GREMLIN Database
YRRO - Uncharacterized protease YrrO
UniProt: O32034 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 422 (372)
Sequences: 2699 (1693)
Seq/√Len: 87.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_L286_I4.1601.00
26_A279_V3.8381.00
119_I153_L3.8091.00
283_R287_D3.6731.00
133_L153_L3.4611.00
38_V78_A3.3291.00
96_L118_I3.0591.00
168_R172_E2.9661.00
82_V103_L2.9181.00
255_M263_L2.7621.00
47_I80_I2.7611.00
111_I129_V2.7001.00
171_K261_D2.6851.00
254_K320_E2.6121.00
62_T65_E2.5741.00
74_K109_A2.5621.00
171_K178_I2.5051.00
73_A80_I2.4541.00
250_E303_L2.4351.00
22_P290_C2.4311.00
67_A71_E2.4061.00
130_E154_D2.3961.00
70_V108_V2.3481.00
385_T393_E2.3401.00
149_K175_D2.3151.00
100_L122_C2.2481.00
368_E380_T2.2451.00
49_G99_Y2.2181.00
39_H72_F2.2071.00
70_V106_A2.1791.00
145_V176_I2.0411.00
63_I102_A1.9971.00
34_L69_G1.9971.00
180_S255_M1.9661.00
22_P256_I1.9631.00
256_I286_I1.9611.00
38_V72_F1.9561.00
265_I279_V1.9471.00
155_R177_E1.9081.00
31_L68_E1.8881.00
82_V108_V1.8871.00
40_Y276_A1.8811.00
252_I286_I1.8811.00
30_N33_K1.8771.00
251_S316_T1.8611.00
169_E173_K1.8561.00
256_I263_L1.8551.00
362_F396_A1.8241.00
145_V156_V1.8211.00
31_L69_G1.8171.00
280_S284_K1.8151.00
35_K72_F1.8141.00
26_A265_I1.8031.00
48_G53_G1.7751.00
84_T100_L1.7531.00
30_N59_D1.7421.00
168_R257_E1.7411.00
300_K304_E1.7111.00
90_N142_W1.7111.00
248_L251_S1.7081.00
146_Q149_K1.6931.00
38_V76_Y1.6881.00
84_T96_L1.6881.00
149_K176_I1.6811.00
253_P257_E1.6781.00
251_S320_E1.6661.00
92_N207_R1.6551.00
252_I289_Y1.6551.00
142_W173_K1.6141.00
249_I281_V1.6141.00
110_G132_H1.6071.00
24_L283_R1.5881.00
71_E75_K1.5861.00
248_L319_F1.5841.00
47_I66_I1.5801.00
21_K290_C1.5741.00
111_I122_C1.5531.00
96_L100_L1.5521.00
145_V170_M1.5411.00
369_V383_I1.5321.00
356_T405_K1.5221.00
249_I285_V1.5211.00
37_A275_V1.5171.00
368_E382_T1.5161.00
31_L35_K1.5111.00
103_L108_V1.5061.00
347_N356_T1.5051.00
139_L144_A1.4901.00
35_K68_E1.4851.00
220_L241_M1.4851.00
164_A258_M1.4810.99
116_P147_F1.4800.99
343_G357_L1.4650.99
20_K261_D1.4640.99
122_C131_V1.4620.99
72_F76_Y1.4580.99
222_Q225_G1.4550.99
51_E95_G1.4500.99
165_L168_R1.4380.99
104_G128_N1.4320.99
102_A106_A1.4180.99
158_L167_I1.4160.99
147_F151_E1.4120.99
220_L240_A1.4060.99
180_S260_I1.4060.99
180_S319_F1.4030.99
251_S254_K1.3980.99
119_I133_L1.3980.99
113_V119_I1.3840.99
213_S218_Y1.3700.99
38_V73_A1.3510.99
158_L178_I1.3460.99
222_Q226_A1.3200.99
256_I289_Y1.3160.99
34_L73_A1.3080.99
100_L118_I1.3060.99
25_L262_S1.3000.99
288_A302_W1.2770.98
67_A106_A1.2710.98
133_L137_Q1.2700.98
387_W393_E1.2670.98
284_K302_W1.2570.98
162_T166_E1.2520.98
74_K80_I1.2410.98
97_E121_T1.2310.98
146_Q150_E1.2280.98
120_E124_R1.2240.98
34_L45_V1.2240.98
397_A404_V1.2200.98
87_F114_A1.2200.98
162_T170_M1.2200.98
281_V306_L1.2110.98
171_K175_D1.2090.98
33_K272_I1.2020.98
131_V153_L1.2010.98
146_Q173_K1.1970.98
158_L180_S1.1770.97
311_N314_T1.1770.97
130_E177_E1.1750.97
342_V369_V1.1660.97
53_G83_T1.1610.97
246_L315_A1.1550.97
23_E262_S1.1540.97
394_L402_Q1.1510.97
139_L145_V1.1490.97
363_F404_V1.1370.97
277_T309_C1.1330.97
316_T320_E1.1140.96
121_T125_V1.1110.96
39_H76_Y1.1100.96
119_I131_V1.1100.96
278_V306_L1.1080.96
100_L126_A1.0960.96
101_K125_V1.0960.96
348_Y353_Q1.0920.96
196_L200_M1.0890.96
169_E172_E1.0860.96
139_L148_W1.0810.96
50_Q65_E1.0780.96
56_S209_G1.0780.96
149_K174_V1.0770.96
286_I289_Y1.0740.96
44_A262_S1.0740.96
253_P289_Y1.0700.95
247_K303_L1.0610.95
186_M315_A1.0580.95
35_K39_H1.0570.95
67_A102_A1.0480.95
369_V381_H1.0460.95
47_I82_V1.0460.95
158_L170_M1.0440.95
88_A96_L1.0440.95
356_T403_I1.0390.95
98_D101_K1.0380.95
263_L286_I1.0380.95
348_Y355_V1.0380.95
101_K126_A1.0370.95
97_E118_I1.0350.95
201_T211_C1.0290.94
203_R211_C1.0260.94
113_V122_C1.0240.94
52_Y95_G1.0240.94
324_G327_E1.0220.94
97_E124_R1.0200.94
138_S193_R1.0200.94
89_H166_E1.0200.94
171_K174_V1.0200.94
138_S159_A1.0020.94
257_E289_Y1.0010.94
180_S258_M0.9980.93
104_G129_V0.9970.93
69_G73_A0.9950.93
70_V80_I0.9910.93
145_V178_I0.9810.93
354_M405_K0.9810.93
68_E71_E0.9740.93
103_L111_I0.9710.92
256_I290_C0.9690.92
341_F360_R0.9680.92
93_M121_T0.9680.92
58_A269_M0.9660.92
47_I61_F0.9650.92
142_W169_E0.9630.92
258_M263_L0.9620.92
113_V131_V0.9620.92
22_P261_D0.9570.92
100_L121_T0.9560.92
359_Q363_F0.9540.92
298_I302_W0.9520.92
64_E67_A0.9440.91
178_I260_I0.9430.91
57_N269_M0.9410.91
143_K146_Q0.9410.91
122_C126_A0.9400.91
73_A78_A0.9370.91
167_I180_S0.9300.91
196_L240_A0.9290.91
24_L287_D0.9290.91
198_N204_D0.9280.91
345_V371_F0.9260.91
217_D223_T0.9260.91
289_Y296_F0.9240.90
346_L358_Q0.9200.90
305_E308_K0.9170.90
346_L356_T0.9120.90
401_L404_V0.9110.90
257_E293_P0.9100.90
34_L61_F0.9070.90
281_V302_W0.9050.90
32_E272_I0.9040.90
186_M246_L0.9040.90
112_I157_V0.9010.89
103_L106_A0.8990.89
34_L38_V0.8980.89
250_E316_T0.8970.89
24_L278_V0.8930.89
248_L320_E0.8930.89
286_I290_C0.8920.89
57_N209_G0.8880.89
50_Q62_T0.8870.89
248_L316_T0.8870.89
40_Y279_V0.8840.88
399_H402_Q0.8820.88
386_I394_L0.8820.88
25_L44_A0.8740.88
247_K314_T0.8690.88
364_K396_A0.8680.88
23_E44_A0.8670.87
53_G86_I0.8630.87
133_L139_L0.8620.87
99_Y103_L0.8560.87
67_A105_D0.8560.87
60_N269_M0.8550.87
69_G80_I0.8530.87
63_I66_I0.8520.87
124_R150_E0.8490.86
136_Q206_N0.8490.86
123_R150_E0.8490.86
137_Q148_W0.8480.86
289_Y293_P0.8480.86
373_G376_I0.8410.86
164_A319_F0.8410.86
387_W405_K0.8390.86
280_S305_E0.8380.86
263_L290_C0.8380.86
255_M258_M0.8370.86
180_S263_L0.8360.85
70_V74_K0.8340.85
252_I256_I0.8320.85
116_P148_W0.8320.85
391_G405_K0.8270.85
303_L307_D0.8240.85
36_I40_Y0.8240.85
387_W391_G0.8230.85
97_E101_K0.8220.85
389_E402_Q0.8190.84
21_K286_I0.8180.84
28_A60_N0.8180.84
133_L148_W0.8110.84
288_A291_A0.8050.83
293_P296_F0.8040.83
112_I263_L0.8040.83
117_L127_P0.7980.83
275_V279_V0.7970.83
101_K105_D0.7970.83
365_K393_E0.7970.83
120_E150_E0.7970.83
358_Q401_L0.7950.83
57_N205_S0.7940.82
168_R254_K0.7930.82
63_I67_A0.7900.82
309_C314_T0.7890.82
22_P263_L0.7880.82
359_Q399_H0.7850.82
102_A105_D0.7830.82
234_E237_A0.7790.81
115_D185_A0.7780.81
343_G367_D0.7770.81
50_Q60_N0.7760.81
107_N129_V0.7760.81
66_I106_A0.7740.81
94_D97_E0.7720.81
84_T99_Y0.7700.80
339_Y367_D0.7700.80
342_V357_L0.7700.80
47_I73_A0.7700.80
167_I258_M0.7700.80
285_V302_W0.7680.80
112_I182_I0.7660.80
26_A275_V0.7600.80
204_D207_R0.7590.80
167_I170_M0.7570.79
154_D177_E0.7530.79
365_K386_I0.7520.79
53_G56_S0.7510.79
89_H198_N0.7490.79
296_F299_Q0.7430.78
304_E361_N0.7410.78
365_K384_E0.7370.77
371_F381_H0.7340.77
54_L86_I0.7320.77
139_L153_L0.7310.77
260_I319_F0.7300.77
365_K385_T0.7290.77
113_V118_I0.7270.77
253_P256_I0.7260.76
36_I344_L0.7210.76
97_E125_V0.7200.76
82_V106_A0.7200.76
104_G127_P0.7190.76
104_G126_A0.7180.76
253_P296_F0.7170.76
104_G125_V0.7160.75
288_A293_P0.7130.75
135_T159_A0.7130.75
53_G57_N0.7120.75
84_T118_I0.7110.75
185_A212_Q0.7090.75
358_Q403_I0.7040.74
251_S319_F0.7030.74
97_E126_A0.7030.74
198_N205_S0.7020.74
253_P292_D0.6930.73
349_D354_M0.6910.73
288_A292_D0.6910.73
123_R154_D0.6910.73
212_Q243_P0.6900.73
145_V158_L0.6890.73
397_A402_Q0.6890.73
142_W146_Q0.6850.72
163_S166_E0.6840.72
140_S159_A0.6840.72
196_L213_S0.6830.72
241_M311_N0.6770.71
111_I131_V0.6770.71
389_E392_N0.6770.71
177_E261_D0.6740.71
156_V176_I0.6730.71
221_Y225_G0.6730.71
81_Y110_G0.6730.71
310_A335_K0.6720.71
79_K154_D0.6720.71
246_L319_F0.6710.71
260_I263_L0.6700.71
159_A162_T0.6700.71
292_D296_F0.6690.70
242_S330_F0.6680.70
93_M142_W0.6680.70
162_T167_I0.6660.70
188_I329_M0.6640.70
123_R131_V0.6640.70
171_K260_I0.6630.70
36_I272_I0.6620.70
36_I39_H0.6620.70
216_W239_F0.6590.69
62_T68_E0.6580.69
349_D356_T0.6560.69
49_G66_I0.6470.68
142_W170_M0.6470.68
386_I397_A0.6470.68
148_W153_L0.6460.68
247_K250_E0.6460.68
108_V241_M0.6450.68
21_K283_R0.6410.67
45_V78_A0.6380.67
108_V129_V0.6370.67
144_A148_W0.6370.67
54_L114_A0.6360.67
285_V288_A0.6350.66
394_L404_V0.6340.66
186_M243_P0.6330.66
354_M387_W0.6330.66
392_N395_D0.6310.66
248_L318_F0.6270.65
91_E98_D0.6260.65
66_I82_V0.6250.65
38_V80_I0.6250.65
165_L254_K0.6220.65
126_A129_V0.6210.65
21_K43_D0.6210.65
49_G53_G0.6200.65
49_G69_G0.6190.64
345_V355_V0.6190.64
68_E72_F0.6170.64
364_K367_D0.6150.64
43_D78_A0.6150.64
49_G60_N0.6130.64
30_N60_N0.6130.64
310_A337_T0.6120.64
283_R286_I0.6070.63
146_Q175_D0.6070.63
145_V149_K0.6070.63
87_F205_S0.6030.62
54_L269_M0.6020.62
244_K315_A0.6010.62
244_K313_D0.5970.62
183_H282_Y0.5960.62
346_L403_I0.5960.62
182_I265_I0.5950.61
195_V198_N0.5940.61
54_L339_Y0.5940.61
200_M337_T0.5930.61
193_R200_M0.5930.61
284_K299_Q0.5920.61
39_H276_A0.5920.61
70_V102_A0.5910.61
389_E403_I0.5910.61
52_Y92_N0.5910.61
140_S193_R0.5900.61
34_L80_I0.5890.61
340_D343_G0.5880.61
93_M96_L0.5870.60
278_V282_Y0.5860.60
40_Y53_G0.5860.60
188_I243_P0.5840.60
116_P133_L0.5830.60
54_L212_Q0.5820.60
344_L358_Q0.5810.60
164_A320_E0.5800.59
335_K339_Y0.5790.59
203_R209_G0.5790.59
355_V386_I0.5780.59
81_Y114_A0.5780.59
363_F386_I0.5770.59
365_K369_V0.5770.59
33_K36_I0.5760.59
100_L125_V0.5750.59
350_E353_Q0.5740.59
199_H204_D0.5730.59
363_F383_I0.5710.58
253_P293_P0.5700.58
96_L306_L0.5700.58
281_V284_K0.5680.58
284_K288_A0.5680.58
186_M193_R0.5680.58
139_L156_V0.5680.58
263_L306_L0.5670.58
124_R146_Q0.5670.58
202_A213_S0.5660.58
240_A343_G0.5660.58
113_V117_L0.5660.58
258_M261_D0.5650.57
157_V242_S0.5630.57
31_L65_E0.5630.57
189_A213_S0.5630.57
365_K404_V0.5630.57
117_L122_C0.5610.57
49_G57_N0.5610.57
242_S332_E0.5580.57
336_K368_E0.5580.57
205_S211_C0.5580.57
51_E63_I0.5570.56
308_K340_D0.5570.56
137_Q193_R0.5560.56
341_F358_Q0.5540.56
389_E405_K0.5540.56
248_L255_M0.5540.56
140_S190_Y0.5530.56
94_D98_D0.5530.56
112_I147_F0.5530.56
58_A135_T0.5520.56
32_E278_V0.5520.56
120_E165_L0.5490.55
83_T112_I0.5490.55
182_I263_L0.5490.55
317_A320_E0.5490.55
359_Q398_R0.5480.55
390_D397_A0.5470.55
298_I301_E0.5470.55
298_I303_L0.5460.55
104_G123_R0.5460.55
390_D395_D0.5460.55
299_Q302_W0.5430.55
331_G336_K0.5420.54
237_A242_S0.5400.54
318_F330_F0.5380.54
380_T384_E0.5380.54
180_S248_L0.5370.54
123_R128_N0.5370.54
54_L216_W0.5370.54
159_A246_L0.5360.54
389_E393_E0.5360.54
171_K258_M0.5350.53
21_K291_A0.5340.53
34_L72_F0.5340.53
209_G213_S0.5330.53
70_V82_V0.5330.53
158_L261_D0.5320.53
122_C129_V0.5320.53
331_G334_A0.5320.53
354_M385_T0.5300.53
244_K330_F0.5300.53
279_V310_A0.5280.53
247_K282_Y0.5270.52
357_L397_A0.5260.52
66_I157_V0.5250.52
304_E308_K0.5240.52
389_E394_L0.5230.52
175_D178_I0.5230.52
136_Q203_R0.5220.52
21_K287_D0.5210.52
380_T383_I0.5160.51
316_T323_P0.5160.51
45_V69_G0.5150.51
372_F378_N0.5150.51
70_V78_A0.5140.51
394_L405_K0.5140.51
79_K130_E0.5140.51
60_N72_F0.5130.50
250_E300_K0.5130.50
133_L156_V0.5110.50
290_C296_F0.5110.50
382_T393_E0.5100.50
316_T322_T0.5100.50
386_I404_V0.5100.50
371_F379_F0.5090.50
63_I103_L0.5090.50
242_S339_Y0.5080.50
350_E395_D0.5070.50
101_K121_T0.5070.50
31_L47_I0.5070.50
88_A118_I0.5070.50
329_M334_A0.5070.50
345_V357_L0.5060.50
116_P151_E0.5060.50
88_A185_A0.5060.50
139_L159_A0.5050.49
394_L403_I0.5040.49
365_K383_I0.5040.49
243_P273_H0.5030.49
149_K154_D0.5030.49
155_R262_S0.5030.49
311_N337_T0.5030.49
138_S190_Y0.5020.49
384_E387_W0.5020.49
54_L92_N0.5010.49
57_N213_S0.5000.49
189_A243_P0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4he6A 1 0.2109 99.5 0.899 Contact Map
2bdqA 2 0.436 98.6 0.933 Contact Map
3f4wA 2 0.3768 97.5 0.949 Contact Map
1xi3A 2 0.4502 97.4 0.95 Contact Map
3vndA 3 0.5379 97.3 0.951 Contact Map
3iixA 1 0.4265 97.2 0.952 Contact Map
4a29A 1 0.3578 97 0.953 Contact Map
3qjaA 1 0.3886 97 0.953 Contact Map
3q58A 2 0.3436 97 0.953 Contact Map
3o63A 2 0.4502 96.9 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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