0.6570.78
34_F99_F0.6540.78
227_E231_V0.6540.78
56_G123_Y0.6540.78
224_N347_V0.6510.78
271_T371_Y0.6480.77
98_A299_T0.6480.77
264_S300_L0.6480.77
164_I364_A0.6470.77
285_V440_A0.6470.77
35_L103_A0.6470.77
335_A339_F0.6430.77
76_I363_F0.6410.77
172_F179_T0.6410.77
12_L426_V0.6380.76
438_K443_A0.6350.76
71_V297_I0.6350.76
107_V444_L0.6350.76
157_P399_I0.6320.76
269_Q422_L0.6300.75
91_V95_W0.6300.75
54_E118_K0.6300.75
128_A378_N0.6280.75
154_F398_I0.6270.75
63_L294_S0.6260.75
357_A361_F0.6260.75
142_V145_A0.6250.75
212_G358_I0.6250.75
249_L316_Y0.6240.75
156_M426_V0.6210.74
73_T163_S0.6200.74
124_R380_A0.6180.74
235_I311_L0.6170.74
28_F437_A0.6170.74
157_P371_Y0.6170.74
212_G216_L0.6160.74
46_Q286_K0.6140.74
213_Y217_S0.6140.74
435_L439_P0.6140.74
242_L246_F0.6110.73
84_A319_Q0.6100.73
69_G269_Q0.6100.73
315_M318_T0.6100.73
152_M156_M0.6100.73
106_F440_A0.6070.73
94_M299_T0.6070.73
24_I28_F0.6050.73
220_I313_T0.6020.72
297_I301_F0.6020.72
47_M297_I0.6020.72
37_V41_K0.6020.72
110_T440_A0.6010.72
112_A273_P0.5950.71
180_G184_V0.5930.71
320_A338_G0.5900.71
96_A236_F0.5900.71
81_T411_A0.5890.71
110_T443_A0.5890.71
227_E234_L0.5860.70
309_M344_I0.5860.70
405_Y408_V0.5830.70
218_L221_I0.5830.70
17_V427_W0.5830.70
40_L102_A0.5810.70
98_A101_G0.5810.70
316_Y343_A0.5800.69
45_V48_F0.5800.69
315_M339_F0.5790.69
70_R276_A0.5790.69
97_I262_I0.5790.69
253_A256_W0.5790.69
159_V414_A0.5790.69
131_I137_I0.5780.69
241_A249_L0.5760.69
313_T317_N0.5760.69
130_Y429_N0.5760.69
114_I442_L0.5750.69
77_A335_A0.5740.69
59_S279_A0.5740.69
187_L191_I0.5720.68
95_W236_F0.5700.68
214_I301_F0.5700.68
249_L252_M0.5680.68
151_A422_L0.5680.68
276_A287_Q0.5670.68
179_T183_L0.5670.68
145_A382_L0.5670.68
340_T343_A0.5660.68
195_V199_A0.5660.68
431_I435_L0.5660.68
81_T415_W0.5650.67
143_L146_A0.5650.67
243_D246_F0.5650.67
173_G176_P0.5640.67
127_P274_H0.5630.67
81_T336_G0.5630.67
107_V433_I0.5620.67
395_L399_I0.5620.67
191_I396_K0.5600.67
168_I172_F0.5590.67
142_V381_Y0.5580.66
277_A396_K0.5570.66
110_T444_L0.5560.66
182_G185_L0.5540.66
272_G374_I0.5530.66
33_R438_K0.5520.66
57_V65_I0.5520.66
128_A274_H0.5520.66
92_F236_F0.5500.65
43_M47_M0.5490.65
216_L361_F0.5490.65
379_I394_G0.5480.65
122_Q196_K0.5470.65
39_H452_K0.5460.65
225_V230_A0.5450.65
73_T164_I0.5450.65
105_A116_K0.5430.64
179_T182_G0.5420.64
104_S272_G0.5420.64
112_A272_G0.5410.64
229_P232_I0.5400.64
120_D385_G0.5400.64
75_N90_A0.5400.64
176_P179_T0.5390.64
57_V278_A0.5390.64
146_A149_L0.5390.64
368_I399_I0.5390.64
77_A360_L0.5380.64
20_I431_I0.5380.64
28_F440_A0.5380.64
35_L106_F0.5360.63
410_T413_L0.5360.63
55_A281_V0.5360.63
245_A253_A0.5350.63
345_D352_G0.5350.63
140_F435_L0.5330.63
158_G414_A0.5320.63
401_A404_F0.5320.63
360_L367_T0.5290.62
35_L40_L0.5290.62
84_A338_G0.5280.62
104_S265_N0.5270.62
88_P316_Y0.5270.62
5_V9_N0.5270.62
241_A245_A0.5260.62
12_L420_A0.5250.62
53_S280_E0.5240.62
154_F399_I0.5240.62
449_R452_K0.5230.61
446_D449_R0.5230.61
448_E452_K0.5230.61
263_Y418_G0.5220.61
316_Y319_Q0.5220.61
89_G239_A0.5210.61
158_G411_A0.5210.61
265_N299_T0.5210.61
450_Q453_Q0.5210.61
190_I365_F0.5190.61
70_R109_S0.5190.61
380_A385_G0.5190.61
135_L432_A0.5160.60
59_S287_Q0.5150.60
62_A275_P0.5150.60
35_L289_L0.5140.60
164_I361_F0.5130.60
220_I346_S0.5120.60
424_I428_L0.5120.60
107_V437_A0.5110.60
210_A368_I0.5110.60
152_M399_I0.5100.60
79_V264_S0.5100.60
81_T163_S0.5100.60
141_A147_A0.5090.59
155_L263_Y0.5090.59
287_Q295_V0.5080.59
119_Q122_Q0.5070.59
245_A252_M0.5070.59
63_L67_L0.5060.59
232_I235_I0.5060.59
181_C404_F0.5050.59
447_Y451_K0.5050.59
360_L364_A0.5050.59
158_G410_T0.5050.59
17_V420_A0.5040.59
166_A336_G0.5040.59
134_G137_I0.5040.59
165_A407_T0.5030.59
255_S420_A0.5020.58
76_I340_T0.5020.58
413_L417_L0.5020.58
69_G367_T0.5010.58
67_L297_I0.5010.58
122_Q377_T0.5010.58
166_A176_P0.5000.58
105_A294_S0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.7831 99.9 0.862 Contact Map
3giaA 1 0.7872 99.8 0.872 Contact Map
4djkA 2 0.7293 99.6 0.895 Contact Map
2xq2A 2 0.8512 98.3 0.942 Contact Map
3dh4A 3 0.8223 98.1 0.944 Contact Map
4wgvA 2 0.75 97.8 0.949 Contact Map
4us3A 1 0.7872 97.1 0.954 Contact Map
2a65A 2 0.814 97 0.955 Contact Map
4xp4A 1 0.8058 96.5 0.958 Contact Map
4c7rA 3 0.8926 95.8 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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