GREMLIN Database
YRZE - Uncharacterized membrane protein YrzE
UniProt: O32051 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 150 (120)
Sequences: 226 (188)
Seq/√Len: 17.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_F126_H3.0300.99
47_S141_V2.7580.98
53_L57_T2.3310.94
42_A75_S2.3040.93
107_L138_I2.1690.91
66_W99_A2.1190.90
87_G94_I2.1090.90
30_K41_S2.0920.89
66_W102_F2.0000.87
124_I128_G1.9590.86
49_A132_V1.9480.86
96_A130_L1.9070.84
33_L119_T1.8160.81
36_L52_L1.8160.81
99_A102_F1.7540.79
75_S143_M1.7130.77
127_L138_I1.7080.77
87_G133_C1.6890.76
43_M55_T1.6880.76
102_F115_G1.6500.74
74_L97_L1.6420.74
103_S126_H1.6240.73
30_K48_L1.6240.73
31_G43_M1.6180.73
128_G135_L1.5960.72
107_L118_F1.5860.71
46_T93_M1.5630.70
80_G84_G1.5470.69
97_L101_S1.5440.69
84_G98_T1.5130.67
76_L133_C1.4980.67
54_L61_E1.4960.67
135_L139_F1.4700.65
99_A130_L1.4500.64
76_L87_G1.4500.64
50_V114_F1.4220.63
61_E98_T1.3530.59
39_I125_F1.3120.56
43_M50_V1.2890.55
70_A144_R1.2610.53
72_S102_F1.2570.53
69_T132_V1.2570.53
110_Q122_Q1.2450.52
74_L121_E1.2260.51
107_L126_H1.2220.51
86_K115_G1.2200.51
27_Q42_A1.2130.50
49_A108_L1.1950.49
73_F118_F1.1770.48
36_L89_E1.1710.48
28_V83_S1.1670.47
28_V90_R1.1520.47
43_M72_S1.1260.45
71_I132_V1.1050.44
99_A127_L1.0990.43
54_L57_T1.0900.43
103_S118_F1.0840.43
47_S80_G1.0690.42
44_L68_I1.0430.40
40_F141_V1.0250.39
79_G141_V1.0130.38
34_Y38_A1.0020.38
71_I83_S0.9900.37
48_L134_M0.9800.37
57_T63_S0.9740.36
124_I135_L0.9730.36
68_I74_L0.9730.36
66_W70_A0.9600.35
84_G112_L0.9540.35
136_G141_V0.9510.35
48_L104_L0.9430.35
64_F71_I0.9330.34
34_Y55_T0.9300.34
70_A99_A0.9140.33
105_I139_F0.9130.33
53_L145_G0.9110.33
76_L94_I0.9070.33
104_L145_G0.9010.32
78_I114_F0.8970.32
70_A74_L0.8950.32
80_G111_Y0.8930.32
36_L138_I0.8870.32
33_L103_S0.8820.31
80_G112_L0.8780.31
41_S52_L0.8670.31
74_L131_G0.8660.30
84_G111_Y0.8650.30
33_L96_A0.8580.30
29_G109_F0.8530.30
37_I143_M0.8490.30
51_S86_K0.8470.30
39_I118_F0.8450.29
42_A90_R0.8450.29
41_S71_I0.8360.29
37_I59_L0.8340.29
40_F51_S0.8270.29
84_G113_G0.7990.27
74_L124_I0.7980.27
36_L92_W0.7950.27
54_L80_G0.7950.27
48_L51_S0.7920.27
118_F122_Q0.7890.27
82_I100_L0.7780.26
33_L88_K0.7750.26
38_A82_I0.7720.26
50_V63_S0.7680.26
122_Q125_F0.7640.26
123_L127_L0.7610.25
89_E109_F0.7590.25
69_T130_L0.7590.25
112_L141_V0.7480.25
56_A131_G0.7430.25
102_F105_I0.7320.24
98_T125_F0.7310.24
45_L120_A0.7240.24
54_L136_G0.7220.24
87_G120_A0.7170.23
45_L48_L0.7120.23
81_F143_M0.7110.23
86_K126_H0.7040.23
57_T116_K0.7010.23
29_G33_L0.7000.23
70_A108_L0.6970.23
80_G107_L0.6890.22
104_L144_R0.6870.22
46_T72_S0.6840.22
86_K138_I0.6820.22
51_S79_G0.6760.22
34_Y47_S0.6760.22
45_L58_S0.6740.22
115_G134_M0.6630.21
53_L139_F0.6610.21
110_Q145_G0.6610.21
61_E74_L0.6590.21
31_G110_Q0.6550.21
31_G72_S0.6380.20
80_G136_G0.6360.20
98_T108_L0.6190.19
68_I83_S0.6190.19
32_I96_A0.6170.19
43_M56_A0.6130.19
73_F85_G0.6110.19
39_I47_S0.6110.19
31_G113_G0.6100.19
33_L40_F0.6080.19
71_I114_F0.6020.19
62_S114_F0.5970.19
57_T81_F0.5920.18
45_L85_G0.5920.18
109_F114_F0.5870.18
41_S89_E0.5870.18
36_L132_V0.5850.18
77_F144_R0.5840.18
33_L131_G0.5820.18
78_I81_F0.5810.18
80_G90_R0.5760.18
47_S84_G0.5610.17
52_L62_S0.5600.17
88_K110_Q0.5600.17
36_L97_L0.5600.17
48_L70_A0.5590.17
59_L81_F0.5560.17
46_T101_S0.5550.17
62_S81_F0.5470.17
86_K113_G0.5460.17
92_W112_L0.5460.17
34_Y110_Q0.5380.17
27_Q97_L0.5360.17
32_I43_M0.5360.17
48_L97_L0.5350.17
39_I133_C0.5350.17
90_R143_M0.5240.16
62_S127_L0.5190.16
53_L59_L0.5180.16
87_G92_W0.5130.16
125_F133_C0.5110.16
78_I82_I0.5060.16
74_L100_L0.5040.16
77_F141_V0.5010.15
45_L104_L0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ev6A 3 0.5533 46.9 0.928 Contact Map
2xq2A 2 0.8267 31.4 0.935 Contact Map
4i0uA 4 0.54 30 0.935 Contact Map
3dh4A 3 0.8333 28.9 0.936 Contact Map
2i68A 2 0.52 21.2 0.94 Contact Map
4od4A 1 0.8467 19.7 0.941 Contact Map
3o7qA 1 0.7867 18.2 0.941 Contact Map
4m64A 1 0.8267 16.9 0.942 Contact Map
4tq3A 1 0.8267 16.6 0.942 Contact Map
4j05A 3 0.7933 16.1 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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