PBPI - BACSU - GREMLIN Contacts

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PBPI - Penicillin-binding protein 4B

UniProt:	O32032	Sequences: MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLIQESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGMSEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASHTIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGNPLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVLGIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYGEPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLYHETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGEKRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQDLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTNSVFYDIVKKVHEIEINQK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	584 (495)
Sequences:	15502 (11276)
Seq/√Len:	506.8

ECOLI - PBP2 FTSI PBPC PBPB PBPA
BACSU - PBPI PBPH SP5D PBPB YQGF PBPC PBPA PBPG PBPF PBPD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
267_L	551_L	3.301	1.00
539_A	552_V	3.283	1.00
154_K	157_L	3.180	1.00
490_Q	541_Y	3.128	1.00
439_A	552_V	3.048	1.00
265_A	572_I	3.000	1.00
274_S	455_K	2.959	1.00
462_Y	466_T	2.920	1.00
274_S	458_E	2.895	1.00
346_D	495_R	2.843	1.00
129_S	132_S	2.784	1.00
190_T	194_E	2.773	1.00
317_N	371_V	2.723	1.00
189_G	192_G	2.709	1.00
251_M	265_A	2.709	1.00
145_Y	155_P	2.697	1.00
325_T	342_T	2.665	1.00
270_I	550_A	2.651	1.00
255_L	263_G	2.628	1.00
183_P	193_L	2.561	1.00
450_E	479_E	2.514	1.00
65_L	238_Q	2.493	1.00
343_L	353_C	2.486	1.00
269_D	272_N	2.456	1.00
494_R	513_T	2.442	1.00
316_E	485_T	2.406	1.00
516_G	538_F	2.402	1.00
346_D	491_K	2.394	1.00
240_K	459_Q	2.332	1.00
269_D	274_S	2.288	1.00
347_E	351_Q	2.268	1.00
267_L	572_I	2.264	1.00
374_D	378_K	2.247	1.00
570_Y	574_K	2.208	1.00
67_R	244_D	2.198	1.00
63_S	71_A	2.151	1.00
348_S	356_T	2.134	1.00
440_N	451_K	2.129	1.00
309_V	441_M	2.117	1.00
250_A	575_K	2.104	1.00
350_A	501_S	2.076	1.00
254_V	571_D	2.073	1.00
350_A	495_R	2.056	1.00
66_D	70_R	2.029	1.00
321_K	324_Q	2.028	1.00
268_L	439_A	2.014	1.00
324_Q	363_Q	2.008	1.00
65_L	240_K	2.006	1.00
257_E	571_D	1.991	1.00
347_E	350_A	1.983	1.00
306_F	376_S	1.979	1.00
327_N	342_T	1.952	1.00
276_L	549_Y	1.933	1.00
183_P	190_T	1.912	1.00
340_K	353_C	1.910	1.00
313_A	375_M	1.872	1.00
344_S	347_E	1.870	1.00
312_A	485_T	1.853	1.00
63_S	238_Q	1.844	1.00
67_R	276_L	1.835	1.00
371_V	374_D	1.835	1.00
269_D	548_K	1.826	1.00
249_K	253_E	1.822	1.00
24_R	27_E	1.807	1.00
549_Y	576_V	1.797	1.00
271_E	548_K	1.797	1.00
67_R	274_S	1.790	1.00
247_I	576_V	1.778	1.00
448_G	487_Q	1.777	1.00
316_E	482_D	1.776	1.00
240_K	458_E	1.772	1.00
250_A	254_V	1.769	1.00
247_I	276_L	1.762	1.00
251_M	572_I	1.759	1.00
482_D	485_T	1.758	1.00
483_K	487_Q	1.747	1.00
252_E	279_V	1.747	1.00
251_M	277_G	1.747	1.00
193_L	197_F	1.741	1.00
261_K	557_D	1.735	1.00
515_A	541_Y	1.733	1.00
494_R	498_E	1.733	1.00
440_N	454_V	1.728	1.00
269_D	276_L	1.716	1.00
569_F	573_V	1.700	1.00
268_L	454_V	1.698	1.00
71_A	74_G	1.698	1.00
481_I	486_S	1.693	1.00
453_Q	474_Q	1.692	1.00
435_P	552_V	1.682	1.00
361_A	425_A	1.681	1.00
267_L	549_Y	1.674	1.00
265_A	553_V	1.669	1.00
448_G	483_K	1.669	1.00
443_A	550_A	1.661	1.00
238_Q	461_E	1.637	1.00
495_R	501_S	1.637	1.00
540_G	569_F	1.637	1.00
308_T	445_I	1.613	1.00
343_L	347_E	1.606	1.00
83_F	86_L	1.591	1.00
442_M	493_L	1.586	1.00
302_P	433_V	1.559	1.00
89_Q	92_P	1.558	1.00
553_V	569_F	1.557	1.00
491_K	494_R	1.533	1.00
359_S	363_Q	1.529	1.00
180_E	197_F	1.528	1.00
266_V	436_L	1.500	1.00
442_M	539_A	1.478	1.00
381_L	433_V	1.474	1.00
373_E	377_E	1.469	1.00
84_P	92_P	1.464	1.00
361_A	372_I	1.455	1.00
448_G	490_Q	1.454	1.00
316_E	378_K	1.442	1.00
255_L	279_V	1.441	1.00
70_R	245_Q	1.440	1.00
275_V	456_I	1.438	1.00
312_A	481_I	1.436	1.00
335_E	560_G	1.430	1.00
555_H	568_V	1.430	1.00
444_T	451_K	1.426	1.00
479_E	483_K	1.420	1.00
349_F	492_I	1.417	1.00
540_G	573_V	1.414	1.00
497_V	516_G	1.411	1.00
459_Q	470_T	1.410	1.00
256_D	281_K	1.409	1.00
497_V	514_V	1.405	1.00
348_S	357_F	1.401	1.00
242_T	274_S	1.401	1.00
312_A	379_L	1.393	1.00
214_D	218_N	1.393	1.00
180_E	193_L	1.379	1.00
326_F	363_Q	1.375	1.00
445_I	489_L	1.367	1.00
320_V	345_F	1.361	1.00
240_K	461_E	1.357	1.00
247_I	277_G	1.356	1.00
328_C	353_C	1.354	1.00
70_R	246_S	1.347	1.00
181_S	184_I	1.343	1.00
212_H	242_T	1.341	1.00
293_Q	299_P	1.340	1.00
91_W	144_I	1.333	1.00
467_T	470_T	1.332	1.00
447_R	452_R	1.331	1.00
438_V	539_A	1.327	1.00
314_A	360_L	1.325	1.00
166_N	190_T	1.321	1.00
181_S	185_T	1.311	1.00
253_E	575_K	1.307	1.00
266_V	435_P	1.306	1.00
94_K	104_E	1.306	1.00
132_S	135_K	1.304	1.00
322_P	492_I	1.304	1.00
63_S	74_G	1.303	1.00
446_A	515_A	1.298	1.00
446_A	541_Y	1.292	1.00
322_P	488_Q	1.280	1.00
315_I	492_I	1.274	1.00
265_A	551_L	1.273	1.00
575_K	578_E	1.272	1.00
268_L	550_A	1.264	1.00
509_D	570_Y	1.262	1.00
523_T	556_M	1.262	1.00
251_M	279_V	1.261	1.00
320_V	324_Q	1.249	1.00
498_E	508_Q	1.243	1.00
32_F	35_S	1.240	1.00
84_P	131_Q	1.237	1.00
329_N	359_S	1.236	1.00
317_N	375_M	1.236	1.00
268_L	443_A	1.235	1.00
461_E	467_T	1.233	1.00
305_V	438_V	1.232	1.00
542_F	577_H	1.229	1.00
551_L	573_V	1.225	1.00
551_L	572_I	1.221	1.00
311_A	357_F	1.221	1.00
295_Y	558_T	1.220	1.00
379_L	481_I	1.216	1.00
197_F	239_I	1.216	1.00
242_T	455_K	1.210	1.00
451_K	478_G	1.197	1.00
345_F	356_T	1.190	1.00
23_L	27_E	1.189	1.00
84_P	135_K	1.188	1.00
320_V	363_Q	1.185	1.00
455_K	471_F	1.181	1.00
334_G	353_C	1.180	1.00
375_M	378_K	1.180	1.00
487_Q	490_Q	1.180	1.00
438_V	537_W	1.180	1.00
278_I	296_M	1.175	1.00
167_Q	170_A	1.170	1.00
266_V	439_A	1.166	1.00
459_Q	467_T	1.165	1.00
370_S	374_D	1.151	1.00
340_K	351_Q	1.149	1.00
90_D	158_A	1.147	1.00
362_E	422_A	1.146	1.00
312_A	489_L	1.133	1.00
490_Q	515_A	1.122	1.00
498_E	501_S	1.122	1.00
495_R	498_E	1.115	1.00
26_A	30_L	1.110	1.00
128_L	136_I	1.107	1.00
439_A	550_A	1.106	1.00
258_Q	568_V	1.103	1.00
91_W	158_A	1.097	1.00
560_G	563_A	1.092	1.00
378_K	478_G	1.089	1.00
497_V	538_F	1.088	1.00
214_D	217_G	1.088	1.00
553_V	568_V	1.085	1.00
253_E	257_E	1.081	1.00
336_P	339_D	1.079	1.00
377_E	383_D	1.078	1.00
355_Y	359_S	1.078	1.00
198_D	202_L	1.077	1.00
255_L	265_A	1.077	1.00
128_L	132_S	1.076	1.00
316_E	375_M	1.074	1.00
180_E	184_I	1.073	1.00
19_F	23_L	1.072	1.00
484_Y	488_Q	1.066	1.00
156_S	199_E	1.066	1.00
270_I	549_Y	1.063	1.00
333_Y	337_G	1.057	1.00
365_M	371_V	1.057	1.00
514_V	542_F	1.057	1.00
343_L	356_T	1.055	1.00
267_L	576_V	1.054	1.00
536_K	561_D	1.054	1.00
35_S	39_K	1.053	1.00
123_K	126_K	1.050	1.00
317_N	364_L	1.040	1.00
24_R	28_I	1.040	1.00
452_R	477_K	1.037	1.00
92_P	131_Q	1.036	1.00
308_T	442_M	1.032	1.00
312_A	375_M	1.031	1.00
496_V	504_G	1.031	1.00
486_S	490_Q	1.030	1.00
312_A	486_S	1.026	1.00
254_V	568_V	1.025	1.00
523_T	557_D	1.024	1.00
308_T	493_L	1.021	1.00
320_V	360_L	1.019	1.00
246_S	249_K	1.017	1.00
254_V	257_E	1.017	1.00
309_V	376_S	1.015	1.00
27_E	32_F	1.011	1.00
450_E	477_K	1.010	1.00
250_A	253_E	1.007	1.00
278_I	294_N	1.006	1.00
65_L	71_A	1.006	1.00
237_L	468_L	1.006	1.00
194_E	197_F	1.003	1.00
375_M	379_L	1.002	1.00
311_A	345_F	1.002	1.00
130_K	134_T	1.001	1.00
300_I	432_K	1.000	1.00
543_P	548_K	0.999	1.00
315_I	488_Q	0.998	1.00
154_K	245_Q	0.997	1.00
501_S	505_R	0.995	1.00
343_L	351_Q	0.995	1.00
445_I	490_Q	0.989	1.00
346_D	492_I	0.985	1.00
219_P	222_G	0.983	1.00
353_C	356_T	0.981	1.00
266_V	278_I	0.981	1.00
95_K	98_D	0.980	1.00
371_V	375_M	0.979	1.00
452_R	473_D	0.978	1.00
245_Q	249_K	0.975	1.00
270_I	443_A	0.975	1.00
134_T	138_S	0.974	1.00
440_N	453_Q	0.974	1.00
326_F	356_T	0.974	1.00
161_T	243_I	0.971	1.00
268_L	440_N	0.969	1.00
309_V	379_L	0.966	1.00
374_D	377_E	0.965	1.00
571_D	574_K	0.962	1.00
194_E	198_D	0.960	1.00
490_Q	493_L	0.959	1.00
433_V	438_V	0.954	1.00
446_A	550_A	0.950	1.00
537_W	554_L	0.948	1.00
314_A	320_V	0.944	1.00
159_S	283_D	0.942	1.00
123_K	127_T	0.940	1.00
193_L	241_T	0.939	1.00
263_G	555_H	0.937	1.00
382_T	437_E	0.933	1.00
310_I	372_I	0.932	1.00
308_T	349_F	0.931	1.00
310_I	425_A	0.927	1.00
312_A	445_I	0.926	1.00
325_T	344_S	0.924	1.00
84_P	87_L	0.922	1.00
254_V	575_K	0.921	1.00
561_D	566_N	0.921	1.00
247_I	267_L	0.920	1.00
251_M	267_L	0.919	1.00
345_F	360_L	0.917	1.00
191_T	195_R	0.914	1.00
66_D	245_Q	0.910	1.00
428_Q	522_Q	0.908	1.00
88_T	91_W	0.905	1.00
219_P	223_M	0.904	1.00
264_G	296_M	0.903	1.00
328_C	340_K	0.903	1.00
264_G	435_P	0.903	1.00
328_C	334_G	0.897	1.00
326_F	359_S	0.896	1.00
258_Q	571_D	0.895	1.00
190_T	193_L	0.889	1.00
133_I	137_N	0.888	1.00
381_L	441_M	0.886	1.00
457_A	460_I	0.886	1.00
340_K	343_L	0.886	1.00
512_Y	548_K	0.886	1.00
149_M	153_D	0.886	1.00
36_F	39_K	0.881	1.00
212_H	216_K	0.881	1.00
542_F	573_V	0.878	1.00
188_I	193_L	0.878	1.00
262_K	295_Y	0.877	1.00
375_M	481_I	0.875	1.00
26_A	31_F	0.874	1.00
155_P	285_D	0.874	1.00
278_I	297_L	0.873	1.00
270_I	446_A	0.873	1.00
252_E	256_D	0.871	1.00
435_P	439_A	0.870	1.00
349_F	493_L	0.868	1.00
69_G	240_K	0.865	1.00
485_T	488_Q	0.862	1.00
491_K	495_R	0.861	1.00
551_L	569_F	0.861	1.00
383_D	437_E	0.860	1.00
536_K	565_T	0.857	1.00
535_E	554_L	0.855	1.00
265_A	568_V	0.851	1.00
315_I	485_T	0.850	1.00
172_L	190_T	0.850	1.00
336_P	340_K	0.849	1.00
115_K	119_I	0.848	1.00
504_G	518_S	0.847	1.00
125_I	132_S	0.845	1.00
497_V	504_G	0.845	1.00
200_F	237_L	0.845	1.00
423_Q	428_Q	0.842	1.00
485_T	489_L	0.841	1.00
294_N	297_L	0.841	1.00
330_L	334_G	0.840	1.00
264_G	554_L	0.834	1.00
359_S	362_E	0.832	1.00
420_A	423_Q	0.830	1.00
381_L	438_V	0.830	1.00
118_V	121_Q	0.827	1.00
488_Q	491_K	0.827	1.00
366_K	370_S	0.824	1.00
80_V	128_L	0.823	1.00
59_D	206_D	0.822	1.00
309_V	438_V	0.819	1.00
251_M	254_V	0.819	1.00
372_I	376_S	0.811	1.00
33_T	37_S	0.810	1.00
555_H	565_T	0.809	1.00
111_L	115_K	0.805	1.00
358_T	426_I	0.804	1.00
94_K	98_D	0.803	1.00
180_E	183_P	0.803	1.00
112_G	116_K	0.801	1.00
319_M	363_Q	0.801	1.00
487_Q	491_K	0.801	1.00
87_L	92_P	0.800	1.00
183_P	188_I	0.797	1.00
345_F	492_I	0.796	1.00
434_T	437_E	0.796	1.00
562_K	566_N	0.795	1.00
336_P	353_C	0.794	1.00
158_A	243_I	0.793	1.00
343_L	348_S	0.791	1.00
193_L	239_I	0.785	1.00
305_V	539_A	0.784	1.00
278_I	456_I	0.783	1.00
275_V	436_L	0.783	1.00
484_Y	487_Q	0.780	1.00
266_V	552_V	0.779	1.00
183_P	197_F	0.778	1.00
244_D	247_I	0.778	1.00
242_T	458_E	0.776	1.00
486_S	489_L	0.776	1.00
82_L	87_L	0.775	1.00
192_G	195_R	0.775	1.00
64_F	72_L	0.775	1.00
319_M	364_L	0.773	1.00
436_L	454_V	0.773	1.00
64_F	75_Q	0.773	1.00
247_I	572_I	0.772	1.00
26_A	29_Q	0.772	1.00
315_I	489_L	0.769	1.00
509_D	574_K	0.768	1.00
488_Q	492_I	0.767	1.00
364_L	371_V	0.765	1.00
504_G	538_F	0.763	1.00
361_A	366_K	0.761	1.00
516_G	566_N	0.759	1.00
334_G	339_D	0.755	1.00
16_I	20_L	0.753	1.00
438_V	552_V	0.749	1.00
96_V	136_I	0.748	1.00
319_M	371_V	0.747	1.00
220_L	224_D	0.744	1.00
15_L	19_F	0.741	1.00
505_R	508_Q	0.741	1.00
110_T	114_A	0.738	1.00
118_V	122_Q	0.738	1.00
246_S	250_A	0.737	1.00
447_R	450_E	0.736	1.00
68_N	244_D	0.735	1.00
272_N	455_K	0.734	1.00
435_P	537_W	0.732	1.00
293_Q	298_T	0.728	1.00
536_K	564_L	0.726	1.00
514_V	569_F	0.724	1.00
313_A	317_N	0.724	1.00
218_N	221_F	0.722	1.00
117_P	121_Q	0.722	1.00
119_I	122_Q	0.721	1.00
220_L	223_M	0.720	1.00
309_V	381_L	0.719	1.00
340_K	347_E	0.716	1.00
573_V	577_H	0.715	1.00
117_P	120_L	0.714	1.00
215_G	456_I	0.714	1.00
328_C	341_G	0.711	1.00
27_E	31_F	0.711	1.00
439_A	539_A	0.709	1.00
365_M	370_S	0.709	1.00
442_M	550_A	0.707	1.00
507_F	566_N	0.706	1.00
303_G	521_A	0.704	1.00
448_G	486_S	0.702	1.00
494_R	497_V	0.702	1.00
12_I	16_I	0.700	1.00
331_N	334_G	0.698	1.00
266_V	296_M	0.696	1.00
298_T	301_Y	0.695	1.00
97_A	124_K	0.694	1.00
272_N	452_R	0.694	1.00
440_N	443_A	0.694	1.00
346_D	350_A	0.691	1.00
32_F	36_F	0.691	1.00
432_K	435_P	0.689	1.00
428_Q	432_K	0.689	1.00
365_M	421_I	0.689	1.00
489_L	492_I	0.689	1.00
30_L	33_T	0.689	1.00
86_L	145_Y	0.689	1.00
222_G	226_K	0.688	1.00
158_A	161_T	0.688	1.00
310_I	361_A	0.687	1.00
440_N	444_T	0.687	1.00
347_E	501_S	0.686	1.00
249_K	252_E	0.685	1.00
301_Y	535_E	0.685	1.00
444_T	480_T	0.683	1.00
251_M	263_G	0.682	1.00
355_Y	358_T	0.682	1.00
138_S	144_I	0.681	1.00
182_L	198_D	0.678	1.00
334_G	340_K	0.678	1.00
327_N	359_S	0.676	1.00
443_A	452_R	0.674	1.00
254_V	572_I	0.673	1.00
514_V	538_F	0.670	1.00
379_L	444_T	0.668	1.00
95_K	139_L	0.668	1.00
535_E	556_M	0.667	1.00
504_G	507_F	0.666	1.00
62_G	239_I	0.665	1.00
188_I	198_D	0.664	1.00
349_F	357_F	0.664	1.00
490_Q	494_R	0.663	1.00
350_A	496_V	0.663	1.00
80_V	146_G	0.662	1.00
125_I	133_I	0.662	1.00
209_L	212_H	0.660	1.00
357_F	360_L	0.658	1.00
542_F	549_Y	0.658	1.00
135_K	139_L	0.657	1.00
538_F	569_F	0.656	1.00
424_T	431_V	0.653	1.00
328_C	339_D	0.653	1.00
268_L	275_V	0.652	1.00
90_D	192_G	0.651	1.00
512_Y	577_H	0.650	1.00
450_E	478_G	0.650	1.00
197_F	457_A	0.650	1.00
302_P	306_F	0.649	1.00
116_K	119_I	0.648	1.00
311_A	349_F	0.648	1.00
160_H	163_G	0.645	1.00
306_F	310_I	0.645	1.00
182_L	187_E	0.642	1.00
246_S	575_K	0.642	1.00
115_K	118_V	0.641	1.00
223_M	226_K	0.641	1.00
320_V	326_F	0.641	1.00
387_W	456_I	0.640	1.00
329_N	355_Y	0.640	1.00
237_L	460_I	0.638	1.00
506_R	563_A	0.638	1.00
440_N	452_R	0.637	1.00
549_Y	573_V	0.635	1.00
114_A	117_P	0.635	1.00
113_Q	117_P	0.634	1.00
364_L	372_I	0.634	1.00
159_S	284_A	0.634	1.00
306_F	309_V	0.633	1.00
328_C	343_L	0.632	1.00
304_S	307_K	0.631	1.00
93_I	125_I	0.630	1.00
195_R	199_E	0.630	1.00
564_L	567_S	0.630	1.00
11_V	15_L	0.629	1.00
306_F	431_V	0.629	1.00
29_Q	33_T	0.629	1.00
322_P	346_D	0.627	1.00
379_L	441_M	0.626	1.00
339_D	355_Y	0.626	1.00
87_L	91_W	0.626	1.00
110_T	113_Q	0.625	1.00
572_I	576_V	0.625	1.00
197_F	200_F	0.625	1.00
571_D	575_K	0.621	1.00
81_V	145_Y	0.621	1.00
29_Q	32_F	0.621	1.00
93_I	97_A	0.620	1.00
172_L	175_K	0.619	1.00
493_L	541_Y	0.619	1.00
351_Q	501_S	0.618	1.00
271_E	448_G	0.618	1.00
553_V	565_T	0.618	1.00
481_I	485_T	0.618	1.00
166_N	171_L	0.617	1.00
377_E	382_T	0.616	1.00
573_V	576_V	0.616	1.00
67_R	458_E	0.615	1.00
13_A	17_V	0.614	1.00
268_L	552_V	0.614	1.00
275_V	278_I	0.613	1.00
131_Q	135_K	0.613	1.00
217_G	220_L	0.612	1.00
167_Q	185_T	0.612	1.00
302_P	438_V	0.611	1.00
313_A	364_L	0.610	1.00
536_K	562_K	0.609	1.00
315_I	345_F	0.608	1.00
18_F	22_L	0.608	1.00
156_S	283_D	0.605	0.99
541_Y	550_A	0.605	0.99
262_K	556_M	0.604	0.99
458_E	470_T	0.603	0.99
51_R	212_H	0.603	0.99
496_V	503_T	0.602	0.99
47_S	50_Q	0.602	0.99
326_F	360_L	0.601	0.99
373_E	424_T	0.601	0.99
436_L	440_N	0.599	0.99
69_G	458_E	0.599	0.99
332_L	423_Q	0.598	0.99
48_V	51_R	0.596	0.99
169_P	172_L	0.594	0.99
97_A	103_S	0.594	0.99
156_S	196_T	0.594	0.99
358_T	362_E	0.594	0.99
317_N	320_V	0.593	0.99
311_A	492_I	0.593	0.99
183_P	194_E	0.593	0.99
357_F	425_A	0.592	0.99
361_A	422_A	0.592	0.99
60_G	81_V	0.591	0.99
311_A	360_L	0.591	0.99
301_Y	556_M	0.590	0.99
536_K	560_G	0.589	0.99
542_F	548_K	0.588	0.99
305_V	537_W	0.588	0.99
225_V	228_T	0.588	0.99
308_T	489_L	0.588	0.99
109_Q	113_Q	0.588	0.99
328_C	355_Y	0.588	0.99
335_E	339_D	0.588	0.99
482_D	486_S	0.587	0.99
510_L	570_Y	0.586	0.99
350_A	492_I	0.581	0.99
297_L	436_L	0.581	0.99
302_P	428_Q	0.580	0.99
366_K	421_I	0.578	0.99
182_L	186_T	0.578	0.99
227_Y	230_E	0.578	0.99
105_D	110_T	0.578	0.99
462_Y	468_L	0.576	0.99
455_K	458_E	0.575	0.99
555_H	564_L	0.574	0.99
361_A	424_T	0.574	0.99
291_T	295_Y	0.573	0.99
446_A	490_Q	0.573	0.99
63_S	75_Q	0.573	0.99
68_N	246_S	0.571	0.99
97_A	100_L	0.570	0.99
68_N	245_Q	0.570	0.99
243_I	456_I	0.569	0.99
23_L	26_A	0.568	0.99
224_D	227_Y	0.568	0.99
239_I	460_I	0.568	0.99
426_I	522_Q	0.566	0.99
496_V	502_G	0.566	0.99
334_G	355_Y	0.566	0.99
244_D	276_L	0.566	0.99
170_A	174_K	0.565	0.99
247_I	250_A	0.563	0.99
439_A	443_A	0.562	0.99
330_L	358_T	0.561	0.99
22_L	29_Q	0.560	0.99
101_G	104_E	0.560	0.99
264_G	280_S	0.559	0.99
33_T	38_K	0.558	0.99
323_S	346_D	0.557	0.99
258_Q	567_S	0.557	0.99
326_F	348_S	0.556	0.99
333_Y	339_D	0.556	0.99
451_K	480_T	0.556	0.99
33_T	36_F	0.555	0.99
14_F	18_F	0.555	0.99
95_K	99_I	0.554	0.99
88_T	92_P	0.553	0.99
271_E	447_R	0.552	0.99
213_V	217_G	0.552	0.99
462_Y	465_G	0.552	0.99
311_A	489_L	0.552	0.99
97_A	104_E	0.551	0.99
428_Q	521_A	0.550	0.99
506_R	566_N	0.550	0.99
507_F	570_Y	0.550	0.99
136_I	141_Y	0.550	0.99
116_K	120_L	0.549	0.99
307_K	354_N	0.549	0.99
182_L	188_I	0.549	0.99
120_L	124_K	0.548	0.99
141_Y	165_T	0.548	0.99
330_L	333_Y	0.548	0.99
433_V	437_E	0.545	0.99
80_V	144_I	0.544	0.99
536_K	555_H	0.543	0.99
120_L	123_K	0.543	0.99
366_K	424_T	0.542	0.99
324_Q	356_T	0.542	0.99
183_P	186_T	0.542	0.99
133_I	146_G	0.542	0.99
268_L	436_L	0.540	0.99
480_T	486_S	0.539	0.99
196_T	200_F	0.539	0.99
280_S	296_M	0.538	0.99
215_G	218_N	0.537	0.99
174_K	177_P	0.537	0.99
210_L	224_D	0.536	0.99
11_V	14_F	0.535	0.99
268_L	452_R	0.534	0.99
315_I	322_P	0.534	0.99
261_K	559_P	0.533	0.99
97_A	102_M	0.533	0.99
438_V	442_M	0.533	0.99
496_V	516_G	0.532	0.99
188_I	192_G	0.532	0.99
114_A	119_I	0.531	0.99
79_A	147_V	0.531	0.99
128_L	133_I	0.531	0.99
344_S	356_T	0.530	0.99
55_V	209_L	0.530	0.99
122_Q	126_K	0.529	0.99
189_G	193_L	0.529	0.99
207_T	236_P	0.529	0.99
72_L	245_Q	0.527	0.99
25_L	29_Q	0.527	0.99
273_S	452_R	0.526	0.99
248_Q	252_E	0.526	0.99
315_I	320_V	0.526	0.99
300_I	434_T	0.526	0.99
302_P	431_V	0.524	0.99
380_A	451_K	0.522	0.99
119_I	123_K	0.521	0.98
24_R	29_Q	0.521	0.98
121_Q	125_I	0.521	0.98
498_E	505_R	0.520	0.98
99_I	104_E	0.520	0.98
385_A	437_E	0.520	0.98
453_Q	477_K	0.519	0.98
332_L	358_T	0.519	0.98
182_L	193_L	0.518	0.98
494_R	515_A	0.518	0.98
445_I	541_Y	0.517	0.98
438_V	441_M	0.517	0.98
267_L	270_I	0.517	0.98
512_Y	574_K	0.516	0.98
497_V	507_F	0.516	0.98
357_F	492_I	0.516	0.98
497_V	505_R	0.515	0.98
239_I	457_A	0.515	0.98
21_L	24_R	0.514	0.98
74_G	151_N	0.512	0.98
300_I	437_E	0.512	0.98
28_I	31_F	0.512	0.98
170_A	176_Y	0.511	0.98
27_E	33_T	0.509	0.98
496_V	538_F	0.509	0.98
444_T	481_I	0.509	0.98
130_K	133_I	0.508	0.98
548_K	577_H	0.508	0.98
561_D	567_S	0.505	0.98
53_E	213_V	0.505	0.98
111_L	118_V	0.504	0.98
217_G	221_F	0.504	0.98
212_H	215_G	0.504	0.98
319_M	322_P	0.503	0.98
25_L	28_I	0.503	0.98
264_G	295_Y	0.503	0.98
455_K	473_D	0.503	0.98
510_L	574_K	0.502	0.98
145_Y	149_M	0.502	0.98
451_K	454_V	0.502	0.98
97_A	101_G	0.501	0.98
270_I	543_P	0.501	0.98
302_P	432_K	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ye5A	1	0.8322	100	0.254	Contact Map
2wadA	1	0.8459	100	0.256	Contact Map
4ovdA	2	0.6781	100	0.267	Contact Map
3equA	1	0.6952	100	0.269	Contact Map
1qmeA	1	0.6901	100	0.292	Contact Map
3ue3A	1	0.6901	100	0.293	Contact Map
3vskA	2	0.8784	100	0.3	Contact Map
4bjpA	2	0.6627	100	0.305	Contact Map
3pbtA	1	0.7997	100	0.305	Contact Map
4r23A	1	0.6781	100	0.309	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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