GREMLIN Database
YRVC - Uncharacterized protein YrvC
UniProt: O32046 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 165 (152)
Sequences: 2115 (1659)
Seq/√Len: 134.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_K141_D4.8421.00
120_I135_T4.7601.00
93_A137_I4.5151.00
21_N24_K4.2641.00
31_H39_Y3.0781.00
20_R24_K2.6541.00
7_E12_G2.4811.00
20_R23_D2.4681.00
103_T106_D2.3641.00
66_L69_M2.3631.00
108_N111_Q2.3181.00
17_M30_H2.2331.00
104_I117_V2.0001.00
122_K138_D1.9961.00
113_Y151_G1.9961.00
102_Q106_D1.9581.00
105_G134_E1.9461.00
99_A107_L1.8911.00
100_I139_E1.8881.00
17_M37_L1.8731.00
120_I141_D1.8701.00
148_E151_G1.8701.00
30_H33_G1.8551.00
73_P77_E1.8301.00
20_R25_I1.7801.00
10_G13_Q1.7671.00
57_A60_R1.7521.00
103_T136_V1.7051.00
90_W144_V1.6111.00
67_G70_A1.5451.00
114_H151_G1.5231.00
122_K135_T1.5211.00
73_P76_L1.5001.00
145_I155_L1.4881.00
101_H138_D1.4691.00
110_G116_T1.4671.00
20_R26_S1.4301.00
21_N25_I1.3851.00
95_A139_E1.3801.00
59_A62_M1.3171.00
88_I146_S1.3091.00
34_R37_L1.3081.00
51_S55_D1.2861.00
93_A100_I1.2691.00
109_V117_V1.2601.00
23_D26_S1.2451.00
35_R41_D1.2401.00
109_V155_L1.2391.00
101_H139_E1.2261.00
137_I143_L1.1981.00
103_T107_L1.1690.99
58_E63_S1.1580.99
39_Y42_E1.1530.99
50_A56_D1.1440.99
70_A73_P1.1380.99
30_H34_R1.1380.99
52_V55_D1.1260.99
58_E62_M1.1060.99
66_L73_P1.1050.99
118_I146_S1.1010.99
50_A55_D1.0900.99
63_S67_G1.0870.99
66_L70_A1.0730.99
40_F43_N1.0700.99
105_G132_S1.0690.99
51_S54_F1.0600.99
9_P14_K1.0590.99
6_S9_P1.0350.99
28_I31_H1.0200.98
138_D141_D1.0130.98
39_Y43_N1.0120.98
19_T24_K0.9910.98
109_V113_Y0.9900.98
65_I68_G0.9890.98
68_G71_Y0.9880.98
11_I17_M0.9880.98
59_A63_S0.9810.98
52_V56_D0.9790.98
70_A75_A0.9770.98
109_V115_V0.9770.98
123_K126_D0.9630.98
108_N112_E0.9590.98
104_I131_P0.9440.97
35_R42_E0.9390.97
63_S66_L0.9360.97
51_S56_D0.9330.97
42_E47_E0.9320.97
62_M67_G0.9300.97
49_V52_V0.9200.97
75_A78_Q0.9120.97
153_K157_R0.9050.97
24_K104_I0.9020.97
50_A54_F0.8890.96
48_C52_V0.8850.96
116_T133_S0.8600.95
31_H35_R0.8550.95
80_E145_I0.8460.95
72_K75_A0.8460.95
31_H34_R0.8450.95
122_K128_Q0.8420.95
53_Q56_D0.8390.95
57_A62_M0.8330.95
6_S14_K0.8300.95
115_V155_L0.8270.94
9_P18_I0.8250.94
37_L41_D0.8210.94
22_R25_I0.8200.94
70_A74_K0.7990.93
35_R40_F0.7890.93
15_V18_I0.7880.93
119_A144_V0.7740.92
48_C55_D0.7580.91
67_G71_Y0.7390.90
62_M69_M0.7370.90
91_C148_E0.7370.90
19_T25_I0.7360.90
110_G113_Y0.7260.90
59_A65_I0.7220.89
19_T23_D0.7100.89
61_Q66_L0.7030.88
38_Y41_D0.6990.88
22_R26_S0.6980.88
126_D154_R0.6970.88
31_H57_A0.6920.87
147_G151_G0.6900.87
91_C155_L0.6890.87
130_N133_S0.6880.87
112_E154_R0.6860.87
31_H152_L0.6850.87
96_G100_I0.6780.86
93_A97_A0.6780.86
90_W142_T0.6700.85
57_A66_L0.6670.85
147_G155_L0.6670.85
104_I133_S0.6660.85
62_M66_L0.6630.85
62_M71_Y0.6630.85
61_Q68_G0.6620.85
72_K137_I0.6620.85
56_D59_A0.6590.85
71_Y79_V0.6580.84
24_K27_I0.6540.84
11_I33_G0.6520.84
69_M72_K0.6520.84
135_T138_D0.6500.84
85_D143_L0.6500.84
26_S30_H0.6480.84
29_I50_A0.6460.83
42_E51_S0.6440.83
34_R38_Y0.6420.83
40_F47_E0.6410.83
128_Q135_T0.6390.83
57_A61_Q0.6380.83
48_C51_S0.6300.82
117_V145_I0.6250.81
73_P78_Q0.6250.81
121_V142_T0.6240.81
58_E61_Q0.6220.81
71_Y74_K0.6200.81
64_A69_M0.6180.81
91_C108_N0.6170.80
9_P30_H0.6130.80
132_S137_I0.6110.80
30_H37_L0.6100.80
110_G133_S0.6100.80
69_M73_P0.6070.79
77_E144_V0.6040.79
59_A117_V0.6030.79
43_N47_E0.6020.79
58_E65_I0.6000.79
110_G117_V0.5990.79
100_I134_E0.5970.78
145_I152_L0.5950.78
136_V140_G0.5950.78
81_S84_D0.5910.78
86_L146_S0.5900.77
150_T154_R0.5880.77
43_N46_E0.5860.77
105_G133_S0.5790.76
86_L89_E0.5790.76
28_I32_D0.5780.76
110_G118_I0.5780.76
67_G73_P0.5770.76
28_I54_F0.5770.76
67_G72_K0.5750.76
19_T41_D0.5730.75
53_Q124_N0.5720.75
66_L72_K0.5700.75
5_E9_P0.5700.75
30_H35_R0.5640.74
34_R39_Y0.5600.74
60_R63_S0.5600.74
154_R157_R0.5590.74
46_E115_V0.5590.74
71_Y75_A0.5580.73
99_A155_L0.5550.73
148_E153_K0.5470.72
77_E117_V0.5460.72
110_G152_L0.5440.72
94_E112_E0.5440.72
115_V151_G0.5430.71
29_I37_L0.5430.71
32_D35_R0.5420.71
102_Q105_G0.5400.71
22_R144_V0.5400.71
35_R48_C0.5370.71
71_Y86_L0.5340.70
45_H140_G0.5310.70
101_H136_V0.5270.69
75_A79_V0.5240.69
123_K136_V0.5230.69
39_Y47_E0.5220.69
102_Q112_E0.5200.68
65_I69_M0.5190.68
61_Q64_A0.5160.68
110_G115_V0.5140.67
62_M115_V0.5130.67
95_A100_I0.5130.67
72_K86_L0.5120.67
63_S142_T0.5070.66
74_K77_E0.5060.66
107_L135_T0.5060.66
95_A98_P0.5040.66
14_K17_M0.5040.66
14_K41_D0.5040.66
96_G124_N0.5010.65
132_S135_T0.5000.65
38_Y68_G0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2aefA 2 0.9879 99.9 0.397 Contact Map
4gx0A 3 0.9636 99.9 0.404 Contact Map
1lnqA 6 0.9697 99.9 0.41 Contact Map
3mt5A 5 0.9333 99.9 0.435 Contact Map
3nafA 3 0.9636 99.9 0.44 Contact Map
4g65A 2 0.9636 99.9 0.44 Contact Map
4hpfA 3 0.9273 99.8 0.457 Contact Map
3l4bC 2 0.9394 99.8 0.477 Contact Map
4j91A 3 0.9394 99.7 0.536 Contact Map
1vctA 3 0.8667 99.7 0.548 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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