GREMLIN Database
YRRN - Uncharacterized protease YrrN
UniProt: O32035 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 309 (291)
Sequences: 4119 (2661)
Seq/√Len: 156.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
264_R268_D3.8601.00
6_L267_I3.6611.00
114_W134_A3.4131.00
100_L134_A3.0831.00
55_H90_D2.9011.00
20_I59_A2.8101.00
8_V260_T2.8091.00
92_A110_L2.6571.00
77_L99_V2.4661.00
152_K242_D2.4061.00
16_I50_A2.4011.00
43_S46_D2.3791.00
126_C137_S2.3771.00
29_V61_V2.3761.00
149_V153_E2.3211.00
4_P271_V2.2761.00
236_L244_F2.2231.00
20_I53_I2.2141.00
152_K159_I2.1981.00
130_G156_E2.1911.00
54_A61_V2.1861.00
44_R83_F2.1331.00
63_V89_V2.1321.00
63_V84_L2.1301.00
21_Q53_I2.0471.00
17_L53_I2.0341.00
4_P237_I2.0301.00
81_L103_A1.9721.00
231_D285_I1.9321.00
51_V89_V1.9161.00
229_I232_E1.8511.00
111_K135_A1.8451.00
48_T52_E1.8431.00
261_K265_E1.8411.00
12_S15_D1.8341.00
114_W118_T1.8021.00
273_N276_E1.7981.00
13_T49_K1.7421.00
136_R158_E1.7311.00
139_L148_I1.7231.00
22_A257_I1.7141.00
230_I266_A1.7121.00
233_L270_C1.6741.00
235_E304_F1.6571.00
164_H263_Y1.6501.00
52_E56_K1.6481.00
161_I236_L1.6481.00
13_T17_L1.6391.00
123_Y154_N1.6091.00
149_V238_D1.6051.00
31_E80_Y1.5901.00
232_E304_F1.5831.00
232_E300_T1.5761.00
13_T50_A1.5741.00
51_V87_A1.5571.00
33_R76_E1.5541.00
237_I267_I1.5431.00
274_R277_Y1.5301.00
29_V47_V1.5211.00
53_I57_E1.5131.00
127_N130_G1.5001.00
101_M105_E1.4841.00
201_L221_I1.4581.00
49_K52_E1.4451.00
65_V81_L1.4361.00
128_Y132_K1.3991.00
130_G157_V1.3961.00
7_L243_S1.3891.00
6_L264_R1.3871.00
84_L89_V1.3861.00
150_E154_N1.3831.00
246_I260_T1.3831.00
234_E238_D1.3781.00
51_V61_V1.3731.00
232_E235_E1.3711.00
20_I57_E1.3631.00
82_A106_S1.3621.00
54_A59_A1.3531.00
20_I54_A1.3521.00
85_A109_D1.3491.00
145_M239_A1.3381.00
62_Y91_A1.3371.00
300_T304_F1.3281.00
161_I241_I1.3221.00
120_G129_W1.3191.00
127_N131_R1.3081.00
17_L49_K1.2981.00
273_N277_Y1.2971.00
237_I270_C1.2951.00
91_A113_H1.2931.00
17_L21_Q1.2881.00
143_L151_I1.2771.00
146_D149_V1.2761.00
103_A112_L1.2711.00
269_L284_W1.2621.00
191_E195_K1.2561.00
120_G125_T1.2561.00
258_E291_I1.2551.00
34_Y76_E1.2541.00
25_T59_A1.2521.00
230_I262_M1.2391.00
65_V77_L1.2311.00
12_S40_G1.2281.00
30_G35_G1.2231.00
16_I54_A1.2151.00
102_A106_S1.2111.00
265_E284_W1.2081.00
161_I303_F1.2081.00
16_I27_F1.2031.00
229_I303_F1.2021.00
15_D253_P1.1991.00
148_I161_I1.1981.00
287_R290_S1.1961.00
262_M288_I1.1951.00
126_C157_V1.1901.00
21_Q57_E1.1881.00
19_L256_L1.1881.00
270_C274_R1.1721.00
82_A107_A1.1721.00
71_N123_Y1.1661.00
48_T87_A1.1551.00
78_G102_A1.1541.00
237_I271_V1.1341.00
83_F87_A1.1321.00
145_M229_I1.1311.00
126_C151_I1.1311.00
139_L161_I1.1291.00
202_H209_K1.1211.00
79_E82_A1.1071.00
228_C285_I1.0960.99
124_Y127_N1.0930.99
237_I244_F1.0920.99
286_E290_S1.0910.99
82_A86_E1.0890.99
149_V235_E1.0740.99
228_C231_D1.0690.99
112_L134_A1.0680.99
139_L159_I1.0650.99
94_F100_L1.0590.99
295_N298_I1.0590.99
7_L26_A1.0560.99
73_K188_M1.0550.99
94_F99_V1.0540.99
143_L147_S1.0530.99
51_V55_H1.0520.99
50_A61_V1.0480.99
114_W129_W1.0290.99
194_K199_M1.0270.99
8_V246_I1.0230.99
160_E245_K1.0180.99
94_F112_L1.0180.99
5_E60_K1.0150.99
19_L27_F1.0110.99
77_L81_L1.0070.99
26_A243_S1.0060.99
38_L190_I1.0050.99
85_A110_L1.0030.99
152_K155_A1.0000.99
127_N154_N0.9870.99
78_G105_E0.9850.99
136_R243_S0.9820.99
203_D206_R0.9820.99
78_G82_A0.9780.99
148_I239_A0.9750.99
294_V298_I0.9740.99
262_M284_W0.9740.99
29_V63_V0.9710.99
234_E270_C0.9680.99
158_E242_D0.9680.99
103_A110_L0.9670.99
234_E237_I0.9660.99
14_A253_P0.9610.99
55_H61_V0.9510.98
144_N147_S0.9510.98
130_G155_A0.9470.98
163_V244_F0.9390.98
100_L112_L0.9370.98
270_C277_Y0.9370.98
285_I289_E0.9350.98
235_E238_D0.9340.98
97_P129_W0.9320.98
201_L222_M0.9210.98
26_A60_K0.9000.98
126_C159_I0.8980.98
32_Q43_S0.8970.98
83_F86_E0.8970.98
145_M235_E0.8970.98
159_I241_I0.8910.98
118_T129_W0.8840.98
233_L267_I0.8830.98
261_K287_R0.8820.98
269_L272_E0.8790.97
163_V229_I0.8780.97
75_G78_G0.8730.97
26_A62_Y0.8720.97
18_P22_A0.8720.97
4_P242_D0.8710.97
49_K53_I0.8690.97
94_F103_A0.8680.97
48_T83_F0.8680.97
48_T86_E0.8680.97
135_A158_E0.8670.97
78_G106_S0.8670.97
286_E289_E0.8640.97
65_V99_V0.8620.97
190_I194_K0.8600.97
227_V299_D0.8590.97
244_F267_I0.8580.97
114_W120_G0.8550.97
175_S191_E0.8520.97
81_L107_A0.8450.97
256_L260_T0.8440.97
167_T299_D0.8410.97
45_E48_T0.8400.97
269_L274_R0.8340.97
120_G126_C0.8330.96
74_V102_A0.8320.96
283_D286_E0.8320.96
78_G107_A0.8300.96
68_I95_G0.8300.96
28_L160_E0.8290.96
257_I261_K0.8280.96
123_Y150_E0.8240.96
5_E243_S0.8240.96
119_T174_R0.8230.96
152_K156_E0.8190.96
119_T140_A0.8180.96
182_E192_R0.8130.96
70_H179_N0.8080.96
142_E165_G0.8070.96
81_L99_V0.8010.96
10_P16_I0.7980.96
269_L273_N0.7950.95
142_E172_S0.7930.95
29_V42_F0.7920.95
78_G99_V0.7920.95
100_L114_W0.7890.95
92_A103_A0.7890.95
26_A136_R0.7880.95
111_K158_E0.7860.95
69_F77_L0.7810.95
267_I270_C0.7800.95
139_L151_I0.7780.95
103_A107_A0.7770.95
4_P244_F0.7770.95
22_A260_T0.7710.95
6_L259_V0.7700.95
82_A102_A0.7690.95
267_I271_V0.7690.95
121_T140_A0.7670.94
229_I304_F0.7670.94
150_E153_E0.7640.94
167_T227_V0.7630.94
203_D208_N0.7600.94
70_H147_S0.7600.94
141_R162_Q0.7570.94
294_V297_K0.7540.94
80_Y84_L0.7540.94
46_D49_K0.7530.94
275_D278_E0.7520.94
18_P257_I0.7520.94
18_P21_Q0.7400.93
21_Q257_I0.7400.93
229_I300_T0.7380.93
92_A112_L0.7380.93
238_D270_C0.7340.93
138_V160_E0.7330.93
16_I42_F0.7300.93
179_N185_G0.7300.93
239_A244_F0.7300.93
185_G188_M0.7290.93
219_T222_M0.7290.93
35_G38_L0.7290.93
161_I239_A0.7260.93
238_D274_R0.7230.93
265_E269_L0.7210.92
115_S245_K0.7130.92
164_H228_C0.7110.92
79_E83_F0.7050.92
65_V80_Y0.7030.91
259_V263_Y0.7020.91
164_H251_K0.7020.91
123_Y127_N0.7020.91
177_I181_F0.7010.91
289_E298_I0.6980.91
161_I229_I0.6980.91
145_M303_F0.6970.91
44_R48_T0.6950.91
125_T129_W0.6940.91
228_C298_I0.6920.91
201_L204_K0.6900.91
84_L87_A0.6880.91
85_A103_A0.6870.91
127_N156_E0.6870.91
163_V246_I0.6830.90
264_R267_I0.6810.90
149_V239_A0.6790.90
147_S150_E0.6790.90
27_F61_V0.6790.90
44_R47_V0.6780.90
289_E297_K0.6740.90
5_E26_A0.6730.90
228_C263_Y0.6730.90
60_K111_K0.6730.90
259_V288_I0.6720.90
107_A110_L0.6710.89
50_A53_I0.6700.89
200_F209_K0.6680.89
97_P128_Y0.6670.89
85_A106_S0.6660.89
81_L102_A0.6660.89
82_A85_A0.6650.89
18_P253_P0.6640.89
231_D234_E0.6630.89
16_I20_I0.6620.89
75_G79_E0.6600.89
245_K248_G0.6590.89
85_A107_A0.6580.89
25_T264_R0.6580.89
31_E47_V0.6560.88
251_K255_Y0.6550.88
203_D207_D0.6500.88
175_S195_K0.6440.87
121_T174_R0.6400.87
272_E276_E0.6360.87
164_H226_D0.6340.87
93_V138_V0.6320.86
50_A54_A0.6320.86
231_D300_T0.6300.86
131_R156_E0.6290.86
43_S49_K0.6280.86
15_D18_P0.6260.86
164_H259_V0.6230.86
41_E250_L0.6220.86
262_M287_R0.6200.85
94_F98_A0.6180.85
202_H208_N0.6160.85
229_I236_L0.6100.85
51_V54_A0.6050.84
166_M226_D0.6040.84
297_K300_T0.6030.84
104_R135_A0.6030.84
36_L67_A0.6020.84
70_H169_M0.6010.84
262_M265_E0.6010.84
6_L263_Y0.6010.84
266_A269_L0.6000.84
270_C273_N0.5970.83
291_I298_I0.5970.83
152_K241_I0.5940.83
88_G110_L0.5930.83
22_A261_K0.5930.83
207_D211_P0.5920.83
47_V87_A0.5900.83
161_I244_F0.5900.83
66_N245_K0.5880.82
168_C245_K0.5860.82
225_N299_D0.5820.82
122_N125_T0.5810.82
116_T140_A0.5810.82
35_G64_A0.5810.82
146_D235_E0.5810.82
184_Q192_R0.5810.82
16_I53_I0.5780.81
187_V191_E0.5750.81
116_T251_K0.5750.81
301_G304_F0.5730.81
152_K239_A0.5710.80
138_V162_Q0.5710.80
104_R131_R0.5690.80
202_H207_D0.5670.80
196_E199_M0.5610.79
104_R112_L0.5590.79
115_S175_S0.5590.79
206_R209_K0.5580.79
113_H243_S0.5570.79
105_E131_R0.5560.79
32_Q41_E0.5560.79
115_S168_C0.5550.79
102_A105_E0.5540.78
115_S162_Q0.5520.78
166_M193_K0.5520.78
169_M224_P0.5470.78
283_D289_E0.5470.78
210_Y223_S0.5460.77
116_T141_R0.5450.77
117_E187_V0.5450.77
85_A108_P0.5400.77
39_A250_L0.5380.76
186_K192_R0.5370.76
100_L129_W0.5370.76
97_P100_L0.5360.76
67_A117_E0.5360.76
162_Q245_K0.5350.76
105_E127_N0.5350.76
9_T245_K0.5340.76
71_N74_V0.5340.76
266_A284_W0.5340.76
127_N155_A0.5330.76
146_D304_F0.5320.76
72_D79_E0.5310.75
46_D50_A0.5310.75
66_N168_C0.5310.75
76_E79_E0.5280.75
197_S222_M0.5280.75
225_N297_K0.5270.75
233_L266_A0.5260.75
198_G204_K0.5250.75
32_Q46_D0.5240.75
140_A143_L0.5240.75
203_D219_T0.5230.74
31_E35_G0.5210.74
236_L239_A0.5210.74
162_Q247_D0.5190.74
84_L92_A0.5160.73
35_G67_A0.5130.73
241_I244_F0.5130.73
258_E262_M0.5100.73
210_Y221_I0.5090.72
274_R278_E0.5090.72
98_A176_L0.5080.72
178_G189_D0.5080.72
28_L93_V0.5080.72
9_T249_V0.5080.72
120_G140_A0.5080.72
289_E299_D0.5080.72
15_D256_L0.5070.72
126_C155_A0.5070.72
13_T42_F0.5060.72
141_R168_C0.5040.72
19_L23_G0.5030.72
137_S155_A0.5020.71
269_L276_E0.5020.71
168_C248_G0.5020.71
298_I301_G0.5010.71
245_K249_V0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bdqA 2 0.6019 97.6 0.892 Contact Map
3iwpA 3 0.7379 96.7 0.908 Contact Map
2ftpA 3 0.6117 96.1 0.913 Contact Map
3ktsA 1 0.5696 95.5 0.917 Contact Map
3f4wA 2 0.4693 95.5 0.917 Contact Map
1ydoA 3 0.6084 95.3 0.918 Contact Map
3iixA 1 0.5566 95.3 0.918 Contact Map
3o63A 2 0.6246 95.1 0.919 Contact Map
3q58A 2 0.4304 95.1 0.919 Contact Map
1wa3A 3 0.4498 94.9 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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