GREMLIN Database
URK - Uridine kinase
UniProt: O32033 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 211 (184)
Sequences: 4771 (2853)
Seq/√Len: 210.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_D81_R4.9531.00
89_D96_S4.8931.00
42_Y73_H4.3231.00
72_E76_D3.0721.00
69_Y73_H3.0101.00
70_L110_L2.8971.00
9_G125_M2.8851.00
82_P101_H2.8491.00
139_I162_V2.7911.00
122_R179_Y2.3901.00
78_L126_D2.2461.00
50_P56_N2.1901.00
82_P103_E2.1191.00
84_E101_H2.1181.00
48_H52_E2.1061.00
166_R170_N2.0861.00
153_S156_S2.0481.00
137_L140_I2.0031.00
84_E99_T1.9981.00
33_S106_D1.9831.00
121_L125_M1.9101.00
165_V168_M1.8771.00
110_L125_M1.8161.00
39_Q115_V1.8081.00
26_Y109_I1.7971.00
85_K100_V1.7841.00
75_Q124_L1.7391.00
75_Q120_R1.6851.00
73_H76_D1.6791.00
75_Q79_N1.6621.00
66_D95_R1.6601.00
46_Q59_Y1.6571.00
88_Y93_H1.6561.00
47_S94_T1.6471.00
45_D48_H1.6331.00
55_L63_L1.6161.00
132_D177_K1.6061.00
26_Y36_M1.5841.00
139_I143_I1.5671.00
11_A116_L1.5651.00
45_D94_T1.5371.00
89_D92_L1.5321.00
8_I107_V1.5031.00
24_S27_E1.4831.00
46_Q57_T1.4361.00
134_D137_L1.4301.00
144_M148_N1.4161.00
116_L128_K1.4101.00
41_L85_K1.3841.00
166_R169_H1.3831.00
135_A170_N1.3711.00
167_P171_Q1.3641.00
127_I182_I1.3591.00
22_T36_M1.3531.00
13_G138_R1.3121.00
154_I158_I1.3101.00
140_I144_M1.2961.00
71_I75_Q1.2861.00
21_V131_V1.2671.00
71_I120_R1.2661.00
128_K181_D1.2501.00
66_D69_Y1.2381.00
174_E177_K1.2291.00
22_T109_I1.2211.00
61_H172_F1.2051.00
6_V127_I1.2011.00
44_K48_H1.1851.00
68_D120_R1.1771.00
156_S159_E1.1721.00
7_V78_L1.1651.00
6_V107_V1.1591.00
35_L105_K1.1441.00
38_Q41_L1.1341.00
170_N174_E1.1081.00
7_V125_M1.0951.00
52_E56_N1.0841.00
152_R160_Q1.0751.00
165_V169_H1.0701.00
77_L108_I1.0661.00
87_I98_E1.0651.00
21_V25_I1.0521.00
152_R156_S1.0491.00
52_E55_L1.0371.00
157_V160_Q1.0331.00
48_H53_E1.0291.00
139_I158_I1.0241.00
62_P117_E1.0011.00
39_Q67_N1.0001.00
92_L96_S0.9971.00
71_I121_L0.9961.00
26_Y34_I0.9961.00
90_Y93_H0.9701.00
147_I157_V0.9611.00
46_Q93_H0.9521.00
10_I22_T0.9430.99
39_Q65_F0.9420.99
46_Q55_L0.9260.99
158_I162_V0.9250.99
4_N78_L0.9240.99
46_Q94_T0.9160.99
164_V168_M0.9120.99
30_K33_S0.9120.99
43_Y65_F0.9100.99
68_D72_E0.8820.99
43_Y60_D0.8760.99
22_T26_Y0.8730.99
87_I95_R0.8710.99
63_L119_K0.8610.99
10_I21_V0.8600.99
74_I125_M0.8550.99
156_S160_Q0.8550.99
8_I109_I0.8480.99
87_I96_S0.8480.99
146_D150_R0.8450.99
76_D79_N0.8430.99
33_S105_K0.8410.99
23_R26_Y0.8340.99
21_V184_I0.8260.99
161_Y164_V0.8250.99
116_L180_A0.8140.98
159_E164_V0.8110.98
38_Q100_V0.8060.98
147_I154_I0.8050.98
23_R27_E0.8030.98
14_S165_V0.8020.98
41_L87_I0.8010.98
142_R165_V0.8000.98
90_Y96_S0.8000.98
69_Y86_P0.7990.98
49_L64_A0.7970.98
44_K66_D0.7960.98
114_L117_E0.7900.98
162_V167_P0.7860.98
73_H85_K0.7850.98
164_V167_P0.7840.98
69_Y97_E0.7800.98
87_I100_V0.7770.98
138_R169_H0.7740.98
177_K183_I0.7710.98
73_H83_I0.7710.98
46_Q56_N0.7700.98
118_D123_D0.7680.98
119_K123_D0.7680.98
86_P95_R0.7630.98
143_I158_I0.7590.98
58_N168_M0.7580.98
14_S169_H0.7570.98
24_S28_Q0.7530.97
135_A138_R0.7530.97
155_D158_I0.7490.97
37_I102_V0.7480.97
49_L57_T0.7460.97
9_G116_L0.7350.97
74_I121_L0.7330.97
155_D159_E0.7310.97
29_F107_V0.7290.97
117_E176_T0.7280.97
22_T38_Q0.7250.97
84_E96_S0.7240.97
26_Y30_K0.7230.97
35_L108_I0.7210.97
135_A174_E0.7140.96
59_Y88_Y0.7110.96
9_G121_L0.7100.96
132_D185_P0.7060.96
102_V108_I0.7060.96
103_E106_D0.7040.96
140_I158_I0.7020.96
39_Q70_L0.7000.96
11_A128_K0.6970.96
16_S138_R0.6930.96
90_Y95_R0.6880.96
58_N61_H0.6790.95
33_S103_E0.6780.95
120_R123_D0.6670.95
41_L100_V0.6640.95
50_P53_E0.6600.95
13_G130_Y0.6590.95
69_Y95_R0.6560.94
45_D95_R0.6540.94
170_N178_R0.6530.94
136_D140_I0.6500.94
60_D168_M0.6500.94
67_N71_I0.6480.94
13_G169_H0.6430.94
30_K34_I0.6420.94
82_P104_P0.6400.94
37_I85_K0.6360.93
30_K106_D0.6300.93
74_I110_L0.6290.93
44_K49_L0.6280.93
35_L100_V0.6270.93
26_Y35_L0.6270.93
40_D145_R0.6250.93
70_L74_I0.6210.93
134_D185_P0.6210.93
78_L124_L0.6200.93
25_I109_I0.6190.92
135_A162_V0.6170.92
135_A166_R0.6160.92
59_Y90_Y0.6150.92
77_L83_I0.6150.92
7_V124_L0.6120.92
160_Q164_V0.6120.92
87_I99_T0.6100.92
28_Q31_G0.6090.92
88_Y94_T0.6080.92
139_I166_R0.6080.92
143_I154_I0.6070.92
12_G17_G0.6040.92
58_N165_V0.6040.92
55_L93_H0.6000.91
72_E75_Q0.6000.91
7_V74_I0.5990.91
43_Y142_R0.5990.91
47_S50_P0.5960.91
29_F34_I0.5900.91
162_V166_R0.5900.91
89_D94_T0.5900.91
67_N115_V0.5870.90
46_Q49_L0.5840.90
88_Y91_K0.5840.90
8_I129_L0.5810.90
147_I153_S0.5810.90
98_E101_H0.5780.90
42_Y83_I0.5770.90
45_D97_E0.5760.90
67_N118_D0.5760.90
46_Q50_P0.5750.89
82_P99_T0.5730.89
115_V125_M0.5720.89
60_D142_R0.5680.89
44_K84_E0.5660.89
23_R123_D0.5660.89
7_V108_I0.5630.88
59_Y165_V0.5620.88
69_Y72_E0.5620.88
14_S43_Y0.5620.88
152_R157_V0.5600.88
137_L141_R0.5540.88
149_E152_R0.5540.88
71_I124_L0.5540.88
58_N63_L0.5530.88
82_P85_K0.5510.87
8_I106_D0.5500.87
148_N155_D0.5430.87
168_M171_Q0.5400.86
60_D64_A0.5390.86
61_H64_A0.5390.86
23_R36_M0.5360.86
35_L102_V0.5340.86
43_Y49_L0.5330.86
62_P119_K0.5330.86
157_V161_Y0.5310.85
159_E162_V0.5280.85
58_N171_Q0.5280.85
154_I159_E0.5260.85
12_G18_K0.5210.84
36_M109_I0.5200.84
14_S90_Y0.5180.84
41_L98_E0.5160.84
14_S142_R0.5150.84
9_G12_G0.5140.84
102_V105_K0.5130.83
123_D179_Y0.5100.83
105_K108_I0.5090.83
14_S40_D0.5080.83
168_M172_F0.5060.83
41_L113_I0.5060.83
122_R125_M0.5050.83
5_P106_D0.5050.83
55_L59_Y0.5040.82
9_G115_V0.5040.82
88_Y92_L0.5020.82
12_G16_S0.5000.82
11_A125_M0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jeoA 3 0.9573 100 0.439 Contact Map
3tqcA 2 0.9431 100 0.444 Contact Map
2ga8A 1 0.891 100 0.449 Contact Map
1a7jA 5 0.9621 100 0.465 Contact Map
1uj2A 3 0.9668 100 0.516 Contact Map
3w34A 2 0.9858 100 0.516 Contact Map
1rz3A 1 0.7583 100 0.517 Contact Map
2qt1A 1 0.872 99.9 0.549 Contact Map
4bfzA 2 0.9431 99.9 0.551 Contact Map
4ne2A 2 0.9384 99.9 0.554 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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