GREMLIN Database
TCDA - tRNA threonylcarbamoyladenosine dehydratase
UniProt: O32037 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 254 (235)
Sequences: 4638 (3066)
Seq/√Len: 200.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_R93_E4.4731.00
82_K86_A3.9781.00
24_T50_L3.7891.00
75_Q83_A3.6741.00
71_S87_D3.6491.00
48_R95_I3.2471.00
117_V134_C3.2051.00
9_E14_K3.1701.00
37_A118_I3.1371.00
24_T48_R2.8531.00
237_H240_M2.8441.00
76_P98_K2.7661.00
27_V38_A2.7041.00
118_I238_V2.5141.00
38_A85_I2.5021.00
144_S234_M2.3711.00
42_A85_I2.3371.00
82_K96_A2.3371.00
26_A114_L2.3361.00
79_D98_K2.2141.00
85_I92_C2.1921.00
131_M141_L2.1691.00
164_T167_D2.1211.00
79_D96_A2.1121.00
67_H81_M2.0881.00
50_L114_L2.0781.00
116_Y238_V1.9901.00
78_V96_A1.9551.00
75_Q79_D1.9301.00
8_N17_L1.8561.00
26_A52_V1.8341.00
76_P79_D1.7891.00
20_L239_V1.7741.00
4_Q70_L1.7731.00
155_R192_D1.7601.00
72_T75_Q1.7581.00
176_K180_E1.7501.00
133_E137_R1.7451.00
112_Y137_R1.7161.00
187_Q237_H1.7161.00
130_L141_L1.6841.00
18_E22_N1.6601.00
56_D76_P1.6401.00
121_S126_Y1.5961.00
159_A163_K1.5921.00
6_S10_L1.5861.00
78_V98_K1.5721.00
23_S242_L1.5611.00
131_M186_V1.5601.00
30_V81_M1.5571.00
50_L95_I1.5311.00
178_R182_I1.5121.00
50_L97_L1.4921.00
132_K136_K1.4571.00
35_S67_H1.4561.00
101_Y106_Y1.4541.00
231_G235_G1.4481.00
38_A51_L1.4441.00
119_D130_L1.4241.00
28_L52_V1.4161.00
85_I94_V1.3711.00
61_N77_K1.3651.00
175_T179_K1.3591.00
14_K18_E1.3581.00
165_H192_D1.3461.00
62_V73_V1.3431.00
55_D77_K1.3371.00
75_Q80_L1.3171.00
179_K182_I1.3031.00
36_F39_E1.2961.00
79_D83_A1.2901.00
229_V233_I1.2751.00
12_I17_L1.2701.00
57_V67_H1.2251.00
32_G227_P1.2161.00
44_S224_A1.2031.00
89_N92_C1.1841.00
152_D155_R1.1721.00
27_V41_L1.1641.00
42_A92_C1.1591.00
24_T95_I1.1531.00
18_E21_K1.1491.00
49_I92_C1.1461.00
228_S232_L1.1461.00
19_T23_S1.1441.00
192_D195_P1.1391.00
132_K180_E1.1371.00
129_H133_E1.1231.00
133_E136_K1.1201.00
35_S66_L1.1101.00
101_Y129_H1.1091.00
142_I234_M1.1021.00
28_L130_L1.0981.00
177_L182_I1.0981.00
30_V78_V1.0871.00
86_A92_C1.0761.00
151_T223_N1.0711.00
54_K100_F1.0701.00
69_L87_D1.0651.00
9_E17_L1.0521.00
69_L84_R1.0381.00
86_A93_E1.0371.00
15_E19_T1.0371.00
30_V51_L1.0081.00
39_E43_R1.0021.00
156_F230_A0.9931.00
119_D122_D0.9921.00
12_I16_G0.9911.00
12_I223_N0.9891.00
118_I234_M0.9881.00
159_A190_F0.9751.00
178_R181_G0.9720.99
158_I161_I0.9630.99
42_A49_I0.9600.99
166_T169_I0.9590.99
69_L72_T0.9570.99
103_E129_H0.9560.99
218_M221_S0.9480.99
57_V68_A0.9450.99
28_L101_Y0.9410.99
82_K94_V0.9380.99
12_I151_T0.9370.99
128_I132_K0.9370.99
107_E133_E0.9220.99
169_I174_R0.9160.99
38_A81_M0.9140.99
158_I189_I0.9140.99
151_T230_A0.9070.99
5_F89_N0.9030.99
8_N44_S0.8980.99
59_I73_V0.8920.99
37_A234_M0.8890.99
170_A173_V0.8860.99
62_V70_L0.8850.99
19_T244_K0.8840.99
80_L83_A0.8830.99
17_L21_K0.8790.99
123_T126_Y0.8770.99
188_V192_D0.8740.99
106_Y133_E0.8730.99
131_M143_S0.8660.99
25_V116_Y0.8650.99
26_A50_L0.8640.99
49_I85_I0.8630.99
188_V195_P0.8590.99
216_A219_P0.8560.99
194_S197_V0.8510.99
144_S230_A0.8480.99
31_G121_S0.8480.99
83_A87_D0.8460.99
133_E139_I0.8460.99
119_D127_K0.8460.99
167_D174_R0.8450.99
70_L87_D0.8420.99
116_Y241_D0.8420.99
41_L49_I0.8360.98
35_S81_M0.8350.98
16_G23_S0.8330.98
176_K179_K0.8320.98
62_V72_T0.8270.98
110_F139_I0.8270.98
163_K168_P0.8260.98
20_L47_G0.8260.98
165_H168_P0.8250.98
211_A214_R0.8210.98
36_F66_L0.8150.98
153_P236_G0.8000.98
193_E196_I0.7970.98
13_G16_G0.7910.98
131_M135_L0.7900.98
154_T233_I0.7880.98
36_F228_S0.7870.98
61_N65_Q0.7840.98
20_L46_V0.7780.98
55_D61_N0.7770.98
51_L96_A0.7730.97
191_S195_P0.7690.97
37_A40_A0.7640.97
43_R88_I0.7630.97
167_D170_A0.7580.97
166_T171_K0.7560.97
20_L243_L0.7560.97
106_Y129_H0.7520.97
34_G65_Q0.7490.97
224_A227_P0.7460.97
47_G89_N0.7410.97
126_Y129_H0.7400.97
44_S239_V0.7380.97
31_G34_G0.7380.97
226_V229_V0.7380.97
162_S185_G0.7350.97
57_V80_L0.7300.96
72_T84_R0.7240.96
107_E137_R0.7200.96
233_I236_G0.7170.96
110_F137_R0.7170.96
214_R218_M0.7140.96
188_V191_S0.7130.96
187_Q191_S0.7110.96
169_I172_V0.7100.96
24_T114_L0.7090.96
107_E136_K0.7090.96
30_V38_A0.7050.96
27_V118_I0.7050.96
215_K219_P0.7030.96
84_R87_D0.7030.96
166_T170_A0.7020.96
37_A120_A0.7010.95
39_E66_L0.7010.95
31_G55_D0.7000.95
167_D173_V0.6950.95
196_I199_R0.6950.95
38_A49_I0.6940.95
166_T173_V0.6940.95
172_V175_T0.6930.95
54_K98_K0.6920.95
101_Y133_E0.6860.95
170_A174_R0.6820.95
40_A232_L0.6780.95
217_K222_S0.6780.95
164_T168_P0.6770.95
199_R203_R0.6740.94
55_D60_T0.6720.94
24_T113_G0.6700.94
166_T174_R0.6700.94
168_P172_V0.6680.94
25_V46_V0.6650.94
127_K143_S0.6650.94
213_I217_K0.6650.94
169_I173_V0.6640.94
33_V144_S0.6640.94
151_T196_I0.6620.94
199_R202_V0.6620.94
208_N211_A0.6620.94
186_V193_E0.6620.94
31_G222_S0.6580.94
27_V34_G0.6570.94
8_N12_I0.6560.94
168_P173_V0.6540.93
55_D122_D0.6480.93
127_K145_M0.6470.93
4_Q62_V0.6430.93
39_E84_R0.6410.93
131_M173_V0.6400.93
176_K182_I0.6380.93
165_H172_V0.6370.93
166_T172_V0.6360.93
210_E214_R0.6350.92
99_M105_T0.6340.92
29_G34_G0.6330.92
23_S115_D0.6330.92
142_I237_H0.6330.92
61_N64_R0.6300.92
190_F193_E0.6300.92
25_V41_L0.6290.92
172_V176_K0.6270.92
190_F194_S0.6270.92
64_R122_D0.6270.92
6_S9_E0.6250.92
110_F133_E0.6250.92
38_A67_H0.6240.92
83_A86_A0.6200.92
49_I94_V0.6190.91
225_F236_G0.6180.91
175_T178_R0.6140.91
116_Y187_Q0.6010.90
37_A66_L0.5970.90
72_T80_L0.5960.90
31_G65_Q0.5950.90
33_V37_A0.5950.90
5_F10_L0.5950.90
209_D213_I0.5950.90
56_D98_K0.5920.90
110_F113_G0.5920.90
196_I200_E0.5850.89
115_D139_I0.5840.89
37_A41_L0.5830.89
159_A162_S0.5780.88
163_K167_D0.5780.88
36_F43_R0.5740.88
166_T194_S0.5730.88
31_G120_A0.5720.88
147_A230_A0.5700.88
197_V200_E0.5680.88
64_R222_S0.5670.88
110_F114_L0.5670.88
6_S12_I0.5630.87
213_I216_A0.5620.87
122_D127_K0.5610.87
79_D82_K0.5610.87
193_E197_V0.5600.87
188_V193_E0.5590.87
158_I162_S0.5570.87
158_I237_H0.5560.87
198_I203_R0.5530.86
165_H169_I0.5530.86
161_I168_P0.5510.86
116_Y142_I0.5510.86
134_C141_L0.5510.86
164_T170_A0.5490.86
171_K174_R0.5480.86
200_E203_R0.5480.86
192_D196_I0.5470.86
118_I235_G0.5450.85
208_N213_I0.5450.85
209_D212_K0.5440.85
105_T108_Q0.5430.85
212_K215_K0.5430.85
116_Y242_L0.5430.85
224_A232_L0.5420.85
20_L41_L0.5410.85
165_H190_F0.5400.85
33_V64_R0.5400.85
194_S199_R0.5390.85
142_I241_D0.5380.85
210_E213_I0.5360.84
165_H171_K0.5350.84
143_S152_D0.5350.84
8_N11_A0.5340.84
217_K221_S0.5310.84
71_S83_A0.5300.84
189_I192_D0.5290.84
222_S227_P0.5280.84
28_L119_D0.5250.83
163_K166_T0.5230.83
64_R227_P0.5230.83
188_V199_R0.5220.83
36_F232_L0.5210.83
109_F114_L0.5200.83
214_R217_K0.5200.83
235_G238_V0.5200.83
146_G227_P0.5190.83
99_M109_F0.5180.82
36_F81_M0.5180.82
168_P171_K0.5180.82
25_V118_I0.5170.82
162_S166_T0.5160.82
97_L109_F0.5150.82
23_S46_V0.5130.82
12_I240_M0.5120.82
105_T129_H0.5100.81
34_G77_K0.5090.81
16_G20_L0.5070.81
239_V243_L0.5070.81
72_T83_A0.5060.81
162_S168_P0.5060.81
148_A220_P0.5040.81
189_I193_E0.5040.81
60_T64_R0.5030.81
118_I144_S0.5030.81
187_Q241_D0.5000.80
142_I238_V0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p22A 2 0.9646 100 0.205 Contact Map
4ii2A 1 0.9685 100 0.22 Contact Map
4nnjA 2 0.9764 100 0.221 Contact Map
1y8qA 1 0.9567 100 0.221 Contact Map
1tt5A 1 0.9882 100 0.229 Contact Map
1tt5B 1 0.9764 100 0.263 Contact Map
1y8qB 1 0.9449 100 0.276 Contact Map
2nvuB 1 0.9764 100 0.3 Contact Map
1zud1 2 0.8189 100 0.349 Contact Map
4d79A 2 0.9173 100 0.357 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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