GREMLIN Database
YRZF - Putative serine/threonine-protein kinase YrzF
UniProt: O32057 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 215 (178)
Sequences: 80648 (47624)
Seq/√Len: 3569.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_A50_K3.2711.00
142_I152_I3.0951.00
31_T43_A2.7751.00
32_L40_Y2.6361.00
44_L51_M2.3551.00
124_S128_A2.3251.00
44_L53_L2.3191.00
137_H172_A2.2791.00
120_E191_L2.2701.00
97_K145_E2.1961.00
32_L35_K2.1841.00
102_Y139_R2.1571.00
118_Q149_V2.1561.00
144_T148_A2.1291.00
76_G82_D2.1201.00
118_Q148_A2.0531.00
28_E47_G2.0511.00
77_S125_D2.0291.00
171_S176_L2.0041.00
141_L149_V2.0031.00
94_E150_R1.9691.00
123_L191_L1.9261.00
119_V141_L1.9181.00
28_E45_T1.9031.00
43_A95_Y1.8951.00
30_L45_T1.8801.00
144_T150_R1.8681.00
45_T50_K1.8551.00
177_Y186_I1.7771.00
84_Y94_E1.7021.00
82_D94_E1.6731.00
96_I144_T1.6551.00
26_K46_E1.6451.00
100_T103_N1.6351.00
136_I194_I1.5811.00
112_S115_M1.5721.00
32_L42_F1.5691.00
123_L136_I1.5631.00
79_F122_A1.5481.00
35_K40_Y1.4721.00
53_L92_L1.4621.00
113_D116_I1.4621.00
49_R84_Y1.4431.00
175_A197_L1.4261.00
30_L43_A1.4121.00
102_Y106_K1.4121.00
99_E107_K1.4061.00
122_A151_V1.3901.00
138_L175_A1.3901.00
131_L157_F1.3341.00
79_F121_E1.3271.00
55_V90_F1.3051.00
141_L194_I1.2951.00
51_M92_L1.2931.00
73_K159_Q1.2821.00
96_I150_R1.2801.00
41_V52_A1.2781.00
116_I199_K1.2531.00
125_D129_A1.2511.00
138_L194_I1.2401.00
105_L197_L1.2381.00
104_C108_G1.2291.00
50_K95_Y1.2211.00
102_Y197_L1.1971.00
180_P186_I1.1741.00
30_L50_K1.1521.00
70_I157_F1.1491.00
123_L127_R1.1441.00
42_F55_V1.1411.00
134_S170_K1.1331.00
29_E42_F1.1311.00
96_I142_I1.1281.00
119_V149_V1.1221.00
133_P136_I1.1171.00
177_Y180_P1.1121.00
53_L90_F1.1101.00
87_G90_F1.1081.00
73_K129_A1.1071.00
138_L197_L1.1061.00
51_M84_Y1.1031.00
46_E49_R1.0761.00
87_G92_L1.0721.00
96_I152_I1.0711.00
81_P152_I1.0651.00
33_I95_Y1.0641.00
83_I86_T1.0541.00
193_I196_F1.0481.00
81_P93_M1.0461.00
108_G115_M1.0451.00
71_Y83_I1.0441.00
121_E124_S1.0361.00
113_D117_Q1.0301.00
143_L149_V1.0241.00
191_L195_A1.0231.00
104_C143_L1.0221.00
81_P96_I1.0181.00
58_P88_D1.0141.00
99_E152_I1.0121.00
131_L159_Q1.0091.00
61_Q65_V1.0031.00
156_R170_K1.0021.00
50_K97_K0.9991.00
135_D140_N0.9891.00
189_F193_I0.9831.00
80_Y126_A0.9831.00
52_A95_Y0.9811.00
79_F148_A0.9781.00
119_V136_I0.9731.00
126_A154_V0.9581.00
79_F118_Q0.9471.00
119_V194_I0.9411.00
65_V69_A0.9301.00
144_T147_G0.9271.00
40_Y57_F0.9231.00
140_N153_D0.9231.00
104_C111_I0.9221.00
29_E44_L0.9151.00
27_S85_E0.9071.00
196_F200_K0.8921.00
68_A86_T0.8881.00
76_G125_D0.8841.00
71_Y93_M0.8761.00
114_D117_Q0.8641.00
136_I151_V0.8611.00
116_I198_Y0.8611.00
74_L125_D0.8591.00
74_L126_A0.8581.00
119_V191_L0.8541.00
100_T139_R0.8541.00
111_I116_I0.8531.00
74_L131_L0.8511.00
83_I91_I0.8471.00
102_Y138_L0.8421.00
26_K48_G0.8361.00
193_I197_L0.8171.00
98_G147_G0.8171.00
125_D128_A0.8151.00
27_S92_L0.8141.00
126_A131_L0.8141.00
34_G41_V0.8131.00
179_K186_I0.8041.00
40_Y55_V0.8021.00
26_K85_E0.7991.00
105_L198_Y0.7941.00
77_S121_E0.7931.00
112_S116_I0.7871.00
120_E188_G0.7861.00
78_A148_A0.7811.00
70_I131_L0.7781.00
83_I93_M0.7631.00
29_E55_V0.7621.00
99_E103_N0.7591.00
66_K69_A0.7591.00
78_A121_E0.7501.00
99_E104_C0.7481.00
119_V122_A0.7391.00
34_G52_A0.7361.00
69_A72_E0.7331.00
68_A72_E0.7331.00
65_V88_D0.7271.00
104_C115_M0.7261.00
44_L92_L0.7241.00
46_E51_M0.7151.00
101_F198_Y0.7141.00
35_K57_F0.7101.00
188_G192_E0.7001.00
96_I143_L0.7001.00
177_Y181_I0.6961.00
27_S46_E0.6951.00
137_H140_N0.6941.00
27_S51_M0.6891.00
82_D150_R0.6841.00
77_S80_Y0.6831.00
174_H189_F0.6791.00
36_G39_A0.6781.00
30_L44_L0.6771.00
169_L176_L0.6771.00
80_Y125_D0.6761.00
137_H153_D0.6701.00
176_L180_P0.6691.00
195_A198_Y0.6671.00
101_F194_I0.6631.00
36_G52_A0.6631.00
60_Y63_T0.6591.00
70_I159_Q0.6581.00
46_E85_E0.6581.00
134_S158_E0.6571.00
68_A83_I0.6531.00
62_A65_V0.6491.00
61_Q88_D0.6491.00
118_Q121_E0.6431.00
26_K47_G0.6431.00
68_A91_I0.6401.00
29_E53_L0.6341.00
49_R82_D0.6331.00
135_D172_A0.6321.00
29_E32_L0.6271.00
77_S122_A0.6251.00
111_I115_M0.6231.00
58_P89_S0.6221.00
98_G144_T0.6111.00
96_I99_E0.6111.00
176_L181_I0.6091.00
56_F64_A0.6081.00
95_Y99_E0.6071.00
185_K188_G0.6061.00
24_K27_S0.6001.00
99_E142_I0.5991.00
69_A73_K0.5981.00
104_C147_G0.5961.00
186_I190_W0.5951.00
80_Y154_V0.5941.00
139_R172_A0.5931.00
172_A175_A0.5931.00
105_L138_L0.5901.00
118_Q122_A0.5891.00
115_M147_G0.5891.00
164_T167_D0.5881.00
174_H193_I0.5801.00
132_N186_I0.5771.00
195_A199_K0.5771.00
46_E84_Y0.5751.00
158_E166_W0.5721.00
97_K144_T0.5721.00
127_R187_P0.5711.00
126_A151_V0.5691.00
116_I195_A0.5681.00
191_L194_I0.5681.00
30_L42_F0.5671.00
110_A113_D0.5641.00
69_A159_Q0.5611.00
67_E71_Y0.5591.00
24_K29_E0.5571.00
85_E92_L0.5561.00
39_A56_F0.5541.00
132_N187_P0.5541.00
123_L188_G0.5531.00
98_G145_E0.5521.00
94_E144_T0.5521.00
62_A66_K0.5511.00
81_P150_R0.5491.00
132_N160_T0.5471.00
39_A54_K0.5451.00
103_N106_K0.5441.00
163_C166_W0.5431.00
81_P122_A0.5431.00
166_W169_L0.5401.00
103_N107_K0.5381.00
176_L186_I0.5351.00
133_P151_V0.5341.00
197_L200_K0.5311.00
27_S87_G0.5311.00
33_I43_A0.5301.00
123_L151_V0.5291.00
59_E62_A0.5281.00
80_Y122_A0.5251.00
101_F141_L0.5221.00
67_E135_D0.5211.00
63_T66_K0.5181.00
81_P94_E0.5181.00
119_V151_V0.5141.00
70_I154_V0.5111.00
25_E47_G0.5111.00
120_E124_S0.5111.00
45_T48_G0.5091.00
33_I41_V0.5031.00
38_S156_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lqsA 1 0.9302 100 0.204 Contact Map
4aw2A 2 0.9953 100 0.204 Contact Map
4fr4A 1 0.9163 100 0.209 Contact Map
4im0A 2 0.8279 100 0.214 Contact Map
4dc2A 1 0.8977 100 0.218 Contact Map
4gv1A 1 0.907 100 0.222 Contact Map
4euuA 2 0.9163 100 0.223 Contact Map
3zonA 1 0.9116 100 0.223 Contact Map
4kikA 2 0.9256 100 0.223 Contact Map
3v8sA 2 0.9907 100 0.228 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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