GREMLIN Database
YRVD - Uncharacterized protein YrvD
UniProt: O32045 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 107 (95)
Sequences: 213 (169)
Seq/√Len: 17.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_E75_R5.3821.00
32_Y35_G3.8851.00
71_I74_L3.2810.99
18_A46_L2.9920.99
23_I33_L2.8580.98
44_V48_S2.8250.98
11_L14_T2.2240.92
14_T63_Q2.0810.89
5_W16_I1.9780.87
20_F30_V1.7610.79
10_A17_V1.6740.76
27_S70_E1.5960.72
19_I23_I1.5740.71
22_V45_I1.5330.69
22_V25_V1.5130.68
3_K6_T1.4880.67
15_L46_L1.4760.66
32_Y51_M1.4730.66
47_G56_V1.4700.66
32_Y37_S1.4560.65
3_K32_Y1.4240.63
53_A60_G1.4030.62
8_I57_F1.3790.60
23_I42_I1.3630.60
57_F65_M1.3370.58
77_E82_I1.3270.57
15_L22_V1.3070.56
44_V49_V1.2940.55
3_K59_V1.2760.54
17_V49_V1.2600.53
6_T62_F1.2510.53
32_Y44_V1.2280.51
49_V64_V1.1910.49
14_T46_L1.1660.48
9_F17_V1.1520.47
36_R42_I1.1490.47
11_L15_L1.1310.46
16_I86_E1.1150.45
36_R72_K1.0720.42
13_F69_R1.0620.42
73_T77_E1.0540.41
25_V30_V1.0460.41
13_F43_L1.0330.40
2_N68_K1.0270.39
39_W44_V0.9950.38
5_W47_G0.9760.37
9_F55_I0.9730.36
72_K75_R0.9730.36
2_N81_A0.9430.35
15_L47_G0.9410.35
81_A88_T0.9400.35
30_V74_L0.9300.34
12_I56_V0.9290.34
3_K63_Q0.9150.33
16_I79_R0.9040.33
39_W64_V0.8970.32
6_T56_V0.8810.31
5_W37_S0.8700.31
33_L37_S0.8560.30
25_V50_L0.8560.30
77_E81_A0.8530.30
83_H87_D0.8500.30
6_T18_A0.8370.29
54_L94_T0.8300.29
33_L66_K0.8190.28
76_K94_T0.8190.28
79_R87_D0.8130.28
19_I38_E0.8110.28
17_V55_I0.8070.28
26_R68_K0.8060.28
37_S51_M0.7930.27
34_F50_L0.7900.27
84_K87_D0.7900.27
27_S79_R0.7800.26
90_L95_D0.7790.26
20_F23_I0.7760.26
65_M68_K0.7720.26
12_I42_I0.7590.25
5_W39_W0.7550.25
16_I35_G0.7550.25
48_S76_K0.7530.25
35_G49_V0.7330.24
86_E90_L0.7160.24
30_V50_L0.7120.23
72_K92_D0.7100.23
23_I29_E0.7080.23
76_K84_K0.7030.23
60_G67_L0.6960.23
84_K88_T0.6930.23
2_N63_Q0.6910.22
48_S59_V0.6880.22
19_I66_K0.6860.22
16_I83_H0.6850.22
81_A84_K0.6790.22
10_A31_D0.6660.21
25_V39_W0.6600.21
21_A43_L0.6570.21
20_F50_L0.6540.21
11_L85_Q0.6520.21
71_I83_H0.6480.21
17_V90_L0.6470.21
75_R80_T0.6450.21
45_I49_V0.6350.20
7_I14_T0.6290.20
17_V61_I0.6260.20
4_Q30_V0.6230.20
16_I71_I0.6140.19
56_V59_V0.6120.19
6_T57_F0.6090.19
78_N81_A0.6060.19
15_L43_L0.6040.19
17_V77_E0.5990.19
81_A85_Q0.5960.19
37_S44_V0.5950.19
82_I88_T0.5900.19
6_T58_S0.5870.18
53_A84_K0.5830.18
16_I76_K0.5770.18
25_V42_I0.5760.18
53_A69_R0.5730.18
35_G70_E0.5610.17
89_H92_D0.5590.17
87_D91_A0.5570.17
8_I13_F0.5520.17
82_I86_E0.5510.17
15_L56_V0.5490.17
17_V72_K0.5480.17
8_I18_A0.5430.17
63_Q68_K0.5400.17
18_A63_Q0.5390.17
3_K66_K0.5330.17
22_V67_L0.5330.17
21_A45_I0.5310.16
50_L62_F0.5290.16
38_E83_H0.5280.16
2_N71_I0.5270.16
16_I42_I0.5220.16
7_I57_F0.5150.16
27_S38_E0.5140.16
23_I35_G0.5100.16
26_R38_E0.5040.16
19_I76_K0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qinA 2 0.9533 55.3 0.903 Contact Map
3pjsK 4 0.9813 40.5 0.911 Contact Map
4etpA 1 0.4112 35.2 0.914 Contact Map
3rvyA 3 0.5794 34.5 0.915 Contact Map
4q4gX 1 0 30.5 0.917 Contact Map
4cgkA 3 0.271 25.9 0.92 Contact Map
4c7rA 3 0.8505 25.7 0.92 Contact Map
2mn6B 2 0.3738 24.3 0.921 Contact Map
2ksdA 1 0.6822 23.8 0.921 Contact Map
2j5uA 4 0.3551 21.6 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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