GREMLIN Database
COMN - Post-transcriptional regulator ComN
UniProt: O32049 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 98 (82)
Sequences: 172 (135)
Seq/√Len: 14.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_W72_Y3.2610.99
13_V34_L3.0020.98
40_Y64_V2.9960.98
24_F37_L2.9120.97
28_G78_F2.2110.88
74_T77_S2.1240.86
10_K35_E2.0330.84
41_L46_W1.7480.73
13_V61_I1.7220.72
21_L37_L1.7070.71
14_R34_L1.6720.70
48_K56_E1.5890.65
9_Y73_A1.5640.64
54_I61_I1.5320.63
47_K78_F1.5140.62
37_L64_V1.5070.61
67_G70_M1.4670.59
42_T50_T1.4590.59
27_L73_A1.4590.59
9_Y37_L1.4440.58
26_I64_V1.3950.55
30_D76_E1.3860.55
44_K56_E1.3630.53
22_E58_A1.3300.51
13_V26_I1.3140.51
6_A57_L1.3120.50
27_L69_F1.2790.49
27_L47_K1.2200.45
22_E78_F1.1930.44
62_L86_S1.1910.44
78_F81_S1.1600.42
46_W51_E1.1510.42
42_T55_Y1.0900.38
45_K83_W1.0880.38
31_D73_A1.0840.38
19_S65_K1.0830.38
8_L59_S1.0690.37
35_E56_E1.0560.36
76_E79_K1.0400.36
17_L42_T1.0280.35
30_D58_A1.0260.35
28_G64_V1.0220.35
77_S81_S1.0060.34
33_E54_I0.9890.33
46_W76_E0.9760.32
52_L86_S0.9710.32
7_D42_T0.9630.32
64_V73_A0.9560.31
60_D72_Y0.9530.31
82_N85_G0.9420.31
53_S56_E0.9300.30
44_K60_D0.9280.30
37_L40_Y0.9200.30
7_D66_I0.9200.30
6_A9_Y0.9130.29
69_F73_A0.9070.29
10_K27_L0.9010.29
17_L35_E0.8930.29
10_K57_L0.8690.27
18_Y32_V0.8640.27
5_P9_Y0.8630.27
37_L59_S0.8620.27
66_I71_N0.8460.26
18_Y24_F0.8420.26
18_Y22_E0.8410.26
35_E80_T0.8260.26
24_F66_I0.8040.25
29_Y40_Y0.8030.25
7_D26_I0.8010.24
5_P8_L0.7820.24
55_Y85_G0.7730.23
40_Y73_A0.7570.23
7_D37_L0.7500.22
36_S49_K0.7430.22
30_D80_T0.7360.22
31_D42_T0.7350.22
31_D69_F0.7340.22
9_Y45_K0.7230.21
7_D11_D0.7200.21
51_E57_L0.7170.21
72_Y81_S0.7100.21
22_E67_G0.7070.21
65_K71_N0.7040.21
67_G75_V0.6990.21
65_K69_F0.6920.20
25_K65_K0.6830.20
17_L34_L0.6750.20
51_E62_L0.6690.19
18_Y53_S0.6540.19
32_V63_S0.6520.19
17_L57_L0.6500.19
31_D74_T0.6490.19
15_P76_E0.6290.18
26_I54_I0.6240.18
25_K32_V0.6170.18
18_Y25_K0.6100.17
58_A70_M0.6070.17
45_K52_L0.6050.17
30_D71_N0.6030.17
8_L35_E0.5940.17
17_L77_S0.5890.17
26_I78_F0.5890.17
44_K74_T0.5880.17
41_L74_T0.5840.17
40_Y54_I0.5810.17
21_L34_L0.5780.16
60_D70_M0.5780.16
5_P70_M0.5780.16
25_K30_D0.5780.16
21_L64_V0.5650.16
19_S26_I0.5620.16
11_D35_E0.5520.16
21_L70_M0.5480.16
39_S75_V0.5470.16
43_D46_W0.5440.15
66_I86_S0.5390.15
24_F86_S0.5280.15
17_L51_E0.5230.15
26_I56_E0.5160.15
5_P54_I0.5160.15
49_K79_K0.5120.15
8_L86_S0.5090.14
14_R47_K0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oavB 2 0.8163 23.7 0.923 Contact Map
3vx8D 1 0.9184 8.7 0.936 Contact Map
4zuzA 1 0.9286 8.4 0.937 Contact Map
3t7hA 1 0.9388 7.3 0.939 Contact Map
4akgA 2 0.8571 6.2 0.941 Contact Map
3vkgA 2 0.8878 6 0.941 Contact Map
1t7lA 1 0.7143 5.8 0.941 Contact Map
2c9wA 1 0.3265 4.6 0.944 Contact Map
3vx6A 2 0.8878 4.5 0.945 Contact Map
4ddgA 3 0.9592 4.4 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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