GREMLIN Database
SYH - Histidine--tRNA ligase
UniProt: O32039 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 424 (406)
Sequences: 7989 (5166)
Seq/√Len: 256.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
395_K408_E3.8431.00
29_D154_K3.3571.00
407_I417_V3.3221.00
294_E300_E3.1951.00
163_V253_D3.1581.00
398_V417_V3.0271.00
107_Y129_G3.0081.00
400_D403_T2.9621.00
69_E73_G2.8591.00
244_N250_Y2.7431.00
344_Y347_S2.6751.00
393_Q408_E2.6581.00
410_A413_E2.6321.00
347_S351_K2.6241.00
413_E416_H2.6181.00
298_G302_P2.4741.00
389_D393_Q2.4061.00
395_K410_A2.3751.00
397_N406_Q2.3461.00
26_I154_K2.3431.00
349_V359_S2.3361.00
69_E75_S2.3041.00
383_I401_A2.2801.00
222_P237_E2.2711.00
30_T154_K2.1811.00
331_D358_S2.1531.00
28_R38_E2.1001.00
229_N232_S2.0851.00
27_M151_I2.0721.00
9_T44_F2.0691.00
31_C128_F2.0501.00
25_Q29_D2.0501.00
142_A242_Y2.0331.00
388_E392_A2.0321.00
334_I349_V2.0061.00
21_Q24_E1.9871.00
367_K370_G1.9751.00
178_E182_K1.9741.00
47_T51_A1.9111.00
332_C357_I1.9051.00
16_E318_D1.8641.00
413_E417_V1.8561.00
169_D172_S1.8371.00
67_T75_S1.8281.00
33_T150_S1.8261.00
344_Y391_L1.8161.00
134_G139_A1.7971.00
70_D74_R1.7781.00
21_Q38_E1.7761.00
39_I89_A1.7581.00
241_Q245_D1.7561.00
34_Y150_S1.7511.00
23_V314_L1.7491.00
179_A227_Y1.7111.00
130_I144_V1.7041.00
372_F385_I1.7011.00
36_Y104_K1.7011.00
39_I86_A1.6961.00
33_T154_K1.6951.00
19_R318_D1.6921.00
349_V353_R1.6881.00
331_D357_I1.6871.00
219_K223_S1.6871.00
149_M153_E1.6771.00
148_A270_I1.6571.00
382_F398_V1.6541.00
22_F26_I1.6381.00
146_A150_S1.6301.00
389_D392_A1.6291.00
241_Q244_N1.6251.00
349_V361_I1.6241.00
263_Y266_T1.6121.00
382_F418_M1.6071.00
32_R106_Y1.6071.00
351_K411_L1.6061.00
237_E241_Q1.6041.00
134_G141_D1.5931.00
236_F252_I1.5911.00
29_D33_T1.5871.00
43_I109_G1.5721.00
384_A396_I1.5671.00
126_Y311_E1.5561.00
172_S229_N1.5501.00
340_K388_E1.5481.00
287_G291_G1.5421.00
161_K251_E1.5221.00
150_S350_Y1.5221.00
387_G390_E1.5201.00
27_M310_I1.5161.00
368_M372_F1.5071.00
21_Q28_R1.5021.00
193_S196_Q1.4941.00
43_I112_F1.4821.00
130_I147_L1.4771.00
244_N249_S1.4611.00
6_P44_F1.4551.00
351_K354_E1.4491.00
47_T77_T1.4291.00
185_E200_H1.4271.00
216_E220_S1.4251.00
340_K392_A1.4221.00
110_P124_Q1.4221.00
79_R109_G1.4181.00
52_R91_N1.4111.00
343_D347_S1.4001.00
47_T75_S1.3981.00
336_T371_Q1.3921.00
333_Y375_A1.3901.00
396_I411_L1.3891.00
238_K242_Y1.3891.00
169_D229_N1.3791.00
209_C268_F1.3711.00
240_K244_N1.3711.00
82_G129_G1.3701.00
82_G107_Y1.3671.00
382_F400_D1.3661.00
398_V409_V1.3621.00
192_C195_C1.3611.00
397_N408_E1.3541.00
338_G388_E1.3341.00
336_T345_S1.3301.00
212_D216_E1.3271.00
146_A246_L1.3261.00
132_A140_I1.3251.00
188_I196_Q1.3241.00
212_D217_L1.3141.00
197_S201_T1.3011.00
15_G18_D1.2991.00
143_E146_A1.2991.00
182_K185_E1.2961.00
234_A238_K1.2961.00
161_K273_N1.2951.00
245_D343_D1.2911.00
6_P9_T1.2901.00
394_N412_D1.2841.00
148_A284_A1.2811.00
19_R314_L1.2741.00
240_K250_Y1.2731.00
355_A415_I1.2681.00
238_K241_Q1.2671.00
177_R180_L1.2671.00
184_F206_I1.2651.00
47_T67_T1.2641.00
24_E40_R1.2631.00
332_C352_L1.2561.00
350_Y354_E1.2521.00
414_F418_M1.2431.00
187_R190_E1.2381.00
205_R208_D1.2381.00
87_V293_V1.2371.00
60_I288_R1.2321.00
317_I327_D1.2271.00
409_V414_F1.2231.00
193_S197_S1.2201.00
334_I345_S1.2201.00
104_K360_E1.2161.00
163_V251_E1.2011.00
332_C384_A1.2011.00
287_G303_G1.1921.00
21_Q25_Q1.1831.00
122_Y311_E1.1831.00
128_F310_I1.1821.00
338_G341_A1.1711.00
82_G111_M1.1711.00
87_V133_I1.1611.00
20_W126_Y1.1591.00
194_D197_S1.1581.00
163_V271_M1.1561.00
21_Q32_R1.1551.00
237_E240_K1.1541.00
351_K415_I1.1501.00
71_R114_Y1.1461.00
335_V368_M1.1451.00
332_C359_S1.1441.00
34_Y147_L1.1421.00
241_Q343_D1.1381.00
6_P76_L1.1371.00
36_Y132_A1.1351.00
221_A224_I1.1341.00
74_R114_Y1.1311.00
27_M128_F1.1271.00
17_S21_Q1.1221.00
7_R116_R1.1211.00
242_Y246_L1.1201.00
298_G301_A1.1141.00
195_C209_C1.1121.00
24_E28_R1.1111.00
162_L165_N1.1081.00
366_K370_G1.1031.00
213_R216_E1.1011.00
399_K406_Q1.0871.00
344_Y411_L1.0801.00
215_H224_I1.0791.00
325_P373_K1.0721.00
43_I124_Q1.0711.00
20_W311_E1.0711.00
381_R400_D1.0691.00
44_F78_L1.0611.00
398_V414_F1.0581.00
48_E51_A1.0571.00
38_E106_Y1.0541.00
13_L89_A1.0541.00
372_F376_D1.0541.00
28_R108_V1.0491.00
256_L259_G1.0491.00
411_L415_I1.0441.00
43_I110_P1.0431.00
299_P302_P1.0421.00
337_L368_M1.0371.00
396_I409_V1.0371.00
12_I20_W1.0351.00
185_E188_I1.0331.00
389_D408_E1.0321.00
192_C209_C1.0321.00
215_H221_A1.0321.00
51_A75_S1.0181.00
10_Q311_E1.0071.00
176_Y180_L1.0051.00
27_M31_C1.0001.00
90_F105_L1.0001.00
230_E234_A0.9971.00
34_Y104_K0.9961.00
240_K252_I0.9951.00
125_F307_A0.9911.00
236_F239_V0.9901.00
399_K404_G0.9871.00
344_Y386_L0.9861.00
334_I348_L0.9851.00
162_L167_L0.9781.00
235_Y239_V0.9781.00
351_K355_A0.9771.00
231_E234_A0.9751.00
346_V350_Y0.9691.00
25_Q28_R0.9611.00
336_T361_I0.9601.00
137_D303_G0.9541.00
357_I418_M0.9521.00
243_L249_S0.9521.00
341_A391_L0.9521.00
18_D32_R0.9511.00
341_A344_Y0.9501.00
233_A237_E0.9441.00
150_S154_K0.9441.00
10_Q16_E0.9411.00
186_P189_E0.9331.00
22_F358_S0.9331.00
119_T122_Y0.9281.00
242_Y245_D0.9261.00
333_Y380_A0.9241.00
265_H268_F0.9231.00
153_E160_V0.9181.00
376_D399_K0.9161.00
400_D405_E0.9161.00
376_D401_A0.9151.00
67_T77_T0.9111.00
268_F271_M0.9051.00
192_C196_Q0.9041.00
172_S180_L0.9041.00
112_F124_Q0.9021.00
370_G373_K0.9021.00
384_A398_V0.9021.00
150_S354_E0.8991.00
41_T85_A0.8961.00
257_V270_I0.8941.00
86_A129_G0.8911.00
175_S178_E0.8871.00
216_E219_K0.8851.00
26_I155_A0.8841.00
347_S411_L0.8801.00
68_F76_L0.8791.00
26_I29_D0.8751.00
144_V304_I0.8741.00
6_P46_H0.8721.00
150_S153_E0.8721.00
211_K217_L0.8701.00
384_A414_F0.8691.00
79_R82_G0.8671.00
214_D218_M0.8671.00
41_T86_A0.8641.00
172_S175_S0.8631.00
25_Q32_R0.8631.00
315_A318_D0.8631.00
335_V383_I0.8621.00
242_Y249_S0.8500.99
172_S232_S0.8490.99
396_I414_F0.8450.99
160_V270_I0.8420.99
44_F76_L0.8410.99
244_N248_I0.8390.99
149_M249_S0.8380.99
381_R402_Q0.8360.99
82_G109_G0.8350.99
273_N276_G0.8340.99
309_S312_R0.8320.99
263_Y267_A0.8300.99
409_V417_V0.8280.99
230_E233_A0.8280.99
260_L263_Y0.8250.99
342_K346_V0.8240.99
288_R292_L0.8240.99
135_S297_G0.8220.99
260_L265_H0.8210.99
121_R309_S0.8170.99
183_H187_R0.8140.99
133_I293_V0.8140.99
188_I199_L0.8140.99
163_V167_L0.8140.99
149_M162_L0.8100.99
28_R32_R0.8090.99
386_L396_I0.8060.99
72_K114_Y0.8040.99
235_Y265_H0.8040.99
259_G262_Y0.7980.99
108_V128_F0.7970.99
18_D37_K0.7950.99
208_D211_K0.7900.99
104_K130_I0.7900.99
17_S20_W0.7870.99
57_S77_T0.7870.99
20_W40_R0.7870.99
28_R106_Y0.7860.99
209_C245_D0.7830.99
266_T270_I0.7830.99
172_S176_Y0.7820.99
86_A105_L0.7800.99
227_Y231_E0.7790.99
152_Y284_A0.7780.99
151_I308_M0.7760.99
217_L220_S0.7720.99
44_F66_Y0.7700.99
348_L411_L0.7700.99
257_V260_L0.7670.99
410_A414_F0.7660.99
260_L268_F0.7660.99
212_D215_H0.7630.99
407_I413_E0.7620.99
376_D383_I0.7610.99
362_D366_K0.7610.99
163_V166_S0.7610.99
191_F194_D0.7600.99
203_P206_I0.7590.99
125_F312_R0.7570.99
238_K244_N0.7560.99
383_I406_Q0.7550.99
179_A182_K0.7550.99
176_Y183_H0.7540.99
227_Y232_S0.7530.99
30_T151_I0.7500.99
263_Y268_F0.7490.99
180_L183_H0.7490.99
26_I30_T0.7470.99
208_D212_D0.7450.99
199_L206_I0.7450.99
239_V242_Y0.7420.99
256_L267_A0.7410.99
360_E380_A0.7400.99
64_E67_T0.7380.98
297_G301_A0.7370.98
237_E244_N0.7360.98
339_E343_D0.7350.98
258_R261_D0.7350.98
184_F187_R0.7340.98
212_D218_M0.7330.98
188_I200_H0.7320.98
267_A270_I0.7310.98
170_Q180_L0.7290.98
140_I285_G0.7290.98
173_R180_L0.7290.98
332_C414_F0.7280.98
24_E310_I0.7260.98
291_G294_E0.7250.98
339_E342_K0.7250.98
43_I78_L0.7230.98
334_I359_S0.7220.98
260_L264_N0.7200.98
180_L184_F0.7180.98
5_I92_E0.7180.98
169_D232_S0.7170.98
170_Q173_R0.7140.98
243_L248_I0.7140.98
331_D381_R0.7140.98
245_D248_I0.7140.98
44_F68_F0.7120.98
24_E38_E0.7120.98
22_F25_Q0.7110.98
33_T353_R0.7110.98
152_Y160_V0.7110.98
145_M283_L0.7110.98
181_V185_E0.7100.98
369_K373_K0.7090.98
177_R181_V0.7090.98
236_F240_K0.7080.98
353_R359_S0.7080.98
10_Q122_Y0.7040.98
259_G263_Y0.7030.98
259_G264_N0.7010.98
211_K214_D0.6970.98
33_T357_I0.6960.98
262_Y267_A0.6950.98
142_A246_L0.6940.98
30_T150_S0.6920.98
30_T34_Y0.6880.98
161_K165_N0.6850.98
277_F280_I0.6840.98
202_N205_R0.6820.97
322_R325_P0.6810.97
209_C214_D0.6800.97
17_S40_R0.6800.97
24_E108_V0.6790.97
115_E121_R0.6760.97
204_L208_D0.6760.97
9_T41_T0.6750.97
184_F218_M0.6730.97
181_V200_H0.6700.97
115_E312_R0.6690.97
336_T342_K0.6680.97
162_L270_I0.6670.97
184_F191_F0.6670.97
351_K412_D0.6670.97
368_M385_I0.6670.97
334_I361_I0.6660.97
407_I411_L0.6610.97
243_L247_G0.6610.97
341_A388_E0.6560.97
53_G285_G0.6550.97
234_A237_E0.6540.97
218_M222_P0.6530.97
32_R358_S0.6530.97
239_V243_L0.6520.97
172_S185_E0.6480.97
86_A133_I0.6470.97
262_Y265_H0.6460.97
81_E84_A0.6460.97
158_E320_E0.6430.96
334_I384_A0.6420.96
373_K376_D0.6420.96
115_E309_S0.6420.96
86_A107_Y0.6380.96
7_R117_P0.6370.96
174_K180_L0.6360.96
263_Y269_E0.6350.96
373_K377_R0.6350.96
160_V165_N0.6340.96
157_L316_A0.6330.96
286_G289_Y0.6330.96
61_V64_E0.6320.96
194_D198_R0.6320.96
12_I16_E0.6310.96
165_N168_G0.6300.96
88_R92_E0.6300.96
18_D358_S0.6280.96
213_R217_L0.6270.96
293_V301_A0.6230.96
211_K271_M0.6220.96
335_V371_Q0.6220.96
192_C214_D0.6190.96
409_V415_I0.6180.96
191_F198_R0.6180.96
145_M164_I0.6160.95
284_A308_M0.6140.95
214_D217_L0.6140.95
334_I386_L0.6130.95
263_Y270_I0.6130.95
258_R269_E0.6130.95
152_Y313_L0.6120.95
113_R125_F0.6120.95
143_E353_R0.6120.95
90_F301_A0.6110.95
182_K187_R0.6080.95
260_L266_T0.6070.95
170_Q182_K0.6070.95
191_F195_C0.6070.95
39_I105_L0.6050.95
230_E237_E0.6050.95
239_V244_N0.6040.95
34_Y144_V0.6020.95
256_L262_Y0.6020.95
184_F189_E0.6000.95
400_D404_G0.5990.95
110_P126_Y0.5940.94
188_I191_F0.5930.94
178_E181_V0.5920.94
146_A350_Y0.5920.94
190_E213_R0.5910.94
174_K178_E0.5890.94
352_L414_F0.5870.94
169_D173_R0.5870.94
193_S198_R0.5860.94
121_R125_F0.5860.94
40_R109_G0.5860.94
145_M149_M0.5850.94
132_A144_V0.5850.94
170_Q177_R0.5850.94
348_L351_K0.5830.94
252_I256_L0.5830.94
237_E245_D0.5820.94
29_D356_G0.5820.94
392_A395_K0.5810.94
364_E374_T0.5810.94
159_N273_N0.5810.94
121_R312_R0.5780.94
403_T406_Q0.5780.94
350_Y353_R0.5770.94
331_D380_A0.5760.94
130_I306_F0.5750.93
271_M282_T0.5750.93
204_L207_L0.5730.93
262_Y269_E0.5710.93
17_S38_E0.5710.93
245_D249_S0.5710.93
240_K243_L0.5710.93
19_R323_E0.5710.93
168_G235_Y0.5700.93
215_H244_N0.5690.93
207_L210_K0.5680.93
23_V155_A0.5680.93
355_A416_H0.5670.93
372_F383_I0.5670.93
36_Y130_I0.5660.93
171_D175_S0.5650.93
90_F101_Q0.5650.93
155_A313_L0.5640.93
222_P234_A0.5620.93
88_R91_N0.5620.93
34_Y353_R0.5610.93
220_S223_S0.5600.93
49_L296_I0.5600.93
270_I284_A0.5580.92
345_S361_I0.5580.92
332_C382_F0.5570.92
30_T33_T0.5560.92
123_R309_S0.5560.92
195_C199_L0.5550.92
210_K221_A0.5550.92
259_G266_T0.5520.92
260_L269_E0.5510.92
347_S350_Y0.5510.92
152_Y308_M0.5500.92
210_K224_I0.5500.92
205_R210_K0.5480.92
385_I406_Q0.5470.92
372_F401_A0.5450.92
238_K245_D0.5450.92
192_C198_R0.5450.92
317_I321_K0.5450.92
348_L386_L0.5440.91
72_K75_S0.5430.91
262_Y266_T0.5430.91
23_V26_I0.5390.91
89_A93_N0.5390.91
257_V262_Y0.5380.91
257_V261_D0.5380.91
195_C198_R0.5370.91
219_K222_P0.5370.91
5_I11_D0.5360.91
140_I363_Y0.5360.91
394_N411_L0.5360.91
136_K302_P0.5350.91
91_N296_I0.5350.91
241_Q246_L0.5340.91
203_P208_D0.5330.91
206_I217_L0.5330.91
346_V361_I0.5320.91
246_L346_V0.5320.91
155_A317_I0.5300.90
141_D144_V0.5300.90
11_D42_P0.5290.90
196_Q199_L0.5290.90
51_A57_S0.5270.90
188_I192_C0.5260.90
229_N233_A0.5250.90
90_F133_I0.5250.90
215_H218_M0.5250.90
104_K132_A0.5240.90
351_K416_H0.5240.90
400_D407_I0.5230.90
49_L88_R0.5220.90
259_G265_H0.5210.90
40_R110_P0.5200.90
333_Y362_D0.5190.89
256_L270_I0.5190.89
262_Y268_F0.5180.89
272_S316_A0.5180.89
270_I273_N0.5180.89
22_F324_L0.5170.89
180_L185_E0.5170.89
410_A415_I0.5160.89
137_D287_G0.5150.89
238_K243_L0.5150.89
228_L232_S0.5140.89
286_G305_G0.5140.89
204_L210_K0.5140.89
243_L250_Y0.5130.89
146_A149_M0.5130.89
148_A306_F0.5110.89
212_D220_S0.5100.89
222_P229_N0.5090.89
290_D295_Q0.5090.89
159_N276_G0.5080.88
26_I151_I0.5080.88
162_L166_S0.5060.88
90_F103_T0.5050.88
170_Q175_S0.5040.88
72_K76_L0.5030.88
125_F309_S0.5030.88
70_D73_G0.5010.88
346_V349_V0.5000.88
190_E193_S0.5000.88
235_Y238_K0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1httA 2 0.8561 100 0.194 Contact Map
1h4vB 2 0.9481 100 0.201 Contact Map
4phcA 2 0.9741 100 0.205 Contact Map
1wu7A 2 0.9552 100 0.211 Contact Map
1qe0A 2 0.9175 100 0.214 Contact Map
3netA 2 0.9481 100 0.221 Contact Map
4e51A 2 0.9646 100 0.223 Contact Map
3lc0A 2 0.9269 100 0.224 Contact Map
4g84A 2 0.9599 100 0.232 Contact Map
3od1A 2 0.8585 100 0.284 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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