GREMLIN Database
QUEA - S-adenosylmethionine:tRNA ribosyltransferase-isomerase
UniProt: O32054 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 342 (336)
Sequences: 3277 (1968)
Seq/√Len: 107.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_D324_H4.8681.00
233_E237_A3.9351.00
7_D302_K3.6631.00
315_R319_L3.3001.00
218_E221_E3.0241.00
55_C242_V2.9921.00
41_S45_H2.9731.00
58_L201_F2.9501.00
60_N201_F2.8201.00
13_R329_E2.7361.00
14_L329_E2.6321.00
40_D330_Y2.5481.00
198_Q238_A2.4811.00
190_Q194_D2.4591.00
193_K199_I2.4261.00
323_N327_E2.3601.00
242_V247_G2.3341.00
41_S49_F2.1731.00
118_I131_E2.1611.00
200_E238_A2.1471.00
22_Q25_A2.1231.00
147_E158_L2.1141.00
229_Y274_S2.0751.00
200_E235_T2.0691.00
171_E230_Q2.0241.00
107_V118_I2.0121.00
241_K245_N2.0021.00
237_A241_K1.9871.00
60_N203_T1.9841.00
36_G317_N1.9741.00
18_V159_D1.9501.00
250_I293_G1.9221.00
25_A44_K1.9191.00
230_Q275_S1.9191.00
31_L317_N1.9181.00
317_N320_R1.8611.00
190_Q193_K1.8541.00
30_V49_F1.8471.00
48_S195_K1.8371.00
51_N247_G1.8291.00
26_S163_R1.8231.00
91_K131_E1.8141.00
248_R293_G1.7991.00
282_I286_Y1.7831.00
61_T174_S1.7731.00
24_D185_T1.7521.00
168_Y181_G1.7421.00
65_P161_K1.7171.00
232_S235_T1.7001.00
150_L154_I1.6891.00
72_K106_T1.6851.00
107_V116_K1.6821.00
62_R162_E1.6751.00
243_R292_D1.6451.00
41_S48_S1.6321.00
120_T131_E1.6291.00
43_F295_I1.6031.00
60_N170_K1.6011.00
58_L199_I1.5921.00
251_S260_L1.5851.00
70_G108_V1.5761.00
31_L321_A1.5761.00
313_A321_A1.5691.00
214_V307_M1.5691.00
251_S257_T1.5591.00
47_I195_K1.5541.00
239_L271_F1.5451.00
288_F311_A1.5341.00
198_Q242_V1.5131.00
251_S291_I1.5101.00
81_L96_A1.4981.00
264_A290_A1.4931.00
233_E273_A1.4881.00
102_V108_V1.4861.00
51_N248_R1.4851.00
27_R328_E1.4751.00
236_A271_F1.4751.00
57_V200_E1.4751.00
83_L92_W1.4711.00
198_Q241_K1.4701.00
293_G340_L1.4651.00
91_K129_K1.4531.00
54_D248_R1.4521.00
85_K277_W1.4521.00
60_N171_E1.4451.00
137_I140_E1.4401.00
257_T291_I1.4281.00
17_Q154_I1.4131.00
67_R80_E1.4111.00
235_T238_A1.4101.00
3_V219_V1.4071.00
226_A279_S1.4031.00
324_H327_E1.3951.00
306_I318_I1.3921.00
88_T91_K1.3911.00
147_E157_Q1.3901.00
50_F197_V1.3831.00
110_F117_A1.3721.00
69_F147_E1.3681.00
231_M263_I1.3671.00
55_C238_A1.3661.00
51_N195_K1.3581.00
14_L326_V1.3521.00
28_L338_A1.3401.00
324_H328_E1.3360.99
224_M304_S1.3330.99
3_V302_K1.3310.99
262_T278_T1.3190.99
8_F280_I1.3190.99
265_G268_D1.3150.99
216_A221_E1.2950.99
26_S43_F1.2890.99
47_I191_Q1.2840.99
31_L313_A1.2830.99
32_D39_T1.2730.99
18_V156_E1.2730.99
117_A130_M1.2690.99
48_S191_Q1.2660.99
265_G286_Y1.2620.99
62_R169_S1.2620.99
257_T294_M1.2600.99
55_C198_Q1.2560.99
156_E335_F1.2530.99
47_I192_L1.2510.99
223_N279_S1.2500.99
191_Q195_K1.2480.99
50_F250_I1.2480.99
46_I188_I1.2380.99
121_E129_K1.2360.99
323_N326_V1.2360.99
55_C200_E1.2340.99
4_D302_K1.2330.99
32_D35_T1.2310.99
20_L24_D1.2230.99
236_A240_N1.2150.99
30_V41_S1.2100.99
242_V245_N1.2080.99
324_H330_Y1.2080.99
239_L290_A1.1960.99
313_A318_I1.1940.99
229_Y259_T1.1940.99
31_L341_I1.1890.99
202_I231_M1.1870.99
118_I133_Q1.1820.99
51_N54_D1.1730.99
104_K121_E1.1630.99
240_N270_Q1.1620.99
29_M324_H1.1540.98
86_Q139_Y1.1520.98
24_D44_K1.1490.98
85_K93_E1.1440.98
94_T130_M1.1390.98
31_L318_I1.1390.98
2_K218_E1.1380.98
198_Q245_N1.1360.98
87_E91_K1.1340.98
220_E283_Y1.1320.98
310_S315_R1.1290.98
81_L110_F1.1240.98
20_L25_A1.0980.98
160_D335_F1.0960.98
98_P101_R1.0910.98
57_V260_L1.0900.98
238_A242_V1.0870.98
68_L83_L1.0790.98
173_G205_H1.0760.98
3_V216_A1.0750.98
259_T263_I1.0710.98
202_I259_T1.0700.98
236_A273_A1.0650.97
102_V119_C1.0640.97
262_T276_G1.0620.97
239_L249_I1.0570.97
46_I295_I1.0520.97
265_G272_K1.0520.97
81_L108_V1.0490.97
132_F138_F1.0470.97
318_I341_I1.0460.97
55_C247_G1.0450.97
191_Q194_D1.0410.97
271_F290_A1.0390.97
228_F277_W1.0340.97
312_L341_I1.0330.97
87_E129_K1.0270.97
167_V189_L1.0200.97
115_L141_V1.0160.97
189_L199_I1.0150.97
309_V318_I1.0150.97
186_E190_Q1.0110.97
109_T116_K1.0090.96
243_R290_A1.0090.96
32_D37_E1.0070.96
119_C130_M1.0040.96
58_L189_L1.0040.96
5_L315_R1.0010.96
188_I295_I0.9880.96
91_K120_T0.9800.96
8_F306_I0.9780.96
320_R324_H0.9780.96
198_Q247_G0.9750.96
72_K75_T0.9690.96
250_I340_L0.9620.95
186_E193_K0.9600.95
260_L291_I0.9570.95
244_E270_Q0.9520.95
62_R172_I0.9510.95
81_L130_M0.9440.95
64_L172_I0.9390.95
219_V283_Y0.9380.95
2_K5_L0.9370.95
31_L38_L0.9320.95
2_K217_D0.9290.94
286_Y289_K0.9290.94
252_V295_I0.9230.94
84_L95_L0.9170.94
24_D188_I0.9150.94
95_L208_L0.9140.94
117_A132_F0.9130.94
17_Q155_K0.9110.94
43_F184_F0.9110.94
300_L333_F0.9010.93
243_R246_G0.8990.93
92_W138_F0.8940.93
122_E128_R0.8920.93
265_G289_K0.8800.93
187_E191_Q0.8800.93
96_A128_R0.8770.93
4_D7_D0.8770.93
74_D107_V0.8750.92
50_F56_L0.8740.92
82_L148_M0.8730.92
72_K77_A0.8720.92
84_L208_L0.8710.92
116_K133_Q0.8700.92
111_G145_L0.8690.92
123_L127_G0.8650.92
45_H49_F0.8600.92
166_T181_G0.8560.92
158_L335_F0.8540.92
320_R323_N0.8510.91
294_M309_V0.8510.91
206_V255_T0.8480.91
90_D134_Y0.8440.91
96_A102_V0.8430.91
143_E172_I0.8300.90
326_V329_E0.8260.90
235_T239_L0.8250.90
3_V220_E0.8210.90
40_D328_E0.8200.90
170_K201_F0.8150.90
45_H48_S0.8070.89
39_T49_F0.8050.89
38_L324_H0.8010.89
37_E317_N0.7990.89
3_V7_D0.7980.89
3_V218_E0.7970.88
314_G317_N0.7920.88
214_V304_S0.7910.88
35_T317_N0.7870.88
96_A130_M0.7860.88
52_E195_K0.7850.88
326_V333_F0.7820.88
25_A42_S0.7810.87
27_R329_E0.7810.87
242_V249_I0.7760.87
222_H304_S0.7740.87
49_F340_L0.7730.87
108_V130_M0.7640.86
231_M259_T0.7610.86
168_Y256_S0.7570.86
46_I50_F0.7560.86
316_E319_L0.7540.86
4_D217_D0.7510.85
6_F307_M0.7480.85
83_L138_F0.7470.85
30_V340_L0.7400.84
201_F235_T0.7390.84
128_R132_F0.7380.84
228_F275_S0.7340.84
188_I338_A0.7340.84
187_E190_Q0.7330.84
176_A179_T0.7330.84
192_L199_I0.7320.84
249_I290_A0.7300.84
22_Q187_E0.7300.84
14_L27_R0.7300.84
20_L331_R0.7300.84
304_S307_M0.7270.83
315_R318_I0.7270.83
47_I188_I0.7240.83
67_R82_L0.7220.83
79_V98_P0.7150.82
82_L175_A0.7120.82
181_G256_S0.7110.82
234_E237_A0.7020.81
306_I310_S0.6990.81
56_L250_I0.6970.81
169_S172_I0.6960.81
287_E323_N0.6950.81
30_V39_T0.6930.80
38_L320_R0.6930.80
31_L339_M0.6920.80
148_M158_L0.6880.80
107_V133_Q0.6880.80
29_M38_L0.6880.80
3_V304_S0.6870.80
77_A101_R0.6850.80
202_I235_T0.6850.80
294_M312_L0.6840.80
175_A208_L0.6840.80
29_M321_A0.6810.79
77_A98_P0.6800.79
69_F78_K0.6790.79
139_Y172_I0.6740.79
265_G270_Q0.6730.78
319_L323_N0.6700.78
90_D131_E0.6690.78
241_K244_E0.6690.78
127_G130_M0.6680.78
53_G242_V0.6660.78
62_R165_Q0.6660.78
55_C239_L0.6660.78
192_L197_V0.6650.78
99_A119_C0.6640.78
176_A334_S0.6620.77
140_E144_S0.6620.77
139_Y143_E0.6610.77
173_G203_T0.6590.77
313_A341_I0.6580.77
214_V222_H0.6570.77
313_A317_N0.6570.77
38_L321_A0.6560.77
179_T334_S0.6560.77
234_E238_A0.6520.76
110_F132_F0.6510.76
21_E163_R0.6500.76
26_S331_R0.6480.76
162_E169_S0.6480.76
8_F326_V0.6470.76
102_V106_T0.6460.76
317_N321_A0.6460.76
2_K6_F0.6430.75
229_Y276_G0.6420.75
212_R215_S0.6410.75
71_T78_K0.6390.75
294_M308_L0.6390.75
248_R292_D0.6360.74
36_G320_R0.6340.74
27_R326_V0.6330.74
226_A277_W0.6320.74
46_I340_L0.6310.74
237_A240_N0.6300.74
40_D283_Y0.6290.74
239_L242_V0.6290.74
42_S45_H0.6280.74
264_A289_K0.6240.73
141_V145_L0.6240.73
176_A210_T0.6210.73
189_L192_L0.6190.72
268_D272_K0.6180.72
113_G144_S0.6170.72
12_E17_Q0.6170.72
224_M281_F0.6150.72
251_S256_S0.6100.71
84_L175_A0.6090.71
98_P102_V0.6080.71
281_F307_M0.6070.71
93_E127_G0.6070.71
111_G115_L0.6060.71
54_D197_V0.6040.71
208_L304_S0.6040.71
156_E160_D0.6030.71
71_T109_T0.6030.71
188_I192_L0.6010.70
193_K201_F0.6000.70
175_A335_F0.6000.70
295_I340_L0.6000.70
280_I306_I0.5980.70
231_M239_L0.5960.70
148_M161_K0.5950.69
254_T294_M0.5940.69
92_W98_P0.5940.69
263_I271_F0.5920.69
99_A128_R0.5920.69
225_H333_F0.5900.69
31_L36_G0.5890.69
231_M235_T0.5890.69
37_E320_R0.5880.69
89_G131_E0.5880.69
219_V307_M0.5860.68
265_G279_S0.5850.68
312_L315_R0.5850.68
193_K198_Q0.5830.68
115_L138_F0.5820.68
263_I276_G0.5820.68
53_G247_G0.5810.68
95_L127_G0.5790.67
105_G118_I0.5780.67
77_A99_A0.5780.67
291_I312_L0.5770.67
60_N232_S0.5760.67
224_M278_T0.5750.67
200_E232_S0.5750.67
264_A268_D0.5740.67
22_Q163_R0.5700.66
267_H287_E0.5680.66
186_E189_L0.5680.66
148_M280_I0.5600.65
92_W185_T0.5600.65
206_V210_T0.5590.65
60_N174_S0.5570.64
263_I274_S0.5570.64
269_G272_K0.5550.64
32_D317_N0.5540.64
232_S236_A0.5530.64
150_L174_S0.5530.64
53_G192_L0.5530.64
259_T274_S0.5520.64
72_K76_G0.5520.64
3_V221_E0.5510.64
70_G110_F0.5490.63
161_K335_F0.5480.63
65_P148_M0.5480.63
12_E155_K0.5460.63
306_I326_V0.5460.63
69_F79_V0.5460.63
176_A211_F0.5450.63
10_L15_I0.5440.63
239_L264_A0.5420.62
16_A331_R0.5390.62
264_A269_G0.5390.62
18_V335_F0.5380.62
41_S47_I0.5360.62
210_T334_S0.5350.61
123_L129_K0.5340.61
111_G116_K0.5320.61
6_F220_E0.5320.61
86_Q92_W0.5320.61
83_L132_F0.5320.61
56_L252_V0.5310.61
240_N271_F0.5310.61
231_M262_T0.5310.61
293_G312_L0.5310.61
243_R247_G0.5300.61
49_F52_E0.5280.60
56_L295_I0.5280.60
32_D36_G0.5280.60
182_L206_V0.5270.60
318_I321_A0.5270.60
32_D341_I0.5260.60
306_I319_L0.5260.60
104_K122_E0.5260.60
115_L145_L0.5250.60
81_L94_T0.5230.60
229_Y262_T0.5230.60
174_S203_T0.5230.60
232_S238_A0.5220.60
136_G144_S0.5220.60
160_D163_R0.5180.59
202_I256_S0.5180.59
26_S288_F0.5170.59
127_G134_Y0.5170.59
143_E161_K0.5160.59
44_K47_I0.5160.59
318_I326_V0.5150.58
281_F304_S0.5150.58
257_T306_I0.5140.58
77_A102_V0.5140.58
257_T312_L0.5140.58
98_P119_C0.5130.58
189_L201_F0.5130.58
111_G141_V0.5130.58
150_L160_D0.5130.58
179_T211_F0.5130.58
251_S312_L0.5120.58
87_E231_M0.5110.58
68_L142_L0.5100.58
176_A206_V0.5100.58
56_L197_V0.5100.58
310_S313_A0.5090.58
53_G197_V0.5080.57
94_T117_A0.5080.57
130_M134_Y0.5080.57
29_M306_I0.5080.57
216_A219_V0.5080.57
158_L161_K0.5070.57
236_A259_T0.5070.57
65_P83_L0.5070.57
154_I333_F0.5070.57
17_Q150_L0.5070.57
41_S330_Y0.5050.57
316_E320_R0.5050.57
240_N268_D0.5040.57
119_C128_R0.5040.57
55_C235_T0.5040.57
267_H270_Q0.5040.57
269_G290_A0.5030.57
28_L188_I0.5030.57
42_S295_I0.5030.57
192_L195_K0.5030.57
122_E125_H0.5020.57
22_Q44_K0.5010.56
147_E161_K0.5000.56
20_L26_S0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yy3A 1 0.9211 100 -0.002 Contact Map
1wdiA 1 0.8333 100 0.01 Contact Map
1vkyA 2 0.8275 100 0.012 Contact Map
1ds1A 1 0.3158 32.8 0.977 Contact Map
4uu5A 1 0.2018 21.4 0.979 Contact Map
1earA 2 0.4152 18.4 0.98 Contact Map
3tj8A 2 0.4444 17.9 0.98 Contact Map
3j60A 1 0.4035 17.5 0.98 Contact Map
1e0tA 3 0.7544 15.1 0.981 Contact Map
3uyxA 1 0.1725 14.9 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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