GREMLIN Database
YRRM - Putative O-methyltransferase YrrM
UniProt: O32036 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (202)
Sequences: 4079 (2766)
Seq/√Len: 194.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_R100_E3.8101.00
84_I117_L3.7251.00
99_K104_D3.1901.00
20_P74_L3.1321.00
80_E108_H2.9991.00
140_Q192_W2.8061.00
158_T189_Y2.7921.00
58_I72_M2.5391.00
150_L154_G2.4721.00
56_K78_S2.4171.00
119_D145_L2.4021.00
82_Y127_Y2.3681.00
63_T83_T2.3471.00
50_L72_M2.3401.00
143_F199_Y2.2791.00
88_E92_E2.1761.00
43_M71_R2.1581.00
138_Q141_N2.1581.00
115_L141_N2.1151.00
82_Y110_F2.1071.00
147_E199_Y2.0301.00
145_L148_P2.0231.00
129_V157_I2.0121.00
91_H111_Y1.9481.00
191_H195_N1.8931.00
76_L79_A1.8351.00
135_A138_Q1.8341.00
28_A32_E1.8161.00
157_I212_I1.7871.00
57_K80_E1.7561.00
76_L81_I1.7491.00
59_L127_Y1.7361.00
19_R27_E1.6601.00
144_H192_W1.6571.00
134_A142_F1.6081.00
87_N90_R1.5911.00
130_I150_L1.5911.00
51_S200_Q1.5901.00
10_D14_A1.5701.00
130_I146_Y1.5591.00
147_E198_D1.5551.00
110_F117_L1.5321.00
113_D116_E1.5091.00
29_Y96_N1.4821.00
91_H109_V1.4661.00
112_G117_L1.4601.00
189_Y213_S1.4521.00
158_T213_S1.4501.00
47_L75_E1.4341.00
70_I103_L1.4001.00
50_L129_V1.3931.00
98_I107_I1.3881.00
137_G182_L1.3511.00
30_A37_I1.3471.00
85_E91_H1.3111.00
22_N101_F1.3081.00
201_T213_S1.3071.00
69_A81_I1.2951.00
51_S214_K1.2951.00
52_V155_V1.2851.00
147_E196_H1.2771.00
160_N208_D1.2481.00
163_F183_V1.2481.00
21_D24_K1.2181.00
115_L138_Q1.2011.00
96_N100_E1.1911.00
57_K125_A1.1901.00
45_V212_I1.1721.00
27_E40_K1.1691.00
126_P151_S1.1641.00
29_Y33_H1.1611.00
143_F158_T1.1591.00
36_P64_A1.1521.00
30_A65_I1.1511.00
13_E41_A1.1481.00
132_I156_I1.1471.00
150_L215_K1.1461.00
95_V111_Y1.1461.00
161_V211_A1.1411.00
72_M81_I1.1371.00
193_L201_T1.1351.00
200_Q214_K1.1121.00
49_I157_I1.1021.00
82_Y108_H1.1001.00
201_T211_A1.0991.00
187_D191_H1.0951.00
78_S106_R1.0941.00
139_Y158_T1.0901.00
58_I81_I1.0691.00
193_L211_A1.0671.00
38_M68_S1.0641.00
98_I103_L1.0521.00
47_L71_R1.0511.00
189_Y211_A1.0491.00
15_L191_H1.0471.00
157_I210_L1.0381.00
88_E111_Y1.0201.00
24_K28_A1.0141.00
42_G210_L1.0141.00
91_H95_V1.0041.00
21_D25_R1.0021.00
158_T193_L1.0011.00
9_N13_E0.9951.00
69_A98_I0.9901.00
48_Q214_K0.9790.99
188_E192_W0.9710.99
50_L75_E0.9690.99
69_A72_M0.9640.99
11_Y190_N0.9610.99
25_R29_Y0.9370.99
95_V99_K0.9300.99
22_N97_N0.9280.99
196_H199_Y0.9270.99
96_N99_K0.9220.99
77_P106_R0.9160.99
70_I98_I0.9150.99
140_Q188_E0.9130.99
192_W196_H0.9130.99
92_E96_N0.9110.99
140_Q144_H0.9100.99
132_I158_T0.9080.99
57_K82_Y0.9040.99
86_R113_D0.9010.99
47_L51_S0.8980.99
188_E191_H0.8940.99
180_R183_V0.8880.99
48_Q52_V0.8870.99
193_L213_S0.8840.99
70_I101_F0.8810.99
128_D151_S0.8810.99
130_I154_G0.8800.99
184_A187_D0.8800.99
154_G215_K0.8710.99
113_D117_L0.8700.99
55_P79_A0.8660.99
139_Y186_I0.8640.99
112_G116_E0.8590.99
98_I109_V0.8590.99
60_E81_I0.8510.98
46_L157_I0.8510.98
143_F196_H0.8500.98
143_F147_E0.8470.98
73_A107_I0.8450.98
61_I84_I0.8450.98
50_L58_I0.8430.98
12_I203_I0.8260.98
41_A207_G0.8260.98
137_G185_K0.8260.98
19_R67_Y0.8210.98
23_V70_I0.8160.98
12_I205_P0.8100.98
136_K139_Y0.8080.98
181_R185_K0.8070.98
141_N144_H0.8060.98
48_Q202_A0.8060.98
28_A31_E0.8030.98
38_M43_M0.8030.98
23_V74_L0.8010.98
53_K151_S0.7990.98
47_L74_L0.7970.98
162_L167_V0.7940.98
22_N70_I0.7900.98
50_L55_P0.7830.97
193_L199_Y0.7820.97
116_E120_A0.7790.97
49_I52_V0.7740.97
110_F120_A0.7730.97
46_L50_L0.7710.97
19_R24_K0.7700.97
190_N211_A0.7690.97
136_K159_D0.7680.97
166_L169_E0.7680.97
58_I76_L0.7670.97
84_I113_D0.7650.97
29_Y93_E0.7620.97
44_E47_L0.7580.97
29_Y32_E0.7580.97
48_Q155_V0.7570.97
83_T107_I0.7550.97
101_F104_D0.7510.97
43_M67_Y0.7460.97
150_L156_I0.7420.96
61_I114_A0.7360.96
148_P152_P0.7300.96
38_M42_G0.7270.96
115_L142_F0.7200.96
73_A81_I0.7190.96
57_K127_Y0.7190.96
45_V49_I0.7130.96
151_S154_G0.7130.96
144_H188_E0.7130.96
93_E96_N0.7130.96
22_N26_L0.7090.95
68_S131_F0.7070.95
103_L106_R0.7050.95
203_I211_A0.6980.95
73_A103_L0.6960.95
26_L70_I0.6930.95
169_E187_D0.6920.95
23_V67_Y0.6910.95
46_L72_M0.6860.95
42_G46_L0.6860.95
136_K160_N0.6650.94
50_L53_K0.6650.94
29_Y97_N0.6640.94
131_F159_D0.6620.93
184_A188_E0.6610.93
161_V203_I0.6600.93
19_R40_K0.6590.93
85_E97_N0.6550.93
63_T109_V0.6510.93
29_Y65_I0.6460.93
76_L106_R0.6430.92
10_D13_E0.6420.92
58_I129_V0.6420.92
57_K126_P0.6410.92
115_L145_L0.6400.92
22_N100_E0.6390.92
29_Y100_E0.6380.92
97_N100_E0.6370.92
189_Y193_L0.6370.92
30_A35_V0.6350.92
190_N194_M0.6290.92
164_K167_V0.6280.92
202_A214_K0.6260.91
68_S133_D0.6260.91
72_M83_T0.6260.91
116_E119_D0.6230.91
83_T98_I0.6230.91
95_V104_D0.6210.91
43_M75_E0.6180.91
26_L30_A0.6180.91
30_A64_A0.6160.91
118_A146_Y0.6140.91
117_L120_A0.6080.90
72_M129_V0.6080.90
45_V210_L0.6070.90
27_E37_I0.6070.90
138_Q142_F0.6060.90
35_V64_A0.6050.90
163_F186_I0.6030.90
135_A142_F0.6020.90
84_I114_A0.6010.90
204_I212_I0.5990.90
152_P215_K0.5990.90
143_F189_Y0.5980.89
113_D138_Q0.5960.89
11_Y15_L0.5960.89
132_I142_F0.5930.89
59_L130_I0.5930.89
63_T69_A0.5910.89
182_L186_I0.5910.89
199_Y213_S0.5900.89
167_V190_N0.5890.89
43_M46_L0.5810.88
143_F156_I0.5810.88
178_R182_L0.5780.88
22_N25_R0.5710.87
71_R75_E0.5680.87
131_F160_N0.5680.87
38_M131_F0.5660.87
159_D208_D0.5660.87
181_R184_A0.5630.86
204_I210_L0.5550.86
18_P24_K0.5520.85
143_F192_W0.5510.85
146_Y150_L0.5500.85
126_P152_P0.5500.85
60_E159_D0.5490.85
178_R181_R0.5470.85
124_T148_P0.5450.85
42_G207_G0.5430.84
61_I118_A0.5380.84
144_H196_H0.5350.84
42_G161_V0.5340.83
26_L97_N0.5320.83
7_Q10_D0.5310.83
92_E95_V0.5300.83
136_K208_D0.5280.83
84_I110_F0.5280.83
61_I146_Y0.5260.83
55_P58_I0.5260.83
166_L183_V0.5250.82
47_L50_L0.5220.82
69_A73_A0.5190.82
48_Q212_I0.5170.81
179_R184_A0.5170.81
9_N41_A0.5160.81
182_L185_K0.5160.81
163_F182_L0.5160.81
139_Y160_N0.5150.81
45_V206_V0.5140.81
127_Y130_I0.5130.81
53_K129_V0.5110.81
63_T98_I0.5090.80
12_I190_N0.5040.80
8_I168_A0.5040.80
144_H147_E0.5040.80
134_A138_Q0.5040.80
190_N203_I0.5040.80
144_H198_D0.5030.80
163_F180_R0.5020.80
141_N145_L0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tr6A 2 0.9724 100 0.42 Contact Map
3dr5A 2 0.9539 100 0.449 Contact Map
3tosA 5 0.9078 100 0.452 Contact Map
1suiA 2 0.9908 100 0.456 Contact Map
3cbgA 2 0.9677 100 0.466 Contact Map
2gpyA 2 0.8571 100 0.47 Contact Map
3c3yA 2 0.9954 100 0.471 Contact Map
4ymhA 2 0.9862 100 0.479 Contact Map
3r3hA 2 0.9585 100 0.483 Contact Map
2hnkA 2 0.9677 100 0.486 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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