GREMLIN Database
SECDF - Protein translocase subunit SecDF
UniProt: O32047 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 737 (684)
Sequences: 14733 (9688)
Seq/√Len: 370.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
659_D662_H3.9261.00
228_I231_A3.9031.00
183_D186_K3.7491.00
230_N233_A3.6781.00
65_V88_N3.6501.00
44_L49_P3.4871.00
45_Y49_P3.2871.00
445_Q717_Y3.2591.00
611_F706_V3.2191.00
234_L237_K3.1831.00
341_S344_S3.0521.00
235_P238_L3.0481.00
447_W665_N2.9981.00
223_K252_Q2.9451.00
340_K348_S2.9331.00
45_Y48_Q2.7841.00
202_V205_E2.7571.00
44_L48_Q2.7291.00
531_G534_D2.7231.00
65_V84_I2.7221.00
43_V49_P2.6901.00
136_Q151_L2.6401.00
500_Q503_K2.6341.00
199_A202_V2.5881.00
194_P202_V2.5821.00
593_M646_R2.5681.00
294_I392_T2.5561.00
443_P669_Q2.5481.00
77_V92_V2.5361.00
182_G186_K2.5361.00
522_S528_R2.5281.00
505_F522_S2.5101.00
198_S202_V2.4851.00
502_E506_E2.4531.00
263_I267_A2.4461.00
298_I388_L2.4051.00
226_A246_V2.3121.00
220_Q224_D2.2991.00
43_V48_Q2.2481.00
46_D49_P2.2401.00
615_T702_I2.2351.00
137_T140_S2.2201.00
235_P239_T2.1881.00
78_S95_A2.1761.00
58_K62_V2.1641.00
141_T146_I2.1201.00
237_K243_S2.0951.00
199_A203_S2.0931.00
648_H651_K2.0851.00
199_A205_E2.0741.00
664_V724_L2.0721.00
78_S93_Q2.0691.00
543_T547_D2.0411.00
451_S661_N2.0411.00
540_K544_Y2.0401.00
690_L705_L2.0281.00
452_K455_Y2.0241.00
260_F264_V2.0021.00
661_N724_L2.0011.00
542_K546_K1.9861.00
649_M723_W1.9841.00
136_Q148_T1.9701.00
648_H653_K1.9621.00
198_S203_S1.9561.00
437_N441_H1.9461.00
334_E338_L1.9391.00
200_P205_E1.9391.00
234_L238_L1.9291.00
224_D227_S1.9281.00
335_E352_R1.9151.00
196_F202_V1.9141.00
194_P199_A1.9021.00
539_A542_K1.8961.00
197_V202_V1.8861.00
653_K666_L1.8811.00
200_P203_S1.8781.00
653_K659_D1.8731.00
648_H666_L1.8661.00
181_K184_S1.8571.00
469_I472_L1.8541.00
344_S348_S1.8451.00
23_F27_A1.8431.00
147_V150_K1.8381.00
256_H260_F1.8351.00
335_E340_K1.8351.00
47_V88_N1.8341.00
522_S534_D1.8301.00
437_N440_P1.8281.00
442_T668_L1.8261.00
509_G513_D1.8131.00
183_D187_K1.8111.00
28_A300_D1.8071.00
194_P203_S1.8031.00
134_A155_D1.7811.00
468_I472_L1.7791.00
220_Q223_K1.7781.00
448_D451_S1.7731.00
462_A466_A1.7491.00
522_S529_F1.7441.00
235_P243_S1.7251.00
492_S496_L1.7221.00
194_P198_S1.7191.00
646_R650_K1.7181.00
448_D452_K1.7091.00
223_K227_S1.7071.00
539_A543_T1.6961.00
194_P204_Q1.6941.00
528_R534_D1.6901.00
331_R352_R1.6891.00
99_N102_R1.6761.00
365_I391_L1.6751.00
529_F534_D1.6651.00
60_V64_T1.6601.00
287_T396_T1.6561.00
180_D184_S1.6421.00
453_R724_L1.6391.00
530_V533_P1.6321.00
647_E651_K1.6291.00
68_L72_A1.6271.00
198_S205_E1.6231.00
469_I473_V1.6231.00
72_A92_V1.6201.00
236_V239_T1.6191.00
457_F461_S1.6131.00
302_M388_L1.6131.00
509_G512_P1.6071.00
537_T542_K1.5941.00
226_A230_N1.5911.00
201_N517_L1.5901.00
544_Y547_D1.5871.00
149_I153_D1.5841.00
194_P205_E1.5651.00
234_L239_T1.5601.00
441_H444_F1.5491.00
233_A239_T1.5461.00
537_T541_V1.5441.00
198_S201_N1.5441.00
197_V203_S1.5381.00
457_F725_A1.5341.00
76_G98_T1.5321.00
617_L702_I1.5291.00
92_V107_L1.5281.00
537_T540_K1.5171.00
194_P200_P1.5141.00
224_D228_I1.5061.00
443_P447_W1.4901.00
140_S143_N1.4871.00
304_A384_T1.4841.00
582_I594_A1.4841.00
683_V705_L1.4791.00
490_V505_F1.4741.00
257_D260_F1.4731.00
153_D157_F1.4731.00
68_L90_I1.4721.00
540_K543_T1.4671.00
530_V534_D1.4591.00
25_K297_Q1.4571.00
140_S144_E1.4551.00
270_F285_V1.4441.00
19_G293_Y1.4421.00
216_H221_E1.4421.00
464_T468_I1.4421.00
533_P536_E1.4221.00
334_E670_Q1.4211.00
152_K156_K1.4201.00
529_F533_P1.4161.00
335_E338_L1.4141.00
525_G528_R1.4131.00
179_Y185_F1.4101.00
123_L133_G1.4091.00
332_I405_L1.4041.00
649_M727_K1.4011.00
496_L500_Q1.3921.00
538_I542_K1.3901.00
80_P92_V1.3841.00
661_N665_N1.3831.00
492_S504_D1.3821.00
503_K506_E1.3811.00
683_V709_L1.3781.00
33_L483_A1.3771.00
179_Y188_E1.3771.00
72_A90_I1.3751.00
522_S525_G1.3701.00
56_I59_D1.3691.00
267_A271_L1.3691.00
562_V565_E1.3671.00
76_G95_A1.3671.00
384_T388_L1.3661.00
441_H445_Q1.3661.00
676_I680_L1.3621.00
445_Q448_D1.3611.00
236_V243_S1.3611.00
600_S638_T1.3461.00
295_T389_S1.3451.00
65_V82_I1.3371.00
150_K153_D1.3361.00
228_I232_G1.3331.00
331_R334_E1.3321.00
199_A502_E1.3311.00
44_L47_V1.3311.00
18_T294_I1.3311.00
477_N618_E1.3261.00
612_F623_F1.3201.00
153_D156_K1.3161.00
340_K344_S1.3081.00
504_D507_S1.3051.00
531_G535_K1.3041.00
136_Q141_T1.3001.00
112_Q115_F1.2991.00
84_I88_N1.2931.00
662_H666_L1.2921.00
649_M660_L1.2901.00
146_I150_K1.2891.00
234_L243_S1.2881.00
444_F448_D1.2851.00
98_T103_A1.2841.00
503_K507_S1.2841.00
21_G297_Q1.2841.00
246_V249_Q1.2781.00
252_Q256_H1.2761.00
348_S351_R1.2651.00
550_G553_P1.2641.00
488_I526_V1.2621.00
79_E93_Q1.2571.00
194_P197_V1.2571.00
43_V47_V1.2531.00
523_N526_V1.2421.00
197_V205_E1.2411.00
443_P666_L1.2361.00
509_G515_V1.2351.00
444_F447_W1.2331.00
150_K191_K1.2311.00
199_A204_Q1.2241.00
328_T350_N1.2231.00
647_E650_K1.2231.00
335_E348_S1.2211.00
201_N205_E1.2181.00
25_K300_D1.2181.00
227_S231_A1.2161.00
538_I541_V1.2161.00
223_K226_A1.2141.00
522_S526_V1.2141.00
68_L114_S1.2141.00
331_R644_R1.2131.00
458_I462_A1.2041.00
465_V469_I1.2031.00
449_F721_Q1.2011.00
193_H202_V1.2001.00
298_I302_M1.1971.00
465_V468_I1.1961.00
60_V84_I1.1931.00
440_P444_F1.1921.00
610_T614_I1.1921.00
568_R571_L1.1901.00
617_L698_T1.1901.00
155_D188_E1.1881.00
608_I627_I1.1881.00
108_A112_Q1.1861.00
304_A310_G1.1851.00
233_A241_K1.1851.00
361_N394_F1.1811.00
161_T165_M1.1801.00
634_S711_G1.1791.00
12_F591_Y1.1771.00
72_A107_L1.1741.00
532_V536_E1.1721.00
102_R106_I1.1711.00
196_F203_S1.1701.00
259_V263_I1.1691.00
391_L395_I1.1681.00
660_L664_V1.1681.00
239_T243_S1.1671.00
343_R347_R1.1661.00
497_T500_Q1.1661.00
347_R351_R1.1651.00
490_V508_L1.1621.00
443_P665_N1.1611.00
196_F199_A1.1601.00
646_R649_M1.1591.00
492_S501_V1.1571.00
455_Y458_I1.1571.00
362_I584_Y1.1551.00
238_L243_S1.1541.00
81_N93_Q1.1511.00
473_V613_S1.1511.00
239_T242_Y1.1461.00
458_I465_V1.1461.00
523_N534_D1.1381.00
561_T564_K1.1361.00
227_S230_N1.1311.00
453_R728_G1.1291.00
290_V400_L1.1261.00
60_V88_N1.1231.00
466_A470_I1.1181.00
141_T151_L1.1161.00
26_P259_V1.1151.00
366_I580_G1.1121.00
523_N528_R1.1121.00
461_S465_V1.1111.00
611_F702_I1.1111.00
644_R648_H1.1091.00
119_N122_E1.1071.00
324_A636_N1.1041.00
645_V664_V1.1011.00
234_L240_E1.1001.00
69_N82_I1.0991.00
683_V708_L1.0961.00
77_V80_P1.0921.00
283_I404_L1.0921.00
198_S204_Q1.0911.00
257_D697_I1.0911.00
344_S347_R1.0891.00
217_F220_Q1.0861.00
162_K165_M1.0851.00
222_A226_A1.0831.00
236_V240_E1.0831.00
110_E113_L1.0811.00
460_S718_I1.0811.00
666_L669_Q1.0801.00
359_D584_Y1.0791.00
509_G514_T1.0771.00
501_V504_D1.0761.00
680_L684_I1.0751.00
727_K730_E1.0731.00
184_S187_K1.0731.00
666_L670_Q1.0721.00
532_V535_K1.0721.00
71_R113_L1.0691.00
46_D88_N1.0691.00
237_K240_E1.0691.00
333_K337_K1.0681.00
354_F358_F1.0671.00
449_F456_F1.0651.00
502_E505_F1.0651.00
525_G534_D1.0631.00
405_L409_V1.0611.00
118_A122_E1.0591.00
15_L400_L1.0571.00
164_V175_I1.0561.00
505_F508_L1.0561.00
477_N620_D1.0521.00
332_I349_G1.0521.00
298_I392_T1.0511.00
528_R531_G1.0431.00
19_G23_F1.0371.00
375_G569_N1.0351.00
331_R335_E1.0321.00
575_A579_I1.0321.00
516_V529_F1.0311.00
43_V46_D1.0261.00
115_F123_L1.0261.00
446_K450_T1.0221.00
342_V346_F1.0221.00
679_V712_V1.0211.00
331_R353_S1.0201.00
13_V583_I1.0201.00
436_E440_P1.0171.00
71_R114_S1.0161.00
236_V242_Y1.0151.00
531_G536_E1.0121.00
442_T446_K1.0111.00
522_S531_G1.0101.00
29_N296_L1.0101.00
12_F16_I1.0101.00
165_M172_Q1.0091.00
644_R670_Q1.0061.00
198_S207_N1.0051.00
462_A465_V1.0041.00
454_K458_I1.0031.00
256_H259_V0.9991.00
589_F639_I0.9951.00
522_S532_V0.9941.00
359_D588_R0.9911.00
454_K725_A0.9891.00
526_V529_F0.9891.00
64_T122_E0.9871.00
687_V691_I0.9851.00
665_N669_Q0.9841.00
221_E224_D0.9831.00
194_P201_N0.9811.00
525_G531_G0.9781.00
154_A188_E0.9781.00
78_S565_E0.9751.00
10_F587_I0.9721.00
558_V561_T0.9711.00
102_R105_E0.9681.00
652_R666_L0.9681.00
522_S527_A0.9671.00
360_A394_F0.9631.00
450_T724_L0.9621.00
72_A80_P0.9601.00
98_T106_I0.9601.00
451_S454_K0.9581.00
68_L111_A0.9571.00
653_K662_H0.9571.00
200_P204_Q0.9561.00
197_V200_P0.9561.00
496_L501_V0.9561.00
116_R119_N0.9561.00
299_F304_A0.9561.00
253_Q256_H0.9551.00
541_V545_F0.9551.00
541_V557_T0.9531.00
434_T437_N0.9511.00
352_R647_E0.9511.00
71_R117_D0.9461.00
571_L575_A0.9461.00
434_T438_T0.9461.00
687_V705_L0.9431.00
603_Y714_S0.9421.00
287_T401_S0.9411.00
466_A469_I0.9411.00
447_W451_S0.9401.00
453_R725_A0.9401.00
439_E443_P0.9401.00
518_S521_K0.9391.00
528_R533_P0.9391.00
467_G609_V0.9381.00
522_S530_V0.9331.00
286_I404_L0.9301.00
542_K564_K0.9281.00
471_L609_V0.9271.00
240_E243_S0.9271.00
364_T636_N0.9261.00
596_A722_I0.9251.00
94_L103_A0.9251.00
19_G290_V0.9241.00
339_G345_A0.9211.00
528_R535_K0.9201.00
612_F703_A0.9191.00
12_F407_L0.9171.00
82_I90_I0.9161.00
608_I703_A0.9141.00
222_A248_A0.9131.00
645_V723_W0.9121.00
290_V396_T0.9111.00
471_L474_F0.9101.00
365_I387_I0.9091.00
463_V606_F0.9081.00
286_I400_L0.9081.00
522_S533_P0.9081.00
611_F615_T0.9061.00
229_L233_A0.9041.00
94_L107_L0.9031.00
472_L475_R0.9021.00
645_V667_S0.8981.00
46_D87_N0.8971.00
295_T388_L0.8961.00
66_E70_R0.8941.00
545_F548_K0.8941.00
486_A526_V0.8921.00
47_V122_E0.8911.00
354_F398_V0.8901.00
363_T636_N0.8901.00
543_T546_K0.8861.00
554_N559_S0.8841.00
721_Q724_L0.8831.00
518_S528_R0.8831.00
299_F385_M0.8821.00
336_L342_V0.8821.00
264_V267_A0.8781.00
501_V505_F0.8781.00
470_I610_T0.8771.00
377_S380_K0.8761.00
499_E503_K0.8761.00
461_S468_I0.8741.00
310_G381_G0.8731.00
196_F200_P0.8721.00
522_S535_K0.8691.00
545_F555_V0.8671.00
529_F532_V0.8671.00
343_R406_A0.8661.00
547_D550_G0.8651.00
161_T164_V0.8651.00
83_Q91_R0.8651.00
196_F205_E0.8631.00
514_T529_F0.8631.00
226_A242_Y0.8611.00
435_D439_E0.8601.00
615_T706_V0.8591.00
582_I591_Y0.8591.00
436_E439_E0.8581.00
648_H670_Q0.8581.00
684_I687_V0.8571.00
572_Y575_A0.8561.00
449_F717_Y0.8561.00
139_D142_T0.8551.00
47_V68_L0.8541.00
620_D623_F0.8531.00
249_Q252_Q0.8491.00
679_V683_V0.8481.00
525_G533_P0.8471.00
586_S594_A0.8461.00
660_L724_L0.8441.00
189_V192_E0.8431.00
513_D517_L0.8401.00
146_I190_Q0.8371.00
672_F676_I0.8371.00
526_V534_D0.8341.00
226_A248_A0.8331.00
297_Q300_D0.8321.00
459_F463_V0.8311.00
226_A233_A0.8301.00
709_L713_Y0.8281.00
456_F718_I0.8271.00
439_E669_Q0.8271.00
36_D215_G0.8271.00
637_D711_G0.8261.00
456_F459_F0.8261.00
74_V110_E0.8221.00
715_S719_A0.8211.00
518_S523_N0.8211.00
193_H196_F0.8171.00
690_L702_I0.8171.00
332_I346_F0.8141.00
459_F466_A0.8141.00
470_I613_S0.8141.00
372_F384_T0.8131.00
686_V705_L0.8121.00
518_S522_S0.8121.00
595_I599_A0.8111.00
287_T325_N0.8101.00
512_P515_V0.8091.00
467_G470_I0.8081.00
664_V668_L0.8071.00
523_N533_P0.8061.00
648_H652_R0.8021.00
24_T28_A0.8021.00
450_T665_N0.8001.00
105_E109_T0.7981.00
579_I583_I0.7971.00
186_K200_P0.7971.00
72_A111_A0.7961.00
387_I391_L0.7961.00
501_V522_S0.7961.00
470_I473_V0.7921.00
297_Q301_W0.7921.00
525_G529_F0.7921.00
500_Q504_D0.7911.00
582_I586_S0.7901.00
149_I152_K0.7901.00
567_A571_L0.7901.00
346_F406_A0.7891.00
537_T544_Y0.7881.00
603_Y718_I0.7871.00
490_V522_S0.7851.00
380_K384_T0.7851.00
197_V502_E0.7801.00
413_W416_R0.7781.00
219_A252_Q0.7771.00
601_L631_I0.7771.00
234_L242_Y0.7751.00
524_I528_R0.7751.00
641_T668_L0.7741.00
193_H198_S0.7701.00
526_V531_G0.7701.00
509_G517_L0.7701.00
197_V201_N0.7671.00
199_A506_E0.7671.00
101_N105_E0.7671.00
450_T721_Q0.7671.00
337_K412_R0.7651.00
185_F188_E0.7641.00
295_T392_T0.7631.00
722_I726_W0.7621.00
470_I474_F0.7621.00
328_T357_I0.7611.00
450_T664_V0.7611.00
549_Y553_P0.7591.00
514_T517_L0.7591.00
460_S603_Y0.7581.00
447_W662_H0.7581.00
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435_D440_P0.5070.95
464_T603_Y0.5060.95
327_I357_I0.5060.95
269_I281_G0.5050.95
294_I396_T0.5050.95
60_V65_V0.5040.95
441_H448_D0.5040.95
11_L403_F0.5040.95
637_D712_V0.5040.95
453_R457_F0.5040.95
444_F451_S0.5030.95
576_I580_G0.5020.95
29_N306_L0.5020.95
521_K526_V0.5020.95
453_R661_N0.5010.95
168_A172_Q0.5000.95
158_G179_Y0.5000.95
721_Q725_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k0jA 3 0.9132 100 0.295 Contact Map
3ne5A 3 0.9444 100 0.358 Contact Map
3w9iA 3 0.9742 100 0.359 Contact Map
4mt1A 3 0.9484 100 0.362 Contact Map
4dx5A 3 0.9796 100 0.371 Contact Map
3aqpA 1 0.9308 100 0.476 Contact Map
4r86A 1 0.2849 100 0.803 Contact Map
3aqoA 1 0.2754 99.1 0.92 Contact Map
2l2tA 2 0.0597 48.7 0.977 Contact Map
2jwaA 2 0.0583 45.3 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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